Rheumatoid arthritis

This study looked at how safe and effective two shingles vaccines (Zostavax and Shingrix) are in people with rheumatoid arthritis who are taking the drug abatacept. About 154 adults took part, and researchers measured their immune response and any side effects. The goal was to se…

This study tests whether a substance produced by umbilical cord cells can help control moderate rheumatoid arthritis. Participants receive weekly injections of either the cell substance or a placebo for six weeks, alongside their usual medication. The goal is to see if it improve…

This study tests whether adding metformin, a diabetes drug, to standard methotrexate therapy helps more people with rheumatoid arthritis achieve disease control. About 128 adults with active RA who have not recently taken methotrexate will receive either methotrexate plus metform…

This early-stage trial evaluates an experimental drug called ZB002, given as an injection under the skin. In the first part, healthy volunteers receive a single dose to check safety and how the drug moves through the body. In the second part, people with rheumatoid arthritis rece…

This pilot study tested whether a butyrate supplement, a type of short-chain fatty acid, could change the gut microbiome and immune responses in people with rheumatoid arthritis who didn't respond well to methotrexate. Twenty participants took the supplement for up to two months.…

This trial is testing whether combining certolizumab pegol, an injectable biologic, with methotrexate, a standard oral medication, can help adults with early active rheumatoid arthritis achieve and maintain remission. Participants are newly diagnosed, have not yet taken disease-m…

This trial tests whether combining certolizumab pegol (Cimzia) with methotrexate can help adults with early, active rheumatoid arthritis achieve and maintain low disease activity without flare-ups. Participants who already responded well to this combination in a prior study conti…

This early-stage trial is evaluating an experimental oral drug called IA-14069, first in healthy volunteers and then in people with rheumatoid arthritis who are already taking methotrexate. The main goals are to check the drug's safety, how the body processes it, and whether it s…

This study tests whether the oral drug upadacitinib works better than the injected drug adalimumab for adults with moderate to severe rheumatoid arthritis who still have symptoms after trying one TNF blocker. About 480 participants will be randomly assigned to receive either upad…

This trial compares two surgical approaches for total hip replacement: the minimally invasive SuperPATH technique and the conventional posterior approach. Adults with hip arthritis or related conditions are randomly assigned to one of the two procedures. The study tracks recovery…

This trial is testing the long-term safety and tolerability of the drug filgotinib in people with rheumatoid arthritis who have already completed an earlier filgotinib study. Researchers are monitoring side effects, lab abnormalities, and vital signs over an extended period. The …

This trial tests whether adding a clinical pharmacist to standard drug therapy helps people with early rheumatoid arthritis achieve better disease control. Participants receive pharmacist-led education, counseling, and medication management alongside their usual DMARD treatment. …

This study compares the safety of baricitinib, an oral medication, against TNF inhibitors (injectable drugs like etanercept and adalimumab) in people with rheumatoid arthritis. The main focus is on the risk of venous thromboembolism (blood clots in veins). Participants include th…

This completed Phase 4 study compared the safety of baricitinib (a daily pill) to TNF inhibitors (injections) in over 2,600 adults with rheumatoid arthritis. The main goal was to see if baricitinib had a higher risk of blood clots. Participants had to be at least 60, have a histo…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This Phase 1 study tested a single injection of SHR-3045 in 16 healthy adults to see if it is safe and how the body processes it. The drug is being developed as a potential treatment for rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. Because this…

This study looked at how safe and effective peficitinib is for people with rheumatoid arthritis (RA) in everyday medical practice. About 3,000 patients who were starting peficitinib for the first time took part. Researchers tracked side effects and measured disease activity using…

This study followed 152 people who received the Sidus Stem-Free Shoulder implant for severe shoulder pain and disability due to arthritis or other joint diseases. The implant is designed to replace the shoulder joint without a long stem, potentially preserving more bone. Research…

This early-stage trial tested the safety of a new drug called SHR-3045 in 40 healthy adults. The study was randomized, double-blind, and placebo-controlled, meaning some participants got the drug and some got a dummy shot. The main goal was to see if the drug causes any side effe…

