DIABETES MELLITUS, TYPE 2

This study was designed to see if adding an experimental drug called ofirnoflast to the standard diabetes medication semaglutide helps obese or overweight adults with type 2 diabetes control their blood sugar and lose more weight. The trial planned to compare the combination agai…

This study tests whether a probiotic (Lactobacillus reuteri) is as good as a standard mouthwash (chlorhexidine) at reducing harmful bacteria in people with both gum disease and type 2 diabetes. Twenty participants will use one of the treatments for 30 days. The goal is to see if …

This early study tests a new procedure that uses heat to treat the lining of the small intestine in people with type 2 diabetes who need insulin. The goal is to see if this treatment, alone or with a diabetes drug called semaglutide, can safely help them stop taking insulin and k…

This study tests whether teaching community clinics through video calls can help them start a program for Latino adults with type 2 diabetes. The program includes support from community health workers, help getting medication, and diabetes education. Researchers will compare bloo…

This study tests whether a natural substance called spermidine can improve heart and muscle health in people aged 65 and older with coronary artery disease. Participants take spermidine or a placebo for a period, and researchers measure changes in heart mass, muscle mass, inflamm…

This study aimed to see if combining two diabetes medications (SGLT2 inhibitor and DPP-4 inhibitor) works better than each drug alone for people with type 2 diabetes whose blood sugar is not well controlled on metformin. It planned to enroll adults aged 18 to 80. However, the stu…

This study tests an experimental drug called MN-001 in 40 adults with fatty liver disease, type 2 diabetes, and high triglycerides. Participants take either the drug or a placebo daily for 24 weeks. The main goals are to see if the drug reduces liver fat and lowers blood fat leve…

This study tests a procedure that uses gentle electric pulses to regenerate the lining of the small intestine in people with type 2 diabetes who need insulin. The goal is to see if this treatment, combined with a diabetes drug, can help patients stop using insulin and control the…

This study compares two ways to lose weight and reduce liver damage in people with cardiometabolic risks like type 2 diabetes or obesity. One group will follow a Mediterranean diet with intermittent fasting, while the other group takes a weight-loss medication (naltrexone/bupropi…

This study looks at whether using a continuous glucose monitor (CGM) helps people with diabetes who are on dialysis keep their blood sugar in a healthy range. About 96 adults on either hemodialysis or peritoneal dialysis will be split into three groups: one using standard finger-…

This study looks at whether giving monthly money for healthy home-delivered food can lower blood sugar levels in adults with type 2 diabetes. About 1,000 Kaiser Permanente members with Medi-Cal insurance and high blood sugar are taking part. The goal is to see if better access to…

This study looks at whether using a continuous glucose monitor (FreeStyle Libre 3) helps adults with type 2 diabetes improve their blood sugar levels compared to traditional finger-stick testing. About 470 people whose blood sugar is not well controlled will use either the monito…

This study looks at how semaglutide, a diabetes medicine, affects diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, added to their usual diabetes care. The goal is to see if semaglutide sl…

This study tests a new once-weekly injection, retatrutide, against the established drug semaglutide in adults with type 2 diabetes whose blood sugar is not well controlled by metformin. About 1,250 participants will receive either drug for up to 26 months to see which better lowe…

This study compares two diabetes treatments—a combination drug (iGlarLixi) versus insulin alone—to see which better reduces liver fat in people with type 2 diabetes and fatty liver disease. About 36 participants will take the assigned medication for 12 weeks. The goal is to find …

This early-phase study tests a new approach for people with type 2 diabetes who need insulin. Doctors will take a small sample of pancreatic tissue, grow insulin-making cells in the lab, and transplant them under the belly skin. The goal is to see if these cells can safely produc…

This study looks at whether eating all meals earlier in the day and using timed light therapy can help control blood sugar in adults with type 2 diabetes. About 344 participants will follow these routines to see if they improve glucose levels, sleep, weight, and mood. The goal is…

This study looks at how well Envlo or Envlomet SR tablets control blood sugar in 15,000 adults with type 2 diabetes over 24 weeks. Participants take the medicine as part of their normal care. The goal is to see if these tablets safely lower blood sugar levels.

