DIABETES

This pilot study tested two computer algorithms designed to automatically control blood sugar levels in people with type 1 diabetes. Five adults who already use an insulin pump and continuous glucose monitor participated. The goal was to see if the systems could keep blood sugar …

This study tested whether lifestyle coaching delivered through a patient portal helps adults maintain weight loss. 269 participants who had already lost at least 5% of their body weight were randomly assigned to receive either coaching plus tracking tools or tracking tools alone …

This study tested a fully automated system that delivers both insulin and glucagon to manage blood sugar in adults with type 1 diabetes. Over 12 months, 243 participants used either the dual-hormone device or their usual care. The goal was to see if the system helps keep blood su…

This study looked at whether treating gum disease (periodontitis) can improve blood sugar control in people with diabetes. 91 patients were randomly assigned to receive either gum treatment or no treatment (with treatment offered later). The main measure was change in hemoglobin …

This early study tested a device that uses mild electric pulses to regenerate the lining of the upper small intestine in 20 adults with type 2 diabetes. The goal was to see if the procedure is safe and could help lower blood sugar. Participants were on 2-3 diabetes pills and had …

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…

This study tested whether a natural plant compound called phytosterol can help people with non-alcoholic fatty liver disease (NAFLD). 27 adults took the supplement for 3 months. Researchers measured changes in liver enzymes, cholesterol, insulin, and inflammation. The goal was to…

This study tested an AI-based lifestyle guidance system called X-Life in 124 adults with type 2 diabetes. Participants used a smartphone app that combined glucose readings and wearable device data to receive personalized diet and activity recommendations. The goal was to see if t…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study tested whether a flexible lifestyle program could help people with obesity and related health issues like insulin resistance, diabetes, or high blood pressure. Forty adults first received either nutrition or exercise counseling, and those who didn't improve enough afte…

This study tested whether adding the antibiotic rifampin to standard treatment helps diabetic patients with foot bone infections avoid amputation. Over 800 veterans took part, receiving either rifampin or a placebo for six weeks. The goal was to see if rifampin improves amputatio…

This study tested whether the diabetes pill glyburide works as well as insulin shots for treating gestational diabetes in pregnant women. Over 900 women participated, and researchers looked at baby health issues like high birth weight, low blood sugar, and jaundice. The goal was …

This study tested a small, wearable sensor that sits just under the skin and measures blood sugar continuously for up to 5 days in adults with diabetes. 247 participants wore the sensor along with a standard monitor and took fingerstick tests to compare accuracy. The goal was to …

This early study tested whether a protein called apelin can improve how the body uses insulin in people with type 2 diabetes. Nine volunteers received both apelin and a placebo infusion to compare effects. The goal was to see if apelin increases the amount of sugar the body can p…

This early-stage trial tested a new drug called CT-388 in 129 overweight or obese adults, including some with type 2 diabetes. The study aimed to check the drug's safety and how the body processes it, while also measuring weight loss and blood sugar changes. Participants received…

This study tested an AI system called X Life that gives personalized diet and exercise tips to people with prediabetes or type 2 diabetes. Twenty participants used the system for 7 days via AR glasses or a smartphone. The goal was to see if people found it easy and helpful, not t…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested whether a special education program that focuses on patient empowerment helps people with type 2 diabetes better manage their blood sugar and daily care. 50 adults aged 40 and older with type 2 diabetes took part. The program aimed to improve self-management ski…

This pilot study tested a 6-month program of healthy eating and physical activity to help people with early Type 2 diabetes achieve remission. 35 adults with diabetes and overweight participated, with some receiving the program and others standard care. The goal was to see if the…

This study tested a new insulin (22011) to see if it works as well as an existing insulin (Ryzodeg) for people with type 2 diabetes. About 414 adults in China took part. The goal was to compare blood sugar control and safety. Results suggest the new insulin is a similar option fo…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This study tested a new way to deliver HIV and chronic disease care by bringing services into community microfinance groups in rural Kenya. About 1,200 adults with HIV took part, with some receiving care in the community and others at usual clinics. The goal was to see if combini…

This study tested whether a mobile app helps elderly people (70+) with diabetes better control their blood sugar, maintain physical function, and improve quality of life. Sixty participants were split into two groups: one used the app, the other did not. The app was designed to b…

This study looked at whether a class of diabetes drugs called GLP-1 receptor agonists can improve heart function and reduce fat around the heart in obese people with type 2 diabetes. The researchers measured heart fat and function using MRI scans in 44 participants. The goal was …

This study tested a program called Family Check-Up Heart, which adds heart-health coaching to regular home visits for new moms and their babies. About 150 mothers who had Medicaid and recently gave birth took part. The goal was to see if the program could help moms manage weight,…

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This study tested a personalized lifestyle program for 232 overweight or obese Hispanic pregnant women to help them gain a healthy amount of weight during pregnancy and lose it after birth. The program included diet and exercise guidance tailored to their culture and language. Th…

