Weill Medical College Of Cornell University

This early-phase study was designed to test a new treatment combination for people with advanced liver cancer that can be surgically removed. Participants would have received three sessions of focused radiation to the tumor, along with immunotherapy drugs (one dose of tremelimuma…

This study tests a new way to choose cord blood for transplant in people with blood cancers like leukemia or lymphoma. Patients receive a cord blood transplant plus stem cells from a family member. The goal is to find the lowest safe cord blood dose that still leads to successful…

This study tests whether adding lenalidomide to the standard chemotherapy (melphalan) before a stem cell transplant can improve outcomes for people with relapsed multiple myeloma. About 52 participants will receive the combination, followed by maintenance lenalidomide. The goal i…

This study is for men with advanced prostate cancer that has spread and is no longer controlled by hormone therapy. Researchers are testing a drug called 177Lu-PSMA-617, which delivers radiation directly to cancer cells. The goal is to find the highest dose that can be given safe…

This study tests a combination of an experimental drug (paxalisib), a diabetes drug (metformin), and a high-fat, low-carbohydrate (ketogenic) diet in people with a type of brain cancer called glioblastoma. The goal is to see if this approach is safe and can slow tumor growth. The…

This study tests whether combining an experimental targeted radiation drug (177Lu-J591) with hormone therapy (ketoconazole) can keep prostate cancer from spreading in men whose cancer has returned after initial treatment. About 55 men with high-risk, castration-resistant prostate…

This study tests whether the common antibiotic doxycycline can slow the worsening of emphysema in people living with HIV. About 133 current or former smokers with HIV will take doxycycline for 72 weeks. Researchers will measure lung function, walking ability, and check for antibi…

This study tests a combination of three drugs (acalabrutinib, lenalidomide, and either rituximab or obinutuzumab) in people with untreated mantle cell lymphoma, a rare blood cancer. About 37 participants will receive the treatment for about a year, then continue on a lower mainte…

This study tests a personalized approach for people with chronic lymphocytic leukemia (CLL). Instead of giving everyone three drugs from the start, participants first receive two oral medications (zanubrutinib and venetoclax). Only those who still have detectable cancer cells aft…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with locally advanced esophageal adenocarcinoma. About 42 adults whose cancer has not spread far but is too large for immediate surgery will receive the com…

This study tests a combination of four drugs (daratumumab, clarithromycin, pomalidomide, and dexamethasone) in people with multiple myeloma whose cancer returned or stopped responding after previous treatment with daratumumab. The goal is to see if this combo can shrink tumors mo…

This study tests whether replacing a standard immune-suppressing drug with tocilizumab can improve stem cell transplant success in 21 adults with blood cancers. The goal is to prevent graft failure and graft-versus-host disease while reducing cancer relapse. Participants receive …

This study looks at giving a short, precise course of radiation before surgery to remove the prostate in men with high-risk prostate cancer. The goal is to see if this approach is safe and helps control the disease better. Sixteen men with aggressive prostate cancer (Gleason scor…

This study tests if a very short course of radiotherapy (5 treatments over 2 weeks) causes similar bowel and urinary side effects as a standard shorter course (20 treatments over 4 weeks) in men whose prostate cancer has returned after prostate removal. About 134 men will partici…

This study tests a combination of two drugs, tazemetostat (pills) and mosunetuzumab (injections), in people with untreated follicular lymphoma. The goal is to see if the combo works better than either drug alone while remaining safe. About 23 adults will take part, and the study …

This study tests a new approach for men with intermediate-risk prostate cancer. First, doctors use a special electric pulse (IRE) to destroy tumor cells, then follow up with precise radiation (MRgRT). The goal is to see if this combination is safe and can keep cancer away for at …

This study compares the effects of a whole-food plant-based diet versus standard nutritional counseling on weight in overweight or obese men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). About 76 participants will be followed for up to 26 …

This study aims to find the most effective screening method for detecting early signs of cervical cancer in women living with HIV in Latin America. Researchers will compare different tests (cervical swabs, self-collected vaginal swabs, urine tests, and biopsies) on 1,002 particip…