This study followed 155 French adults with moderate-to-severe rheumatoid arthritis who were prescribed filgotinib (Jyseleca) for the first time. Over two years, researchers measured how many patients stayed on the drug and how well it controlled their disease activity. The goal w…

This study tested an experimental oral drug called LY3871801 in 164 adults with moderately-to-severe rheumatoid arthritis. The goal was to see if it reduces joint swelling and pain better than a placebo. The trial is complete, and results will help decide if further testing is wa…

This study looked at whether using a robotic system (ROSA) during knee replacement surgery leads to more accurate implant placement compared to traditional methods. It included 252 adults with knee pain, arthritis, or deformities who were already scheduled for knee replacement. R…

This study tested the drug filgotinib (Jyseleca) in 118 Korean adults with rheumatoid arthritis. The goal was to see how many patients experienced at least a 20% improvement in symptoms after 12 weeks of treatment. The trial is complete, and results will help determine if filgoti…

This phase 3 trial tested whether adding paroxetine, an antidepressant, to standard methotrexate therapy can better control rheumatoid arthritis. 100 adults with active RA took part. The main goal was to see if the combination lowers disease activity scores more than methotrexate…

This study tested an injectable drug called CT-P13 in 192 adults with moderate-to-severe rheumatoid arthritis. The goal was to see if it reduces joint pain and swelling better than a placebo. Participants received either the drug or a dummy shot, and researchers measured improvem…

This study tested whether ultrasound could detect signs of rheumatoid arthritis (RA) relapse before symptoms appear in patients treated with rituximab. Thirty adults with RA who had not responded to at least one TNF-blocking drug were included. Researchers used ultrasound to meas…

This study tested whether people with rheumatoid arthritis, psoriatic arthritis, or spine arthritis could safely switch from receiving infliximab through an IV infusion at a clinic to giving themselves a simple shot under the skin at home. 22 adults who were already stable on IV …

This study tested a compound called 2-HOBA in 32 adults with rheumatoid arthritis. Participants took either 2-HOBA or a placebo three times a day for 4 weeks. The goal was to see if 2-HOBA is safe and reduces markers of inflammation. This early research helps plan larger future s…

This study tested a new shoulder implant called the Catalyst CSR System in 87 people with shoulder arthritis or bone damage. The implant is designed to preserve more natural bone than traditional replacements. Researchers measured pain, movement, and implant safety over two years…

This early-stage trial tested a new biologic drug called KD6005 in 73 people: first in healthy volunteers, then in patients with rheumatoid arthritis. The main goal was to check safety and how the body processes the drug. It is too soon to know if KD6005 works, but this study is …

This completed study looked at whether the DASH diet, known for lowering blood pressure, can help people with rheumatoid arthritis. Forty-nine adults with active disease followed a personalized DASH diet for 12 weeks. Researchers measured changes in disease activity, pain, and in…

This study looked at how safe and effective upadacitinib is for Korean patients with rheumatoid arthritis, atopic dermatitis, ankylosing spondylitis, or psoriatic arthritis. Over 2,300 adults took the drug as prescribed by their doctor and were followed for about 28 weeks. Resear…

This study looked at 300 adults with active rheumatoid arthritis whose first anti-TNF treatment stopped working. Researchers compared two strategies: switching to a different type of biologic drug or trying a second anti-TNF. The goal was to see which approach better controls the…

This study tested what happens when patients with rheumatoid arthritis, Crohn's disease, or eye inflammation switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Over 260 adults who had been on Remicade for at least 4 months were switched. The main goal …

This early study tested a new drug called EF-M2 (Immutalon) in 48 adults with moderate-to-severe rheumatoid arthritis. The drug is designed to shift immune cells from a pro-inflammatory to an anti-inflammatory state. Participants received injections for 4 weeks, and researchers m…

This Phase 2 trial tested Proximod, a daily pill that calms the immune system, in 179 adults with moderate-to-severe rheumatoid arthritis who had not responded well to standard treatments. Participants took either 5 mg, 10 mg, or a placebo daily for three months, with one month o…

This early-stage study tested a new biologic drug called SOL-116 in 56 healthy volunteers and people with rheumatoid arthritis. The main goal was to check safety and how the body processes the drug, not whether it works. Participants received a single injection of SOL-116 or a pl…

