Anxiety

This trial tests whether two types of talk therapy, Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT), can ease depression and related issues better than usual care in people who have major depression and are facing marital crisis. About 120 adults wi…

Researchers at UC San Diego are testing whether a computer-based working memory training session, done right before a brief exposure exercise, can improve fear extinction learning in adults with social anxiety disorder. Participants will be randomly assigned to either the working…

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This study tests a harm reduction approach for people who use anabolic-androgenic steroids (AAS) without a prescription. Participants will receive four counseling sessions to help them reduce their steroid use and improve their health. The trial will measure changes in steroid us…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study will test if a smartphone app that analyzes speech can accurately screen for depression and anxiety in university students. Researchers will enroll 80 students aged 16 to 25 and compare the app's results with standard questionnaires. The goal is to see if voice pattern…

This pilot trial tests a two-hour educational workshop called SCREEN, designed to raise awareness of prostate cancer, its symptoms, and the benefits of early screening. The study enrolls men aged 18 to 79 who are not up to date with their prostate cancer screening. Researchers wi…

Researchers are testing a 10-session bilingual therapy program called PrEPared Minds/Mentes PrEParadas. The program uses cognitive behavioral therapy to reduce anxiety and depression in men who have sex with men. The goal is to see if improving mental health helps these men learn…

This study tests a new media-based program called CONSCIOUS to help men in Nigeria recognize symptoms of mental health issues like anxiety and suicide risk, and encourage them to seek support. The program uses videos or other media to reduce stigma and improve help-seeking. 74 me…

This study will test whether a personalized smartphone app can help prevent anxiety and depression in adults who do not currently have these conditions. About 2,595 people in Spain and Chile will use either a highly interactive app (Pandora-1), a simpler educational app (Pandora-…

This trial tests whether a traditional Chinese music therapy, called Ziwu Liuzhu Five-Element Music Therapy, can reduce anxiety in people with pancreatic cancer who are undergoing chemotherapy. The study will enroll 320 patients with mild-to-moderate anxiety and randomly assign t…

This study looks at whether drawing different colors and shapes can help calm adults who are anxious while waiting for surgery. About 175 people scheduled for elective surgery will participate. Researchers will measure their anxiety levels before and after the drawing activity to…

This study tests whether a mobile app that combines digital cognitive behavioral therapy (CBT) with personal mental health coaching can reduce anxiety in adults with hearing or mobility disabilities. Participants use either the active program or a sham version for 8 weeks, with f…

Researchers at Massachusetts General Hospital are testing whether a wearable patch can help autistic teenagers manage anxiety. The patch senses heart rate and guides paced breathing through a phone app, offering practice sessions and prompts during stressful moments. The trial en…

Researchers at Peking University are studying a 49-day digital mindfulness program for adults with emotional distress, depression, or anxiety. About 100 participants use a mobile app that delivers daily guided meditations, short lessons on emotions, and practical exercises. The t…

This trial tests two sedatives—remimazolam and dexmedetomidine—to see which better relieves anxiety while keeping pregnant women comfortable and safe during spinal anesthesia placement for scheduled C-sections. The study includes 150 women at full term and measures success by pat…

Researchers are testing whether squeezing a stress ball during femoral arterial sheath removal after coronary angiography can reduce pain and anxiety and improve patient satisfaction. The trial enrolls 34 adults who had a stent or balloon angioplasty through the femoral artery. H…

This trial tests whether progressive muscle relaxation, a technique where you tense and then relax different muscle groups, can lower anxiety in parents who are the primary caregivers of children with cancer. Researchers will randomly assign 112 parents to either join relaxation …

This trial tests whether six sessions of receptive music therapy, using a specific method called Kigonki, can reduce anxiety in people with advanced cancer who are hospitalized in palliative care units. Participants will be randomly assigned to receive the music therapy or to hav…

This trial tests whether a structured, one-on-one educational session led by a nurse before an endoscopic retrograde cholangiopancreatography (ERCP) can reduce patient anxiety and improve knowledge about the procedure. Sixty adults scheduled for elective ERCP will be randomly ass…

This trial tests whether wearing virtual reality glasses during double J stent removal can lower patient anxiety and pain. The procedure, common after kidney stone surgery, often causes distress. Researchers will compare patients who use VR distraction with those receiving standa…

Researchers are testing whether a dexmedetomidine nasal spray can reduce anxiety in patients scheduled for brain tumor surgery. Participants receive the spray the night before and the morning of surgery, and their anxiety levels are measured before and after the procedure. The tr…

This trial tests whether an 8-day mindfulness body scan can reduce stress, anxiety, and depression in adults who survived tidal flooding in Sayung, Demak, Indonesia. Participants will practice guided body scan meditation and have their blood tested for inflammation markers before…