This study tests whether the nine-valent HPV vaccine can prevent persistent oral HPV infections in 700 men living with HIV. Participants receive either the vaccine or a placebo and are followed for up to four years. The goal is to see if the vaccine reduces the risk of HPV-relate…

This study looks at whether a shorter, more intense course of radiation (called accelerated radiation) is safe for women with breast cancer who have already had chemotherapy and surgery. About 88 women with stage I to III breast cancer will receive this faster radiation to the br…

This study looks at whether older adults (age 60+) with a type of heart failure called HFpEF can safely stop taking beta-blockers and feel better. Participants are randomly assigned to either gradually reduce their beta-blocker dose or continue taking it for about 4 months. The g…

This study tests a special tablet app designed to help older adults (age 50+) who have been living with HIV for at least 15 years. The app provides easy access to resources, social connections, and memory support to reduce loneliness and depression. About 68 participants will use…

This study looks at whether older adults (65+) with a specific type of heart disease (TTR cardiac amyloidosis) feel better when they stop taking beta-blockers, a common heart medication. Twenty participants will go through two periods—one on the drug and one off—to compare exerci…

This study tests whether injecting methotrexate directly into the nail area can improve nail psoriasis symptoms like pitting, crumbling, and discoloration. One adult with at least three affected fingernails is enrolled. Each nail is scored before and after treatment to measure ch…

This study tests whether using a FitBit and a mobile app can help people who have had surgery for stomach, liver, colon, or other GI cancers avoid going back to the hospital. About 107 adults who own a smartphone and are scheduled for surgery will either use the devices or get us…

This study tests two different radiation schedules for postmenopausal women with early-stage breast cancer. One group gets 5 daily doses, the other gets 3 doses every other day, both over one week. The goal is to see which schedule causes less breast scarring (fibrosis) while kee…

This study is testing a program that uses short videos and a health coach to help people aged 60 and older with a type of heart failure called HFpEF. The goal is to see if the program is practical and helps people manage their condition better. Fifty participants will be followed…

This study checks if drinking caffeine changes blood pressure or heart rate in people taking the antifungal pill terbinafine for nail fungus. About 52 adults will have their heart rate and blood pressure measured. The goal is to see if there is a significant interaction, helping …

This study gives a targeted drug called abemaciclib to 20 people with bladder cancer who cannot take standard chemotherapy. The drug is taken for a short time before the bladder is removed surgically. Researchers compare tumor samples taken before and after the drug to see how it…

This study follows about 3,000 adults in Port-au-Prince, Haiti, for up to 7 years to track heart disease risks like high blood pressure, diabetes, and smoking. Researchers will measure how common these risks are and how they lead to heart attacks, strokes, or heart failure. The g…

This study aims to create a questionnaire that captures how chronic pelvic pain truly affects women's lives. Researchers will interview 55 women with this condition to develop and test the new tool. The goal is to provide a better way to measure treatment benefits in future resea…

This study looks at whether replacing a person's own red blood cells with healthy donor cells can improve brain function in people with GLUT1 deficiency syndrome, a rare condition that causes seizures and movement problems. The trial involves about 12 people aged 16 to 80 who hav…

This study tests whether using MRI to guide radiation therapy for breast cancer is as good as the standard CT-guided method. About 17 women aged 50 or older with early-stage breast cancer who had lumpectomy will receive either CT-based or MRI-based radiation. The main goal is to …

This study tests a personalized approach called N-of-1 trials to help older adults with a type of heart failure (HFpEF) decide whether to continue or stop taking beta-blockers. About 20 participants will try different medication schedules and report their confidence and preferenc…

This study tests whether a phone app called StudyU can help people with heart failure reach the recommended dose of their beta blocker medicine. Five adults aged 65 and older with heart failure will use the app. The goal is to see if the app is practical and acceptable for patien…

This study is tracking 452 adults with a family history of Alzheimer's or early memory problems to see how personalized medicine approaches affect their thinking and memory over time. Researchers will regularly measure blood markers, genetics, and cognitive test results. The goal…