INSOMNIA

This study tests a program called TAILOR that helps teenagers with insomnia and suicidal thoughts improve their sleep. The goal is to see if fixing sleep problems can lower the risk of suicidal behavior. The study will involve 235 teens aged 11 to 18 who have had recent suicidal …

This study tests whether a sleep drug (lemborexant) can lower levels of brain-damage-related proteins in the blood of adults with insomnia. Twenty participants aged 40–65 will take the drug or a placebo for two weeks each. The goal is to see if improving sleep can reduce markers …

This study tests if wearable devices like movement sensors, EEG headbands, and smartphones can accurately measure sleep stages compared to the standard sleep lab test (polysomnography). Researchers will first test 48 healthy volunteers, then 60 people with sleep problems like ins…

This study tests a mindfulness-based sleep program for pregnant women with insomnia to see if it can prevent depression during and after pregnancy. About 500 pregnant women will either take the program or receive standard care. The goal is to improve sleep and reduce the risk of …

This study tests a wellness program for adults with cystic fibrosis who struggle with fatigue and poor sleep. About 80 participants will either join the program or continue their usual care. The program includes coaching sessions and uses a fitness tracker to monitor activity and…

This study tests a fast, 5-day group therapy program for veterans and active-duty military who struggle with PTSD, insomnia, and nightmares. Participants will receive either a specialized cognitive-behavioral therapy or basic sleep advice, both combined with a proven PTSD writing…

This study tests whether a non-invasive brain stimulation technique called TMS can improve sleep in people with insomnia. Over 2 weeks, 144 adults will receive either real TMS to different brain areas or a sham (fake) treatment. Researchers will monitor sleep at home and in the l…

This study tests a virtual cognitive behavioral therapy program designed to improve sleep for people with cirrhosis who also have insomnia. Ten adults with cirrhosis and sleep difficulties will try the program from home. The goal is to see if the program is practical and well-lik…

This study tests two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV. Participants must be 25-65, have HIV, chronic pain, and in…

This study tests a short program designed to help young adults (ages 18-29) who drink heavily, use cannabis, and have trouble sleeping. The program aims to reduce alcohol and marijuana use and improve sleep quality. Researchers will enroll 800 people in Washington State to see if…

This study aims to find out if a shorter insomnia treatment works as well as a longer one for adults who are socioeconomically disadvantaged. 350 participants will receive either tele-Brief Behavioral Treatment for Insomnia or tele-Cognitive-Behavioral Therapy for Insomnia. The g…

This study compares two online sleep treatments for 200 adults who have trouble sleeping and use cannabis. One group gets cognitive behavioral therapy tailored for cannabis users, the other gets basic sleep tips. The goal is to see if better sleep reduces cannabis use and improve…

This study tests an online sleep course for adults who have trouble falling or staying asleep, and feel tired or distressed during the day. About 56 people from Saskatchewan will take part. The course teaches healthy sleep habits and thinking patterns, and researchers will check …

This early study tests whether a type of talk therapy for insomnia (CBTi) can improve sleep, blood sugar control, and quality of life in adults with type 1 diabetes. Fifteen participants will either get 8 virtual therapy sessions or health education emails and calls. The study fo…

This study tests a new way to improve sleep in people with mild cognitive impairment (MCI). It combines gentle brain stimulation (transcranial magnetic stimulation) with talk therapy (cognitive behavioral therapy for insomnia). The goal is to see if this approach can reduce insom…

This study tests a parent-led sleep program delivered online for children aged 6-12 with autism and insomnia. About 195 families will try the program, with some getting extra personal support. The goal is to improve the child's sleep, daytime behavior, and also help parents sleep…

This study tests whether using a mindfulness meditation app at bedtime can help people with chronic insomnia fall asleep more easily. Thirty adults with long-term sleep problems will be split into three groups: one using the app with guided meditation, one using the app without g…

This study tests whether personalized sleep strategies or guided aerobic exercise can improve sleep in first-time mothers struggling with insomnia. About 135 women between 4 and 12 months after childbirth will join. Participants will either follow a sleep management program, an e…

This study looks at two different methods to help babies with insomnia sleep better. One method only limits parent-child interaction at bedtime, while the other also targets night-wakings. The goal is to see which approach works faster and is easier for parents to stick with, whi…