This study tested a biosimilar version of the drug infliximab (made by Pfizer) in 77 people with rheumatoid arthritis. The goal was to see how safe and effective it is in real-world use. Participants received the drug by IV infusion, and researchers tracked side effects and disea…

This study tested whether increasing the dose of infliximab (a drug that blocks inflammation) helps people with active rheumatoid arthritis who did not improve enough with methotrexate alone. 327 adults received one of three doses (3, 6, or 10 mg/kg) by IV infusion over nearly a …

This study tested whether adding an experimental drug called MP-435 to standard methotrexate treatment helps people with rheumatoid arthritis who don't get enough relief from methotrexate alone. 112 adults took either MP-435 or a placebo (dummy pill) plus their usual methotrexate…

This study tested whether cilostazol, a drug normally used for leg pain from blocked arteries, can help control rheumatoid arthritis when added to standard medications. 70 adults with moderate to severe arthritis took either cilostazol plus their usual drugs or just their usual d…

This study tested a new shoulder implant called PyroTITAN HRA in 156 people with arthritis. The implant resurfaces the ball part of the shoulder joint to relieve pain and improve function. Researchers tracked how long the device lasted and whether it caused problems, aiming to se…

This study looked at over 9,000 people with rheumatoid arthritis to compare how well different treatments work in everyday medical practice. Researchers compared drugs like TNF inhibitors and tofacitinib, given alone or with methotrexate, to see which combination controls disease…

This study tested a protein called GcMAF, which is made from vitamin D-binding protein and is thought to calm the immune system. Researchers gave it to 120 adults with chronic inflammatory conditions like rheumatoid arthritis or cystitis that didn't improve with standard treatmen…

This study looked at whether treating gum disease (periodontitis) can reduce the severity of rheumatoid arthritis (RA) in people who have both conditions. Researchers enrolled 22 adults with RA and gum disease, providing periodontal treatment and measuring changes in RA activity …

This early-stage trial tested ARD-885, a new oral drug that targets two proteins involved in inflammation, in 94 healthy volunteers and people with rheumatoid arthritis. The main goal was to check safety and how the body processes the drug. Researchers gave single and multiple do…

This large study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of developing autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or …

This early-stage study tested two versions of an experimental drug called ianalumab in 48 adults with active rheumatoid arthritis. The goal was to see if the two forms are similar enough in safety and how the body processes them. Participants received multiple injections, and res…

This early-stage trial tested a single dose of the experimental drug AZD6912 in 40 healthy adults to see if it is safe and how the body processes it. The study is a first step toward possibly treating rheumatoid arthritis, but it does not involve people with the disease. Results …

This study tested two methods to help people with rheumatoid arthritis stop taking steroids (prednisone) safely. 102 adults with low disease activity or remission were given either a gradual dose reduction or a replacement with hydrocortisone. The goal was to see which approach a…

This study compared two types of knee implants—the Vanguard Cruciate Retaining and the AGC Total Condylar—in 150 patients with knee arthritis. The goal was to see which implant provides better pain relief and function after knee replacement surgery. Patients were followed for sev…

This study tested whether rebamipide, a drug normally used for stomach ulcers, can help control rheumatoid arthritis when added to standard methotrexate therapy. Sixty adults with active arthritis took either rebamipide or a placebo three times daily. Researchers measured joint p…

This study looked at the long-term safety and effectiveness of a daily pill called ABX464 in 40 adults with moderate to severe rheumatoid arthritis. Participants had already completed 12 weeks of treatment in an earlier study. The goal was to see if ABX464 can help keep the disea…

This study tested a robotic system called CORI that helps surgeons plan and perform knee replacement surgery. The goal was to see if the robot helps place the new knee joint more accurately. 126 adults who needed a partial or total knee replacement took part. The results showed t…

This study tested a program to help people with rheumatoid arthritis (RA) get their cholesterol checked and treated. Many RA patients are at higher risk for heart attacks and strokes but often miss out on proper screening. The program used peer coaches and educational materials t…

This study tested whether adding nipocalimab to the standard drug certolizumab works better than certolizumab alone for people with active rheumatoid arthritis. It involved 103 adults who still had moderate to severe symptoms despite trying other advanced treatments. The main goa…

