DIABETES

This study compares the effects of drinking whole milk versus nonfat milk on body composition and health in 200 children aged 9-12 who have a higher BMI. Participants receive weekly milk deliveries and monthly check-ins for one year. The goal is to see which type of milk better s…

This study tests whether a 10-week peer support program led by community health workers can improve heart health and reduce stress in rural farmworker women aged 18-50. Participants will meet in small groups to learn about healthy behaviors, manage stress, and connect with commun…

This study is testing a new continuous glucose monitoring system called ROME GS in 60 adults with type 1 or type 2 diabetes. The goal is to see if it measures blood sugar accurately and is safe to use. Participants will wear the sensor and have their glucose levels checked agains…

This study looks at how fat cells work differently in normal-weight people with type 2 diabetes compared to those without diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adults aged 30-7…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This study tests a computer program called GlucAlert-CDS that alerts doctors when hospitalized patients have dangerously high or low blood sugar. The tool suggests care recommendations to improve glucose control. Researchers will compare periods when the tool is active versus ina…

This study is testing whether adding registered dietitian counseling or occupational therapy home safety tips to regular home-delivered meals can reduce fall risk in older adults. Researchers will compare four groups: meals alone, meals plus dietitian, meals plus occupational the…

This study is testing whether taking an antibiotic pill for 7 days after surgery to fix a broken leg, ankle, or foot can lower the chance of wound infection in adults with poorly controlled diabetes. About 40 participants will either receive the antibiotic or standard care (no ex…

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG) can help people with obesity and a serious liver condition called MASH. ESG reduces stomach size by about 70% using an endoscope, leading to significant weight loss. Researchers wi…

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar. About 376 people will be placed into one of four groups: usual care, pharmacist help, community health worker help, or both…

This study tests whether a mobile health app that gives personalized, real-time tips can help older adults with diabetes better manage their blood sugar and daily habits. Researchers will compare app users to those receiving usual care over six months. The goal is to see if the a…

This study tests a program that helps people with high blood pressure, diabetes, or kidney disease manage their health at home. Participants use a blood pressure monitor that sends readings to their care team, and they get support from community health workers and pharmacists. Th…

This study tests whether screening for social needs like housing and food access, combined with referrals to community resources, can improve chronic disease outcomes for patients of color. Researchers will track blood pressure, cholesterol, blood sugar, depression, and asthma co…

This study tests whether using a continuous glucose monitor (CGM) can improve blood sugar control in people with type 2 diabetes who are uninsured or on Medicaid and take daily insulin. Fifty participants will be randomly assigned to use a CGM or standard care for 6 months. The g…

This study tests a program called Med AAAction for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. The program provides free medications, delivers them to the bedside and then home, and assigns a health coach to help with follow-…

This study compares three types of weight-loss surgery (sleeve gastrectomy, gastric bypass, and duodenal switch) with standard medical care for people with type 2 diabetes and a BMI of 35 or higher. The goal is to see which approach leads to long-term diabetes remission and impro…

This study is testing the Omnipod 5, a tubeless insulin pump that automatically adjusts insulin delivery, in real-world settings for people with type 1 diabetes. About 304 participants aged 2 and older will use the system for the first time. Researchers will track blood sugar con…

This study provides 400 adults with diabetes or prediabetes who struggle to afford food with free fresh food boxes and nutrition classes twice a month for six months. Researchers will check if this program helps lower blood sugar levels and reduces food insecurity. The goal is to…

This study aims to help people with diabetes living in rural Kentucky by connecting them with community resources for food, housing, transportation, and other social needs. About 12,000 adults with diabetes will take part. The goal is to see if linking clinics with local organiza…

This study tests whether a weekly injection of dulaglutide, a GLP-1 drug used for diabetes, can improve early insulin release in adults with cystic fibrosis who have trouble processing sugar. About 30 participants will receive the drug or no drug in a crossover design. The goal i…

This study tests whether a special adhesive patch (COVER PATCH) can help keep continuous glucose monitors (CGMs) stuck to the skin for their full recommended wear time. About 194 people with type 1 or type 2 diabetes, aged 6 and older, will either use the patch or not for 4 month…

This study tests a program called Inspire HER for Black women aged 30-79 with heart, kidney, and metabolic risks. The program provides health education, physical activity, and social support to improve heart health and reduce stress. About 90 women in the Birmingham, AL area will…

