New weekly shot challenges semaglutide in major diabetes showdown
NCT ID NCT06260722
First seen Apr 22, 2026 · Last updated May 25, 2026 · Updated 8 times
Summary
This study tests a new once-weekly injection, retatrutide, against the established drug semaglutide in adults with type 2 diabetes whose blood sugar is not well controlled by metformin. About 1,250 participants will receive either drug for up to 26 months to see which better lowers blood sugar and body weight. The goal is to improve long-term disease management, not to cure diabetes.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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9109-0126 Quebec Inc.
Montreal, Quebec, H4N 2W2, Canada
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Advanced Clinical Research, LLC
Bayamón, 00959, Puerto Rico
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Aggarwal and Associates Limited
Brampton, Ontario, L6T 0G1, Canada
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Alberta Diabetes Institute
Edmonton, Alberta, T6G 2E1, Canada
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Alliance for Multispecialty Research, LLC
Norman, Oklahoma, 73069, United States
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Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, 48098, United States
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Arrow Clinical Trials
Daytona Beach, Florida, 32117, United States
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Bluewater Clinical Research Group Inc.
Sarnia, Ontario, N7T 4X3, Canada
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Brigham and Women's Hospital Diabetes Program
Boston, Massachusetts, 02115, United States
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CARE - Centro de Alergia y Enfermedades Respiratorias
Ciudad Autónoma de Buenos Aires, Buenos Aires, 1414, Argentina
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CEMEDIAB
C.a.b.a., Buenos Aires F.D., C1205AAO, Argentina
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CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
Godoy Cruz, Mendoza Province, 5501, Argentina
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CIPREC
Buenos Aires, Buenos Aires F.D., C1061AAS, Argentina
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Cardiolink Clin Trials
Monterrey, Nuevo León, 64060, Mexico
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Central States Research
Tulsa, Oklahoma, 74136, United States
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Central Washington Health Services Association d/b/a Confluence Health
Wenatchee, Washington, 98801, United States
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Centricity Research Brampton Endocrinology
Brampton, Ontario, L6S 0C6, Canada
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Centro Diabetológico Dr. Waitman
Córdoba, 5000, Argentina
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Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
Mexico City, Mexico City, 11650, Mexico
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Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Buenos Aires, Buenos Aires F.D., C1425AGC, Argentina
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Centro Medico Privado San Vicente Diabetes
Córdoba, Córdoba Province, 5006, Argentina
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Centro Médico Viamonte
Buenos Aires, Buenos Aires F.D., C1120AAC, Argentina
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Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, Santa Fe Province, 2152, Argentina
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Centro de Investigaciones Metabólicas (CINME)
Buenos Aires, C1056ABI, Argentina
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Clinical Research of Central Florida
Winter Haven, Florida, 33880, United States
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Clínica García Flores SC
Monterrey, Nuevo León, 64610, Mexico
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Consano Clinical Research, LLC
Shavano Park, Texas, 78231, United States
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Deaconess Clinic - Gateway Health Center
Newburgh, Indiana, 47630, United States
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Diseno y Planeacion en Investigacion Medica
Guadalajara, Jalisco, 44130, Mexico
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Enclifar Ensayos Clínicos Farmacológicos Sc
Chihuahua City, 31110, Mexico
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Fundación Respirar
Buenos Aires, C1426ABP, Argentina
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GCM Medical Group, PSC - Hato Rey Site
San Juan, 00917, Puerto Rico
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Hamilton Medical Research Group
Hamilton, Ontario, L8L5G4, Canada
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Herman Clinical Research
Suwanee, Georgia, 30024, United States
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Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Nuevo León, 66460, Mexico
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Hospital de Jésus, I.A.P.
Mexico City, Mexico City, 06090, Mexico
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IMA Clinical Research Monroe - Armand
Monroe, Louisiana, 71201, United States
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IMA Clinical Research West Virginia
Morgantown, West Virginia, 26505, United States
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Instituto Centenario
CABA, Buenos Aires F.D., 1204, Argentina
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Instituto Veracruzano en Investigación Clínica S.C.
Veracruz, 91851, Mexico
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Instituto de Diabetes, Obesidad y Nutricion
Cuernavaca, Morelos, 62250, Mexico
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Instituto de Investigaciones Clinicas Rosario
Rosario, Santa Fe Province, S2000CVD, Argentina
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Juno Research
Houston, Texas, 77040, United States
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Long Beach Research Institute
Long Beach, California, 90805, United States
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Maple Leaf Research
Toronto, Ontario, M5G 1K2, Canada
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Mautalen Salud e Investigación
Buenos Aires, Buenos Aires F.D., C1128AAF, Argentina
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MedStar Health Research Institute (MedStar Physician Based Research Network)
Hyattsville, Maryland, 20782, United States
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Medication Management
Greensboro, North Carolina, 27405, United States
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Medrasa Clinical Research
Wylie, Texas, 75098, United States
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NECCR PrimaCare Research
Fall River, Massachusetts, 02721, United States
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NYC Research INC
Long Island City, New York, 11106, United States
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Neighborhood Healthcare Institute of Health
Escondido, California, 92025, United States
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New Age Medical Research Corporation
Miami, Florida, 33186, United States
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North Georgia Clinical Research
Woodstock, Georgia, 30189, United States
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Pacific Diabetes & Endocrine Center
Honolulu, Hawaii, 96817, United States
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Palm Research Center Sunset
Las Vegas, Nevada, 89148, United States
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Palm Research Center Tenaya
Las Vegas, Nevada, 89128, United States
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Prime Health Clinical Research
Toronto, Ontario, M4S 1Y2, Canada
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Private Practice - Dr. Nigel Jagan
Whitby, Ontario, L1N 2L1, Canada
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RM Pharma Specialists
Mexico City, Mexico City, 03100, Mexico
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Rancho Cucamonga Clinical Research
Rancho Cucamonga, California, 91730, United States
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Remington Davis Clinical Research
Columbus, Ohio, 43215, United States
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Rocky Mountain Clinical Research
Idaho Falls, Idaho, 83404, United States
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South Broward Research
Miramar, Florida, 33027, United States
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Southern Endocrinology Associates
Mesquite, Texas, 75149, United States
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Stat Research S.A.
Buenos Aires, Buenos Aires F.D., C1023AAB, Argentina
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Texas Valley Clinical Research
Weslaco, Texas, 78596, United States
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The Corvallis Clinic, P.C.
Corvallis, Oregon, 97330, United States
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The Wharton Medical Clinic Clinical Trials Inc
Hamilton, Ontario, L8L 5G8, Canada
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Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
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University of Alabama - Department of Nutrition Sciences
Birmingham, Alabama, 35294, United States
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University of Calgary - Clinical Trials Unit
Calgary, Alberta, T2T 5C7, Canada
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University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045, United States
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Valley Clinical Trials, Inc.
Northridge, California, 91325, United States
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Valley Institute of Research - Fort Worth
Fort Worth, Texas, 76164, United States
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Velocity Clinical Research, Dallas
Dallas, Texas, 75230, United States
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Winterberry Research Inc.
Hamilton, Ontario, L8J 0B6, Canada
Conditions
Explore the condition pages connected to this study.