This study tests a culturally adapted internet-based therapy for Farsi/Dari-speaking migrants and refugees aged 15-29 who have mild to moderate anxiety or depression. Participants will receive the therapy over 6-10 weeks, and researchers will measure changes in symptoms compared …

This study tests a small, non-invasive earbud device that gently stimulates a nerve in the ear to treat insomnia in adults who survived childhood acute lymphoblastic leukemia (ALL). About 40 survivors with moderate to severe insomnia will use the device nightly for up to 8 weeks.…

This study tests whether the sleep medication suvorexant can help people with opioid use disorder who also have trouble sleeping. About 300 adults on stable medication for opioid use disorder will receive either suvorexant or a placebo for 8 weeks. Researchers will measure sleep …

This study tests whether a proven sleep treatment (CBT-I) can improve depression and anxiety by targeting the brain's emotion control network. Researchers will use brain scans to see if better sleep changes brain activity. The study involves 120 adults with insomnia and depressio…

This study tests whether a smartphone app called SleepUp can help people with insomnia sleep better. The app provides online therapy based on proven techniques (CBTi). About 280 adults with at least mild insomnia will be split into groups: some get the app, some get standard vide…

This study trains psychotherapists to give personalized talk therapy to cancer patients and their caregivers who are feeling very distressed. Therapists will learn several proven methods, like cognitive behavioral therapy and mindfulness, to help with anxiety, depression, pain, f…

This study looks at whether treating ongoing sleep problems after PTSD therapy can also improve heart health in older adults. About 167 veterans aged 50 and older with PTSD and insomnia will receive talk therapy for PTSD, followed by a non-drug sleep program if needed. Researcher…

This study tests whether a mobile health program (mPATH) can improve memory and sleep in low-income older adults who are not very active and have trouble sleeping. About 176 participants will use a smartphone app to guide physical activity. The goal is to see if this approach hel…

This study tests whether a special breathing device (adaptive servo ventilation) can help people with moderate to severe chronic insomnia sleep better. About 25 adults who have not tried sleep apnea treatments before will use the device for 4 weeks. Researchers will measure chang…

This study tests whether adding a meditation program or pain education to standard sleep therapy (CBT for insomnia) can better reduce pain in adults with chronic low back pain and insomnia. About 300 participants will be assigned to one of these add-on treatments. The goal is to …

This study compares two types of talk therapy for insomnia in 160 active-duty military personnel who have had a mild traumatic brain injury at least three months ago and still have sleep and other symptoms. One therapy is six sessions of Cognitive Behavioral Therapy for Insomnia …

This study tests two treatments for insomnia in perimenopausal women: hormone replacement therapy (HRT) and cognitive behavioral therapy (CBT-I). 54 women will receive one of these treatments or sleep hygiene advice for 8 weeks. The goal is to see which approach best reduces inso…

This study is testing whether using a special blanket for 4 weeks can improve sleep in 672 young people aged 16-24 who have trouble sleeping. Participants will be randomly assigned to use one of two special blankets or no blanket at all. The goal is to find a safe, non-drug way t…

This study tests if stimulating specific points on the ear can improve stomach discomfort and sleep in people with functional dyspepsia (chronic indigestion) and insomnia. Researchers will enroll 176 adults and measure symptom relief after 2 and 8 weeks. The goal is to find a saf…

This study looks at 250 women who have had early-stage breast cancer and now struggle with both insomnia and being overweight. Researchers want to see if a special sleep therapy before a weight loss program helps them lose more weight than just learning about sleep. The goal is t…

This study tests whether a special sleep education program can improve sleep quality and reduce depression in menopausal women. About 500 women will be randomly assigned to either receive the education or be in a control group. The program teaches good sleep habits based on the I…

This study tests whether one-on-one sleep therapy via video calls works better than a self-guided website for improving sleep and reducing fatigue in people with multiple sclerosis (MS). About 90 adults with MS and insomnia will receive either live therapy, web-based lessons, or …

This study compares three common insomnia treatments—two medications (trazodone and daridorexant) and an online behavioral program—in 1,000 women aged 40-62 who are in or near menopause. Participants will take their assigned treatment for 12 months, wear a Fitbit, keep a sleep di…

This study looks at whether adding a sleep improvement program to personalized exercise coaching can reduce knee pain more than exercise alone. About 288 older adults with knee osteoarthritis and insomnia will take part remotely. The goal is to see if treating both pain and sleep…

