DIABETES MELLITUS, TYPE 2

This study tests whether taking taurine, a common amino acid supplement, can improve blood sugar control, cholesterol levels, and inflammation in people with type 2 diabetes. About 94 adults with diabetes will take taurine or a placebo for 12 weeks. The goal is to see if taurine …

This study looks at how family support can help people with type 2 diabetes eat better and be more active. Researchers will work with 75 adults from rural Kentucky and their families to create a 6-month nutrition and exercise plan. The goal is to see if family involvement improve…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will take the drugs or a placebo for 48 weeks. The main goal is to see how much weight they l…

This study tests a Norwegian e-health program called DiaMester for adults with type 2 diabetes. The program aims to help participants lose weight and improve their diabetes control, with the goal of achieving remission. About 99 people will take part, and the study will measure w…

This study looks at whether mobile health apps like Weight Watchers and Healthi can help low-income Hispanic adults with type 2 diabetes lose weight and improve blood sugar control. About 45 participants will use an app or a standard program for 6 months, weighing themselves dail…

This study tests a culturally tailored diabetes education program for Arab Americans with type 2 diabetes. Participants will receive peer-led classes in Arabic and text message support for 3 months. The goal is to improve diabetes knowledge, self-care, and blood sugar levels.

This study tests whether a digital diet program, combined with extra vegetables and soy foods, can lower blood pressure in adults with hypertension, obesity, and type 2 diabetes. 300 participants will be split into three groups: one gets highly processed soy foods, another gets m…

This study tests whether training primary care doctors and nurses can help adults with type 2 diabetes better control their blood sugar and other health measures. About 7,800 participants will be followed for two years. The goal is to improve ongoing disease management, not to cu…

This study tests whether combining exercise with cognitive behavioral therapy (CBT) can improve blood sugar control and quality of life in Black men with type 2 diabetes and depressive symptoms. About 80 participants will receive CBT, and half will also get guided exercise sessio…

This study tests whether choline fenofibrate, a drug that lowers fats in the blood, can reduce plaque buildup in the neck arteries of people with type 2 diabetes and mixed high cholesterol. About 56 adults will receive either choline fenofibrate or a comparison drug (policosanol)…

This study tests whether adding semaglutide (a drug used for diabetes and weight loss) to a standard topical cream can improve psoriasis and reduce inflammation. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will receive either semaglutide or a …

This study tests whether using a mobile health app helps people with type 2 diabetes and obesity lose weight and improve blood sugar control over 6 months. About 30 adults will either use the app or follow a standard program, weighing themselves daily and checking blood sugar bef…

This study tests whether 12 weeks of home-based heat therapy can improve blood sugar control and blood vessel function in adults with type 2 diabetes. Researchers will measure changes in hemoglobin A1C, insulin resistance, and how the body handles fats after a meal. The goal is t…

This study tests a new glucose sensor (ROME GS) to see if it is as accurate and safe as an existing sensor. It involves 60 adults with type 1 or type 2 diabetes. The sensor measures glucose levels continuously, and researchers will check for any side effects or errors.

This study looks at whether eating all your food within a specific 9-hour window each day (time-restricted eating) can improve blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Researchers will compare three different eating windows to see if…

This study tests an experimental drug called ARO-ALK7 in adults with obesity, some of whom also have type 2 diabetes. The goal is to check if the drug is safe and how it affects weight. Participants will receive either the drug or a placebo, and some will also take an existing we…

This study tests whether a total diet replacement program, supported by eHealth (digital tools) or face-to-face visits, can help overweight people with early type 2 diabetes achieve remission. 106 participants will follow the same diet plan but receive different types of support.…

This study tests a new medicine called LY3938577 against a standard insulin (degludec) in 100 adults with type 2 diabetes who already use basal insulin. The goal is to see if the new drug works better at keeping blood sugar in a healthy range over 26 weeks. Participants must have…

This study tests a new way to help people with uncontrolled type 2 diabetes who also face challenges like food or housing insecurity. The program uses a special tool in the medical record system to connect patients with community resources and community health workers. Researcher…

This study looks at how fat cells work in people with normal-weight type 2 diabetes compared to those with overweight diabetes or no diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adult…

