ULCERATIVE COLITIS

This study tests an oral medication called tofacitinib in children aged 2 to 17 with moderate-to-severe ulcerative colitis, a chronic bowel disease causing inflammation and ulcers. The goal is to see if the drug can reduce symptoms and bring about remission, meaning less bleeding…

This study looks at whether a gluten-free diet can help people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). Researchers will track changes in liver enzymes, gut bacteria, and symptoms in 60 adults over time. The goal is to see if avoiding gluten…

This study tests an oral medication called TAK-279 in 207 adults with moderate to severe ulcerative colitis. For the first 12 weeks, some participants get the drug and some get a placebo to see if it reduces bowel inflammation and symptoms. After that, everyone can take TAK-279 f…

This early-phase study tests CP101, a capsule containing beneficial gut bacteria, in 30 adults with mild-to-moderate ulcerative colitis. The goal is to see if the bacteria can safely take hold in the gut and help control the disease. Participants receive either a short or extende…

This study tracks the long-term safety of Simponi in 537 adults with moderate-to-severe ulcerative colitis. Researchers monitor serious side effects, including infections and cancers, while also checking how well the disease is controlled. Participants are already taking or about…

This study tests a new drug called lutikizumab for people with moderate to severe ulcerative colitis, a condition causing colon inflammation and bleeding. About 200 adults will receive either lutikizumab or the standard drug adalimumab to see which works better and is safer. The …

This study tests whether transferring healthy donor stool into the gut (fecal microbiota transplantation) can safely improve symptoms and reduce steroid use in 30 people with mild-to-moderate ulcerative colitis. Participants aged 10–80 will be followed for 48 weeks to see if the …

This study tests whether a plant-based resistant starch, tailored to each child, can help restore a healthier gut microbiome in 100 kids with Crohn's disease or ulcerative colitis. Participants must have mild disease or be in remission. The goal is to boost butyrate production an…

This study looks at whether taking a common ulcerative colitis medication (5-ASA) at a specific time of day can reduce inflammation and improve gut health. About 32 adults with inactive UC but signs of low-level inflammation will take their daily pill either in the morning or eve…

This study tests whether transplanting healthy donor stool into the gut can help control ulcerative colitis, a chronic inflammatory bowel disease. About 150 adults with active disease will receive either a real fecal transplant or a sham procedure. The goal is to see if this appr…

This study planned to give children with mild-to-moderate ulcerative colitis either MitoQ (an antioxidant supplement) or a placebo for 24 weeks, alongside their usual treatment. The goal was to see if MitoQ could improve symptoms, reduce inflammation, and lower the need for stero…

This study tests a new medicine called BI 3032950 in 45 adults with moderate to severe ulcerative colitis who haven't improved with other treatments. The medicine is given first as an IV infusion every 4 weeks, then as a shot under the skin for up to 2 years. Doctors check if sym…

This study looks at the long-term safety and effectiveness of the drug etrasimod for people with moderate to severe ulcerative colitis. Participants have already been in earlier studies and will continue taking etrasimod for up to two years. The goal is to see if the drug can hel…

This study looks at how well and how safely the drug mirikizumab works over the long term (up to 3 years) for people with moderate to severe ulcerative colitis. About 1,058 adults who were already in earlier studies will continue treatment. The goal is to see if the drug can keep…

This study looks at the long-term safety and effectiveness of a daily pill called ABX464 for people with moderate to severe ulcerative colitis. About 200 participants who were already in earlier studies will take the drug for up to 54 months. The goal is to see if the drug can ke…

This study tests an oral medication called upadacitinib in children aged 2–17 with moderate-to-severe ulcerative colitis who haven't responded to standard treatments. The goal is to see if the drug can reduce inflammation and bring the disease under control. The trial involves an…

This study follows about 500 adults with moderate to severe ulcerative colitis who are starting filgotinib, a daily pill. Researchers want to see how long people stay on the drug, how well it controls symptoms, and how it affects quality of life in real-world settings. The goal i…

This study tests whether a plant-based starch, tailored to each child's needs, can improve gut health in 80 children with Crohn's disease or ulcerative colitis. The goal is to boost production of a helpful substance called butyrate and restore a healthier balance of gut bacteria.…

This study tests whether a computer dashboard (iDose) that helps doctors adjust infliximab doses is better than the usual approach for people with Crohn's disease or ulcerative colitis. About 124 adults and teens will be followed for a year to see if the tool leads to more sympto…

