Diabetes mellitus type 2

Researchers are testing UrDiaCare, an Urdu-language app that gives diabetes self-management education and support through WhatsApp or Android. The trial includes 406 adults aged 30 to 70 in Pakistan who have type 2 diabetes and higher-than-recommended blood sugar levels. Particip…

This study looks at the safety and effectiveness of Rybelsus, a pill for type 2 diabetes, in everyday medical practice in Korea. About 600 adults will take the medicine as their doctor prescribes, and researchers will track side effects and blood sugar control for 26 weeks. The g…

Researchers are testing how safely and comfortably people with type 2 diabetes can switch from semaglutide to CagriSema, a weekly injection that combines cagrilintide and semaglutide. About 210 adults who have taken a stable dose of branded semaglutide for at least three months w…

This study tests whether a smartphone app that shows real-time blood sugar and activity data can help adolescents and young adults with type 2 diabetes improve their glucose control. Participants use a continuous glucose monitor and Fitbit, and some receive prompts to reflect on …

This trial tests whether adding a nurse-led telehealth education program to usual diabetes care improves blood sugar control, medication habits, and quality of life in adults with type 2 diabetes in Oman. About 160 participants will be randomly assigned to either receive weekly 2…

This pilot trial tests a personalized AI platform called PIPE-AI, enhanced by DiabetesGPT, to see if it can help adults with prediabetes or type 2 diabetes improve their self-management and knowledge. Participants are randomly assigned to either use the AI platform for three mont…

This trial tests whether online peer education can help people with type 2 diabetes become more physically active. Participants will be placed in groups led by peers who have type 2 diabetes and exercise above recommended levels. The study measures changes in daily step count, al…

This trial is testing whether an investigational drug called AZD6234, given as a weekly injection, can help adults with type 2 diabetes and excess weight lose more weight than a placebo. Participants will receive either AZD6234 or a placebo for 68 weeks, and researchers will meas…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This study tests a new once-daily oral pill called orforglipron against a weekly injection (dulaglutide) in 170 teens aged 10-18 with type 2 diabetes. The goal is to see if the pill works better at controlling blood sugar and is safe. Participants will be followed for about 61 we…

This trial tests whether mazdutide, a weekly injection, can help people with type 2 diabetes achieve normal blood sugar levels—a state called remission. Participants are adults with type 2 diabetes who are not well controlled on diet, exercise, or a single medication. They receiv…

This trial tests whether extending a 6-month exercise coaching program to 12 months helps people with type 2 diabetes maintain a healthier activity level. Participants will be randomly assigned to either the standard 6-month program or an extended version with sessions every two …

This study tests whether two low-calorie versions of the MIND-HK diet can improve blood sugar and heart health in adults with type 2 diabetes. 180 participants aged 40-70 will be split into three groups: one following a low-calorie diet, one a very low-calorie diet, and a control…

This study tests whether an AI-powered intensive lifestyle program can help people with obesity and newly diagnosed type 2 diabetes lose weight and control blood sugar as well as the drug tirzepatide. Adults aged 18 to 65 with a BMI of 28 to 40 and recent diabetes diagnosis are r…

This study compares two 20-week exercise programs for adults aged 30-65 with both type 2 diabetes and obesity. One group attends supervised, in-person sessions twice a week, while another follows the same plan through a mobile app. A third group receives standard medical care onl…

This trial compares an automated insulin delivery system (AID) to standard insulin injections for managing blood sugar in hospitalized adults with type 2 diabetes who have an infection. The AID system uses a continuous glucose monitor and a smart pump to automatically adjust insu…

This study tests a special education program designed to boost confidence in managing type 2 diabetes. About 400 adults will either receive this program or standard care. The goal is to see if the program improves blood sugar monitoring, diabetes knowledge, and quality of life.

