New pill could ease arthritis pain in major trial
NCT ID NCT05848258
First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 34 times
Summary
This study tested an experimental oral drug called LY3871801 in 164 adults with moderately-to-severe rheumatoid arthritis. Participants received either the drug or a placebo to see if it reduces joint swelling and pain. The trial is now complete, and results will show if the drug is safe and effective enough to move forward.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Accellacare - Salisbury
Salisbury, North Carolina, 28144, United States
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Accurate Clinical Research, Inc
Lake Charles, Louisiana, 70605, United States
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Accurate Clinical Research, Inc
Houston, Texas, 77089, United States
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Advanced Clinical Research of Orlando - Ocoee
Ocoee, Florida, 34761, United States
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All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, 441108, India
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Avron Hospitals
Ahmedabad, 380013, India
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Biológicos Especializados
Mexico City, 06700, Mexico
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CENUDIAB
Buenos Aires, C1440AAD, Argentina
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CHD Vendee
La Roche-sur-Yon, 85000, France
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CHU Montpellier Lapeyronie Hospital
Montpellier, 34295, France
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CHU Strasbourg-Hautepierre
Strasbourg, 67098, France
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CHU de Nice
Nice, 06000, France
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CIMAB SA de CV
Torreón, 27000, Mexico
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CIPREC
Buenos Aires, C1061AAS, Argentina
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CRU Hungary Kft.
Encs, 3860, Hungary
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Centre Hospitalier Regional D'Orleans
Orléans, 45067, France
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Centre Hospitalier Universitaire de Reims - l'Hôpital Maison Blanche
Reims, 51092, France
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Centro de Atención e Investigación Cardiovascular del Potosí
San Luis Potosí City, 78200, Mexico
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Centrum Medyczne Reuma Park
Warsaw, 02-665, Poland
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Cicmex Centro de Investigación Clínica de México
Morelia, 58020, Mexico
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Conquest Research
Winter Park, Florida, 32789, United States
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Encore Medical Research - Weston
Weston, Florida, 33331, United States
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Grant Medical Foundation - Ruby Hall Clinic
Pune, 411001, India
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HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T
Hamburg, 20095, Germany
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Hopitaux Universitaires Paris Centre-Hopital Cochin
Paris, 75679, France
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Hospital Aranda de La Parra
León, 37000, Mexico
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Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, 66460, Mexico
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Hull Royal Infirmary
Hull, HU3 2JZ, United Kingdom
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Instituto de Alta Complejidad San Isidro
San Isidro, 1642, Argentina
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Integrity Clinical Research
Doral, Florida, 33122, United States
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Investigacion y Biomedicina de Chihuahua
Chihuahua City, 31000, Mexico
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Joseph S. and Diane H. Steinberg Ambulatory Care Center
Brooklyn, New York, 11201, United States
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Kistarcsai Flor Ferenc Korhaz
Kistarcsa, 2143, Hungary
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Kohler and Milstein Research S.A. de C.V.
Mérida, 97070, Mexico
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MICS Centrum Medyczne Warszawa
Warsaw, 00-874, Poland
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Mautalen Salud e Investigación
Buenos Aires, C1128AAF, Argentina
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Medical Care and Research SA de CV
Mérida, 97070, Mexico
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Medical Plus
Uherské Hradiště, 686 01, Czechia
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Medicina Reumatológica
San Fernando, 1646, Argentina
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Medipoint Hospitals Pvt. Ltd.
Pune, 411007, India
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New Cross Hospital
Wolverhampton, WV10 0QP, United Kingdom
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Newport Huntington Medical Group
Huntington Beach, California, 92648, United States
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Nova Reuma Domyslawska i Rusilowicz Spolka Partnerska Lekarza Reumatologa i Fizjoterapeuty
Bialystok, 15-707, Poland
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Nzoz Bif-Med
Bytom, 41-902, Poland
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Overlake Arthritis and Osteoporosis Center
Bellevue, Washington, 98004, United States
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Regia Med Kft
Székesfehérvár, 8000, Hungary
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Revita Clinic
Budapest, 1027, Hungary
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Sushruta Multispeciality Hospital & Research Centre
Hubli, 580021, India
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Universitaetsklinikum Koeln
Cologne, 50937, Germany
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Vital Medical Center
Veszprém, 8200, Hungary
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Vásárhelyi Sárkányfű KFT
Hódmezővásárhely, 6800, Hungary
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Willow Rheumatology and Wellness PLLC
Willowbrook, Illinois, 60527, United States
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Óbudai Egészségügyi Centrum
Budapest, 1036, Hungary
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LY3871801 (oral drug)
What this could lead to
If successful, this could provide a new oral treatment option to control rheumatoid arthritis symptoms and reduce disease activity.
What could go wrong
This is an early-phase (Phase 2) trial with only 164 participants, so results may not apply to everyone. The drug may not work better than placebo or could have side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.