This study tested a new oral medication called LW402 in 72 adults with moderate to severe rheumatoid arthritis who were already taking methotrexate. Participants received either LW402 or a placebo for 12 weeks to see if the drug could reduce joint swelling and pain. The goal was …

This early-phase trial tested a single infusion of stem cells taken from the patient's own belly fat in 15 adults with active rheumatoid arthritis. The main goal was to see if the treatment is safe over 12 months. Researchers also looked at whether it could lower inflammation mar…

This study tested a smartphone app and a web-based dashboard to help people with rheumatoid arthritis track their symptoms between doctor visits. 190 participants used the app to answer daily questions about pain and function, while study staff monitored the data and connected pa…

This early-stage study tested a new oral drug called SAR441566 in 10 healthy Japanese men to see how safe it is and how the body processes it. The drug is being developed for rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. The study only looked at…

This study tested the DePuy LCS Complete mobile-bearing total knee system in 241 people needing knee replacement due to arthritis. The goal was to see how well the implant and surgical tools work during and after surgery. Researchers measured implant survival, knee function, and …

This study looked at how well the drug tocilizumab (Actemra) works for people with moderate to severe rheumatoid arthritis in everyday medical practice. Researchers followed 322 adults for 12 months after starting treatment. The main goals were to see how many patients achieved l…

This study followed 76 adults who received a total shoulder replacement using the MIRAI modular prosthesis. Researchers measured how well the shoulder functioned and how stable the implant was over five years. The goal was to see if the implant helps patients move better and last…

This completed study followed 413 Canadian adults with moderate to severe rheumatoid arthritis who were prescribed upadacitinib by their doctors. Researchers tracked how well the drug controlled symptoms like joint pain and stiffness over 24 months. The goal was to see if the dru…

This study looked at whether an MRI scan can help doctors diagnose rheumatoid arthritis (RA) sooner in people with joint swelling. 75 adults with early symptoms were given an MRI and followed for a year. The goal was to see if MRI findings could predict who would develop RA, allo…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

This trial tests a new 24-week program called COMFI that combines a cognitive behavioral approach with physical activity to help people with inflammatory arthritis manage fatigue. Participants attend group sessions, an optional individual session, and a booster session, and they …

This study will test whether a 6-week aerobic exercise program can improve quality of life, mood, and fatigue in women with rheumatoid arthritis. Sixty-four participants with low disease activity will either continue standard care or add five weekly exercise sessions. Researchers…

This study tests whether blood flow restriction training (BFRT) — using pressure cuffs during low-load exercise — can help people with rheumatoid or psoriatic arthritis build muscle with less joint strain than conventional strength training. Adults with these conditions will be r…

This study looked at whether the drug Acthar can reduce inflammation and improve symptoms during a rheumatoid arthritis (RA) flare. Forty adults with RA who were having a flare took part. Researchers used ultrasound and disease activity scores to measure changes after treatment.

This study tests whether learning Argentine tango can increase overall physical activity in people with chronic inflammatory arthritis, such as rheumatoid arthritis or spondyloarthritis. Participants will take tango sessions that focus on body awareness, movement, and connection …

This trial tests whether optimizing protein intake—through dietary counseling and whey protein supplements—can reduce household work limitations and overall disability in women with rheumatoid arthritis. Participants will aim for 1.0 gram of protein per kilogram of body weight da…

This pilot study tested whether a care model called PREVAIL is practical and acceptable for adults with rheumatoid arthritis. The model includes a screening tool to identify activity limitations, a recommendation to the rheumatologist for exercise or physical therapy, and an onli…

This study is testing a device called the CORI™ KNEE TENSIONER, which helps surgeons balance the knee during total knee replacement surgery. Fifty adults who need a knee replacement will have the surgery using this device, and their recovery and quality of life will be tracked fo…

This study tested whether a device that gently stimulates the vagus nerve through the ear could help control rheumatoid arthritis in one patient who had their spleen removed. The patient used the device at home for 24 months and visited the clinic every two months for checkups. T…

This study tested whether nurse-led consultations can help people with rheumatoid arthritis become more independent in managing their subcutaneous biotherapy. Many patients struggle to recognize warning signs and delay seeking help. The study enrolled 71 adults with rheumatoid ar…

This completed pilot study tested an 8-week online mindfulness course in 38 people with rheumatoid arthritis. The goal was to see if patients liked the program, what barriers they faced, and how it might affect symptoms. Half the group took the course while the other half receive…

This study tested whether applying cold to painful joints can reduce pain and improve quality of life in people with rheumatoid arthritis. 90 patients with active pain participated. The goal was to see if this simple, low-cost method could be a helpful addition to standard care.