This trial tests whether an 8-day mindfulness body scan can reduce stress and inflammation in people who have survived repeated tidal flooding. Researchers will measure blood markers like IL-6, TNF-α, CRP, and cortisol, along with questionnaires on depression, anxiety, sleep, and…

This study tests whether a four-week online yoga program, tailored to each teen's physical limits, can lower anxiety in adolescents aged 12 to 18 who are being treated for cancer. Participants either join the yoga sessions or receive no extra intervention, and researchers measure…

This study tests whether a 10-session virtual group psychotherapy program can help people with inflammatory bowel disease (IBD) who also have anxiety or depression. The therapy is adapted from a standard manual called Mind Over Mood and includes education on the brain-gut connect…

This study tests whether structured spiritual care from a chaplain can reduce anxiety and improve well-being for family members of ICU patients who cannot make decisions for themselves. The chaplain will meet with the family surrogate several times and stay in touch weekly. The t…

This trial tests whether a 10-session online group cognitive-behavioral skills training program can reduce symptoms of depression and anxiety in university students. About 400 students who screen positive for these symptoms will be randomly assigned to either the online CBT progr…

This pilot study explores whether surface-guided radiotherapy (SGRT) can help head and neck cancer patients who feel anxious or claustrophobic during standard radiation treatment. Instead of a tight thermoplastic mask, SGRT uses a camera system to track patient position in real t…

This trial tests whether a brief multisensory stimulation session before a pediatric surgery clinic visit can lower anxiety and fear in children aged 5 to 10, as well as reduce parental anxiety. Children undergoing their first surgical evaluation will be randomly assigned to rece…

This trial tests whether listening to alpha-frequency binaural beats—a type of auditory stimulation that may promote relaxation—can reduce pain and anxiety after orthodontic separator placement. Participants aged 15-30 with mild crowding will be randomly assigned to either listen…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This trial tests whether using a virtual reality headset during regional anesthesia can lower patients' anxiety and pain. Adults aged 18 to 64 having elective surgery with regional anesthesia will either receive VR distraction or standard care. Researchers will measure anxiety an…

This trial tests whether giving a combination of dexmedetomidine and esketamine during and after laparoscopic ureteral reconstruction can reduce depressive symptoms and anxiety in patients. The study enrolls 658 adults with ureteral stricture who are scheduled for this surgery. P…

This trial tests whether an AI-based system can provide preoperative counseling for elective cesarean delivery as effectively as a physician. Women scheduled for a C-section will be randomly assigned to receive either standard doctor-led counseling or AI-delivered counseling with…

Many cancer patients feel anxious before radiotherapy, partly due to unfamiliar equipment and procedures. This trial tests whether adding a simulation-based education session — a virtual preview of the treatment environment — before standard education can reduce that anxiety and …

This trial tests whether a 12-week Latin dance program—featuring Rumba, Cha-cha, and Jive—can improve psychological health in primary school children aged 6 to 12. Participants are randomly assigned to either the dance program or regular physical education classes. Researchers wi…

This large citizen-science trial is testing whether two prebiotic products can reduce feelings of anxiety and improve related outcomes like sleep in adults. Around 1,000 participants will be randomly assigned to take either an active prebiotic or a placebo for 12 weeks, without k…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve sleep and reduce anxiety in adults over 60 who have chronic insomnia. Sixty participants will receive tACS sessions, and researchers …

This study tests whether virtual reality (VR) can reduce pain, fear, and distress in children aged 6 to 12 during burn dressing changes. Half of the participants will receive standard care plus VR distraction, while the other half receives standard care alone. Pain, fear, and dis…

This trial tests whether a culturally tailored mobile health program, called Self-Compassion, Health, and Empowerment (SHE), can improve mental health in Chinese immigrant women who have experienced intimate partner violence. Participants receive six weekly sessions covering safe…

This pilot study will test whether a 'Comfort Tote' filled with items like aromatherapy oils, stress balls, acupressure guides, and a journal can help teens aged 10-21 feel less pain, anxiety, and stress after scoliosis surgery. Half the participants will get a tote with therapeu…

This trial tests whether a guided digital program delivered through a mobile app can reduce anxiety and depression in young adults (ages 18–40) who have fertility-related distress after a cancer diagnosis. Participants use the app to complete four modules covering coping skills, …

This pilot study tests whether a nurse-led digital cognitive behavioral therapy for insomnia (dCBT-I), delivered through a chatbot on WhatsApp, can help university students with mild to moderate anxiety or depression. Participants will complete a two-week daily sleep diary via th…

