Experimental cell injection aims to heal painful anal fissures
NCT ID NCT06456073
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests whether injections of special cells (E-CEL UVEC) can safely heal chronic anal fissures that haven't responded to other treatments. Twenty adults with long-lasting anal fissures will receive the cell injection directly into the fissure. The study primarily looks at safety and whether the fissure closes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- E-CEL UVEC cells (modified human umbilical vein endothelial cells)
- What this could lead to
- If successful, this could offer a new treatment option for chronic anal fissures that haven't healed with standard therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 20 participants, so safety and effectiveness are not yet proven. The treatment may cause injection site reactions or fail to heal the fissure.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Weill Cornell Medicine
RECRUITINGNew York, New York, 10065, United States
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