Weill Medical College Of Cornell University

This phase 2 trial is testing whether adding radiation therapy to the immunotherapy drug nivolumab can help people with advanced gastroesophageal cancer live longer without their disease getting worse. All 80 participants first receive a short course of chemotherapy (FOLFOX) plus…

This Phase 2 trial tests whether N-Acetylcysteine (NAC), an antioxidant, can help people with ME/CFS (chronic fatigue syndrome). Researchers will give 95 participants different doses of NAC or a placebo for four weeks, then measure brain glutathione levels and markers of oxidativ…

This trial explores whether adding the drug tazemetostat (Tazverik) to standard CAR T cell therapy can help the immune cells better recognize and destroy lymphoma cells. It enrolls people with diffuse large B-cell lymphoma, follicular lymphoma, or mantle cell lymphoma who have al…

This phase 2 trial tests whether leuprolide (Eligard), a drug that lowers certain hormones, can slow memory and thinking decline in 180 women with mild Alzheimer's or mild cognitive impairment. All participants are already taking donepezil. The study compares leuprolide injection…

This study looks at whether a whole-food, plant-based diet can help overweight or obese men with prostate cancer who are on hormone therapy (ADT) control their weight and reduce inflammation. About 76 men will either receive free plant-based meals at home or standard nutrition ad…

This study looks at whether eating proteins and vegetables before carbohydrates (meal sequencing) can improve blood sugar control in 70 adults with diabetes or prediabetes who also experience food insecurity. Participants will receive free produce boxes and either standard nutrit…

This phase 2 pilot study is testing whether giving two immunotherapy drugs, botensilimab and balstilimab, before surgery can shrink tumors in people with colorectal cancer. The trial includes 26 participants across three groups, with some receiving more doses and one group having…

This study tests a combination of four drugs (daratumumab, clarithromycin, pomalidomide, and dexamethasone) in people with multiple myeloma whose cancer returned or didn't respond after previous treatment with daratumumab. The goal is to see if this combo can shrink tumors more e…

This pilot study tests whether high doses of a radioactive sugar (FDG) can safely treat advanced cancers that no longer respond to standard therapies. FDG is taken up by cancer cells because they use a lot of glucose, and the radiation may kill them. The study involves 30 adults …

This phase 3 trial compares a standard 3-week radiation course to an experimental 2-week course for women with early-stage breast cancer. About 400 participants who had lumpectomy will receive whole breast radiation plus an extra boost to the tumor site. The study checks if the s…

This phase 2 trial tests a combination of three drugs—acalabrutinib, lenalidomide, and either rituximab or obinutuzumab—in people with untreated mantle cell lymphoma. The goal is to see how well the combo clears cancer cells from the blood and shrinks tumors. Participants receive…

This phase 2 trial tests whether a radioactive antibody called 177Lu-J591, combined with the hormone-blocking drug ketoconazole, can prevent prostate cancer from spreading in high-risk patients. The study enrolls 55 men whose PSA is rising despite hormone therapy but who have no …

This study tests whether adding lenalidomide (Revlimid) to the standard high-dose melphalan before an autologous stem cell transplant can improve outcomes for people with relapsed multiple myeloma. In the first phase, researchers find the safest dose of lenalidomide to combine wi…

This phase II trial is testing a combination of two drugs—tazemetostat pills and mosunetuzumab injections—in 23 people with follicular lymphoma who have not yet received treatment. The goal is to see if the combination is safe and leads to a complete response (disappearance of ca…

This study tests a new approach for men with intermediate-risk prostate cancer. First, doctors use electric pulses (IRE) to destroy tumor cells, followed by precise radiation (MRgRT). The goal is to see if this combination is safe and can keep cancer away for at least a year. Abo…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with a certain type of esophageal cancer. The trial involves 42 adults whose cancer has not spread far but is locally advanced. The main goal is to see if t…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) before prostate removal surgery is safe and effective for men with high-risk prostate cancer. Sixteen men with aggressive prostate cancer (Gleason score 8 or higher or signs of spread) will receive ra…

This study tests whether giving radiation in just 5 treatments over 2 weeks is as safe and effective as the standard 20 treatments over 4 weeks for men whose prostate cancer has come back after surgery. The 134 participants will be randomly assigned to one of the two schedules. T…