This study tested whether transcutaneous electrical acupoint stimulation (TEAS) — a gentle electrical pulse applied to specific points on the body — could reduce period pain and inflammation in women with autoimmune diseases like rheumatoid arthritis or lupus. Fifty-two women rec…

This study tested a mobile app designed to help people with rheumatoid arthritis manage their condition. 90 adults with stable treatment used the app for 12 weeks, while a control group received usual care. Researchers measured changes in disease activity and quality of life to s…

This study tested a treatment called Dharasana Lep in 35 adults with mild to moderate muscle or joint pain, including rheumatoid arthritis. The goal was to see if it safely reduces pain and improves movement. Participants used the treatment and reported their pain levels using si…

This study tested whether an injection of etanercept, a targeted anti-inflammatory drug, works better than a standard steroid injection for sudden joint swelling in people with rheumatoid arthritis. 34 adults with active arthritis in a knee, wrist, ankle, or elbow took part. The …

This study tested a hand exercise program called SARAH in 6 women with rheumatoid arthritis. The program includes strengthening, stretching, and home exercises along with education. The goal was to see if it improves hand function and reduces pain.

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, rheumatoid arthritis, osteoarthritis, or lupus. Participants followed a 6-week walking program delivered by phone, and researchers measured changes in pain, ph…

This study tested a program called OPERAS that includes a web app for tracking symptoms and a physiotherapist who gives activity advice using a Fitbit. The goal was to see if it helps people with rheumatoid arthritis feel more confident managing their disease. 132 adults with rhe…

This study looked at two ways to manage pain after knee replacement surgery: a shot around the knee joint and a nerve block in the thigh. The goal was to see which method helps patients recover better and feel less pain. Sixty adults who had knee replacement took part, and their …

This completed study tested whether combining underwater ultrasound therapy with custom-made foot orthotics can help people with rheumatoid arthritis who have foot pain. Fifty-five participants received the treatments, and researchers measured pain, balance, and quality of life. …

This study tested a dietary supplement containing Boswellia serrata, curcumin, and MSM in 100 adults with joint pain or stiffness. Participants took either the supplement or a placebo for a period, and researchers measured inflammation markers and arthritis symptoms using a stand…

This completed trial tested whether a medical food called SBD121, a mix of prebiotics and probiotics, could help manage symptoms of early rheumatoid arthritis. 143 adults with newly diagnosed RA (within one year) and taking methotrexate were randomly assigned to receive SBD121 or…

This study tested whether Siwan sand therapy (warm sand baths followed by olive oil massage) could improve lung function, pain, and daily activity in people with rheumatoid arthritis. Thirty adults with moderate to severe RA were split into two groups: one received sand therapy f…

This study tested two hand therapy approaches—task-oriented training (like practicing daily activities) and Mulligan mobilization (a pain-free joint glide)—in 54 adults with rheumatoid arthritis. The goal was to see if these treatments could improve hand strength, function, and q…

This completed trial tested whether kinesiologic taping (a special elastic tape) applied to the knee can reduce pain, improve mobility, and lessen fear of movement in people with rheumatoid arthritis. Thirty adults aged 45 to 60 were randomly assigned to receive either real kines…

This study tested two types of manual therapy (myofascial mobilization and joint mobilization) in 57 people with rheumatoid arthritis who also had jaw joint problems. Participants received therapy twice a week for six weeks, while a control group got no treatment. Both therapy gr…