This study tests whether weight-loss surgery is better than intensive medical treatment for controlling type 2 diabetes in teenagers aged 13 to 19.9. The goal is to see which approach leads to better blood sugar control and fewer health problems. The study involves 88 participant…

This study tests whether choosing diabetes medications based on a person's genetic profile works better than standard care for controlling blood sugar. About 500 adults aged 40-70 with poorly controlled type 2 diabetes will receive either gene-guided or standard treatment. Resear…

This study compares two ways to check blood sugar in adults with type 2 diabetes: the traditional fingerstick method versus a continuous glucose monitor. About 360 people will be randomly assigned to one of the two methods for 12 months. The goal is to see which approach better l…

This study tests a wireless glucose monitoring system that sends blood sugar readings from the patient's bedside to the nursing station. The goal is to help nurses catch and prevent low blood sugar (hypoglycemia) in hospitalized veterans with type 2 diabetes who use insulin. Abou…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplantation) can improve insulin sensitivity and blood sugar control in 16 adults with type 2 diabetes. Participants receive either the transplant or a placebo, and researchers measure changes in gl…

This study tests a new investigational medicine called CagriSema against tirzepatide, an approved drug, in people with type 2 diabetes. About 1023 adults whose blood sugar is not well controlled on metformin or SGLT2 inhibitors will receive weekly injections of either CagriSema o…

This study tests whether a second heat treatment inside the upper gut can help people with type 2 diabetes who did not get better after the first treatment. The procedure uses a special device to apply heat to the lining of the small intestine. The goal is to improve blood sugar …

This study compares a low-carb, high-protein diet to a standard diabetes diet in 100 adults with type 2 diabetes and overweight. Over 12 months, researchers will measure changes in blood sugar, weight, and heart health. The goal is to see if cutting carbs can better control diabe…

This study looks at how different exercise programs (moderate or high-intensity) and a diet plan affect appetite, blood sugar, and body fat in people with type 2 diabetes. About 146 adults will take part in a 12-week program. The goal is to find the best combination to improve he…

This study tests a medicine called imeglimin in adults with type 2 diabetes who currently manage their condition with diet and exercise. About 567 participants will take the drug for up to 3 years to see how long it keeps their blood sugar at healthy levels. The goal is to find o…

This study tests whether a program that involves a family member or close friend can help African American adults with type 2 diabetes better manage their blood sugar and improve their quality of life. About 208 participants will work with a partner to learn diabetes self-care sk…

This study looks at the best way to control blood sugar in pregnant women with diabetes who need steroid shots to help their baby's lungs develop before a possible early birth. Steroids can raise blood sugar, which may be harmful. The trial compares three insulin strategies to fi…

This study tests a special toolkit designed to help people with type 2 diabetes who need to start using insulin after leaving the hospital. About 120 adults will be randomly assigned to use the toolkit or receive usual care. The goal is to see if the toolkit helps keep blood suga…

This study looks at whether a program that combines in-person doctor-patient conversations with text message reminders can help people with type 2 diabetes take their medications as prescribed. The goal is to improve blood sugar, cholesterol, and blood pressure control, and ultim…

This study looks at how safe and effective Ozempic is for adults with type 2 diabetes when used in everyday medical practice in Korea. About 600 people will take the drug as prescribed by their doctor, and researchers will track side effects and blood sugar events over 26 weeks. …

This study tests whether an AI program that shows patients how their health compares to others, plus home blood sugar monitoring, can help people with type 2 diabetes better understand their risks and improve their blood sugar control. About 360 adults aged 36–65 with poorly cont…

This study aimed to see if a virtual weight control program (WW) could lower blood sugar levels in adults with type 2 diabetes and obesity. It planned to enroll about 0 participants aged 18-74 with high blood sugar and overweight. However, the study was withdrawn before any parti…

This study tests whether monthly support sessions led by trained Black men with diabetes can help other Black men better manage their type 2 diabetes. All participants receive diabetes education, and half also get 6 months of peer support followed by ongoing group activities. The…

This study tests an online program to help 2,000 women who had gestational diabetes complete recommended postpartum diabetes tests and join lifestyle programs. The goal is to prevent or delay type 2 diabetes by making follow-up care easier and more accessible.

This study looks at whether making dietary guidelines more culturally relevant can help African American adults eat healthier and lower their risk for type 2 diabetes. About 198 participants will be randomly assigned to one of three eating patterns: a standard healthy U.S. diet, …

This study looks at whether teaching people with type 2 diabetes about good sleep habits and a simple relaxation exercise can reduce anxiety, improve sleep quality, and help control blood sugar. About 52 adults with type 2 diabetes who have poor sleep will take part. They will le…

This study tests whether a new medicine called CagriSema can reduce painful nerve damage in people with type 2 diabetes. About 142 adults will receive either the active drug or a placebo for around 10 months. The main goal is to see if it lowers weekly pain scores.