This study looks at two common treatments for chronic insomnia: cognitive behavioral therapy (CBT-I) and a low-dose medication called trazodone. Researchers want to see if these treatments work differently depending on whether a person sleeps very little or a normal amount. The g…

This study tests a nurse-guided brief behavioral treatment for insomnia in people recovering from traumatic brain injury (TBI). About 93 participants will receive either in-person or mobile-delivered therapy to improve sleep, mood, and thinking skills. The goal is to find a simpl…

This study tests a web-based program called NiteCAPP to improve sleep in 100 rural caregivers of people with dementia. Caregivers with insomnia will use the program and report on sleep, mood, stress, and health over 12 months. The goal is to see if the program helps caregivers sl…

This study tests whether treating both frequent nighttime urination (nocturia) and insomnia together can help older adults sleep better and improve their quality of life. Researchers will enroll 192 people aged 60 and older who wake up at least twice a night to urinate and have t…

This study tests whether helping people sleep better for 4 weeks before knee or hip replacement surgery can reduce pain and speed recovery afterward. About 100 adults with insomnia and osteoarthritis will receive either a brief sleep therapy (CBT-I) or sleep education before thei…

This study tests whether giving rTMS (a non-invasive brain stimulation) in the morning or evening works better for treating insomnia. Ten adults with insomnia will receive 10 sessions over two weeks. Researchers will track sleep quality and brain activity to find the best timing …

This study tests a therapy called CBT-I for children aged 7-11 who have trouble sleeping. It looks at whether a part of this therapy, called sleep restriction therapy, is key to helping them. 120 children will be split into three groups to compare different versions of the therap…

This study is testing a sleep medication called lemborexant in 121 adults who have both a mental health condition and insomnia. Participants will take the drug for 8 weeks to see if it improves their sleep and is safe. The goal is to find better treatment options for people with …

This study tests whether the sleep medication lemborexant can help both sleep problems and movement difficulties in people with Parkinson's disease. Researchers will enroll 44 adults aged 50 and older with Parkinson's and insomnia. The goal is to see if improving sleep also leads…

This study tests an online program that teaches older adults with insomnia and memory complaints better sleep habits. Researchers want to see if improving sleep can also boost thinking skills and mood. The program is compared to a control group over several weeks.

This study tests whether the drug pimavanserin can improve sleep in veterans who have both PTSD and insomnia. About 60 veterans will receive either the drug or a placebo for 8 weeks. Researchers will measure changes in sleep quality and PTSD symptoms to see if the drug helps.

This study tests a combined approach to help people who have used sleeping pills for a long time reduce or stop them safely. Researchers will compare supervised medication tapering alone versus tapering plus a digital cognitive behavioral therapy program for insomnia. The goal is…

This study tests an internet-based therapy for insomnia, called the Sleep Course, designed for public safety personnel like police and firefighters. About 60 participants will try the program to see if it helps them sleep better and is easy to use. The goal is to improve sleep qu…

This study tests whether a digital sleep program (a mobile app and a wrist-worn activity tracker) can help older adults sleep better and protect their brain health after hip or knee replacement surgery. About 50 people aged 65 and older with mild insomnia will use the app before …

This study tests whether a type of talk therapy for insomnia (CBT-I) can also reduce impulsive behavior and risk-taking in young people aged 12 to 24. Researchers will measure changes in impulsivity and sleep quality over time. The goal is to see if improving sleep can help preve…

This study is testing whether a web-based program called SHUTi can help Black/African American prostate cancer survivors sleep better. About 40 people will be randomly assigned to either the SHUTi program or an educational website. The goal is to see if the online treatment is pr…

This study tests three home-based programs for people with long-term muscle or joint pain (like back pain or arthritis) who also sleep poorly. Participants will be randomly assigned to exercise, cognitive behavioral therapy for insomnia, or both, with online coaching for 12 month…

This study tests a digital cognitive behavioral therapy (CBT) program for people with insomnia. Researchers will enroll 200 adults to see if the app-based treatment improves sleep, anxiety, depression, and quality of life, while also measuring costs. The goal is to find a conveni…

This study tests whether a mindfulness-based sleep program can help Black women with insomnia sleep better and reduce stress. Researchers will enroll 340 Black women who have trouble sleeping. The goal is to see if better sleep can lower the risk of heart disease and other health…