This study tests whether a 3-month video-based lifestyle program works better when delivered by a patient's own primary care doctor versus an unfamiliar doctor. The program covers healthy eating, physical activity, and behavior change. Researchers will measure blood sugar control…

This Phase 3 trial tests a new once-weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants receive two weekly shots (active drug plus placebo) to see if the new drug is safe and leads to gr…

This study tests whether a home-based vibrating calf device can help adults with type-2 diabetes improve blood sugar control. 305 participants in Saudi Arabia will be assigned to active vibration, a sham device, or usual care for 12 weeks. The main goal is to see if vibration-ass…

This study tests an experimental injection called IN-B00009 in adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. About 110 participants will receive either the drug or a placebo to see if it safely lowers HbA1c levels over 24 weeks. …

This study tests a 12-week program that uses WhatsApp to teach people with type 2 diabetes and their family members how to manage the disease better. Participants get videos, quizzes, and weekly phone calls to improve self-care and blood sugar levels. The goal is to see if this a…

This study tests whether community pharmacies can help find undiagnosed type 2 diabetes and prediabetes in adults living in Irbid, Jordan. Participants without a diabetes diagnosis will fill out a risk questionnaire and, if their score is high, receive a quick finger-prick HbA1c …

This trial is testing a new implantable sensor called the HALO System in people with type 1 or type 2 diabetes. The sensor is designed to continuously measure glucose, ketones, and lactate in the fluid just beneath the skin, which could give a more complete picture of metabolic h…

This study investigates whether the 4-7-8 breathing technique can help reduce pain and anxiety in people with type 2 diabetes and diabetic neuropathy during an electromyography (EMG) procedure. EMG can be uncomfortable and stressful, and this trial compares the breathing techniqu…

This pilot study tests an 8-week program called DREAM that uses AI-powered text messages to encourage physical activity in adults with type 2 diabetes. Twenty participants will receive twice-weekly messaging and set weekly activity goals. The study focuses on whether the program …

This pilot study tests a virtual program called STRIDE, designed for adults aged 21-44 who have type 2 diabetes and are raising children. The program includes three online sessions focused on self-care, healthy eating, and family activity. Researchers will measure changes in diab…

This study compares two types of exercise programs—Modified Otago Exercises and Dynamic Neuromuscular Stabilization Exercises—to see which better improves balance and daily living activities in older adults with diabetic peripheral neuropathy. The trial will involve 36 participan…

Researchers are testing whether standard blood tests can indicate the quality of stem cells taken from the heel bone during foot or ankle surgery. The study includes adults aged 40 to 80, some with type 2 diabetes and diabetic foot ulcers. Before surgery, participants give blood …

This study investigates whether blood levels of irisin, a protein linked to glucose metabolism and nerve protection, differ in people with type 2 diabetes who have diabetic polyneuropathy (nerve damage) compared to those without it and healthy controls. Researchers will measure i…

This study looks at how removing part or all of the pancreas changes blood sugar control in adults who already have diabetes and need pancreatic surgery. Researchers will track 408 patients over time to see if diabetes gets worse depending on how much pancreas is removed. The goa…

This 5-year study will follow 2,800 overweight or obese Chinese adults aged 18-60 to see how their health changes over time. Participants will use a smartphone app to track their data and get lifestyle support. The goal is to understand who develops diabetes or complications, and…

This study looks for genetic differences that might explain a rare form of diabetes that is not caused by the immune system. Researchers will study 118 adults of African or Indian ancestry in the French West Indies who have this atypical diabetes. The goal is to find gene changes…

This early-stage trial tests a new experimental pill called UI087, which combines three diabetes drugs into one. Researchers want to see if it is safe and how the body processes it compared to taking the three drugs separately. The study involves 44 healthy adults and is not yet …

This study looks at how gut bacteria are linked to obesity and type 2 diabetes in New Caledonia, where these conditions are very common. Researchers will collect blood, urine, and stool samples from 270 adults to analyze their gut microbes and related chemicals. The goal is to be…

This study tests a wrist-worn device that uses light sensors and AI to estimate blood sugar without piercing the skin. Up to 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days while researchers collect data to improve its accuracy. P…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will use a safe ultrasound test to look for early signs of artery hardening in 96 adults who have both type 2 diabetes and stage 3 chronic kidney disease. Many patients with these conditions develop heart problems without symptoms. The goal is to find out how common th…

This study will follow 100 adults with diabetes and foot ulcers to see how non-vascular factors like nerve damage, infection, and poor blood sugar control affect ulcer severity and healing. Researchers hope to find which risk factors can be changed to prevent ulcers from coming b…