Experimental cell injection aims to heal painful anal fissures
NCT ID NCT06456073
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests whether injections of special cells (E-CEL UVEC) can safely heal chronic anal fissures that haven't responded to other treatments. Twenty adults with long-lasting anal fissures will receive the cell injection directly into the fissure. The study primarily looks at safety and whether the fissure closes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
E-CEL UVEC cells (modified human umbilical vein endothelial cells)
What this could lead to
If successful, this could offer a new treatment option for chronic anal fissures that haven't healed with standard therapies.
What could go wrong
This is a very early Phase 1 trial with only 20 participants, so safety and effectiveness are not yet proven. The treatment may cause injection site reactions or fail to heal the fissure.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Weill Cornell Medicine
RECRUITINGNew York, New York, 10065, United States
Contact Email: •••••@•••••