University Hospital, Strasbourg, France

This study looked at 130 kidney transplant patients with BK virus in their blood. It compared two approaches: simply lowering their anti-rejection drugs versus lowering them and switching one drug to everolimus. The goal was to see which method cleared the virus better after 6 mo…

This study tested a new way to rebuild the front part of the lower jaw after it is removed during ear, nose, and throat surgery. Instead of using a piece of bone taken from elsewhere in the body, doctors placed a custom porous titanium implant. The goal was to see if this simpler…

This study tested whether a special plasma product (OctaplasLG) could help treat blood clotting problems in people with septic shock. The trial included 60 adults with septic shock and clotting issues. Researchers measured how quickly treatment was given and looked at survival an…

This early-phase trial tested a special artificial larynx with valves in 10 adults with severe swallowing troubles. The goal was to see if the device could improve swallowing and allow closure of the tracheotomy (breathing tube in the neck). The study focused on safety and basic …

This study tested a special light-activated gel, called FOTOSAN®, to treat severe gum disease (periodontitis). The goal was to see if adding this treatment to standard care helps reduce infection and improve gum health. 36 adults with severe gum disease took part, and their progr…

This early-phase study tested a new approach for stage IIIB/C melanoma, a serious skin cancer that has spread to nearby lymph nodes. Nineteen participants received a procedure that freezes the tumor (cryotherapy) combined with injections of two immunotherapy drugs, ipilimumab and…

This study tested whether acupuncture can help turn a breech baby (feet or bottom first) into the head-down position before birth. 259 pregnant women with a breech baby at 32-34 weeks took part. One group received real acupuncture at a specific point, while the other got a sham t…

This study looked at whether taking L-arginine, a natural amino acid, for 6 weeks could help heart transplant recipients exercise more easily and improve kidney function. Thirty stable male heart transplant patients took part. The goal was to see if this supplement could address …

This study looked at whether adding the drug vildagliptin to insulin can help control blood sugar in people with type 2 diabetes who are on dialysis. About 70 adults on dialysis for at least 3 months took part. The goal was to see if this combination improves glucose levels and r…

This study tested a drug called tocilizumab in 110 adults with primary Sjögren's syndrome, an autoimmune disease that causes severe dry eyes, dry mouth, pain, and fatigue. The drug works by blocking a protein (IL-6) that fuels immune attacks on the body's moisture-producing gland…

This study tested a new way to treat early-stage prostate cancer using MRI-guided ultrasound waves to destroy tumors without surgery. 25 men with low-to-intermediate risk prostate cancer received the treatment. The main goal was to see if no significant cancer remained one year l…

This study looked at 300 adults with active rheumatoid arthritis whose first anti-TNF treatment stopped working. Researchers compared two strategies: switching to a different type of biologic drug or trying a second anti-TNF. The goal was to see which approach better controls the…

This study tested a combination of two drugs, rapamycin and irinotecan, in 42 children aged 1 to 21 with solid tumors that did not respond to standard treatments. The main goal was to find the safest dose and understand side effects. The drugs work by blocking blood vessel growth…

This study looked at how to best give the blood thinner heparin to obese patients during heart surgery that uses a heart-lung machine. The standard dose based on total body weight can lead to too much heparin and more bleeding. Researchers tested a dose based on ideal body weight…

This study tested a freezing technique called cryoablation for people with rare, non-cancerous but aggressive desmoid tumors in areas like the chest or limbs. The goal was to stop tumor growth and relieve pain in 50 patients whose tumors kept growing despite at least two other tr…

This study tested a new method (SRM-MS/MS) to diagnose early Lyme disease from skin samples. 84 people with the early rash (erythema migrans) gave skin biopsies. The new method was compared to two existing tests (culture and PCR) to see which was most sensitive. The goal was to i…

This study tested a new handheld gamma camera (CarolIReS) in 110 breast cancer patients to see if it could find sentinel lymph nodes that standard methods miss. The camera was used before and during surgery to guide removal and check if any nodes were left behind. The goal was to…

This study looked at whether measuring lactate from a finger-prick (capillary blood) can help doctors identify sepsis earlier in patients who are not in the intensive care unit. Sepsis is a life-threatening response to infection, and early detection is key. The researchers enroll…

This study tested a method using both a radioactive tracer and a blue dye to locate sentinel lymph nodes in 100 people with infiltrative breast cancer. The goal was to see if using both together works better than either alone. Researchers also looked at the cost of the procedure.