This completed trial tested a six-week group self-management program for women with rheumatoid arthritis. The program teaches skills to manage symptoms, stick to treatments, and improve quality of life. Researchers measured changes in self-efficacy, self-management behaviors, and…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study checks whether the Four Square Step Test (FSST) is a good way to measure balance in people with rheumatoid arthritis. Researchers will test 50 adults aged 18-65 with RA, comparing FSST results to other measures like disease activity, pain, and muscle strength. The goal…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This trial investigates whether combining group and individual educational sessions helps patients with chronic inflammatory rheumatism (like rheumatoid arthritis or spondyloarthritis) learn safety skills better than individual sessions alone. Participants are starting their firs…

This study tests whether a smartphone-based digital assessment can measure rheumatoid arthritis activity as well as a standard doctor-performed exam. Adults with rheumatoid arthritis will complete a digital questionnaire, record guided videos of their joint movements, and then ha…

This study looked at whether eating less salt can reduce inflammation, lower blood pressure, and decrease sodium levels in the skin of people with rheumatoid arthritis (RA). Researchers measured changes using MRI and disease activity scores in 18 adults with stable, moderate RA. …

This study looks at whether a blood test called Vectra can help doctors make better treatment choices for people with rheumatoid arthritis (RA). The test gives a score from 1 to 100 to show how active the disease is. About 1500 adults with RA will be split into two groups: one wh…

This study explored the connection between gum disease severity and levels of certain antibodies (ACPAs) in people with rheumatoid arthritis. Researchers measured these antibodies in fluid from the gums before and after non-surgical gum treatment. The goal was to better understan…

This study is looking at how nutrition affects disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will measure the nutritional status of 460 participants using several different tools and compare it to how act…

This completed study from France examined joint fluid from 20 people with arthritis to see if acid-sensing ion channels (ASICs) play a role in pain. Researchers wanted to find natural compounds that activate these channels during inflammation. The goal is to validate ASICs as tar…

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This study followed 813 people with early rheumatoid arthritis in France to see how often and why doctors prescribe TNF blockers. Researchers tracked symptoms, joint damage, and treatment success over 5 years. The goal was to learn which patients benefit most and how well doctors…

This study followed 813 people with early rheumatoid arthritis in France to see how often doctors prescribe TNF blockers alone (without other arthritis drugs) and how well they work. Researchers tracked symptoms, joint damage, and how long patients stayed on treatment over 5 year…

This study looked at three ways to help people with rheumatoid arthritis take their methotrexate medication as prescribed: usual doctor visits, text message reminders, or a chat with a pharmacist. The goal was to see which method works best to improve adherence. The study include…

This study looked at whether French doctors follow EULAR recommendations to check heart disease risk every year in patients with rheumatoid arthritis. Over 7000 patients were included. The goal was to see how often tests like blood sugar, cholesterol, and heart scans were prescri…

This completed study looked at 340 people to understand how certain proteins in the lungs, called autoantibodies, might be linked to the start of rheumatoid arthritis (RA). Researchers collected sputum (mucus from the lungs) from people at risk for RA, those already diagnosed, an…

This study tested whether a new version of the arthritis drug abatacept (called KSHB002) works similarly to the approved drug Orencia. Three hundred healthy adults received a single injection of either the new drug or Orencia. Researchers measured drug levels in the blood, checke…

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This study looked at whether healthcare professionals in Saudi Arabia are aware of and follow safety measures for the drug leflunomide, used for rheumatoid and psoriatic arthritis. Researchers surveyed 302 doctors and pharmacists to see if they received and read safety materials,…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study looked at the safety of the drug RINVOQ in over 4,200 Japanese adults with rheumatoid arthritis, a condition causing joint pain and swelling. Researchers reviewed medical records for three years to count serious infections and other side effects that happened during no…

This completed study investigated whether air pollution affects flare-ups in people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis. Researchers followed 86 patients for 6 months, asking them to complete weekly questionnaires about their symptoms. They a…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This completed study from Turkey looked at how well rheumatoid arthritis patients can use their arms and hands. Researchers tested 26 patients using a pegboard and ring test for arm exercise, a hand dynamometer for grip strength, and a daily living test. The goal was to better un…

This study measured phytoestrogens (plant-based compounds) in the blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or no disease. Researchers also asked about diet and measured estradiol levels. The goal was to see if these dietary compounds…