This pilot study tests whether giving free produce boxes to Veterans with kidney disease and food insecurity can improve their health. Researchers will track blood pressure and kidney function in 20 participants, and interview them about their experience. The goal is to see if fo…

This study compares three different programs to help pregnant women maintain a healthy weight during and after pregnancy. About 795 women who are Black, Hispanic, or on Medicaid will join from early pregnancy until one year after giving birth. The goal is to see which program wor…

This study looks at whether a program that combines clinic support and digital health coaching can help low-income patients with diabetes or high blood pressure better manage their conditions. About 600 adults will take part, and researchers will track changes in blood sugar leve…

This study tests a device that uses automated ultrasound to check how well a dialysis fistula (a surgically created blood vessel connection) is maturing in people with end-stage kidney disease and diabetes. About 304 participants will be randomly assigned to get biweekly automate…

This study tests whether adding empagliflozin or semaglutide to insulin can improve blood sugar control in overweight or obese adults with type 1 diabetes. About 105 participants will take one of the two drugs or a placebo for 3 months. The goal is to see if these drugs help lowe…

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This early-stage trial tests transplanting insulin-making cells into the front chamber of the eye to treat diabetes. Only 2 participants with severe vision loss in one eye will receive the transplant, along with immunosuppressive eye drops to prevent rejection. The goal is to see…

This study tests whether a daily tablet of semaglutide (Rybelsus) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the drug or a placebo for 14 weeks, alongside their usual care. The goal is to see if t…

This study looks at how well the Omnipod 5 Automated Insulin Delivery System works in real-world settings for people with type 1 diabetes. About 152 participants aged 2 and older will use the system for the first time. The goal is to see if it helps keep blood sugar levels in a h…

This study compares a smart insulin pump called the iLet Bionic Pancreas to usual care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the pump for 13 weeks or continue their regular treatment. The goal is to see if the pump improves blo…

This study tests a diabetes program called Together Overcoming Diabetes (TOD), designed specifically for Lakota and other American Indian/Alaska Native communities. About 140 adults with type 2 diabetes who care for a young person aged 10-25 will take part. The program focuses on…

This study looks at whether wearing a continuous glucose monitor (CGM) for two weeks after leaving the hospital helps people with diabetes who are starting insulin for the first time. About 150 adults with type 1 or type 2 diabetes will be randomly assigned to use either a CGM or…

This study tests a new insulin drug, GZR4, against another insulin (Insulin Icodec) in 300 adults with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and causes fewer side effects like low blood sugar. Participants may also…

This study is testing a new device that uses Raman spectroscopy—a type of light technology—to measure blood sugar without needing a finger prick. Researchers will compare its readings to traditional blood tests in 49 people with diabetes or healthy volunteers. The goal is to see …

This study tests whether a wearable breath sensor can detect high or low blood sugar in teens with type 1 diabetes. Participants wear the device for 72 hours and provide breath samples while checking blood sugar with a finger prick. The goal is to see if breath chemicals can repl…

This study aims to find the most effective way to screen for diabetes in people who take steroids (glucocorticoids) for more than three months. Steroids can raise blood sugar and cause diabetes, but current screening methods vary. Researchers will compare three tests—fasting bloo…

This study compares a self-administered oral glucose tolerance test (OGTT) at home using a continuous glucose monitor (CGM) with the standard clinic-based OGTT. 75 adults with prediabetes will undergo both tests to see if the home version accurately diagnoses blood sugar problems…

This study tests an AI software called iPredict-DR that analyzes eye photos to find early signs of diabetic retinopathy, a leading cause of blindness. About 922 adults with diabetes will get their eyes checked with a special camera in primary care clinics. The goal is to see if t…

This study tests two lifestyle programs in 400 older African American and non-Hispanic white adults at risk for dementia and diabetes. One group does aerobic exercise three times a week; the other learns to follow the MIND diet, which emphasizes berries, greens, and whole grains.…

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This study compares two common anesthetics—propofol and sevoflurane—to see which one causes less confusion (delirium) after surgery in older adults with diabetes. Researchers will enroll 450 patients aged 60 and older undergoing major non-cardiac surgery. The goal is to find the …

