DIABETES MELLITUS, TYPE 2

This study is investigating whether GLP-1 receptor agonist medications (a class of drugs used for diabetes and weight loss) can help control chronic kidney disease (CKD) by improving unhealthy fat tissue. Researchers will enroll 250 adults with CKD, obesity, or type 2 diabetes to…

This study is testing whether a 12-week low-calorie diet can improve symptoms, heart function, and exercise ability in adults with a common type of heart failure linked to obesity and type 2 diabetes. Sixty-three participants will be randomly assigned to either start the diet imm…

This study is testing different aspirin doses and formulations to find which works best for preventing blood clots in people with type 2 diabetes. Researchers will enroll 30 participants who haven't taken aspirin recently and test their response to various daily doses. The goal i…

This study is testing whether a device called the iLet Bionic Pancreas can be successfully used by regular primary care doctors to help adults with type 1 or type 2 diabetes. Researchers want to see if using this automated insulin delivery system for 13 weeks leads to better bloo…

This study is testing a new investigational drug, LY3938577, to see if it works as well as or better than a standard insulin (degludec) for controlling blood sugar in people with type 2 diabetes. It will involve about 100 adults who are already using a specific type of daily insu…

This study is testing if adding the oral medication semaglutide to standard psoriasis skin cream can better control the skin disease in people who are also overweight or have type 2 diabetes. Researchers will enroll 62 participants to receive either semaglutide or a placebo pill,…

This study is testing whether providing meals and food education after a hospital stay can help people with diabetes who struggle to afford enough food. Researchers will enroll 160 hospitalized patients with diabetes and food insecurity in California. Some will receive 90 days of…

This study is testing if the timing of daily eating affects blood sugar control. Researchers are comparing three different 9-hour eating windows in 120 adults with obesity who have type 2 diabetes or are at risk for it. The goal is to see if starting meals early, mid-day, or late…

This study is testing a new, fast-acting insulin (called NNC0471-0119) for people with type 2 diabetes who use an insulin pump. Researchers want to see how quickly it gets into the blood, how long it works, and how well it lowers blood sugar compared to a commonly used insulin (a…

This early-stage study aims to check the safety and side effects of a new experimental drug called MK-1403 in people with type 2 diabetes. It will involve 52 participants and will measure how the drug moves through the body and its effect on a blood marker linked to inflammation …

This large study is testing whether adding a new oral drug called vicadrostat to an existing diabetes medicine (empagliflozin) provides better protection against heart and kidney problems in adults who have type 2 diabetes, high blood pressure, and existing heart disease. About 1…

This study is testing whether a new oral drug called dapansutrile can help manage type 2 diabetes. The drug works by targeting a specific source of inflammation in the body, which researchers believe contributes to high blood sugar and related complications. About 300 adults with…

This study is testing two new investigational drugs, macupatide and eloralintide, to see if they help with weight loss in adults who have type 2 diabetes and are overweight or have obesity. About 200 participants will receive the drugs alone, in combination, or a placebo for near…

This study is testing a one-time procedure that uses a person's own stem cells, taken from their belly fat, to try to improve blood sugar control in Type 2 Diabetes. The processed cells are injected into the wall of the small intestine during a single procedure. Five adults with …

This study is testing whether transferring gut bacteria from healthy donors to people with type 2 diabetes can improve how their bodies process sugar. Sixteen participants will receive either the bacteria transplant or a placebo, and researchers will measure changes in blood suga…

This study is testing whether a special nurse support program helps formerly incarcerated Black men manage their type 2 diabetes. One hundred men will be randomly assigned to receive either standard diabetes information or the new program, which includes phone-based coaching on d…

This is an early-stage study to check the safety and side effects of a new drug called LY4057996 in healthy volunteers and people with Type 1 or Type 2 diabetes. Researchers will give the drug as an injection under the skin or into a vein and measure how the body processes it. Th…

This study is testing whether using smartphone apps can help people with type 2 diabetes better manage their weight and blood sugar levels. Over six months, participants will track their daily weight and blood glucose using an app, comparing it to a standard program. The goal is …

This study is comparing three diets to see which is best for managing heart disease and diabetes risk. It will test a keto diet using canola oil, a traditional high-saturated-fat keto diet, and a standard low-fat diet. About 175 adults who are overweight and at high risk for type…

This study is testing a diabetes education program designed specifically for Arab Americans. It aims to see if providing peer-led classes in Arabic and a text message support program can help people better manage their type 2 diabetes. The goal is to improve knowledge, self-care …

This study aims to find out if wearing a continuous glucose monitor (CGM) for two weeks each month works just as well as wearing it all the time for controlling blood sugar. Researchers will enroll 150 adults with type 2 diabetes who do not use insulin. After everyone wears the m…

This study is testing whether continuous glucose monitors (CGMs) help kidney transplant patients with diabetes better control their blood sugar. Researchers will track 80 patients who recently received transplants to see if wearing a CGM device improves their time in the healthy …