This study compares two ways of using laser treatment for proliferative diabetic retinopathy, a leading cause of blindness in working-age adults. Researchers will give 40 participants either a single laser session or multiple sessions to see which is safer and works better. The g…

This study looks at whether using a continuous glucose monitor (CGM) can help people who have had a kidney transplant and have type 2 diabetes keep their blood sugar in a healthy range. About 80 adults who received a kidney transplant in the past year and use insulin will wear a …

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, can help people with obesity and a serious liver condition called MASH. Participants will be randomly assigned to receive either ESG plus …

This study is testing whether taking daily vitamin D3 or yeast beta-glucan supplements can help control blood sugar and lower the risk of heart disease in people with type 2 diabetes. The trial will include 2,500 adults aged 40 to 79 and will last 5 years, with 2 years of supplem…

This early-stage study tests a new experimental medicine called NNC1679-0001 for type 2 diabetes. About 80 healthy volunteers and people with type 2 diabetes will receive a single injection of either the study drug or a placebo. The main goal is to check if the drug is safe and h…

This study looks at whether a type of diabetes medication (GLP-1 receptor agonists) can help people with chronic kidney disease by improving how their fat tissue works. Researchers will measure changes in fat around the kidneys and heart, as well as kidney function, in 250 adults…

This study tests whether diabetes self-management education, delivered in churches by trained community health workers, can help people with type 2 diabetes in the Marshall Islands better control their blood sugar. Up to 288 adults with diabetes and their family members will take…

This study looks at how different diabetes medications affect heart and blood vessel function in people with type 2 diabetes who are at high risk for heart problems. About 240 participants will be split into four groups, each receiving a different drug combination. Researchers wi…

This early study tests a new treatment for type 2 diabetes. Doctors take a small amount of fat from the patient, process it with a special laser, and inject the cells into the lining of the small intestine. The goal is to see if this improves blood sugar control and pancreas func…

This study is testing a new way to care for adults with type 2 diabetes at community health centers. The approach uses a team of providers and technology to help patients better control their blood sugar. About 120,000 patients from 16 health centers will take part, with some cen…

This early-stage study tests a new medicine called MK-1403 in 52 adults with type 2 diabetes. The main goals are to check if it is safe and well-tolerated, and to measure how the body processes it. Researchers will also look at its effect on a blood marker of inflammation (hsCRP)…

This study aims to improve long-term diabetes management by combining traditional Chinese medicine with Western medicine through a digital platform. Researchers will enroll 10,000 adults with type 2 diabetes and use an app, smart devices, and expert support to monitor blood sugar…

This study tests a procedure called duodenal mucosal resurfacing (DMR) to see if it can safely improve blood sugar control in people with type 2 diabetes. Participants will be randomly assigned to receive either the real DMR or a sham (fake) procedure. The study will also look at…

This study tests a new device called the Eversense Gemini System, which helps people with diabetes check their blood sugar levels without finger sticks. About 80 adults with type 1 or type 2 diabetes will use the system to see how accurate and safe it is compared to standard moni…

This study tests whether a specially trained nurse case manager can help formerly incarcerated Black men with poorly controlled type 2 diabetes improve their blood sugar levels, blood pressure, and quality of life. One hundred participants will be randomly assigned to receive eit…

This study tests the safety and effectiveness of tirzepatide in 344 Indian adults with type 2 diabetes or obesity. Participants receive the drug for 46 weeks. The goal is to see if it helps control blood sugar and reduce weight.

This study compares a smart insulin pump called the iLet Bionic Pancreas to usual diabetes care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the pump or continue their routine care for 13 weeks to see if the pump improves blood sugar …

This study tests whether adding vicadrostat to the standard drug empagliflozin can lower the chance of heart problems or death in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo plus empa…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching helps adults with HIV and type 2 diabetes (or high risk for it) lose weight and control blood sugar better than meals alone. About 200 participants will be followed for 18 months. …

This study tests a new once-weekly injection called NNC0662-0419 in 270 adults with type 2 diabetes. It compares the new drug against a placebo and the approved medication semaglutide to see how well it controls blood sugar and affects body weight. Participants must be willing to…

This study tests whether drinking traditional kefir for 12 weeks can improve blood sugar control and heart health in people who are overweight and either at risk for or already have type 2 diabetes. Researchers will measure changes in HbA1c (average blood sugar) and other health …

