DIABETES MELLITUS, TYPE 2

This study is testing if probiotic capsules are as good as a standard antiseptic mouthwash at reducing a specific harmful bacteria linked to gum disease. It involves 20 adults in Colima, Mexico, who have both gum disease and type 2 diabetes. All participants will first get a prof…

This study tests whether a family-focused education program helps African American adults with type 2 diabetes better manage their condition. Participants and a family member attend virtual group sessions over 12 weeks to learn about diabetes self-care and family support. Researc…

This study is testing whether a new weekly injection called CagriSema works better than an existing medication called tirzepatide for people with type 2 diabetes. About 1,000 participants whose diabetes isn't well controlled on current pills will receive either CagriSema or tirze…

This study tests whether remotely mentoring local clinic teams can help them successfully start and run a comprehensive diabetes care program. The program includes telehealth support, community health workers, medication access help, and education. Researchers will compare health…

This study is testing whether using a continuous glucose monitor (CGM) can help diabetic patients on dialysis better manage their blood sugar levels. It compares three groups: standard finger-prick checks, using a CGM part-time, or using a CGM full-time over nine months. The goal…

This study is testing whether a personalized brain training program on a tablet can help improve memory and thinking skills in older adults with diabetes who are at high risk for dementia. Participants will be randomly assigned to either the active brain training program or a sim…

This study aims to see if a combination diabetes injection (iGlarLixi) works better than a standard insulin injection (iGlar) at reducing fat in the liver. It will involve 36 adults who have both type 2 diabetes and a fatty liver condition called MASLD. Participants will receive …

This study is testing if delivering healthy, pre-made meals designed for diabetes can help people better manage their blood sugar. It involves 200 adults with type 2 diabetes who also have trouble affording enough food. Half will receive weekly meal deliveries and coaching for 6 …

This study is testing if changing *when* you eat and get light exposure can help control type 2 diabetes. Researchers are enrolling 344 adults with type 2 diabetes to try either eating all meals earlier in the day, using timed bright light therapy, both, or neither for 16 weeks. …

This study is testing whether using patients' genetic information to select diabetes medications works better than standard treatment. Researchers will compare two groups of 504 adults with type 2 diabetes whose blood sugar isn't well controlled. One group will receive medication…

This study is testing whether an oral medication called MN-001 can reduce liver fat and lower triglyceride levels in people who have non-alcoholic fatty liver disease, type 2 diabetes, and high triglycerides. About 40 participants will take either the study drug or a placebo pill…

This study is testing whether a low-carbohydrate, high-protein diet works better than a standard diabetes diet for managing type 2 diabetes. For 12 months, 100 adults with type 2 diabetes and overweight will follow one of these two diets, with most of their food provided in meal …

This 5-year study is testing whether adding a weekly injection called semaglutide to standard diabetes care can slow the progression of diabetic eye disease. About 1,500 adults with type 2 diabetes will receive either semaglutide or a placebo injection. Researchers will track cha…

This study is testing a web-based decision support tool in primary care clinics. The tool provides personalized information to doctors and patients about the potential benefits and risks of different weight loss treatments, like medication or surgery, for people with type 2 diabe…

This study is testing if a heart failure medication might also help people with type 2 diabetes or pre-diabetes. Researchers want to see if the drug helps the body keep more of a natural hormone that lowers blood sugar after eating. The trial involves 25 adults and compares the e…

This study is testing if using a wearable sensor (FreeStyle Libre 3) that continuously tracks blood sugar helps adults with type 2 diabetes manage their condition better than the standard finger-prick method. It involves about 470 adults whose diabetes is not fully controlled des…

This study is testing whether a combination of in-person coaching and text message reminders helps people with type 2 diabetes take their medications more consistently. The goal is to better control blood sugar and reduce the risk of heart disease, especially in low-income and mi…

This study aims to find the best method to control blood sugar in pregnant women with diabetes who need steroid shots to help their baby's lungs develop early due to risk of preterm birth. Researchers are comparing three different insulin management strategies over 5 days to see …