This study looked at whether measuring drug levels and anti-drug antibodies in the blood of rheumatoid arthritis patients can help doctors make better treatment decisions. 52 patients starting adalimumab or certolizumab were randomly assigned to have their test results shared wit…

This completed study looked at nearly 7,000 adults with inflammatory joint diseases like rheumatoid arthritis and psoriatic arthritis. Researchers compared two versions of a standard health survey (EQ-5D-3L and EQ-5D-5L) to see which one better measures health and quality of life…

This completed study looked at how tofacitinib, a rheumatoid arthritis drug, changes body fat, muscle, and bone density in 10 patients. Researchers measured visceral fat, lean mass, and bone marrow fat before and after treatment. The goal was to gather early data, not to prove th…

This study tested whether a smartphone app and a wearable activity tracker are practical and acceptable for people with inflammatory rheumatic diseases like rheumatoid arthritis and spondyloarthritis. Over 14 days, 50 participants answered short surveys on their phone and wore a …

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This study looked at whether regular nurse check-ins could spot the return of rheumatoid arthritis symptoms sooner than standard doctor visits. 51 adults with controlled arthritis on rituximab took part. The goal was to see if nurses could detect early signs of a flare, potential…

This completed study looked at whether adding an integrated care model—including traditional Chinese medicine—to standard treatment could lower inflammation and depressive symptoms in people with rheumatoid arthritis. Researchers measured blood markers of inflammation and used a …

This study looked at whether placing a drain after knee replacement surgery affects how much hemoglobin drops and whether patients need a blood transfusion. 102 patients were randomly assigned to get a drain or not. The goal is to see if drains help or hurt in terms of blood loss…

This completed study tested whether training rheumatology clinicians in shared decision making helps veterans with rheumatoid arthritis. About 900 patients from VA clinics took part. The training taught doctors to acknowledge treatment options and involve patients in choices. Res…

This completed study looked at how psychological resilience and body image relate to pain in people with rheumatoid arthritis or fibromyalgia, compared to healthy volunteers. Researchers measured these factors using questionnaires in 124 adults. The goal was to better understand …

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study looked at a protein called MMP-9, which is involved in breaking down joint tissue in rheumatoid arthritis. Researchers measured genetic variations of MMP-9 in 60 people with active rheumatoid arthritis and compared them to healthy volunteers. The goal was to better und…

This study looked at how small molecules called microRNAs change during pregnancy in women with rheumatoid arthritis or lupus. Researchers collected blood and urine samples before and after pregnancy from 50 women to see if these changes relate to disease activity. The goal is to…

This early-stage trial tested the safety and tolerability of an experimental drug called AZD1163 in 108 healthy volunteers. Participants received either the drug or a placebo by IV or injection, and researchers monitored side effects and how the drug moved through the body. Since…

This study looked at how the drug methotrexate and its main byproduct leave the body in people with rheumatoid arthritis. Researchers measured levels in urine to create a reference range. This could help doctors identify patients who are not taking their medication as prescribed.

This study looked at how core endurance, finger grip strength, and fatigue relate to hand function in people with rheumatoid arthritis. Researchers measured these factors in 113 participants. The goal was to better understand these connections, which could help guide future treat…

This study looked at 50 Egyptian patients with rheumatoid arthritis to see if methotrexate affects lung health. Half were taking methotrexate, and half were on other treatments. Researchers used lung function tests and CT scans to check for lung disease. They found no difference …

This study looked at how reducing inflammation might lower heart disease risk in people with rheumatoid arthritis. Researchers measured heart blood flow in 74 patients before and after treatment with certolizumab, a drug that fights inflammation. The goal was to see if better con…

This study looked back at 54 people who had a hip replacement with a specific part called the CL TRAUMA cemented stem. The goal was to see if the part was safe and worked well. Researchers measured how well patients could move and if they had pain using a standard hip score.