This study tests whether a special computer-based brain training program can improve memory and thinking in older adults (60+) who have type 2 diabetes and are at high risk for dementia. 120 participants will be randomly assigned to either the adaptive training or a placebo versi…

This study tests a web-based tool that gives personalized estimates of benefits and risks of obesity treatments (like surgery or medications) to help doctors and patients with type 2 diabetes and severe obesity make informed decisions. About 10,000 adults across 40 primary care c…

This study looks at two different ways to monitor people with type 2 diabetes from home using technology. The goal is to see which design works best and is most acceptable to patients and healthcare providers. The results will help plan a larger future study. About 60 adults with…

This study observes over 547,000 people in France who started taking SGLT2i drugs for type 2 diabetes. Researchers will describe patient characteristics and how the drugs are prescribed, and track heart, kidney, and safety events. The goal is to understand real-world use and outc…

This study looks at how long you need to fast and how stopping the diabetes drug tirzepatide changes the amount of food and liquid left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 adults with type 2 diabetes or obesity. The goal i…

This study follows over 800 people who either have type 2 diabetes or have a family history of it. Researchers track who develops diabetes over time to improve a risk prediction model. The goal is to better understand how family history and other factors contribute to the disease…

This study looked at how different types of aerobic exercise (moderate steady walking vs. short bursts of high intensity) and diet advice affect the tiny power plants inside cells (mitochondria) and stress levels in people with type 2 diabetes. 146 adults with diabetes or prediab…

This study gives healthy Amish volunteers a diabetes drug called canagliflozin for five days to see how their genes influence the drug's effects. Researchers measure urine sugar and other health markers to find genetic variants linked to drug response. The goal is to learn why pe…

This study looks at whether a medication used for heart failure can also help people with type 2 diabetes or pre-diabetes. The drug blocks an enzyme that breaks down hormones, possibly increasing a hormone called GLP-1 that helps release insulin after meals. Researchers will meas…

This study collects blood, urine, and tissue samples from 500 adults with obesity to help researchers learn why people gain or lose weight, and why some regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up t…

This pilot study looks at 40 adults with type 2 diabetes and age-related cataracts who take metformin. Researchers measure how much metformin reaches the lens capsule and test whether it slows lens cell growth in the lab. The goal is to understand if metformin might help prevent …

This study trains church members to become community health workers who help Latino(a) adults manage diabetes and reduce their risk. About 400 Spanish-speaking participants will learn about diabetes and get support to overcome barriers to healthcare. The goal is to see if this ch…

This study looks at American Indians with type 2 diabetes who have kidney problems. Researchers want to see if a past treatment with the drug losartan still helps protect their kidneys years later. Participants will have tests like blood and urine samples, and some will get a kid…

This study looks at whether routinely checking for heart disease in people with type 2 diabetes who are at very high risk is worth the cost and effort. Researchers will analyze data from 90,000 patients in French health databases to compare those who were screened versus those wh…

This study looks at whether the diabetes drug empagliflozin is as safe and effective in everyday patients as it was in earlier clinical trials. Researchers will analyze health records from over 200,000 adults with type 2 diabetes who started taking empagliflozin or a similar drug…

This study aims to help 880 adults in rural Pennsylvania who are overweight, have type 2 diabetes, or are not very active. Researchers will test different ways to encourage more physical activity. Participants will report their activity and wear a device to track it.

This study will enroll 1,000 adults with type 2 diabetes in Mexico to find out which clinical, lifestyle, and genetic factors are linked to poor blood sugar control and kidney damage. Participants will provide medical history, undergo physical tests, answer questionnaires, and gi…

This study follows 400 children with growth hormone deficiency who are already taking somapacitan (a once-weekly injection) to see how safe it is over the long term. Researchers will track side effects, medication errors, and whether any children develop new health issues like di…

This study looks at how vitamin D levels might influence blood pressure in people with type 2 diabetes. Researchers will collect blood samples from 40 participants to see if certain immune cells (monocytes) trigger a hormone that raises blood pressure. The goal is to better under…

This long-term study followed over 6,400 adults from different racial and ethnic backgrounds to learn how early signs of heart disease develop and lead to serious events like heart attacks or strokes. Participants were healthy at the start and were monitored for years through exa…

This study aims to see if personalized screening invitations—tailored by race, ethnicity, and diabetes risk—are more effective than generic invitations at getting people tested for type 2 diabetes or prediabetes. About 500,000 adults from Parkland clinics will receive either a ta…

This study aims to find genetic variations that increase the risk of type 2 diabetes, its complications like kidney disease, and related conditions such as obesity. Over 2,300 adults, especially American Indians and Mexican Americans, will provide health history, blood samples, a…

This study looks at how well a daily low-dose (80 mg) enteric-coated aspirin works in 50 adults with type 2 diabetes who have not taken aspirin recently. Researchers measure blood platelet function before and after 7 days of aspirin to see if the drug fully prevents clotting. The…

This study looks at whether giving extra support to care teams at community health centers helps them better screen patients for non-medical needs—like food, housing, or transportation—and connect them to community services. About 20 health centers will take part. The goal is to …