This study compares standard gastric bypass surgery to bypass plus a nerve-cutting procedure (truncal vagotomy) for helping type 2 diabetes go into remission. About 40 adults with obesity and diabetes will be randomly assigned to one of the two surgeries and followed for a year. …

This study looks at whether community health workers can help women in urban Indian slums get tested for type 2 diabetes after having a baby. Women who had diabetes during pregnancy are at high risk, but many miss the recommended test. The trial will compare home-based testing by…

This study looks at whether giving people with diabetes who are food insecure access to nutritious meals and education can reduce their food insecurity and improve health. About 160 hospitalized adults with type 1 or type 2 diabetes will be randomly assigned to receive either sta…

This study looks at whether people with type 2 diabetes who don't use insulin can wear a continuous glucose monitor (CGM) for only two weeks each month and still control their blood sugar just as well as wearing it all the time. About 150 adults will first wear the CGM continuous…

This study tests whether wearing a continuous glucose monitor (CGM) every two months helps older adults (60+) with type 2 diabetes improve blood sugar control compared to standard finger-stick monitoring. Participants take oral diabetes drugs but not insulin. The trial lasts 6 mo…

This study tests an oral drug called dapansutrile in 300 adults with type 2 diabetes. The drug targets inflammation, which may help lower blood sugar and reduce diabetes complications. Participants will take either the drug or a placebo for several months to see if it safely impr…

This study looks at whether treating insomnia with cognitive behavioral therapy (CBT-I) can lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will either receive CBT-I or a general health education program. The goal is to see…

This study tests if a once-weekly insulin shot (icodec) works as well as daily insulin shots for controlling blood sugar in people with type 2 diabetes. About 586 adults who have never used insulin before will take either the weekly or a daily insulin for 13 months. The goal is t…

This study tests whether a keto diet using canola oil (healthy fats) is better for heart health than a traditional keto diet high in saturated fat or a low-fat diet. Researchers will measure cholesterol, blood sugar, and inflammation in 175 adults with prediabetes or type 2 diabe…

This study looks at whether adding omega-3 (fish oil) to a common cholesterol-lowering statin can reduce plaque buildup in the carotid arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to receive either atorvastatin plus omeg…

This study tests whether a communication technique called 'linguistic nudging' helps doctors and patients with type 2 diabetes make better treatment decisions together. 250 adults will be split into two groups: one where doctors use nudging and patients use a mobile app, and anot…

This study looks at whether drinking regular milk can lower the risk of type 2 diabetes in people who have trouble digesting lactose (lactose intolerance) and have pre-diabetes. Researchers want to see if milk changes gut bacteria in a way that helps control blood sugar. About 40…

This study compares two ways to prevent heart problems in people with type 2 diabetes, prediabetes, or metabolic syndrome who are at higher risk but have no known heart disease. One group gets care based on a detailed heart scan staging system, while the other gets standard care …

This early-stage study tests a new medicine called LY4057996 in healthy volunteers and people with type 1 or type 2 diabetes. The main goal is to see if the drug is safe and what side effects it may cause. The study will also measure how the drug moves through the body and its ef…

This study tests whether a spinal cord stimulator can reduce leg pain and improve quality of life in people with type 2 diabetes, painful nerve damage, and peripheral artery disease. Fifteen adults who already have a spinal cord stimulator will receive two weeks of active stimula…

This study tests whether a 12-week low-calorie diet can improve heart function, reduce symptoms like breathlessness, and increase exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who also have obesity or type 2 diabetes. About 63 adults will …

This pilot study tests whether semaglutide, a drug used for diabetes, can help adults with type 2 diabetes quit smoking when used alongside nicotine replacement therapy. About 100 participants will be followed for 6 months to see if the approach is feasible and effective. The goa…

This study tests whether an 8-week remote program combining positive psychology and motivational interviewing, plus text messages, can help 280 adults with type 2 diabetes increase their physical activity. Participants must currently be inactive and not using certain insulin. The…

This study tests whether a brief self-affirmation writing exercise before regular doctor visits can reduce feelings of stigma and improve diabetes management in adults with type 2 diabetes. About 150 participants will be randomly assigned to do the full exercise or a shorter vers…