This trial tests whether watching a calming nature video through a virtual reality headset can reduce fear of childbirth and anxiety in high-risk pregnant women who are on bed rest in the hospital. Participants in the intervention group will view a VR nature scene with relaxing s…

This trial tests whether a simple mandala coloring activity can reduce perceived stress and anxiety in women hospitalized with high-risk pregnancies. Sixty participants will be randomly assigned to color mandalas daily for three days or to receive standard care. Stress and anxiet…

This study tests whether video-based education can reduce anxiety, correct myths, and boost motivation in first-time mothers. Pregnant women between 32 and 36 weeks will receive three educational video modules via WhatsApp alongside routine care. The goal is to see if this techno…

This trial tests a smartphone app called E-breathing that detects when a teen is feeling distressed and prompts them to practice slow-paced breathing. The study includes 100 adolescents aged 11 to 17 in Hong Kong who have at least mild symptoms of depression, anxiety, or stress. …

This study tests whether an AI-assisted expressive writing program can reduce anxiety, emotional distress, and improve quality of life in adults receiving chemotherapy for any type of cancer. Participants are randomly assigned to either use the AI writing tool alongside their usu…

This study tests whether applying mild electrical pulses (TENS) to the shins can reduce pain and anxiety in people receiving Botox injections into the bladder for overactive bladder. Participants are randomly assigned to receive either active TENS or a sham device during the inje…

This study tests a 13-week remote stress recovery program for people who had a heart attack before age 55 and still feel distressed. The program includes online sessions with a therapist, a workbook, and videos. The goal is to see if a larger trial is possible by checking how man…

This study investigates whether the 4-7-8 breathing technique can help reduce pain and anxiety in people with type 2 diabetes and diabetic neuropathy during an electromyography (EMG) procedure. EMG can be uncomfortable and stressful, and this trial compares the breathing techniqu…

This study tests whether virtual reality (VR) and cold packs, alone or together, can reduce pain and anxiety in women after a cesarean section. About 120 women will be randomly assigned to receive VR, cold therapy, both, or standard care. The goal is to see if these drug-free app…

This study tests whether immersive virtual reality (VR) can lower stress, anxiety, and pain in adults undergoing their first central or midline catheter insertion. Participants use a VR headset showing calming nature scenes during the procedure. The goal is to see if this distrac…

This study tests whether a set of four gentle osteopathic manual techniques can reduce stress and anxiety in young adults aged 18 to 35. Thirty participants will either receive the real techniques or a placebo simulation, and researchers will measure changes in heart rate variabi…

This study tests whether a virtual debriefing session with a maternal-fetal medicine specialist, held six to eight weeks after a delivery complicated by severe maternal morbidity (such as ICU admission or major blood transfusion), can lower symptoms of post-traumatic stress, depr…

This study tests an online platform called PURSUIT that teaches coping skills to Michigan youth aged 8-18 and their caregivers. The program provides cognitive-behavioral techniques for managing pain, stress, and mood, with extra substance use prevention content for teens 12 and o…

This trial tests whether a dietary supplement called magnesium choline citrate can improve cognitive function and reduce anxiety in healthy adolescents and adults aged 8 and older. Over 84 days, participants take either the supplement or a placebo and complete questionnaires abou…

This study tests whether a virtual reality (VR) session the day before gallbladder surgery can lower patients' anxiety and uncertainty about general anesthesia. Two hundred adults who have never had anesthesia will either watch a VR video showing the operating room and anesthesia…

This study tests whether a 15-20 minute virtual reality (VR) relaxation session can reduce anxiety in adolescents aged 12 to 18 during a primary care visit. Participants use the Healthy Mind® VR platform to explore calming environments like beaches or mountains while doing guided…

This study tests whether watching a short educational video before surgery can lower anxiety in adults having elective procedures. Participants are randomly assigned to receive the video via a QR code they scan on their own phone, via a tablet provided in the waiting area, or to …

This study tests whether using a virtual reality headset with guided imagery—like calming nature scenes and breathing exercises—can reduce pain, anxiety, and fatigue in women with breast cancer during chemotherapy. Participants are randomly assigned to either receive VR-guided im…

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This study tests whether using a virtual reality headset (HypnoVR) during interventional radiology procedures can lower patients' anxiety and pain. Seventy adults will be randomly assigned to either use the VR headset or receive standard care. Researchers will measure anxiety wit…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study will test whether smartphone sensors can detect when someone with early psychosis is feeling anxious or depressed and then offer a short mindfulness or psychoeducation exercise. Ten adults aged 18–50 with early psychosis and mild mood symptoms will use the app for 10 w…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study tests whether using virtual reality (VR) for mindfulness can help people feel less anxious and experience less pain during minor vascular surgery done under local anesthesia. 160 adults with varicose veins will be randomly assigned to either wear VR glasses with guided…

