Weill Medical College Of Cornell University

This study tests if women who had a breast cancer return after previous lumpectomy and radiation can avoid mastectomy by getting a second, targeted radiation treatment. About 120 participants will receive either partial or whole breast radiation depending on their prior treatment…

This study is for women with a common type of advanced breast cancer (HR+ HER2-). It tests whether adding targeted radiation to each tumor site, along with standard hormone therapy and a targeted pill, can help keep the cancer from growing longer. About 102 participants will be r…

This study is testing a new way to deliver radiation for high-risk prostate cancer. Doctors will use advanced PSMA PET/MR scans to precisely target tumors and give a stronger dose to the most aggressive areas. The goal is to improve the chance of staying cancer-free for at least …

This study tests whether adding a radiation drug (225Ac-J591) to standard immunotherapy (pembrolizumab) and hormone therapy can better control advanced prostate cancer that has spread and stopped responding to treatment. About 52 men with this type of cancer will receive either t…

This study tests a new approach for postmenopausal women with HR+ breast cancer. Participants receive standard hormone therapy plus radiation, with or without immunotherapy, to see if this combination can train the immune system to fight the cancer. The goal is to improve respons…

This study looks at two common heart procedures in women with blocked arteries: stenting (a less invasive approach) and bypass surgery (open-heart surgery). The goal is to see which one helps women live longer and feel better. About 600 women will take part, and their survival an…

This study tests whether coaching from community health workers through telehealth can help people with dangerously high blood pressure avoid major heart problems like heart attacks and strokes. About 3,620 adults with severe hypertension will be randomly assigned to receive eith…

This study collects and freezes ovarian tissue from females aged 0-45 who are at risk of early menopause due to cancer treatment or ovary removal. The goal is to develop methods to thaw and mature eggs from the tissue, so they might have a genetically related child later. It is a…

This study tests whether inviting friends, family, or coworkers to join a weight loss program helps Black or Hispanic adults with obesity lose more weight. About 264 participants will be randomly assigned to a lifestyle program either alone or with up to two social network member…

This study tests the drug luspatercept in 50 adults with clonal cytopenias of uncertain significance (CCUS), a condition where blood cell counts are low and there is a risk of developing blood cancer. Participants receive injections every three weeks for up to 48 weeks. The goal …

This study compares two approaches after coronary artery bypass surgery: taking ticagrelor plus low-dose aspirin for one month, then aspirin alone, versus taking only low-dose aspirin. The goal is to see if the short dual therapy reduces death, stroke, heart attack, or graft fail…

This study compares a newer, nerve-sparing prostate surgery to the standard approach in 600 men with localized prostate cancer. The goal is to see if the newer method controls cancer just as well while improving urinary function, reducing penile shortening, and lowering the risk …

This study is testing whether N-Acetylcysteine (NAC), an antioxidant supplement, can help people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Researchers will give different doses of NAC or a placebo to 95 adults aged 21-60 to see how it affects brain glutath…

This study tests different combinations of immunotherapy drugs (with or without radiation) in people with colorectal cancer that has spread to the liver and who are scheduled for surgery. The goal is to see if these combinations change the immune environment in the liver tumors a…

This study tests if eating only during an 8-hour window each day, along with a healthy diet and exercise, can reduce liver fat in people with non-alcoholic fatty liver disease. About 40 adults will be assigned to either the time-restricted eating plan or standard lifestyle advice…

This study looks at whether using two or more artery grafts during heart bypass surgery is better than using just one. About 4,300 people having planned, non-emergency bypass will be randomly assigned to one of the two methods. The goal is to see if multiple grafts lower the chan…

This early-stage study tests a gene therapy for people with alpha-1 antitrypsin deficiency, a condition that can damage the lungs. The treatment is given once through a vein and aims to produce a special protein that protects the lungs. The study will check for safety and side ef…

This study tests whether adding the antifungal drug fluconazole to standard IL-23 therapy helps people with Crohn's disease feel better. About 120 adults with mild to moderate Crohn's will receive either fluconazole or a placebo alongside their usual treatment. The main goal is t…

This early-phase study tests whether the drug propranolol can stimulate new heart muscle growth in infants born with Tetralogy of Fallot, a serious heart defect. About 40 babies under 60 days old will receive propranolol, and researchers will measure heart cell division using a s…

This early-stage trial tests whether adding an experimental drug (TVB-2640) to the standard drug enzalutamide is safe for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. About 30 men will take part. The main goal is to find the best do…

This early-stage study tests a vaccine called dAd5GNE in 150 people with cocaine dependence. The vaccine aims to train the immune system to block cocaine from reaching the brain, reducing its effects. The main goal is to check safety, but researchers will also measure cocaine use…