This study tested a virtual culinary medicine program for 89 adults with type 2 diabetes and high body mass index. Participants took online cooking classes to learn healthy eating habits. Researchers measured changes in blood sugar (HbA1c), weight, and cholesterol to see if the p…

This study tested a program to help South Asian adults with uncontrolled diabetes lower their blood sugar (HbA1c). The program included health coaching, referrals to community resources, and better coordination between patients and their healthcare team. Over 850 people took part…

This study looked at whether getting blood sugar under control for a short time before major abdominal surgery can lower the chance of problems or death. It included 53 adults with uncontrolled diabetes (HbA1c of 7.5% or higher) who were scheduled for surgery lasting over 2 hours…

This completed study tested whether a special laser technique called SERS can tell if someone has diabetes by looking at their blood. Researchers used gold nanoparticles and machine learning to find unique patterns in blood samples from 52 people. The goal is to create a simple, …

This study tested a new automated screening tool called OPTDR01 to detect diabetic retinopathy, an eye disease that can cause vision loss. The goal was to see if the tool works well in primary care settings, making it easier for people with diabetes to get screened. About 300 adu…

This study tested a new device called the Cmate blood glucose analyzer, which measures blood sugar without needing a finger prick. Researchers compared its readings to standard blood tests in 40 healthy, pre-diabetic, and type 2 diabetic adults. The goal was to see if this non-in…

This study tested a program that gives healthy food incentives and coaching to adults at risk for diabetes. The goal was to help them stick with healthy habits and lower their chances of getting diabetes. 61 participants joined the program, and researchers tracked weight, blood s…

This study tested a mobile health program designed to support family caregivers of people with both dementia and diabetes. Sixty caregivers received either standard care or the program, which added weekly online support and resources via a smartphone app. The goal was to see if t…

This study tested a program that sends text reminders and uses social support and game-like features to encourage people with chronic kidney disease, diabetes, and high blood pressure to check their blood pressure regularly. 70 adults from a University of Pennsylvania clinic part…

This study tested a program where community health workers helped young adults (ages 18-35) from underrepresented minority groups with type 1 diabetes start using devices like continuous glucose monitors and insulin pumps. Over 9 months, 119 participants were randomly assigned to…

This study tested a personalized home exercise program for cancer survivors who also have diabetes or high blood pressure. 34 participants chose from walking, yoga, or other exercises and used a wearable device to track progress. The goal was to see if the program could reduce fa…

This study tested whether the diabetes drug acarbose, adjusted using continuous glucose monitoring (CGM), can reduce pain in adults with painful diabetic neuropathy. 170 participants with type 2 diabetes and high blood sugar swings were enrolled. The goal was to see if controllin…

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This study looked at whether foot-ankle exercises or walking exercises can help people with type 2 diabetes who have nerve problems in their feet. 375 adults with diabetes were split into three groups: one did foot-ankle exercises, one did walking exercises, and one received only…

This study tested a new method called inforatio to help heal diabetic foot ulcers. The technique involves making small cuts in the wound to trigger the body's natural healing response. 100 adults with diabetes and foot ulcers that had not healed for at least 6 weeks took part. Th…

This study tested whether a 12-week foot-ankle exercise program could help adults with type 2 diabetes manage nerve pain, stress, and quality of life better than walking or standard care. 108 participants were split into three groups: foot-ankle exercises, walking, or education o…

This study looked at 142 people who had a sinus lift procedure using cow bone mineral before getting dental implants. Researchers measured how much bone was left around the implants years later, and checked if the original jawbone height, implant type, smoking, or diabetes played…

This pilot study tested a continuous glucose monitor (CGM) in 40 hospitalized adults with type 1 or type 2 diabetes. The goal was to see if using the device could help detect and reduce episodes of low and high blood sugar. Researchers compared CGM readings to standard care to ga…

This completed study looked at how diet and exercise change blood sugar levels in 61 adults with diabetes. Researchers used advanced tests (genomics, proteomics, etc.) to understand the body's complex response. The goal is to build a tool that helps doctors personalize diabetes c…

This pilot study tested a text-based resource platform that sends diabetes educational materials to patients in the emergency department. The goal was to see if it improves diabetes knowledge, reduces distress, and supports self-care. Fifty adults with poorly controlled or new-on…

This pilot study tested whether combining practice facilitation (coaching for clinic teams) with health information technology can increase referrals to diabetes self-management education and support (DSMES). The study involved 22 clinics and measured referral and attendance rate…

This study looked at how well the body clears fats from the blood after a meal (triglyceride tolerance) in 514 people with stable coronary artery disease. Researchers wanted to see if poor fat clearance could help predict future heart attacks or death. Participants were followed …

This study looked at 103 diabetic adults starting chemotherapy for cancer. Researchers used a continuous glucose monitor (Freestyle Libre) to track blood sugar changes. The goal was to see how often blood sugar went too low or too high during treatment, since chemotherapy and rel…

This study looked at how vitamin E is absorbed and used by women who are normal weight, overweight, or have type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after meals with different amounts of fat and vitamin E. The goal was to learn more about vitami…