This study tests a new bandage called exciflex that delivers small electrical pulses to help heal chronic wounds in Veterans with diabetes or spinal cord injury. The bandage can stay on for up to seven days without being changed. Researchers will measure wound size, temperature, …

This study provides free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers will track changes in blood sugar levels and quality of life over time. The goal is to see if easier access to CGM technology helps patients manage their d…

This study tests a program called enCompass Humana, which provides coaching and resources to unpaid caregivers of adults with both cancer and diabetes. The goal is to see if the program is practical and helpful for caregivers, improving their coping skills and reducing loneliness…

This study tests whether a special type of talk therapy, delivered via video calls, can reduce anxiety and depression in young adults (ages 18-64) with type 1 diabetes. The therapy also includes reviewing continuous glucose monitor data to help link emotions and blood sugar level…

This early-phase study tests whether a weight-loss drug called tirzepatide can help overweight or obese men with intermediate-risk prostate cancer lose weight before their prostate removal surgery. The study will enroll 30 participants and focus on safety and how well the program…

This study is looking at why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood, urine, and cells from 5,000 volunteers with and without diabetes. They will also check for genetic differences that might affect how th…

This study tests a tele-education program called ECHO Diabetes for primary care providers at 18 federally qualified health centers across the U.S. Providers attend twice-monthly online sessions for 6 months, led by a team at the University of Florida. The goal is to see if this t…

This study tests a high-resolution imaging system to see tiny structures in the eye that routine tools cannot detect. Researchers will scan 1,200 people with various eye conditions and healthy volunteers. The goal is to better understand diseases like glaucoma, diabetes, and reti…

This study surveys up to 900 adults with type 1 diabetes who use a closed-loop insulin system. It asks how satisfied they are with the special 'physical activity mode' designed to help manage blood sugar during exercise. The goal is to learn what works and what doesn't, so device…

This study follows 2,800 unpaid caregivers of people with chronic conditions like diabetes or Batten disease. Over up to 5 years, participants complete surveys, phone interviews, and optional diaries and blood draws. The goal is to understand how caregiving affects caregivers' so…

This study tests whether a simple fetal ECG monitor worn at home can effectively track the health of babies in high-risk pregnancies. Fifty pregnant women who need weekly fetal testing will use the device for 30-minute sessions, three times a week, starting at 32 weeks. The goal …

This study partners with community organizations to improve participation in health research among Black, Latino, and Native American communities in Colorado. Researchers will track changes in diet, transportation access, and social support over time. The goal is to build lasting…

This study tests a digital tool called CGM ASSIST for people with both diabetes and memory loss (like Alzheimer's). The tool uses a continuous glucose monitor and easy-to-read displays to help patients, caregivers, and doctors work together to manage blood sugar and prevent dange…

This study looks at how lactate, a brain fuel, affects blood flow in the brain. Researchers will compare people with and without obesity, and test if short-term exercise training can improve lactate levels and brain blood flow in those with obesity. 24 healthy adults aged 18-45 w…

This study tests whether a clinical decision framework helps hospital doctors feel more confident when prescribing medications for older adults (65+) with chronic conditions like diabetes and high blood pressure. About 150 doctors will attend an educational session and complete s…

This study tests whether an AI-powered tool can help doctors detect a type of heart failure (HFpEF) that often goes undiagnosed in people with type 2 diabetes. Researchers will use echocardiogram results and an AI algorithm to flag patients at risk, then alert their doctors. The …

This study looks at how often people with cystic fibrosis and diabetes develop complications like eye, kidney, and nerve problems. Researchers will also check blood pressure and cholesterol. The goal is to better understand these risks in a diverse group of 200 adolescents and ad…

This study aims to find biological markers (biomarkers) that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples from 5,000 adults with diabetes and an open foot ulcer. The goal is to develop a point-of-care test to guide personalized trea…

This study looks at how fat buildup in the pancreas (pancreatic steatosis) relates to diabetes and metabolic syndrome. Researchers will use ultrasound to measure this fat and compare it to blood tests and glucose tolerance in 100 adults. The goal is to create a scoring system tha…

This study is following 2,000 adults with metabolic syndrome or prediabetes to understand how these conditions progress over time. Researchers will track risk factors, complications, and changes in nutrition and physical function. The goal is to identify what influences long-term…