This early-phase study tests whether cells from human umbilical veins are safe to use along with standard surgery for simple anal fistulas. The trial enrolls 39 adults who are already scheduled for fistulotomy. Researchers will monitor side effects for two weeks and check if the …

This study is for people with breast cancer that has spread to the brain (at least two tumors). Participants receive an immunotherapy drug called pembrolizumab every three weeks, plus a precise, one-time radiation treatment to just one of the brain tumors. The goal is to see if t…

This study tests whether training religious leaders to measure and educate about blood pressure can lower average blood pressure in their communities. Researchers will compare communities where leaders receive training to those that do not. About 24,000 adults aged 35 and older a…

This early-phase trial tests whether injecting E-CEL UVEC cells directly into a chronic anal fissure is safe and can help it heal. It involves 20 adults whose fissures have not improved with standard treatments. The study is led by colorectal surgeons and focuses on pain reductio…

This study tests a new way to support people with HIV in rural Uganda. Traditional healers will be trained to offer HIV testing, counseling, and help with starting and staying on medication. The goal is to see if this extra support helps more people achieve an undetectable viral …

This study tests a new combination treatment for people with advanced stomach, esophageal, or gastroesophageal junction cancer that has not responded to standard therapy. Participants receive injections of a cancer-killing virus (OBP-301) directly into their tumor during a scope …

This study aims to improve the heart health of home health aides, a group that often neglects their own health while caring for others. Forty home health aides will take part in a 10-week program called Life's Essential 8, guided by trained peer coaches. The program focuses on he…

This is an early-stage study testing the safety of a new gene therapy for the heart damage caused by Friedreich's ataxia. The therapy uses a modified virus to deliver a healthy gene directly to the heart. Researchers will enroll 25 participants to find a safe dose and look for ea…

This study is testing whether a special type of PET/MRI scan (using a radioactive tracer called 68Ga-DOTATATE) can better detect brain tumors, especially meningiomas, and tell the difference between tumor regrowth and changes from previous treatment. About 200 adults with certain…

This study is testing a new MRI technique to see if it can accurately diagnose jaw muscle pain (masticatory myofascial pain syndrome). Researchers will compare MRI scans of jaw muscles from 90 people with and without pain. The goal is to improve how doctors identify and understan…

This study tests whether a radioactive tracer called [Cu64]DOTATATE can help surgeons find meningioma tumors during surgery using a special probe. About 20 people with suspected or confirmed meningioma who need surgery will take part. The goal is to see if this method is feasible…

This study is testing whether a special type of PET scan (PSMA-PET CT) can accurately rule out dangerous prostate cancer in men who are already on active surveillance (watchful waiting). Researchers will compare scan results with yearly biopsies in 200 men with low- or favorable …

This study is testing a mobile app called MAYA that offers cognitive behavioral therapy (CBT) to help with anxiety and depression in adults who have had a stroke. Researchers want to see if the app is easy to use and acceptable to stroke survivors. Ten participants aged 40-79 wil…

This study tests a program called Living Healthy to see if it helps home health aides feel better. About 100 aides will take part in an 8-week program that teaches health tips and positive thinking. Some will also get a peer coach—another aide trained to offer extra support. The …

This study is testing whether watching a short animated video about a nail biopsy can help people feel less anxious, understand the procedure better, and be more satisfied with their care. About 30 adults who need a nail biopsy will take part. The goal is to see if a simple educa…

This study tests a device called IVS3 that uses intense visual stimulation to help people with chronic stroke improve arm movement. About 25 participants will use the device in an outpatient rehab center. The goal is to see if the treatment is tolerable, safe, and easy to use in …

This study tests a new type of talk therapy called Engage & Connect for new mothers with postpartum depression. The therapy is delivered remotely over 9 weeks and focuses on reducing social isolation and improving how the brain processes social rewards. The study will enroll 60 w…

This study tests an 8-week group program that teaches mind-body skills like meditation, guided imagery, and relaxation techniques to help medical graduate students manage mood symptoms. About 60 students with mild anxiety or depression will participate. The goal is to see if the …

This study compares two types of nerve blocks (PENG vs femoral) to see which provides better pain relief for people with hip fractures. About 352 adults with hip fractures will receive one of the two blocks based on the month they arrive. Researchers will measure pain scores befo…

This study tests if a safe, gentle electrical current applied to the forehead at home can reduce severe tiredness after a stroke. Researchers will enroll 24 adults who are at least 3 months past their first stroke and have significant fatigue. Participants will use a headset devi…

This study tests a mobile program called WellPATH-PREVENT for adults aged 50 to 90 who were recently hospitalized for suicidal thoughts or a suicide attempt. The goal is to see if the app helps them better manage their emotions and lowers their risk of future suicidal thoughts. P…