This study tests a 12-week telehealth program called PARTNER-MH, where trained peer specialists help minoritized veterans navigate mental health care, address social needs, and improve communication with clinicians. The trial will enroll 268 veterans with depression, anxiety, or …

This pilot study will test whether a 6-week app-based mental fitness program can improve wellbeing and self-compassion in anesthesiology residents. Sixty residents will be randomly assigned to either the mental fitness app or a control program. The main goal is to see if such a p…

This study tests whether reading specific self-help books can lower anxiety, depression, and rumination in university students aged 18-25. 110 students from health science programs will be randomly assigned to read one of two books or join a waiting list. Over 8 weeks, they will …

This study will test two smartphone apps, Tankevirus and Grubl, designed to help people with mild to moderate anxiety and depression. About 1000 Norwegian adults will use one of the apps or a placebo app for two weeks. Researchers will measure changes in symptoms and quality of l…

This pilot study will test whether a weekly 60-minute sound bowl meditation, offered for six weeks, can lower stress and anxiety in unpaid caregivers. Forty adult caregivers who have been helping a chronically ill or disabled family member or friend for at least six months will p…

This study tests whether doing a short 5-minute breathing or mindfulness exercise every day for a month can help Spanish-speaking university students feel less anxious and stressed. 240 participants will be split into four groups, each using a different technique like box breathi…

This study will test an internet-based therapy program for 366 adults with anxiety or depression. The program starts with self-guided modules, and based on early progress, some participants will also get live sessions with a therapist. The goal is to see if personalizing the trea…

This study tests whether watching a short AI-generated educational video before a gynecological exam can reduce women's anxiety and increase their satisfaction. Researchers will enroll 114 women and measure their anxiety and satisfaction levels using standard questionnaires. The …

This study tests whether listening to calming music or using virtual reality can reduce pain, anxiety, and fear in children aged 6-12 with leukaemia who need care for painful mouth sores caused by chemotherapy. Forty-five children will be randomly assigned to a music group, a VR …

This study tests whether a mobile app called SocialRx, which recommends personalized arts and cultural activities, can improve depression, anxiety, and loneliness in teens aged 15-18. About 230 teens with depression or anxiety will either use the app for a year or continue their …

This study tests whether an AI-enhanced virtual reality cognitive behavioral therapy (VR/AI CBT) program can reduce anxiety and improve quality of life in people with inflammatory bowel disease (IBD). Seventy-six adults with IBD and moderate-to-severe anxiety will be randomly ass…

This study tests whether a specially designed AI chatbot can lower anxiety and trauma-related distress in adults recently diagnosed with cancer. Participants will use the chatbot for 12 weeks and complete surveys about their feelings and needs. The goal is to see if this digital …

This study tests whether an AI-assisted writing program can help Chinese teenagers (ages 10-19) who are struggling with prolonged grief after losing a loved one. Participants will complete three guided writing sessions over six days, with some receiving personalized AI feedback. …

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can reduce pain, anxiety, and improve vital signs in women after breast surgery. 126 participants will be randomly assigned to one of three groups: pranayama, pursed-lip breathing, or sta…

This study tests a program called the Brave Elephant Program, designed to help shy preschoolers (ages 3-6) at risk for anxiety. The program trains teachers and uses classroom activities to build social skills and emotional strength. Researchers will check if the program is practi…

This study tests whether a dedicated 30-minute consultation with a healthcare professional before getting an implantable port (a small device under the skin for chemotherapy) can lower patient anxiety. About 150 adults scheduled for the procedure will either get standard care or …

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely help healthcare clinicians who feel depressed and have lost meaning in their work. Seventy-two doctors, nurses, and physician assistants will take part in small groups,…

This study looks at whether listening to music can help lower anxiety in adults who have been on a breathing machine for more than 21 days. Two hundred participants will either get standard care or also listen to calming music through headphones for 30 minutes, twice a day, for t…

This study tests a small, non-drug device called ShotBlocker to see if it can reduce pain and anxiety when placing an IV. One hundred adults who need an IV will be randomly assigned to either use the ShotBlocker or receive standard care. The goal is to find a simple, low-cost way…

This study will test whether listening to Turkish music after a planned cesarean section helps reduce pain, anxiety, and improve mother-baby bonding. Seventy first-time mothers will be enrolled. The researchers will measure pain and anxiety levels using standard scales and assess…

This study tests whether listening to self-selected music before, during, and after interventional pain procedures can reduce anxiety, pain catastrophising, and acute pain in adults with chronic pain. 110 participants will be randomly assigned to either music therapy or standard …