This study tests a new medicine called rosnilimab for people with moderate to severe ulcerative colitis, a condition that causes inflammation in the colon. About 132 adults who have not responded well to other treatments will receive either rosnilimab or a placebo. The main goal …

This study tests an experimental drug called MK-7240 (tulisokibart) in about 1020 people with moderate to severe ulcerative colitis. The goal is to see if the drug can help patients achieve and maintain remission (fewer symptoms and healed gut lining) compared to a placebo. Parti…

This study looks at whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard treatment can help people with severe ulcerative colitis or hard-to-treat inflammatory bowel disease. Researchers will compare remission and symptom improveme…

This study tests a drug called guselkumab in over 1,000 people with moderate to severe ulcerative colitis, a chronic bowel disease. The goal is to see if it can reduce symptoms like diarrhea and bleeding and help heal the gut lining. Participants receive either the drug or a plac…

This study tests a daily medication called ABX464 (25 mg or 50 mg) versus a placebo in over 1,100 people with moderate-to-severe ulcerative colitis. The goal is to see if the drug can safely maintain remission for up to 44 weeks. Participants had already completed an earlier indu…

This study tests a remote monitoring system (app and medication reminders) for people with inflammatory bowel disease (IBD) starting a new oral or injectable treatment. About 123 adults will use the system or standard care for 12 months to see if it improves medication adherence,…

This study tests whether a fecal microbiota transplant (FMT) can safely and effectively treat recurrent C. difficile infections in children, including those with inflammatory bowel disease (IBD). Researchers will give healthy donor stool to 250 participants aged 3 to 21 and monit…

This study tests a new drug called GS-1427 for people with moderate to severe ulcerative colitis, a chronic bowel disease. About 228 adults will receive either the drug or a placebo to see if it improves symptoms like bleeding and stool frequency after 12 weeks. The goal is to co…

This study tests an experimental drug called ALTB-268 in 50 adults with moderate-to-severe ulcerative colitis that did not improve with biologic therapies. The goal is to see if the drug can reduce disease activity, measured by symptoms like stool frequency and rectal bleeding, o…

This early-phase study tests whether delivering a person's own fat-derived stem cells directly into an artery is safe for treating moderate to severe ulcerative colitis. About 20 adults aged 18-65 who have not responded to at least two standard medications will receive the treatm…

This study tests whether atorvastatin, a widely used cholesterol-lowering drug, can reduce the risk of colon cancer in people with long-standing ulcerative colitis who carry a specific genetic mutation (P53). About 42 participants will receive either atorvastatin or a placebo for…

This study tests the drug mirikizumab in 172 adults with moderate-to-severe ulcerative colitis who still have sudden, urgent bowel movements despite other treatments. The main goal is to see if the drug reduces the severity and frequency of this urgency over 36 weeks. Participant…

This study tests Aquamin, a natural mineral supplement from red algae, to see if it can improve symptoms and help maintain remission in people with mild ulcerative colitis. About 40 adults with confirmed ulcerative colitis who are either in stable remission or have mild disease w…

This study is observing over 1,000 adults in Brazil with ulcerative colitis or Crohn's disease who are taking or have taken vedolizumab. Researchers are looking at how long people stay on the treatment and what other therapies they have used. No new treatments are being tested—th…

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if this device can effectively detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's diseas…

This study tests a program to help teenagers with Crohn's disease or ulcerative colitis move from pediatric to adult healthcare. About 90 teens aged 16 to 17.5 will either get standard care or a program with a personal navigator, online skills training, and education. The goal is…

This study looks at how doctors prescribe treatments for ulcerative colitis (UC) and aims to create an updated treatment guide. Researchers will track 4,000 patients from a registry to see which treatments work best and when to switch therapies. The goal is to improve long-term o…

This study compares two ways of taking biopsies during colonoscopy in people with inflammatory bowel disease (IBD). About 1642 participants will be randomly assigned to either a limited biopsy approach or a more extensive random biopsy approach. The goal is to see which method fi…

This study follows 15,000 adults and children (age 2+) with Crohn's disease, ulcerative colitis, or indeterminate colitis for up to 5 years. Researchers will collect data on how patients respond to treatments, side effects, and disease changes in everyday medical practice. The go…

This study looks at whether people with inflammatory bowel disease (IBD) have better outcomes and feel more in control of their health when they can text their medical team and regularly report symptoms via text surveys. About 900 participants will be split into two groups: one g…

This study is a long-term registry that follows nearly 5,000 children with inflammatory bowel disease (Crohn's, ulcerative colitis, or indeterminate colitis) to monitor their safety and health over time. Researchers collect information on side effects from treatments like inflixi…