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Broccoli sprouts: the surprising new hope for gut health?

NCT ID NCT05507931

Symptom relief Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether eating steamed broccoli sprouts daily for 28 days could increase anti-inflammatory compounds in the blood and stool of people with mild ulcerative colitis. 23 participants took either 1 or 3 servings of sprouts per day. The goal was to see if this diet is feasible and could reduce inflammation, paving the way for a larger trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
broccoli sprouts
What this could lead to
If it works, this could point toward a simple dietary addition to help manage mild ulcerative colitis symptoms.
What could go wrong
This is a very small pilot study with only 23 people, so results may not apply to everyone. It only tested feasibility and short-term effects, not long-term benefits or risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

23 people

The number who actually took part.

Started

May 2023

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Documented endoscopic diagnosis of ulcerative colitis * Currently being treated with a stable dose of 5-ASAs, steroids, or any other medication approved for ulcerative colitis * If on 5-ASA, no dose changes within 2 weeks before the Day 0 visit * If on steroids, prednisone dose not more than 20 mg daily and entocort not more than 9 mg daily, with no dose changes within 2 weeks before the Day 0 visit * All other medications require a stable dose for at least 8 weeks prior to enrollment. * No dose changes to any IBD medication anticipated for the duration of the study * Body Mass Index (BMI) values 18.5-40 kg/m2 * Not on total parenteral nutrition (TPN) or receiving tube feeds. * Ability to understand the study procedures, benefits and risks, and sign a written informed consent document. * Able to fill out questionnaires regarding dietary intakes, bowel symptoms, and study experience Exclusion Criteria: * Taking Non-steroidal anti-inflammatory drugs (NSAIDs) * Following a medically-prescribed diet, on Total parenteral nutrition (TPN), or tube feeds * Newly diagnosed (within past month), or uncontrolled diabetes or cardiovascular disease * Antibiotics in the previous 2 weeks * Consumption of more than 5 ½ cups of servings/day of fruits and vegetables as assessed by the National Cancer Institute (NCI) Diet History Questionaire III online Food Questionnaire. * A known allergy or sensitivity to cruciferous vegetables like arugula, bok choy, broccoli, cabbage, cauliflower, or collard greens

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Conditions

The condition(s) this trial relates to.

inflammatory bowel disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ulcerative colitis Ulcerative colitis chronic mild

Contacts and locations

Locations

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.