This study tests whether short, playful activities—like guided drawing, gentle body movement, and acceptance therapy—can reduce stress and anxiety in university students during exams. Sixty students will participate in a single 20-minute session, and a subgroup will have their br…

This study tests whether doing art activities (like drawing or painting) can reduce fatigue, anxiety, and improve quality of life in adults with blood cancers. Fifty-two patients will be split into two groups: one gets six art sessions over two weeks, the other gets standard care…

This study tests whether a structured mandala activity program can reduce anxiety and improve emotional well-being in adolescents who have a sibling with special needs. Sixty-four teens will be randomly assigned to either participate in the mandala program or a control group. Res…

This study tests an 8-week mindfulness program designed to help nursing students reduce stress, anxiety, and depression while improving their emotional control. About 93 students will learn meditation, breathing exercises, and mindful movement. The goal is to see if these techniq…

This study tests an 8-week digital program that helps migrants in Sweden improve their mental health through better sleep, diet, physical activity, and social connections. 240 adults with moderate stress, anxiety, or depression will either get the program or a general wellness mo…

This study tests whether combining breathing exercises with progressive muscle relaxation can reduce shortness of breath, anxiety, and delirium in patients recovering from heart surgery. 116 adults will be randomly assigned to either receive these techniques plus standard care, o…

This study tests whether an interactive virtual reality (VR) program can help reduce pain, anxiety, and fatigue in 20 hospitalized palliative care patients. Participants use a VR headset with sensors to interact with a calming natural environment for 10 minutes daily over 14 days…

This study will develop and test a digital mental health program called 'VIBE in the Parks' for teens aged 13-24 who use Chicago Park District programs. About 268 participants will either get access to this program or a digital CBT workbook. The goal is to see if the program help…

This study tests whether using a stress ball or receiving a hand massage during eye surgery can lower patients' anxiety, pain, and stress levels. 174 adults having eye surgery under local anesthesia will be randomly assigned to one of three groups: stress ball, hand massage, or s…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study tests whether playing music through a sound shower in the ICU waiting room can reduce anxiety in family members. 224 adult relatives of intubated patients will be randomly assigned to wait with or without the music. Their anxiety levels will be measured using a standar…

This study tests a smartphone app designed to help teenagers in rural New Hampshire cope with anxiety. The app sends quick, personalized suggestions for calming activities. Fifty teens aged 13-17 with mild or worse anxiety will use the app for 3 months or be placed on a waitlist.…

This study looks at three simple methods—breastfeeding, using a stress ball, or wearing virtual reality goggles—to help first-time mothers feel less pain and anxiety during episiotomy repair (stitching) after giving birth. About 120 women will be randomly assigned to one of these…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study tests whether a personalized AI-generated video, delivered by a nurse avatar, can improve recovery for people after coronary artery bypass surgery. About 128 patients will either get standard discharge instructions or the AI video plus standard care. Researchers will m…

This study tests whether a guided breathing technique called heart rate variability biofeedback (HRVB) can reduce anxiety in 60 adults who are in the ICU waiting for a heart transplant. Participants will use a biofeedback device or app during a single session led by a trained cli…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study tests whether taking a daily probiotic supplement for 8 weeks can reduce stress and anxiety in healthy university students during exam time. Two hundred students will receive either the probiotic or a placebo. Researchers will measure changes in stress, anxiety, sleep …

This study tests a device that gently stimulates a nerve in the ear during heart surgery. The goal is to see if it lowers the chance of postoperative delirium, anxiety, and depression. About 270 adults having elective heart surgery will be randomly assigned to receive real or sha…

This study looks at whether listening to music can help lower anxiety in people having surgery for the first time. Researchers will measure heart rate, blood pressure, and anxiety levels in 90 adults. Some will choose their own music, others will listen to a standard playlist, an…

This study tests whether playing a virtual reality music-movement game can improve mood and social connection in young adults aged 18-25 with mild to moderate depression or anxiety. Participants will be split into three groups: one playing a social VR game with others, one playin…

This study tests whether watching a 360° relaxing nature video through a VR headset during a Pap smear can lower pain and anxiety. Sixty women aged 18–65 will be randomly assigned to either the VR group or standard care. Researchers will measure pain and anxiety levels to see if …

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) during breast cancer surgery can help prevent or reduce negative emotions like anxiety and depression after the operation. About 232 women will receive either real or sham stimulation for 30 minut…

This study looks at whether listening to music can help lower anxiety and improve sleep in people who have had a heart attack and are spending their first night in a special heart unit. About 64 adults will take part. They will listen to music and then use eye masks and earplugs …

This study tests a new way to help people going through alcohol withdrawal feel less anxious. It combines hypnosis with aromatherapy, using a calming scent to trigger the relaxation learned during hypnosis. About 80 adults in a hospital addiction unit will either get this combine…