This study is building a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to explore how genetic variations relate to heart disease, high blood pressure, diabetes, and obesity. Participants provide samples and data, but no experime…

This study is not testing a treatment. Instead, it checks how accurate and repeatable lab tests and research techniques are for studying conditions like obesity, diabetes, heart disease, and osteoporosis. Up to 100 healthy volunteers or people with these conditions will provide s…

This study looks at whether ultrasound measurements of leg nerves can help explain walking and balance problems in people with type 2 diabetes who have nerve damage. Researchers will measure nerve size and appearance in 86 adults and compare them with balance tests and daily life…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography or CT scans in up to 4000 adults, including healthy volunteer…

This study aims to find biological markers in the blood that show when insulin-making beta cells are damaged or dying. By studying 165 people with type 1 or type 2 diabetes, plus healthy volunteers, researchers hope to better understand how diabetes develops. The goal is to enabl…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study follows over 4,000 adults in Shanghai to see how heart, kidney, and metabolic diseases (like diabetes and obesity) develop and change over time. Researchers will compare current health data with information collected between 2016 and 2017. The goal is to better underst…

This study looks at whether obesity raises heart disease risk differently in African American men and women compared to other groups. Researchers will measure body fat, blood fats, and insulin function in 2,000 healthy non-diabetic African American adults. The goal is to understa…

This study collects genetic and health information from 3,000 people to help doctors choose the safest and most effective medications. Participants include those taking multiple medications or specific drugs for blood pressure or depression. The goal is to reduce side effects and…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that process sugar and fat. Researchers will collect tissue samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more about the link betw…

This study looks at whether stem cells from taste buds can be turned into cells that produce insulin, which could lead to new diabetes treatments. Researchers will take tiny tissue samples from the tongues of 250 healthy adults to isolate and grow these stem cells. The goal is to…

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It then tests a program that combines several lifestyle changes to see if it can prevent or slow down memory loss. About 420 people will take part, and their thinking skills will be com…

This study uses advanced MRI scans to track changes in muscle and fat in the body and heart over 12 months in 50 adults starting semaglutide for type 2 diabetes or weight loss. Participants will undergo MRI scans, physical tests, blood samples, and questionnaires. The goal is to …

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study is a large registry that will follow 20,000 people with type 1 diabetes across China. It aims to track changes in blood sugar, kidney function, heart health, and emotional well-being over many years. The goal is to better understand how the disease progresses and impro…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease manage their health after leaving the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms…

This study is looking for a way to predict which older adults with diabetes might become confused after surgery. Researchers will measure specific proteins in the blood before surgery and see if they are linked to confusion in the days after. The goal is to better understand and …

This study looks at how your genes and your environment work together to influence health conditions like diabetes, heart disease, and asthma. Researchers will collect health information and DNA from 25,000 adults to build a unique resource for future research. Participants must …

This study uses a special PET-MR scan to measure the activity of an enzyme called histone deacetylase in the heart. Researchers will compare enzyme levels in people with aortic stenosis or diabetes to those in healthy volunteers. The goal is to better understand how this enzyme r…

This study will enroll about 2,920 adults with type 2 diabetes to create an early warning system for diabetic retinopathy, an eye complication that can lead to blindness. Researchers will combine eye images, routine health tests, and metabolism markers to better predict who is at…

This study examines whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using standard …

This study aims to learn how cerebral small vessel disease (CSVD) develops and worsens over time. Researchers will follow 50 adults who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Participants will get three MRI scans over 15 m…

This study collects blood, tissue, and other biological samples from 10,000 volunteers, including healthy people and those with conditions like cancer, heart disease, and diabetes. The samples are stored in a biobank and shared with researchers to uncover how diseases develop and…

This study takes a small sample of skin, blood, or urine from people with diabetes and healthy volunteers. Scientists will turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and pave the way for future cell-…

This study uses MRI scans to measure pancreas size in pregnant women and their unborn babies. Researchers want to see how the pancreas changes during pregnancy and how those changes are linked to diabetes. The goal is to better understand diabetes risk for both mother and child. …

This study aims to improve how we measure metabolism by looking at body size and composition in 2,000 people aged 2 and older. Participants include healthy volunteers and those with conditions like diabetes, obesity, or cancer. Over a 2-day hospital stay, they will undergo variou…