This study tests whether giving specialized training to family doctors and nurses helps their adult patients with type 2 diabetes manage the disease better. The training, provided by diabetes specialists, focuses on current best practices for care. Researchers will compare health…

This early-stage study is testing the safety and side effects of an experimental drug called MK-2828 in people with type 2 diabetes. Researchers will give the drug to 64 participants for about a month to see how their bodies handle it and if it affects a blood marker linked to in…

This study has two main goals. First, it aims to find out how common memory and thinking problems are in older adults with type 2 diabetes. Second, it will test a 2-year personalized health program designed to slow down cognitive decline. The program combines medication managemen…

This study is testing a new, comprehensive program to help people manage type 2 diabetes. It combines the approaches of Traditional Chinese Medicine (like body constitution analysis) with standard Western medical care, delivered through a mix of online tools (like an app and smar…

This study tests whether helping people with uncontrolled type 2 diabetes connect with community resources for basic needs like food and housing can improve their health. The program uses community health workers and a new referral system to link 900 patients with local support o…

This study is testing whether taking a taurine supplement helps people with type 2 diabetes better manage their condition. Researchers will give 94 participants either taurine or a placebo powder for 12 weeks to see if it improves blood sugar, cholesterol, and inflammation levels…

This study is testing a Norwegian smartphone app called DiaMester, which connects adults with type 2 diabetes to a health coach for personalized diet and activity advice. The goal is to see if using the app helps people lose a meaningful amount of weight and improve their blood s…

This study is testing if wearing a continuous glucose monitor (CGM) helps older adults with type 2 diabetes, who manage it with pills only, control their blood sugar better than standard finger-prick checks. About 150 participants will either wear the CGM sensor or use standard m…

This study is testing a new way to organize diabetes care at community health centers. It uses a team-based, technology-supported approach to help patients better manage their blood sugar. The goal is to see if this model can reduce the number of patients with poorly controlled d…

This study is testing if adding guided exercise to a standard talk therapy program helps Black men with type 2 diabetes better control their blood sugar and feel better mentally. It will involve 80 men over 7 months, with sessions held online. The goal is to see if this combined …

This study is testing whether training doctors in specific communication techniques helps patients with type 2 diabetes better manage their condition. 250 participants will be randomly assigned to receive either standard care or care where doctors use 'nudge' techniques to encour…

This study is testing whether involving a person's family can help them better manage type 2 diabetes. Researchers will work with 75 adults from rural Kentucky who have diabetes to create personalized nutrition and exercise plans for their entire household to follow for six month…

This study is testing whether a minimally invasive endoscopic procedure to reduce stomach size, combined with lifestyle changes, is better than lifestyle changes alone for treating a serious fatty liver disease called MASH in people with obesity. Researchers will compare the two …

This large study is testing whether taking daily vitamin D or yeast beta-glucan supplements can help people with type 2 diabetes better control their blood sugar and reduce their risk of heart disease. It will involve 2,500 adults with diabetes, who will take the supplements or a…

This study aims to find out which newer type 2 diabetes medications are best at protecting the heart and blood vessels. It will compare four different drug combinations in 240 patients who have diabetes and a high risk for heart problems. Researchers will measure heart function, …

This study is testing whether two popular weight-loss phone apps can help low-income Hispanic adults with type 2 diabetes lose weight and improve their blood sugar control. For 6 months, 45 participants will track their daily weight and blood sugar, using either one of the apps o…

This study is testing whether drinking traditional kefir daily for 12 weeks can help control blood sugar, improve cholesterol, and reduce inflammation in adults who have or are at high risk for Type 2 Diabetes. Participants will be randomly assigned to drink either kefir or a mil…

This study is testing whether a specific type of exercise called High-Intensity Interval Training (HIIT) can help women with type 2 diabetes better manage their blood sugar and reduce body-wide inflammation. It will compare the effects in women who are still having regular period…

This study compares a new once-weekly insulin injection (icodec) with standard daily basal insulin injections for people with type 2 diabetes. Researchers want to see if the weekly insulin works as well as daily insulin at controlling blood sugar levels in real-world medical prac…

This study tests whether diabetes education delivered in churches by community health workers can help Marshallese families better manage type 2 diabetes. Up to 288 people with diabetes and their family members will learn together about managing the condition. The main goal is to…

This study is testing whether a one-time, minimally invasive procedure can help people with type 2 diabetes better control their blood sugar. Doctors use an endoscope to gently resurface the lining of the first part of the small intestine (the duodenum). The goal is to see if thi…

This study is testing a program that uses technology to help women with type 2 diabetes better manage their health, especially if they are thinking about pregnancy. It uses doctor visit prompts and daily text messages to encourage healthy habits and provide important information.…