This study looked at a recently discovered hormone called 26RFa in 62 women who were obese, some with type 2 diabetes and some without. Researchers measured the hormone levels before and after weight-loss surgery (sleeve gastrectomy) and compared them to healthy-weight volunteers…

This study looked at how a class of diabetes drugs called SGLT2 inhibitors changes kidney function in people with chronic kidney disease (CKD). Researchers compared 60 patients with and without diabetes to see if the drug affects their estimated glomerular filtration rate (eGFR) …

This study looked at how the energy people burn through physical activity relates to body weight and diabetes risk. Researchers measured activity levels and body changes in 2500 Black adults from Ghana, South Africa, Seychelles, Jamaica, and the US over two years. The goal was to…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looked at how family members talk about genetic health risks like sickle cell, diabetes, cancer, and heart disease. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand how sharing this information …

This study looked at whether taking short, regular walks during long periods of sitting can lower blood sugar and cholesterol after meals—key risk factors for Type 2 diabetes and heart disease. Researchers compared the effects in normal-weight and overweight/obese South Asian adu…

This study looked at 150 people with coronary artery disease who had bypass surgery, comparing those with and without diabetes. Researchers measured the fat around the heart (epicardial fat) and checked how it relates to death and heart problems after surgery. They also tested if…

This study looked at 146 healthy women of African, African-American, and white backgrounds to find better ways to predict diabetes and heart disease. Participants completed several visits including blood tests, glucose tolerance tests, and body measurements. The goal was to see i…

This study looked at how different types of diets affect the number of calories people burn and their risk for diseases like diabetes and heart problems. 234 adults who were overweight or obese took part. Researchers measured their energy use by having them drink special water an…

This study tested whether taking acetaminophen (like Tylenol) affects the accuracy of a new wearable continuous glucose monitor called the Biolinq System. Thirty-one adults with diabetes wore the device for three days and took fingerstick blood tests to compare readings. The goal…

This study looked at how often low blood sugar (hypoglycemia) occurs in elderly diabetic patients living in nursing homes. Researchers used a continuous glucose monitor worn on the skin for 14 days to track blood sugar levels. The goal was to better understand the frequency and c…

This study looked at whether replacing sitting time with standing and walking can improve daily blood sugar levels in South Asian adults who are overweight or obese. 18 participants changed their daily routines to sit less and move more. The results suggest that even small change…

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This study looked at how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. About 498 adults from Mexican-American households in Houston took part in interviews about their medical history, beliefs, and family communication.…

This study looked at how two drugs, metformin and HRS-7535, behave in the bodies of 18 healthy men aged 18-50. The goal was to measure drug levels and safety, not to treat any disease. Results will help guide future diabetes research.

This study looked at whether online referrals from doctors to the WIC food program help more pregnant women sign up. About 240 pregnant women on public insurance or uninsured took part. Some got usual care, others got a direct digital referral, and some also spoke with a dietitia…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study looked at medical records from over 740,000 older adults with diabetes to see if a drug called semaglutide (used for diabetes) might lower the risk of developing dementia or Alzheimer's disease compared to another class of diabetes drugs (DPP4 inhibitors). The research…

This study looked at whether a Fitbit activity tracker plus health coaching could help people with overweight or obesity who are already taking weight-loss medications (GLP-1s) become more active. Fifteen adults from a primary care clinic took part in a 12-week program. The main …

This study looked at 120 people having hand or wrist surgery to see if those with kidney failure or diabetes recover feeling from a nerve block more slowly than those without these conditions. Researchers measured how long numbness lasted after the block. The goal was to learn ho…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study tested whether a program that combines job training with employer support can lower the risk of chronic diseases like diabetes and heart disease in unemployed, low-income adults. Researchers measured changes in stress, weight, and blood pressure over 12 months. The goa…

This study looked at how often older adults with diabetes in long-term care facilities experience low blood sugar (hypoglycemia). Researchers used a continuous glucose monitor (CGM) worn for 10 days to track blood sugar levels in 86 participants. The goal was to better understand…

This study examined 200 adults who had surgery to remove plaque from their carotid arteries. Researchers identified bacteria living inside the plaques and tracked whether certain types were linked to later strokes, re-narrowing of the artery, or death. The goal was to learn which…

This study looked at how eating a high-fat diet for just 5 days changes the way muscles use sugar and fat. Researchers studied 11 healthy men to see if this short-term diet causes muscle problems similar to those seen in people with diabetes. The goal was to learn more about what…

This study tested a new workbook that uses word games to teach people with diabetes how to manage their condition. 25 participants completed the workbook during clinic visits or at home, and then attended follow-up sessions. The goal was to see if the workbook was easy to use and…

This study looked for rare, single-gene causes of insulin-dependent diabetes in 127 participants. Researchers examined patients' genes, medical histories, and family members to identify new forms of diabetes. The goal was to better understand these genetic subtypes, not to test a…