This study tests a program called REWIRE for teens aged 12-17 who feel anxious or depressed and use social media over 3 hours daily. The program aims to cut social media use by about half and replace it with positive offline activities like hobbies or time with friends. Researche…

This pilot study will test a 'blended' therapy approach for adults with emotional disorders like anxiety and depression. Participants will either receive standard face-to-face therapy, a mix of face-to-face sessions and a smartphone app, or be placed on a waitlist. The goal is to…

This study tests whether a four-week virtual yoga program can improve quality of life and reduce anxiety and depression in people going through IVF. About 80 participants will either take weekly yoga classes or continue with their usual care. Researchers will track changes in moo…

This study looks at whether a program combining yoga, meditation, and mindful eating can lower stress, anxiety, and depression in university students. Sixty students will attend weekly sessions for a semester and fill out questionnaires to measure changes. The goal is to see if t…

This study tests whether a mindfulness-based nursing program can lower anxiety and help stabilize blood pressure in 60 adults undergoing planned open heart surgery. Participants will receive the mindfulness intervention before and after surgery, and their anxiety levels and vital…

This study tests whether a handheld palm stimulator can reduce pain, fear, and anxiety when cancer patients get an IV for chemotherapy. About 90 adults will be randomly assigned to either squeeze the device during the procedure or receive standard care. The goal is to provide a l…

This study tests whether a single 'Braining' group exercise session can quickly reduce anxiety in people receiving psychiatric care. Thirty participants will rate their anxiety before and after the session. The goal is to see if exercise can be a fast-acting tool to ease symptoms…

This study tests whether a short, nurse-guided digital art program on a tablet can lower anxiety and emotional distress in children aged 7-12 in the pediatric ICU. Sixty children will be randomly assigned to either the art program or standard care. Researchers will measure change…

This study looks at whether community health workers (CHWs) can effectively provide a mental health program to Spanish-speaking Latine parents who have symptoms of depression, anxiety, or traumatic stress. About 52 parents will either get the program right away or after a 5-month…

This study tests whether a 10-week program combining strength exercises with muscle relaxation techniques can reduce frailty, anxiety, and burden in people caring for a loved one with Alzheimer's. About 62 caregivers will be randomly assigned to either the combined program or rel…

This study looks at whether listening to guided meditation audio can reduce stress and anxiety in people having open-heart surgery. About 72 adults will either receive meditation sessions or standard care. Researchers will measure stress hormones, blood sugar, and anxiety levels …

This study tests whether a gentle hand-application method called Jin Shin Jyutsu can help perimenopausal women feel better emotionally and physically. Sixty women aged 40-54 will practice the technique daily for two weeks. Researchers will measure changes in quality of life, stre…

This study tests whether using RELAX glasses—a device that plays calming videos and sounds—can lower anxiety in ICU patients during invasive procedures like getting an IV or a catheter. About 456 adults in intensive care will either use the glasses or receive standard care. Their…

This study tests whether internet-based group cognitive behavioral therapy (CBT) delivered over Zoom can reduce symptoms of anxiety and depression in international students in Malaysia. About 128 students with moderate to severe symptoms will be randomly assigned to either the th…

This study tests whether a single low dose of esketamine, given during anesthesia for breast cancer surgery, can reduce severe depression and anxiety symptoms right after the operation. Researchers will enroll 242 women with severe depression who are scheduled for breast cancer r…

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 women having breast cancer surgery will be randomly assigned to receive either esketamine or a placebo during anesthes…

This study looks at whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression in patients who already have mild-to-severe depression. About 142 women will take part, and their mood and sleep quality will be tracked after sur…

This trial tests a non-transdermal biofield patch against a placebo patch in 40 adults who often feel anxious. Over 4 weeks, researchers will measure changes in anxiety, sleep quality, and energy levels. The goal is to see if the patch offers any real benefit beyond a placebo eff…

This study tests whether a special type of acupressure—timed to the body's natural daily rhythms—can improve sleep in nursing home residents aged 60 and older. Eighty participants will receive either real or fake acupressure twice a day for four weeks. Researchers will measure sl…

This study tests whether adding virtual reality (VR) sessions to standard counseling helps university students with public speaking anxiety more than counseling alone. About 72 students will be randomly assigned to either counseling only or counseling plus VR exercises that simul…

This study will give 4,400 adults with anxiety a digital brain training program called LENS, which helps people think more positively in uncertain situations. Researchers want to find out why some people improve more than others by looking at genetic and psychological factors. Th…