This study tests a special bracelet that vibrates gently when it senses nail-biting. Ten adults who bite their nails will wear the bracelet for 12 weeks and track their progress with a phone app. The goal is to see if the gentle buzz helps reduce nail-biting and improve nail heal…

This study compares two types of talk therapy—exposure therapy and interpersonal therapy—for PTSD caused by military sexual trauma. About 208 survivors will receive one of the two treatments to see if they are equally effective at reducing PTSD symptoms. The goal is to offer more…

This study tests whether spiritual care interventions can improve spiritual well-being and readiness to plan future care in Black patients with advanced cancer. About 64 participants will be recruited from outpatient clinics. The goal is to see if a larger trial is possible.

This study tests a small, battery-powered headband that delivers a gentle electrical stimulation to the scalp to reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is…

This study is for people who had a stroke at least 6 months ago and now have depression and trouble with focus or planning. Researchers want to see if using an iPad-based brain training program, along with learning new thinking strategies, can improve mood, memory, and daily life…

This study tests whether virtual reality (VR) can help healthcare workers and COVID-19 patients overcome PTSD. Participants wear VR headsets to safely revisit traumatic experiences in a controlled environment. The goal is to see if this approach is practical and tolerable, and wh…

This is a small pilot study to test a new virtual therapy program designed to treat PTSD and chronic pain at the same time. The program combines techniques from two established therapies over 12 online sessions. Researchers will check if the combined approach is practical and acc…

This study compares how long different numbing medications work during skin surgery. Researchers will test the effect of medication volume on numbing duration at highly vascular sites. About 35 adults with normal skin sensation will participate. Results will help doctors choose t…

This study collects tumor samples from 400 breast cancer patients at key moments—diagnosis, surgery, and if the cancer returns or spreads. Researchers will grow mini-tumors in the lab and study genes and immune cells to better understand the disease. The goal is to learn, not to …

This study tests whether connecting an ambulance to a remote children's emergency doctor via a simple video call can improve care for seriously ill children in low-resource settings. Researchers in Karachi, Pakistan will compare health outcomes for 900 children who either receive…

This study looks at how young women (ages 18-44) newly diagnosed with early-stage breast cancer decide on surgery. Researchers are testing a web-based tool called CONSYDER that provides helpful information and improves talks with surgeons. About 800 participants will fill out sur…

This study creates a registry to collect information on endoscopic bariatric therapies (EBTs), which are non-surgical procedures for weight loss. Researchers will review medical charts and follow up to 9,999 participants for one year to measure weight changes and track any side e…

This study looks at how the dietary supplement L-Phenylalanine changes gut fungi and a related chemical in healthy adults. Researchers will measure levels of a metabolite called phenylpropionic acid and track fungal populations like Candida. The goal is to understand the suppleme…

This study is testing whether an artificial intelligence tool can better predict outcomes for people undergoing in vitro fertilization (IVF) or other assisted reproductive treatments. Researchers will analyze data from 4,000 participants to see if the AI can accurately count eggs…

This study is testing a tool called Transit-Time Flow Measurement (TTFM) that uses sound waves during heart bypass surgery to check blood flow through the new grafts. The goal is to see if using this tool helps prevent grafts from failing. About 1,242 adults having their first no…

This study tests a special shoe called NUSHU that has sensors to measure walking and balance in people with early to advanced Parkinson's disease and in healthy volunteers. The shoe can also give gentle vibrations to help with walking problems. Researchers want to see if the shoe…

This study collects tissue samples, medical data, and family history from 1,120 adults undergoing routine screening for colorectal or endometrial cancer. Researchers aim to discover new genes and immune system clues that could lead to better prevention and targeted treatments for…

This study tests whether offering online genetic counseling and testing to close relatives of people with BRCA mutations helps more of them get tested compared to usual care. About 820 first-degree relatives (parents, siblings, children) will be randomly assigned to either the on…

This study uses heart MRI scans to understand why some COVID-19 survivors continue to have heart and lung symptoms, like shortness of breath or tiredness. Researchers will follow 510 adults who were hospitalized with COVID-19, scanning their hearts and lungs months after infectio…

This study follows over 22,000 children and adults with genetic developmental and epileptic encephalopathy (DEE) to learn how the disease changes over time. Participants join in-person, virtual, or online-only groups and complete surveys and developmental tests. No experimental t…

This study collects blood, airway, and urine samples from up to 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. The goal is to establish normal ranges and understand the genetic changes that lead to lung disease. Participants must be 18 or…

This study collects information about how well different focal therapies work for prostate cancer. Researchers will track 200 patients who receive treatments like ultrasound, freezing, or laser therapy. The goal is to understand treatment patterns, side effects, and quality of li…