This study followed 82 postmenopausal women with rheumatoid arthritis to see how their bone density changed over time. Researchers compared different arthritis medications and osteoporosis treatments to understand which approaches best protect bone health. The goal was to gather …

This study tested whether a non-invasive ultrasound device can reduce inflammation in people with inflammatory arthritis (psoriatic arthritis, rheumatoid arthritis, or ankylosing spondylitis). Sixteen participants received four sessions of focused ultrasound or a sham (placebo) t…

This completed study surveyed 229 people with chronic inflammatory rheumatism (like rheumatoid arthritis) and their doctors to find out what makes it hard to follow care recommendations after a hospital visit. The goal was to identify barriers to good outpatient management. No tr…

This study looked at 69 adults with rheumatoid arthritis who were taking the drug adalimumab (Humira). Researchers measured drug levels in the blood over 6 months to see if they could predict who would respond well to treatment. The goal was to find a way to adjust doses early, i…

This study followed 162 people who received a G7 hip cup system during hip replacement surgery. Researchers measured pain, function, and hip movement using standard scores. The goal was to see how the device performs in everyday patients with arthritis or other joint problems.

This study looked at real-world data from over 140,000 people in Sweden with rheumatoid arthritis or psoriatic arthritis. Researchers tracked how many people developed different types of cancer while taking abatacept or other arthritis drugs. The goal was to better understand the…

This completed study looked at the safety of the arthritis drug abatacept in over 38,000 people with rheumatoid or psoriatic arthritis in Denmark. Researchers used a national health registry to track rates of cancers and other side effects. The goal was to better understand the d…

This study tested whether a deep cleaning of the gums (nonsurgical periodontal therapy) could lower inflammation and improve quality of life in 20 people who have both rheumatoid arthritis and gum disease. Researchers measured changes in immune markers, bacteria in the mouth, and…

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This study tested whether a six-minute pegboard and ring test is a valid and reliable way to measure upper arm exercise capacity in people with rheumatoid arthritis. Forty patients completed the test along with other arm function measures. The goal is to see if this simple test c…

This study looked at the gut bacteria of 55 people—some newly diagnosed with rheumatoid arthritis and some without the disease. Researchers wanted to see if certain bacteria are more common in arthritis patients. The goal is to better understand how gut health might be linked to …

This study looked at 192 people aged 50-85 with knee arthritis who needed knee replacement surgery. Half had computer-navigated surgery and half had the traditional technique. The goal was to see if computer guidance helps the new knee last longer, improves function, or reduces c…

This study looked at how much patients with rheumatoid arthritis or knee osteoarthritis know about cardiovascular disease risks. Researchers surveyed 120 adults aged 40 and older using a 28-item knowledge scale. The goal was to compare awareness between the two groups and identif…

This study involved 1304 adults with rheumatoid arthritis who had at least two risk factors for interstitial lung disease (ILD), such as being male, a smoker, or over 60. Researchers used CT scans to develop a prediction model that helps doctors decide who should be screened for …

This completed pilot study tested whether training doctors to ask personalized questions (individuation) could improve care for Black and lower-income patients with rheumatic diseases like lupus and arthritis. Over 200 patients and their rheumatologists took part. The goal was to…

This completed study examined why people with rheumatoid arthritis (RA) and lupus have a higher risk of heart attacks. Researchers collected blood samples from 176 participants and tested how statins and adenosine A2A receptor agonists affected cholesterol balance in cells. The g…

This study looked at how common joint pain and swelling are in 100 nursing home residents aged 65 and older, both with and without dementia. Researchers performed a physical exam and used simple pain questions or a special checklist for those with severe dementia. The goal was to…

This completed study looked at 1,000 women with autoimmune diseases (like lupus) who had a C-section. Researchers wanted to find out how many had severe bleeding (postpartum hemorrhage) and what factors increased that risk. By analyzing medical records, they hope to identify high…

This study tested whether the experimental drug SAR441566, being developed for rheumatoid arthritis, makes skin more sensitive to ultraviolet (UV) light. Sixty healthy adults aged 18 to 55 received either the drug, a placebo, or ciprofloxacin (a known sun-sensitizer). Researchers…

This study tested whether a questionnaire called the Rheumatoid Arthritis Impact of Disease (RAID) could help doctors make better decisions during virtual consultations. 70 patients with rheumatoid arthritis participated. The goal was to see if using this tool reduced the need fo…

This completed trial looked at whether a center focused on standard care for rheumatoid arthritis (RA) can improve how patients manage their disease. Nearly 1,000 adults with stable RA took part. The study tested two things: a nurse visit to check for and treat common RA-related …