DIABETES

This study compares two treatment plans for people who develop diabetes from taking steroid medications. About 100 adults with conditions like asthma or arthritis will receive either a combination of a GLP-1 drug plus long-acting insulin, or standard intensive insulin therapy. Th…

This study looks at whether adding a low dose of the diabetes medication insulin detemir to a low-calorie diet helps obese adults with type 2 diabetes lose more weight and improve brain function related to food pleasure. About 240 participants will be split into two groups: one o…

This study tests a single dose of an investigational diabetes drug called GZR4 in 36 adults with diabetes who also have mild, moderate, or severe liver impairment. The goal is to see how the drug moves through the body and whether it is safe in people with different levels of liv…

This study compares a new once-weekly insulin (GZR4) with a standard daily insulin (glargine U100) in 580 adults with type 2 diabetes who already use mealtime insulin. The goal is to see if the weekly shot works as well or better at controlling blood sugar, with fewer injections …

This study compares a new nutritional drink (formula) for people with diabetes to an existing one. The goal is to see if the new drink is just as good at improving nutrition in people with type 1 diabetes, type 2 diabetes, or prediabetes who are at risk for malnutrition. About 10…

This study looks at whether taking a yerba mate extract can help improve health markers in overweight individuals. About 80 adults aged 40-65 will take either the extract or a placebo daily for 90 days. Researchers will measure changes in weight, blood sugar, cholesterol, and inf…

This study looks at whether having a cancer survivor's regular doctor work closely with their cancer team can better control high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these heart-related conditions will take par…

This study tests whether teaching kidney transplant recipients to eat a whole-food, plant-based diet improves their heart health and reduces complications like hospital visits. About 49 adults who had a kidney transplant in the past year and have high blood pressure, high blood s…

This study looks at whether treating patients at home for conditions like heart failure, infections, and diabetes can lead to better health outcomes and experiences. About 9,600 adults will receive hospital-level care at home through a digital program. Researchers will measure de…

This study tests a new insulin called GZR4 that is given once a week, compared to a standard daily insulin (glargine), in adults with type 2 diabetes who have never used insulin before. About 580 participants will receive either the weekly shot or the daily shot, along with other…

This study tests whether a natural compound called maslinic acid, found in olive skins, can safely improve metabolism in 50 Chinese adults at risk for obesity and diabetes. Participants take the supplement for 12 weeks while researchers measure changes in blood sugar, body fat, e…

This study tests a new insulin called GZR4 that is taken once a week, compared to a daily insulin (degludec), in adults with type 2 diabetes who already use basal insulin. The goal is to see if the weekly shot works as well or better at controlling blood sugar and is safe. About …

This study tests a new way of caring for children under 10 with diabetes. The clinic uses play, nutrition advice, mental health support, and parent groups to help families feel calmer and more in control. About 100 children and their families will take part to see if this approac…

This study is creating a large database and biobank of 48,000 people with diabetes in Hong Kong. Researchers will collect health information and blood samples to find genetic and other markers that can predict serious complications like kidney failure, heart disease, and stroke. …

This study looks at genes and health in 1,100 adults of African ancestry, including African Americans and Afro-Caribbeans. Researchers want to learn why obesity, diabetes, and heart disease are common in these groups. Participants give a blood sample and answer health questions. …

This study looks at differences in body composition, fitness, and temperature control between young soccer players with type 1 diabetes and healthy ones. About 40 boys will be monitored during exercise using thermal cameras and glucose sensors. The goal is to learn how to better …

This study looks at whether using game-like rewards and personal coaching can encourage older adults (50+) to walk more after leaving the hospital. About 350 participants will wear a Fitbit to track their steps over 26 weeks. The goal is to see if these fun incentives can prevent…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, or heart failure over 7 years. Participants provide blood, stool, and u…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, eggs, and dairy) with plant protein (like beans, nuts, and seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure,…

This study looks at how COVID-19 may change organs like the heart, lungs, or kidneys in people who had the virus. Researchers will compare these changes between people with type 2 diabetes and those without diabetes. The goal is to better understand long-term effects of COVID-19,…

This study aims to find new biological markers (biomarkers) for Adult Onset Autoimmune Diabetes (AOnAD) by analyzing blood samples from 25 adults with type 1 diabetes. Researchers will measure changes in specific microRNAs in tiny particles called exosomes. The goal is to better …

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to see how memory, thinking, and daily activities change over time. Researchers will also look at risk factors for cognitive decline, including after starting dialysis or receiving a …