This study looks at ways to help women with type 2 diabetes learn more about their health and how to take care of themselves before getting pregnant. About 840 women aged 18-44 who are not currently pregnant will take part. The goal is to see if special education and text message…

This study aims to create an AI tool that can predict a person's risk of developing five common diseases: type 2 diabetes, heart disease, breast cancer, low back pain, and osteoarthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical reco…

This study follows 600 adults with type 2 diabetes who do not yet have heart failure or dementia. Researchers will track their health over time to find early warning signs of heart failure and cognitive decline. The goal is to learn how to better predict and prevent these complic…

This study looks at how common memory problems are in people aged 65 and older with type 2 diabetes. It also tests whether a program that combines healthy habits, exercise, and mental activities can help prevent or slow down memory decline. The study involves 420 participants fro…

This study aims to discover new biological factors that lead to type 2 diabetes in people with severe obesity. Researchers will collect tissue samples during planned weight-loss surgery from 270 adults with different metabolic states—some with diabetes, some with insulin resistan…

This study looks at kidney tissue from adults with diabetic kidney disease who are already scheduled for a kidney biopsy or surgery as part of their regular care. Researchers want to understand how SGLT2 inhibitors, a type of diabetes medicine, change the kidney's molecular finge…

This study looks at how social needs like food, housing, or transportation affect self-care and health in African American adults with diabetic kidney disease. Researchers will talk with 330 participants to understand these challenges and design a program that fits their culture.…

This study looks at why bariatric surgery can quickly improve type 2 diabetes. Researchers will track how the body stores and uses dietary fats in 40 adults before and after surgery. Half of the participants have diabetes, and half do not. The goal is to see if changes in fat tis…

This study reviews medical records of 400 adults aged 40-69 in Southeast Asia who were recently diagnosed with type 2 diabetes. Researchers want to understand their heart disease risk by looking at health data from before and after diagnosis. The goal is to see how many patients …

This study follows 100 adults with type 2 diabetes who have moderate to severe diabetic retinopathy, a condition that can lead to blindness. Over two years, researchers will use advanced eye scans to track tiny changes in blood vessels and retinal layers. The goal is to find earl…

This study looks at how well different doses and forms of aspirin work in people with type 2 diabetes. About 30 participants will first take a standard dose of coated aspirin. Those whose blood platelets are not fully blocked will then try three other aspirin regimens to see whic…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome can change the way the body processes certain drugs. Researchers will measure inflammation markers and immune cells in blood samples from 150 adults and children with …

This study is following 1,250 people who are at higher risk for pancreas cancer, such as those with new diabetes, pancreas cysts, or a family history. Researchers will collect blood samples and health information over time to find early warning signs of the disease. The goal is t…

This study from Stanford University looks at why different people have different blood sugar responses to the same foods. Researchers will use continuous glucose monitors (CGMs) in 100 healthy adults, people with prediabetes, and those with type 2 diabetes to track blood sugar af…

This study tests a new smartphone app and continuous glucose monitor in 30 young adults aged 16-24 who were diagnosed with type 2 diabetes before age 18. Participants wear a glucose monitor and Fitbit for 30 days, answer surveys, and give feedback on health messages. The goal is …

This study looks at how Semaglutide, a diabetes drug that helps with weight loss, affects fat stored in the heart and leg muscles of people with type 2 diabetes. Researchers will use special scans to measure fat changes in 60 adults who are not very active. The goal is to underst…

This study looks at why adults with diabetes have trouble taking their medicines as prescribed. Researchers will survey 220 patients to understand barriers like cost, family support, and communication with doctors. The goal is to find ways to help patients stick to their treatmen…

This study is observing 2,000 adults with type 2 diabetes to track changes in their diet, body composition, and grip strength over time. No new treatments or medications are being tested. The goal is to better understand how the disease affects nutrition and physical function.

This study looks at how a natural gut hormone called GIP affects bone breakdown and formation. Researchers will give 12 healthy adults GIP either continuously or for 8 hours a day for 3 days, then measure bone markers in blood and bone cells. The goal is to understand if the way …

This study compares people with high and low genetic risk for type 2 diabetes to see if their bodies handle sugar differently. Researchers will measure blood sugar and insulin responses after a sugary drink. Participants are non-diabetic volunteers aged 10 to 70. No treatment or …