DIABETES

This study tests whether adding empagliflozin or semaglutide to insulin helps overweight or obese adults with type 1 diabetes achieve better blood sugar control. About 105 participants will take one of the two drugs or a placebo for 3 months. The goal is to lower HbA1c levels saf…

This study tests a program called Inspire HER for Black women aged 30-79 with heart, kidney, and metabolic problems. The program provides health education, physical activity, and social support to improve heart health and lower risk of future illness. About 90 women from the Birm…

This study tests a diabetes management program called Together Overcoming Diabetes (TOD), designed specifically for Lakota and other American Indian/Alaska Native communities in South Dakota. The program focuses on improving blood sugar control and addressing unique social and cu…

This small pilot study tests whether eating Greek bottarga (grey mullet fish roe) daily can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare bottarga to a dairy product over 8 weeks. The goal i…

This pilot study is testing whether giving free produce boxes to Veterans with kidney disease and food insecurity can improve their health. Researchers will measure blood pressure and kidney function, and also interview participants about their experience. The study aims to see i…

This study tests a new automated ultrasound system (EchoMark/EchoSure) to see if it can help arteriovenous fistulas mature faster in people with end-stage kidney disease. About 304 adults will be randomly assigned to get biweekly automated scans or standard care. The goal is to s…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, combined with lifestyle changes, can reverse fatty liver disease (MASH) better than lifestyle changes alone. About 132 adults with obesity…

This early-phase study tests whether tirzepatide, a weight-loss medication, can help overweight or obese men with intermediate-risk prostate cancer lose weight before prostate removal surgery. The main goal is to see if the program is safe and feasible. About 30 participants will…

This study looks at whether whole or nonfat milk is better for body composition and heart health in children ages 9 to 12 who have a higher BMI. Researchers will measure fat mass, lean mass, and other health markers over one year. The goal is to find out which type of milk suppor…

This study looks at whether connecting diabetes patients in rural Kentucky with community resources can help them manage their health better. About 12,000 adults with diabetes will take part. The goal is to see if screening for social needs like food or housing and making referra…

This study looks at whether adding occupational therapy and dietitian services to home-delivered meals can reduce fall risk in older adults who have trouble leaving home. About 750 people aged 60 and older will receive either meals alone, meals with dietitian support, meals with …

This study looks at whether weight-loss surgery can help people with type 2 diabetes and severe obesity achieve long-term remission better than the best medical care alone. About 408 participants will be followed to see how surgery affects diabetes, kidney function, heart health,…

This study looks at how well the Omnipod 5 automated insulin delivery system works in real-world conditions for people with type 1 diabetes. About 304 participants aged 2 and older will use the system for the first time. Researchers will measure blood sugar control, quality of li…

This study tests whether a mobile health app that gives personalized, real-time tips can help older adults with diabetes better manage their condition. About 184 participants will use the app for 6 months, and researchers will track changes in blood sugar levels and self-care hab…

This study compares a smart insulin pump called the iLet Bionic Pancreas to usual diabetes care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the pump or continue their routine care for 13 weeks to see if it improves blood sugar contro…

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve their heart health. Participants will receive either the full program (peer support and help finding resources) or basic …

This study gives 400 adults with diabetes or prediabetes free fresh food boxes and nutrition education twice a month for six months. Researchers will check if this helps lower blood sugar levels and reduce food insecurity. The goal is to see if better access to healthy food can i…

This study tests whether a church-based program led by community health workers can improve heart health and reduce racial inequalities in Black communities in New Orleans. About 800 adults aged 40 and older with at least three heart disease risk factors (like high blood pressure…

This study tests a new insulin, GZR4, against another long-acting insulin (Icodec) in 300 adults with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and causes fewer side effects like low blood sugar. Participants may also …

This early-phase trial tests whether transplanting insulin-producing cells into the front chamber of the eye can help control diabetes. Two participants with severe vision loss in one eye will receive the cells through a small incision, along with immunosuppressive eye drops to p…

This study looks at whether a program that combines clinic support and digital health coaching can improve diabetes and blood pressure control in low-income patients. About 600 adults with uncontrolled diabetes or high blood pressure will take part. The goal is to see if better a…

This study gives free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers want to see if easy access to these devices helps lower blood sugar and improves quality of life. Participants wear the sensor for 14-day periods and report o…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after starting insulin in the hospital helps manage blood sugar better than standard finger-stick testing. About 150 adults with type 1 or type 2 diabetes who are new to insulin will be randomly …

This study tests an AI software called iPredict-DR that analyzes eye photos to detect diabetic retinopathy early. Diabetic retinopathy is a leading cause of blindness but often has no symptoms until advanced stages. The trial will enroll 922 adults with diabetes to see if the AI …

This study is testing a new device that uses a special light (Raman spectroscopy) to measure blood sugar without needing to prick your finger. It will enroll 49 people with diabetes and healthy volunteers to see how accurate the painless method is compared to the standard finger-…

This study tests a family-oriented program to help Black families in Southwest Georgia prevent type 2 diabetes. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to reduce diabetes risk factors like weight an…

This study tests whether a special adhesive patch (COVER PATCH) helps keep continuous glucose monitors (CGMs) stuck on for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 months. The goal …

This study tests a new bandage called exciflex that delivers small amounts of electricity to help heal chronic wounds that won't close on their own. The study includes 16 veterans with diabetes or spinal cord injury who have wounds on their lower legs. The bandage can stay on for…

