DIABETES

This study looks at whether a tighter blood sugar target (70-140 mg/dL) works better than the current standard (70-180 mg/dL) for children and teens with Type 1 Diabetes who use automated insulin pumps. About 120 kids from three countries will be randomly assigned to one of the t…

This study looks at whether a GLP-1 RA drug (a type of diabetes medication) can improve liver fat and blood fat levels in people with metabolic fatty liver disease (MASLD), type 2 diabetes, and obesity. About 30 adults already taking a stable dose of GLP-1 RA will have a liver bi…

This study looks at whether adding a supplement called HMB to an exercise program can improve muscle mass, strength, and blood sugar control in older adults (ages 60-80) with type 2 diabetes and low muscle mass. About 120 participants will be randomly assigned to exercise, HMB, b…

This study will enroll 4,450 low-income adults with diabetes or high blood pressure who are part of Covered California. Participants will receive either $80 or $120 each month to spend on groceries. Researchers will track changes in blood sugar, blood pressure, and food insecurit…

This study looks at whether a continuous glucose monitor (CGM) can safely guide insulin therapy in cancer and transplant patients who are not in the ICU but need IV insulin due to steroids and specialized nutrition. About 80 adults with diabetes will be randomly assigned to eithe…

This study tests whether empagliflozin, a diabetes drug, can improve blood sugar control in people who have had islet transplants but still have partial pancreas function. About 40 adults will take either a placebo or one of two doses of the drug for 3 months. The goal is to see …

This study looks at whether pregnant people with type 1 or type 2 diabetes can safely keep using their insulin pump during labor instead of switching to IV insulin. About 30 participants will use their pump with a hospital safety plan, and their results will be compared to past p…

This study tests a 12-week home-based exercise program for adults aged 60+ with type 2 diabetes and early muscle weakness (probable sarcopenia). Participants will do short bouts of aerobic and resistance exercises to see if it improves their physical activity levels and muscle st…

This study looks at whether a special mobile app can reliably send blood sugar readings from continuous glucose monitors (CGMs) used by children with diabetes in the hospital to a central database. Currently, this data is only available on bedside devices, not to the care team in…

This study looks at how healthy people respond to sitagliptin, an FDA-approved diabetes drug. Researchers want to understand why some people produce more insulin after taking the drug. About 400 healthy, non-diabetic volunteers from the Old Order Amish community will take part in…

This study looks at how well doctors can screen for physical inactivity and refer patients to local exercise programs. Researchers will track how many patients get referred and whether the programs improve health. The goal is to make exercise a standard part of healthcare for pre…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just tracking health over time to better understand the co…

This study collects blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, and diabetes. The samples are used to develop and fine-tune new diagnostic tests that can be done right at the patient's bedside. The g…

This study will see if community health workers (CHWs) can help people with two or more chronic health problems, like diabetes and high blood pressure, better understand and manage their health. The CHWs will work with 300 adults who have trouble getting good medical care to crea…

This study will collect health information and samples (blood, saliva, urine, stool) from up to 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or metabolic problems. Researchers want to learn how diabetes and obesity develop and change, especially in younger…

This study is testing a new AI-powered tool called AIManage to help doctors and patients manage medications for diabetes and obesity. The tool will assist with adjusting doses and tracking side effects. The study involves 16 participants and is split into two phases: first, gathe…

This study compares two ways of making treatment decisions for people with severe blockages in all three main heart arteries who also have diabetes. One group gets a real-time online discussion among heart experts during a procedure, while the other gets usual care. The goal is t…