This study looks at whether watching an educational video can lower anxiety in pregnant women who are deciding whether to attempt a vaginal birth after a previous C-section. About 90 women will be randomly assigned to either watch the video or receive standard verbal advice from …

This study compares melatonin, a natural sleep hormone, to midazolam, a common sedative, for calming children before tonsillectomy. About 195 children will receive either melatonin or midazolam before surgery. The goal is to see if melatonin reduces anxiety and confusion after wa…

This study will test whether listening to music or chewing sugar-free gum can reduce pain and anxiety during episiotomy repair—the stitching of a cut made during childbirth. Sixty women who have a vaginal birth with an episiotomy will be randomly assigned to one of three groups: …

This study will test a smartphone app called CONEMO in over 12,000 adults visiting primary care clinics. The app uses cognitive behavioral therapy techniques to help reduce symptoms of depression, anxiety, and insomnia. Participants will use the app on their own phones or tablets…

This study looks at whether using a weighted blanket can reduce nighttime leg cramps, improve sleep quality, and lower anxiety and stress in pregnant women. Fifty women in their third trimester will use the blanket for 14 days and compare results to a 14-day period without it. Th…

This trial will test three simple techniques—box breathing, a cognitive reframing tool called 'Magnify,' and emotion regulation through song lyrics—in 200 middle and high school choir students. Researchers want to see if these music-based interventions can reduce anxiety and impr…

This study tests whether very short (4 or 8 sessions) psychological treatments can reduce symptoms of anxiety, depression, and stress-related physical complaints. About 184 adults with mild to moderate symptoms will be randomly assigned to group or individual therapy, or a relaxa…

This study tests whether increasing ward rounds from twice to four times a day, with structured conversations and simple breathing exercises, can lower anxiety in hospitalized patients waiting for therapeutic gastrointestinal endoscopy. About 1,000 adults with mild anxiety will t…

This study tests whether a digital mental health platform with open peer support can improve quality of life in adults with mild anxiety or depression symptoms. 82 participants will use the platform for 31 days. The goal is to see if their overall well-being, stress, and mood imp…

This study tests whether using a virtual reality headset during a breast biopsy can lower depression, anxiety, and stress. 80 women will either wear a VR headset showing calming nature scenes or receive standard care. Researchers will measure their mood before and after the proce…

This study tests a program that combines doctor care, digital tools, virtual reality, and school-based support to help teens and adults in Morocco with depression and anxiety. About 146 participants will be split into two groups: one gets the new program, the other gets usual car…

This study tests whether a short, intensive psychological program before lung cancer surgery can lower anxiety and depression. About 138 adults scheduled for lung cancer surgery will be split into three groups: one receiving four weekly therapy sessions, one refusing support, and…

This study tests a guided self-help CBT manual called 'Khushi or Khatoon' for cancer patients with anxiety and depression. The manual uses culturally adapted stories and exercises over eight weeks. Researchers will enroll 108 adults in Pakistan to see if the manual is feasible, a…

This study tests whether structured group therapy, including cognitive behavioral therapy and mindfulness, can reduce symptoms of depression and anxiety in adults in Pakistan. About 108 participants will attend 12 weekly group sessions. The goal is to see if this approach improve…

This study looks at whether teaching mindfulness skills to pregnant women admitted to the hospital for risk of preterm delivery can reduce their depression, anxiety, and stress. Researchers will enroll 60 mothers and provide four weeks of mindfulness training. Participants will f…

This study will test a program called Living Well, which includes a mobile app with 21 mental health modules and personal coaching sessions, for breast cancer patients with moderate to severe anxiety. The goal is to see if the program can lower anxiety and reduce overall healthca…

This study tests if watching a virtual reality (VR) video of an MRI scan before the real thing can help children aged 5 to 10 stay calm and still. About 150 kids having their first MRI will be split into three groups: one watches the VR video at home and again at the hospital, on…

This study will test whether watching a virtual reality movie or using a vibrating Buzzy device can reduce pain, fear, and anxiety in children aged 7 to 10 during allergy skin prick tests. About 111 children will be randomly assigned to one of three groups: virtual reality, Buzzy…

This pilot study will test whether virtual reality (VR) or a combination of VR and hypnosis (Hypno-VR) can help reduce pain and anxiety during a diagnostic hysteroscopy, a common gynecological procedure. 45 adult patients will be randomly assigned to standard care, VR, or Hypno-V…

This study tests whether watching a short, informative video before receiving a blood-thinner injection (LMWH) after childbirth can reduce anxiety and pain. 160 new mothers will be randomly assigned to get either the usual verbal explanation or the explanation plus the video. Res…

This study tests whether watching a 20-minute virtual reality video of a calming forest can reduce pain, anxiety, fear, and stress, and improve sleep in people having bariatric surgery. Seventy patients will be randomly assigned to either the VR experience or standard care. Resea…