This study looks at whether one type of anesthesia (propofol) can lower the chance of confusion or delirium after surgery in older adults with diabetes, compared to another (sevoflurane). About 450 people aged 60 and older having non-heart surgery will take part. The goal is to f…

This study explores whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5–7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using the new s…

This study will follow 2000 adults with metabolic syndrome or prediabetes for many years. Researchers will track health changes, nutrition, and physical function to learn how these conditions progress and lead to complications. The goal is to find key factors that affect long-ter…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the need for radiation or invasive tests. Researchers will compare new MRI methods with standard angiography in up to 4,000 adults, including healthy volunteers and those with or at…

This study uses a special PET-MR scan to measure the activity of an enzyme called histone deacetylase in the heart. Researchers will compare enzyme levels in people with aortic stenosis or diabetes to those in healthy volunteers. The goal is to better understand how this enzyme r…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study aims to understand why people with diabetes often have lower vitamin C levels in their blood. Researchers will compare vitamin C in blood and urine from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport to find possib…

This study uses high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand diseases like glaucoma, macular degeneration, and diabetes-related eye problems.…

This study looks at whether stem cells from taste buds can be turned into cells that produce insulin, which could lead to new treatments for diabetes. Researchers will take tiny tissue samples from the tongues of 250 healthy adults to isolate and grow these stem cells. The goal i…

This study looks at people with type 2 diabetes who have nerve damage in their legs. Researchers will use ultrasound to measure the size and appearance of leg nerves and then check how well participants walk and keep their balance. The goal is to see if nerve ultrasound findings …

This study looks at how lactate, a brain fuel, affects blood flow to the brain in people with and without obesity. Researchers will measure brain blood flow and lactate levels during exercise in 24 healthy adults. The goal is to understand if short-term exercise training can impr…

This study looks at whether screening for social needs (like housing or food) and using an antiracist approach in primary care can help reduce chronic diseases such as high blood pressure, diabetes, depression, high cholesterol, and asthma. About 68,000 adults and children with t…

This study is creating a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to study genetic links to heart disease, diabetes, and obesity. The goal is to provide a foundation for future medical discoveries, not to test a treatment.

This study aims to find biomarkers that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples from 5,000 adults with diabetes and an open foot ulcer. The goal is to improve personalized treatment decisions and make future wound-healing trial…

This study looks at how the pancreas changes during pregnancy using MRI scans. Researchers want to see if these changes are linked to diabetes in mothers and their babies. About 87 women under 14 weeks pregnant will be followed through pregnancy and one year after birth. The goal…

This study is creating a smarter system to catch and treat diabetic retinopathy (an eye disease caused by diabetes) earlier. Researchers will use eye images, medical records, and blood tests from nearly 3,000 adults with type 2 diabetes to build models that predict disease risk a…

This study aims to verify that laboratory tests, equipment, and procedures used in research on conditions like obesity, diabetes, heart disease, and bone loss are accurate and give consistent results. About 100 healthy volunteers and people with these conditions will take part. T…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that control sugar and fat metabolism. Researchers will collect biological samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more abou…

This study aims to collect genetic and health information from 3,000 people to help doctors choose the right medications and avoid side effects. Participants include those taking five or more medications, or those on blood pressure or depression drugs. The goal is to learn how ge…

This study looks at how people's bodies use energy (metabolism) and whether current measurement methods are accurate for everyone. Researchers will study up to 2,000 healthy volunteers and people with conditions like diabetes, obesity, or cancer. Participants stay in the hospital…

This study is looking at whether certain proteins in the blood can help predict if older adults with diabetes will become confused after surgery. Researchers will measure these proteins before surgery and then check patients for confusion for three days after. The goal is to find…

This study looks at how genes and lifestyle affect type 2 diabetes in African populations, especially the Yoruba people in Nigeria. Researchers will compare 300 people with diabetes to 300 without, using blood samples and health data. The goal is to find genetic clues that could …

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It also tests whether a program that includes healthy habits, exercise, and mental activities can help prevent or slow down memory decline. About 420 people from diabetes clinics in Den…

This study aims to find out how often people with cystic fibrosis-related diabetes (CFRD) develop complications like eye, kidney, and nerve problems. Researchers will also check blood pressure and cholesterol levels. About 200 adolescents and adults with CFRD for at least 5 years…

This study looks at whether pregnant women with high-risk conditions like diabetes or high blood pressure can use a remote fetal monitor at home instead of going to the clinic. Fifty participants will use the device for 30-minute sessions three times a week starting at 32 weeks o…

This study is a large registry that will follow 20,000 people with type 1 diabetes across China. Researchers will collect health data from medical records and regular checkups to see how the disease progresses and affects quality of life. The goal is to better understand type 1 d…

This study follows 2,800 unpaid caregivers (family or friends) over up to 5 years to understand how the stress of caregiving affects their health and well-being. Participants complete surveys, phone interviews, and optional diaries and blood samples. The goal is to learn what soc…

This study looks at how your genes and your environment work together to affect your health. Researchers are collecting health and lifestyle information from 25,000 adults to better understand diseases like diabetes, heart disease, and asthma. The goal is not to test a new treatm…

This study aims to find biological markers in the blood that show when insulin-making beta cells are damaged or dying. Researchers will compare samples from people with type 1 or type 2 diabetes, those at high risk, and healthy volunteers. The goal is to better understand how dia…

This study looks at whether adding regular physical health checkups to mental health care helps find hidden diseases like heart problems, diabetes, or cancer in people with serious mental illness. About 2,800 adults in Denmark will get these checkups, and their results will be co…