This study tests whether adding daratumumab back to pomalidomide and dexamethasone can improve complete remission rates in 15 adults with relapsed or refractory AL amyloidosis who have already received daratumumab. Participants receive the three-drug combination to control the di…

This phase 2 trial tests a personalized approach for chronic lymphocytic leukemia (CLL). Patients first receive two oral drugs (zanubrutinib and venetoclax). Only those who still have detectable cancer cells after treatment get an additional infusion drug (obinutuzumab). The goal…

This study tests a radioactive drug called 225Ac-J591 in men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The first part finds a safe dose and schedule, and the second part checks if the drug lowers PSA levels by more than half. About 6…

This study tests whether doxycycline, an antibiotic, can slow the worsening of emphysema in people living with HIV. About 133 current or former smokers with HIV will take doxycycline for 72 weeks. Researchers will measure lung function, walking ability, and check for antibiotic r…

This study compares two types of radiation therapy for women with early-stage breast cancer after lumpectomy. One group receives standard CT-guided radiation, while the other receives a newer MRI-guided approach. The goal is to see if MRI-guided radiation works just as well at pr…

This early-phase trial is testing whether glycerol phenylbutyrate (Ravicti), a drug already approved for a different condition, is safe and tolerable for children with genetic disorders like STXBP1 and SLC6A1 that cause seizures and developmental delays. The study will enroll 50 …

This phase 2 trial tests whether adding the drug tocilizumab to a standard transplant regimen can prevent graft failure and graft-versus-host disease in people with blood cancers receiving a special type of bone marrow transplant. The study involves 21 participants and aims to re…

This study tests a combination of an experimental drug (paxalisib), a diabetes drug (metformin), and a high-fat, low-carbohydrate ketogenic diet in people with glioblastoma, an aggressive brain cancer. The goal is to see if this approach is safe and can slow tumor growth. The tri…

This study tests whether a ketogenic diet (high fat, low carb) combined with the diabetes drug metformin is safe and tolerable for people with glioblastoma, an aggressive brain cancer. The idea is to lower blood sugar, which tumors use to grow. The 18 participants prepare their o…

This study tests whether replacing a patient's own red blood cells with healthy donor cells can improve brain function in people with GLUT1 deficiency syndrome, a rare genetic condition that causes seizures and movement problems. The approach aims to boost glucose delivery to the…

This early-phase study tests a new treatment for advanced liver cancer. Participants will receive focused radiation to the tumor along with two immunotherapy drugs (tremelimumab and durvalumab) to help the immune system fight the cancer. The goal is to see if this combination is …

This study tests a drug called abemaciclib in 20 people with bladder cancer who cannot receive standard chemotherapy. Participants take the drug before their scheduled surgery to remove the bladder. Researchers will compare tumor samples taken before and after treatment to see ho…

This study tests a radioactive drug called 177Lu-PSMA-617 in men with advanced prostate cancer that has stopped responding to hormone therapy. The drug seeks out and delivers radiation directly to cancer cells. The trial aims to find the safest effective dose and see if it can lo…

This phase 2 study tested a sequence of four drugs—carfilzomib, clarithromycin, lenalidomide, and dexamethasone—in 74 people newly diagnosed with multiple myeloma. The goal was to see how safe and effective this combination is at controlling the disease. Participants first receiv…

This study tests a new approach to stem cell transplants for people with blood cancers like leukemia and lymphoma. Patients receive a combination of umbilical cord blood and stem cells from a family member, with the cord blood chosen based on specific genetic markers rather than …

This study compares different HPV tests to find the best way to screen for cervical cancer in women living with HIV in Latin America. Over 1,000 participants will provide cervical, vaginal, and urine samples, plus undergo colposcopy and biopsies. The goal is to identify which tes…

This study tests whether the nine-valent HPV vaccine can prevent long-lasting oral HPV infections in men who have HIV. About 700 men will receive either the vaccine or a placebo. The goal is to see if the vaccine reduces new persistent infections with HPV types linked to throat c…