This study aims to find the best way to treat U.S. military veterans who have both insomnia and depression using digital behavioral treatments. Researchers will compare different sequences of treatment to see which order works best. The study enrolls 1,200 veterans and focuses on…

This study tests whether a smartphone app called iCANSleep can help cancer survivors with insomnia sleep better. The app uses a proven therapy called Cognitive Behavioural Therapy for Insomnia (CBT-I). Researchers will compare 146 cancer survivors who use the app to those on a wa…

This study tests a specially adapted version of Cognitive Behavioral Therapy for Insomnia (CBT-I) designed for teenagers. About 28 teens with insomnia will either receive the therapy or be placed on a waitlist. Researchers will measure sleep improvements and how acceptable teens …

This study tests a special sleep therapy (trauma-informed CBT for insomnia) in women veterans who have both PTSD and trouble sleeping. The goal is to see if improving sleep helps them feel more ready and willing to start PTSD treatment. About 100 women will be randomly assigned t…

This study tests two types of talk therapy—cognitive behavioral therapy (CBT) and mindfulness-based therapy—to see which works better for treating insomnia and related depression in people who have had a mild to moderate traumatic brain injury (TBI) and also have post-traumatic s…

This study looks at ways to help people complete an online program for insomnia called digital cognitive behavioral therapy (dCBT-I). Researchers will track 600 adults with insomnia to see what factors—like sleep environment or daily habits—affect whether people finish the progra…

This study tests a guided online program for insomnia in 80 adults who had a moderate to severe traumatic brain injury at least one year ago. The program is a computerized version of cognitive behavioral therapy for insomnia (cCBT-I) and is compared to usual care. The goal is to …

This study explores how poor sleep during pregnancy may increase the risk of stress and mental health problems after giving birth. Researchers will follow 114 pregnant women, measuring sleep quality, stress hormones, and mood. They will also test an online program designed to imp…

This study follows 82 children aged 8-18 who have obstructive sleep apnea and are starting positive airway pressure (PAP) therapy. Researchers want to see if insomnia makes kids less likely to use their PAP machines regularly, and how race and ethnicity may influence this. The go…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep issues. Researchers will track insomnia over the first year using questionnaires to see how it develops and what factors—like treatment or emotional distress—may trigger or worsen it. The goal is to…

This study looks at whether people with insomnia need different amounts of anesthesia during a digestive endoscopy compared to people who sleep normally. Researchers will enroll 3360 adults aged 18-64. The goal is to measure total anesthetic drug use and track any side effects.

This study looks at whether people with insomnia need a different amount of the sedative ciprofol during a digestive endoscopy compared to those who sleep normally. Researchers will enroll 840 adults aged 18-64 who are scheduled for the procedure. The goal is to improve sedation …

This study looks at sleep problems like sleep apnea and insomnia in people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. About 226 stroke survivors will use home sleep tests and wearables to track the…

This study looks at how getting only 4 hours of sleep for three nights, or having insomnia, changes the way people handle their emotions. Researchers will compare these groups to people who sleep normally. They use brain scans and emotion tasks to understand the effects.

This study looks at how insomnia affects a brain chemical called norepinephrine, sleep quality, and thinking skills in adults aged 55 and older. Researchers will compare 60 people with insomnia to those with normal sleep, using blood tests, sleep monitoring, and a light therapy i…

This study looks at whether people with insomnia need more or less of the sedative etomidate during a digestive endoscopy compared to people who sleep normally. Researchers will track the total amount of etomidate used and watch for side effects like low oxygen or low blood press…

This study tests two school-based programs designed to help teenagers sleep better, with the goal of improving mental health and school performance. About 3000 students aged 13-19 in Swedish high schools will take part, and their results will be compared to students who receive u…

This study looks at whether people with insomnia need a different amount of the sedative rimazolen during a digestive endoscopy (a scope procedure) compared to people who sleep normally. Researchers will enroll 840 adults aged 18–64 who are scheduled for the procedure. The goal i…

This study is testing whether brain scans can predict how well people with depression, insomnia, or social anxiety will respond to internet-delivered cognitive behavioral therapy (iCBT). Researchers will compare brain scan data with patients' own expectations to see which is bett…

This study follows about 785 pregnant women with insomnia to see if taking the sleep medication QUVIVIQ affects pregnancy or baby health. Researchers compare outcomes like birth defects and complications between women who took QUVIVIQ and those who used other insomnia treatments …

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…