Researchers at the National Institute of Mental Health are studying how everyday feelings, like stress or frustration, influence decision-making. They will follow 420 adults aged 18 to 55, including healthy volunteers and people with varying levels of depression, anxiety, or addi…

Researchers at Assiut University are asking whether ADHD symptoms in medical students are linked to depression, anxiety, and lower grades. About 52 undergraduate medical students will fill out questionnaires that screen for adult ADHD, depression, and anxiety. The study also coll…

This study looks at whether the ratio of the second to fourth finger (2D:4D) is linked to anxiety and work stress in anesthesiology residents. Researchers will measure finger lengths and use a questionnaire to assess worry and anxiety in about 116 residents aged 20-35. The goal i…

This study uses a non-invasive brain stimulation technique called TMS to temporarily change activity in a brain region linked to anxiety. Researchers will use fMRI scans to see how this affects brain connections and anxiety-related startle responses. 140 adults with anxiety will …

This study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can change how people remember the order of emotional movie clips. Researchers will compare active TBS to a sham (fake) version in 120 healthy adults. The goal is to understan…

This trial tests whether a scenario-based simulation training session can reduce anxiety, boost self-confidence, and improve clinical skills in nursing students when counseling pregnant women about nutrition. Half of the participants will take part in a 20-minute simulated counse…

This study investigates how often older adults in China experience anxiety and depression before undergoing major non-cardiac surgery. Researchers will use standard questionnaires to screen 8,000 patients aged 65 and older across multiple hospitals. The goal is to better understa…

This study looks at whether feeling anxious before an ERCP procedure makes the experience more uncomfortable or harder for patients to cooperate. Adults undergoing ERCP with conscious sedation will fill out anxiety questionnaires before and comfort surveys after the procedure. Do…

This study aims to adapt a digital mental health app called Wysa for adolescent girls aged 13-18 in rural Uttar Pradesh, India, who have anxiety or depression. Researchers will work with the girls, their families, and community members to identify what helps or hinders app use an…

This study will enroll 500 adults with high levels of repetitive negative thinking (like worry or rumination) to understand why cognitive-behavioral therapy helps. Participants will receive one of two digital therapy programs: one focusing on concrete thinking, the other on self-…

This study looks at how people with anxiety make decisions to avoid things that make them anxious. Researchers will use brain scans and phone tracking to see how avoidance behavior works in the lab and in real life. About 163 adults with and without anxiety will take part. The go…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study looks at how anxiety and depression influence shared decision-making in patients aged 65 and older with critical limb threatening ischaemia (CLTI), a severe form of leg artery disease. Researchers will interview patients, their carers, and healthcare staff to understan…

This study looks at whether a video-supported flipped learning model can lower anxiety and improve skill levels in midwifery students learning episiotomy. About 60 third-year midwifery students will be split into two groups: one gets traditional classroom teaching, the other watc…

This study tests a short media campaign (about 3-5 minutes) designed to encourage parents and caregivers in Nigeria to vaccinate their children. The campaign aims to reduce vaccine hesitancy, address fears, and improve vaccine access. About 74 participants whose children are not …

This study looks back at data from 80 veterans and first responders who completed a 12-week program that combined mental health support, physical therapy, nutrition advice, and occupational therapy. Researchers want to see if the program helped improve sleep, anxiety, depression,…

This study tests whether a short educational video, shown alongside standard information, can help first-time heart attack patients better understand their upcoming heart catheterization and feel less anxious. About 140 participants will be randomly assigned to receive either sta…

This study is creating a decision-support tool called CRAFTT to help therapists tailor mental health treatments to the cultural values and experiences of Latine youth (ages 5-15). The goal is to improve how well these treatments work and reduce mental health disparities. Research…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study tests whether a smartphone app, co-created with teens, plus trained peer navigators can help more young people ages 13-22 get mental health care in schools and clinics. Over 8,000 youth will take part across multiple sites. The goal is to see if this approach increases…

This study will survey 400 adults visiting a urology clinic for the first time. Researchers want to learn if patients who use AI chat tools (like ChatGPT) before their appointment feel more or less anxious, satisfied, and informed compared to those who don't. Participants fill ou…

This pilot study tests a 3-5 minute recorded message called PEACE, designed to improve mental wellbeing and public attitudes toward reintegrating former Boko Haram members in Nigeria. Researchers will enroll 74 adults to see if the intervention is acceptable and feasible. The goa…

This study will survey about 289 medical students and interns at Assiut University to find out how common anxiety and depression are among them. Researchers will use standard questionnaires to measure symptoms and look for links to academic performance and other risk factors. The…