This early-stage study is testing a new drug called ARO-ALK7 to see if it is safe and how it affects the body in adults with obesity. Some participants will also take a common diabetes/weight loss medication (tirzepatide) to see if the new drug works alongside it. The main goal i…

This study is testing if a program that delivers healthy, doctor-approved meals and provides lifestyle coaching is better than just receiving meals alone. It aims to help adults with HIV who also have type 2 diabetes or are at high risk for it, and who struggle to afford enough h…

This study compares two common laser treatment schedules for a serious diabetic eye complication that can cause blindness. Researchers want to see if getting all the laser treatment in one session is as safe and effective as spreading it over several visits. They're enrolling 40 …

This study is testing a new, long-term glucose monitoring system called Eversense Gemini. It aims to see if this new device is as accurate and safe as the current Eversense 365 system for people with diabetes. About 80 adults with type 1 or type 2 diabetes will wear both monitors…

This study aims to prevent and manage type 2 diabetes in Latino communities by training church members as community health workers. The program helps Spanish-speaking adults access better healthcare and learn about diabetes prevention. Researchers will test whether this church-ba…

This large study is testing a new way to prevent heart attacks and strokes in people at risk. It compares two approaches: the standard method based on risk factors like age and diabetes versus a personalized method that uses a special heart scan to see actual artery plaque. The g…

This study is testing whether an online program that teaches better sleep habits can help prevent type 2 diabetes in people with prediabetes and insomnia. Researchers will compare the sleep therapy program against general sleep education to see which better lowers blood sugar lev…

This study is testing if a simple writing exercise can help people with Type 2 diabetes feel less stigma and better manage their condition. About 150 adults will be randomly assigned to either complete a guided writing exercise about their personal values before doctor visits or …

This study is testing if a device that sends electrical pulses to the spinal cord can help reduce leg pain in people who have both painful diabetic nerve damage and poor blood circulation. Up to 15 participants who already have the device implanted will try two weeks of real stim…

This study aims to understand why some people with type 2 diabetes develop heart failure or memory problems while others do not. Researchers will follow 600 adults with type 2 diabetes over time, measuring their heart function, brain health, and blood markers. The goal is to iden…

This study aims to understand how fasting and temporarily stopping the medication tirzepatide affect how much food and drink stays in the stomach after a meal. Researchers will use ultrasound scans to measure stomach contents in 40 people with type 2 diabetes or who are overweigh…

This study aims to follow 2000 adults with type 2 diabetes over time to better understand the disease. Researchers will track participants' diet, body composition, strength, and health to see how these factors relate to long-term complications like heart and kidney problems. The …

This study aims to understand the many reasons why adults with diabetes sometimes struggle to take their prescribed medications. Researchers will survey 220 patients to learn how factors like personal beliefs, family support, doctor communication, and medicine costs affect their …

This research aims to understand how a natural gut hormone called GIP affects bone health when given in different patterns. Healthy volunteers aged 18-40 will receive the hormone either continuously or intermittently for three days each. Researchers will measure bone health marke…

This study aims to understand how diabetic eye disease (retinopathy) gets worse over time. Researchers will use advanced, non-invasive eye scans to closely monitor 100 patients with moderate to severe diabetic retinopathy for two years. The goal is to identify early warning signs…

This research study aims to understand how genetic risk affects blood sugar control in people who don't have diabetes. Researchers will compare people with high and low genetic risk scores for type 2 diabetes by measuring their body's response to sugar. The study involves 100 par…

This study aims to find early warning signs of pancreatic cancer by tracking people at higher risk. Researchers will collect health information and blood samples from 1250 participants over time. The goal is to spot patterns that could lead to earlier detection and better surviva…

This study is testing a new smartphone app designed to help young adults (ages 16-24) who were diagnosed with type 2 diabetes as children. Participants will wear a continuous glucose monitor and a Fitbit for 30 days while using the app, which provides health tips. The main goal i…

This study aims to understand why weight-loss surgery can lead to rapid improvement in type 2 diabetes and heart health. Researchers will follow 40 people with and without diabetes who are having the surgery. They will use advanced scans and blood tests to see if better fat stora…

This study aims to understand how chronic inflammatory diseases like type 2 diabetes, irritable bowel disease, and kidney failure might change how the body processes medications. Researchers will collect blood samples and health records from 150 patients with these conditions to …

This study aims to understand how certain diabetes medicines (called SGLT2 inhibitors) affect the kidneys. Researchers will examine stored kidney tissue samples from 200 adults with diabetic kidney disease who are already having a biopsy or surgery as part of their regular care. …

This study aims to understand how challenges like unstable housing, food insecurity, and financial strain affect the health of African American adults living with both chronic kidney disease and type 2 diabetes. Researchers will interview participants and collect health data to i…

This study aims to understand why people have different blood sugar responses to the same foods. Researchers will use continuous glucose monitors to track how 100 participants with varying health statuses react to meals like rice, testing if adding things like fiber or vinegar he…