This study compares two common ways people with type 2 diabetes check their blood sugar: continuous glucose monitors (CGM) worn on the skin versus traditional fingerstick tests. It involves 360 patients across 50 primary care clinics over 12 months to see which method works bette…

This study is testing whether providing monthly money for healthy groceries helps people with type 2 diabetes lower their blood sugar levels more than just offering free grocery delivery. It involves about 1,000 adults with Medi-Cal insurance who have high blood sugar and may str…

This study is testing whether a one-year course of a dietary supplement called spermidine can help older adults with heart disease. Spermidine is a natural compound found in foods like whole grains and nuts. Researchers will check if it improves heart function, muscle mass, physi…

This study is testing whether weight-loss surgery is better than intensive medical therapy for long-term blood sugar control in teenagers with type 2 diabetes. It will involve about 90 teens, comparing the effects of a specific surgery (vertical sleeve gastrectomy) against the be…

This early-stage study is testing a new injectable medicine called NNC0519-0130 for people with type 2 diabetes and excess weight. It will measure how the drug moves through the body and check for side effects in 20 Chinese men with overweight or obesity. Participants will receiv…

This study is testing a new wireless system to monitor blood sugar in hospitalized veterans with type 2 diabetes who are at risk for dangerously low levels. The system sends glucose readings from the patient's bedside directly to the nurses' station, allowing for faster detection…

This small, early-stage study is testing a new medical procedure for people with type 2 diabetes who require insulin. Doctors use a special device to apply radiofrequency energy to the lining of the first part of the small intestine (the duodenum). The main goal is to see if this…

This study is testing whether a new, minimally invasive endoscopic procedure, which uses electrical pulses to regenerate the lining of the small intestine, can help people with type 2 diabetes who use insulin. When combined with the diabetes medication Ozempic, researchers hope t…

This study is checking if the heart benefits seen for the diabetes drug empagliflozin in controlled trials also happen for regular patients in real-world doctor's offices and hospitals. It will follow about 230,000 adults with type 2 diabetes who are starting this drug or a simil…

This study is testing whether adding peer support helps Black men better manage type 2 diabetes. All 48 participants receive standard diabetes education. Half also get 6 months of monthly support sessions led by trained Black men who also have diabetes, followed by 6 months of gr…

This study is testing a second, similar procedure for people with type 2 diabetes whose blood sugar did not improve enough after an initial experimental treatment. The procedure uses heat to treat the lining of the small intestine. Researchers want to see if this repeat treatment…

This study is testing whether a weekly injectable medicine called survodutide helps adults with type 2 diabetes and overweight or obesity lose weight. About 755 participants will be randomly assigned to receive one of two doses of the drug or a placebo (a dummy injection) for 76 …

This study aimed to test if using two diabetes drugs together works better than using either one alone for people whose blood sugar is still too high on metformin. It planned to enroll adults with type 2 diabetes to compare the combination's effectiveness and safety over 16 weeks…

This study aims to see how well two diabetes medications, Envlo and Envlomet SR, control blood sugar in real-world medical practice. It will observe 15,000 adults with type 2 diabetes for 24 weeks to measure changes in their blood sugar levels and check for safety. Unlike a contr…

This study aimed to see if adding a new drug called ofirnoflast to the existing medication semaglutide (like Ozempic®) was better for blood sugar control and weight loss in adults with type 2 diabetes who were overweight or obese. It was designed as a 12-week trial comparing the …

This study aims to see if a specific eating plan is better than a prescription medication for reducing liver fat and scarring. Researchers will compare a Mediterranean diet combined with intermittent fasting against the weight-loss drug naltrexone/bupropion (Mysimba®). The goal i…

This study is testing whether teaching people with Type 2 diabetes about good sleep habits and leading them through relaxation exercises can help them sleep better, feel less anxious, and improve their blood sugar control. Researchers will work with 52 adults who have poor sleep …