This study looks at whether a central outreach program can help more people at high risk for lung cancer get a low-dose CT scan. About 2000 adults aged 50-80 who smoke or used to smoke will be invited to get screened. The goal is to catch lung cancer early, when it's easier to tr…

This study tests a small, battery-powered headband that delivers a gentle electrical pulse to the scalp to help reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is …

This study looks at whether a shorter, more intense course of radiation (accelerated radiation therapy) is safe and tolerable for women with breast cancer who have already had chemotherapy and surgery. About 88 participants will receive the accelerated radiation to the breast and…

This study looks at whether gradually stopping beta-blockers (medicines often used for heart failure) can improve symptoms and daily function in adults aged 60 and older with a specific type of heart failure called HFpEF. About 240 participants will either taper off their beta-bl…

This study tests a program called CHAT for people aged 60 and older with a type of heart failure called HFpEF. Participants get up to four sessions with a health coach and watch seven educational videos, all from home. The goal is to see if this helps them manage their condition …

This study tests a behavioral program called Moving Well to see if it can reduce anxiety and depression in people waiting for knee replacement surgery. About 79 participants will either get the coaching program or a general wellness program. The goal is to improve emotional well-…

This study looks at two different radiation schedules for postmenopausal women with early-stage breast cancer. One group gets 5 daily doses, the other gets 3 doses every other day. The goal is to see which schedule causes less scarring (fibrosis) in the breast. 350 women will be …

This study tests whether using a FitBit and a mobile app can help people recover at home after surgery for stomach, liver, colon, or other GI cancers. About 107 patients will either use the devices plus standard care, or standard care alone. The app tracks activity and symptoms, …

This study looks at whether older adults with a heart condition called cardiac amyloidosis feel better and can exercise more when they stop taking beta-blockers. Twenty participants will each go through two periods: one on their beta-blocker and one off it. Researchers will measu…

This study tests whether offering online educational videos and mailed saliva genetic testing kits helps more first-degree relatives of people with BRCA mutations get tested, compared to standard care with a family letter. About 820 participants will be enrolled across several me…

This study looks at genetic changes in people with H. pylori infection or stomach cancer to understand how the infection can lead to cancer. Researchers will analyze tissue samples from 110 adults undergoing endoscopy. The goal is to find early warning signs and possible ways to …

This study is creating a registry of 452 adults with a family history of Alzheimer's or early memory problems. Researchers will track their health, blood markers, and thinking skills over time to see if personalized care plans can help prevent or treat the disease. The goal is to…

This study tests whether a phone app called StudyU can help people with heart failure reach their recommended beta blocker dose. Five adults aged 65 and older with heart failure will use the app to track their medication. The goal is to see if the app is practical and acceptable …

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study tests a new PET scan method that looks at two things at once: oxygen levels and cell growth in high-grade brain tumors. The goal is to see if these scans can help doctors understand which tumors might resist standard treatment. Only 8 adults with suspected high-grade g…

This study collects kidney tissue from 100 adults with autosomal dominant polycystic kidney disease (ADPKD) who are already scheduled for kidney removal. Researchers will analyze the tissue for additional genetic mutations that may drive cyst formation. The goal is to better unde…

This study involves 55 women with chronic pelvic pain to develop a questionnaire that captures their full experience. Researchers will interview participants to understand symptoms and impacts, then test the questionnaire for clarity and completeness. The goal is to create a reli…

This study follows over 1,000 children aged 0-21 who are getting stem cell transplants. Researchers will check for delirium twice a day during their hospital stay. The goal is to learn how often delirium happens, what raises the risk, and how it affects recovery. This information…

This study tests whether a personalized 'N-of-1' trial can help older adults with a type of heart failure (HFpEF) decide if they want to continue or stop taking beta-blockers. Twenty participants will go through periods on and off their beta-blocker, in a random order, to see how…

This study checks if drinking caffeine changes blood pressure or heart rate in people taking the antifungal medication terbinafine for nail fungus. Researchers will monitor 52 adults before and after they start the drug. The goal is to understand possible side effects, not to tes…

This study aims to develop and test educational content that explains statin side effects, including placebo and nocebo effects. Researchers will gather feedback from 30 adults with cardiovascular risk factors through surveys and interviews. The goal is to see if this content is …