This study is testing how a 12-week program of diet education and different types of exercise affects people with type 2 diabetes and obesity. Researchers want to see if these lifestyle changes can help control appetite, improve body composition, and better manage blood sugar. Th…

This study tests a digital outreach program designed to help women who had diabetes during pregnancy (gestational diabetes) get recommended follow-up screening and join lifestyle programs after giving birth. The goal is to prevent these women from developing type 2 diabetes later…

This study is testing whether making national healthy eating guidelines more culturally relevant helps African American adults improve their diets and lower their risk for type 2 diabetes. Researchers are comparing three different healthy eating patterns over one year to see whic…

This study is gathering feedback from 125 people with type 1 or type 2 diabetes who are already using the DuraTouch® injection device. Over 12 weeks, participants will rate how easy, convenient, and satisfying the device is to use in their daily lives. The goal is to understand t…

This study is testing whether weekly injections of an investigational drug called CagriSema can reduce pain from diabetic nerve damage. It will compare CagriSema to a placebo in 142 adults with type 2 diabetes who have had this specific nerve pain for at least 3 months. The main …

This study is testing whether two different remote monitoring systems are practical for people with type 2 diabetes who don't use insulin. Researchers will enroll 60 adults in Denmark to try monitoring their blood sugar, sleep, and mental health, or a version that also tracks blo…

This study aims to understand how vitamin D levels might influence blood pressure in people with type 2 diabetes. Researchers will collect blood samples from 40 participants to examine their immune cells. They will test if these cells, taken from people with low or high vitamin D…

This long-term study aims to understand how hidden, early-stage heart disease (atherosclerosis) develops and progresses to major events like heart attacks or strokes. It follows over 6,400 adults from four different ethnic backgrounds who started the study with no known heart dis…

This study aims to find out if routinely screening for hidden heart disease in people with type 2 diabetes who are at very high risk is a good use of healthcare resources. Researchers will analyze the health records of 90,000 French patients to compare the costs and outcomes of t…

This study aims to understand why people respond differently to a common diabetes medication called canagliflozin. Researchers are giving the drug to 700 healthy volunteers of Amish descent and measuring how their bodies react. By comparing these reactions to each person's geneti…

This study aims to collect and store blood, urine, and tissue samples from 500 adults with obesity. The goal is to create a research bank to help scientists understand why people gain weight, why treatments sometimes fail, and why weight is often regained. This knowledge could le…

This study aims to understand how different types of exercise and dietary advice affect the body's cells and stress levels in people with type 2 diabetes. Researchers enrolled 146 participants to compare moderate exercise, high-intensity intervals, and diet counseling over 12 wee…

This study aims to understand if the common diabetes medication metformin reaches the eye's lens and can slow the growth of cells that cause cloudy vision after cataract surgery. Researchers will collect lens tissue and blood samples from 40 patients with type 2 diabetes and cata…

This study follows American Indians with type 2 diabetes to understand the long-term effects of a previous kidney treatment trial. Researchers are observing how kidney disease progresses over many years through regular tests, scans, and optional biopsies. No new treatment is prov…

This study aims to understand how SGLT2i diabetes drugs are prescribed and used in France by analyzing health records. It will track over 500,000 patients starting this treatment to see if it is linked to real-world health outcomes like heart attacks, strokes, heart failure, and …

This study aims to understand why some people with type 2 diabetes have a harder time controlling their blood sugar and develop kidney problems. Researchers will collect health information, lifestyle details, and blood samples from 1000 adults with diabetes in Mexico. By analyzin…

This early study aims to understand how well daily low-dose aspirin prevents blood clotting in people with type 2 diabetes. Researchers will give 50 participants aspirin for 7 days and measure their blood's clotting response before and after treatment. The goal is to gather preli…

This study aims to discover the specific genes and biological pathways that influence a person's risk of developing type 2 diabetes and related health problems like kidney and eye disease. Researchers will collect health information, blood samples, and genetic data from over 2,00…