This study tested whether giving intravenous immunoglobulins (IVIG) can prevent BK virus infection after a kidney transplant. The virus can damage the new kidney in up to 10% of patients. 359 adults with low protective antibodies against the virus received either IVIG or no extra…

This study looked at 200 pregnant women who needed a planned C-section. Half had the surgery at 38 weeks after receiving steroids to help the baby's lungs, and the other half had it at 39 weeks without steroids. The goal was to see if the earlier timing could prevent emergency C-…

This study tested whether stronger or gentler back traction (a pulling force on the lower spine) works better for sudden leg pain caused by a slipped disc. Seventeen adults with recent sciatica were treated with either high or low force traction. The goal was to see which level r…

This study looked at a different way to manage pain after chest surgery (thoracotomy) for people who cannot get an epidural. A thin tube placed by the surgeon near the wound delivered either a numbing medicine (ropivacaine) or a saltwater placebo for 48 hours. All participants al…

This study tested whether a special germ-trapping dressing (Sorbact) helps wounds heal faster after surgery for pilonidal sinus, a painful condition near the tailbone. About 250 adults took part, and researchers compared Sorbact to a standard dressing over 75 days. The goal was t…

This study tested a 5-month program of Dialectical Behavior Therapy (DBT) for 92 adults with autism who also had self-harm or suicidal thoughts. The goal was to see if DBT could help them better manage their emotions. The results will show if this therapy is a useful tool for thi…

This study tested whether pimavanserin, a drug already approved for hallucinations in Parkinson's, can reduce impulse control disorders like compulsive gambling or eating. 117 adults with Parkinson's and moderate-to-severe impulsive behaviors took part. The goal was to see if the…

This study looked at whether laparoscopic promontofixation, a common surgery for pelvic organ prolapse, can be safely done as an outpatient procedure. Researchers followed 60 women to see how many needed to be readmitted to the hospital after going home the same day. The goal was…

This study tested an online cognitive behavioral therapy (CBT) program designed to lower stress and prevent mental health problems like depression, anxiety, and insomnia in health workers caring for COVID-19 patients. 156 healthcare workers participated in a randomized trial comp…

This study tested a pain relief method for people having chest surgery who cannot get an epidural. Surgeons placed a small tube near the spine to deliver numbing medicine for 48 hours. All patients also got morphine through a pump. The goal was to see if this approach lowers pain…

This study compared a newer tool called a morcellator with a standard resectoscope for removing uterine polyps in 90 women. The goal was to see which method is faster, safer, and more comfortable. The morcellator may reduce risks like uterine injury and improve vision during surg…

This study looked at whether adding a mindfulness-based stress reduction program to an 8-week exercise plan could improve fitness and quality of life in women with breast cancer. 100 women who had finished chemotherapy and were undergoing radiotherapy or hormone therapy took part…

This study looked at whether flushing the follicles with fluid during egg retrieval helps women who produce few eggs in IVF get more eggs. 257 women with fewer than 5 mature follicles were randomly assigned to standard egg retrieval or retrieval with flushing. The goal was to see…

This study looked at 248 women having laparoscopic womb surgery. It tested four different types of gas used to inflate the belly during surgery. The goal was to see if warming or moistening the gas, or adding pain medicine to it, could help prevent drops in body temperature and r…

This study tested a connected device called EMY that helps women train their pelvic floor muscles after giving birth. The goal was to see if using the probe improves quality of life for those with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising).…

This study looked at how the brain creates the feeling of being in control of our own actions. Researchers compared healthy volunteers with people who have schizophrenia or bipolar disorder, especially those who feel their actions are controlled by an outside force. The goal was …

This study looked at whether a memory technique called retrieval practice works in people with schizophrenia. In this method, being tested on information helps you remember it better later. Researchers had 40 participants (patients and healthy controls) learn word pairs and then …

This study tested a noninvasive navigation system that measures how the knee moves before surgery. The goal was to see if better understanding of each patient's unique knee motion could help doctors choose or place knee implants more accurately. 40 adults with end-stage knee oste…

This study looked at 82 adults infected with Staphylococcus lugdunensis bacteria to find which toxins (harmful substances) the bacteria produce that lead to serious illnesses like blood infections or heart valve infections. Researchers compared samples from patients with differen…

This study collected information from nearly 1,000 people in France with inherited retinal diseases (IRDs) to better understand the genetics behind these conditions. Researchers looked at genetic test results and disease types to help build a national registry. The goal is to imp…

This study looked at how people with schizophrenia organize memories of everyday events. Participants took a 1-hour walk in Strasbourg while wearing an automatic camera. Later, they were asked to put photos from the walk in the correct order and identify where events started and …

This study looked at how autism affects a person's sense of self in adulthood. Researchers asked 102 adults (some with autism, some without) to recall personal memories and describe what defines them. The goal was to understand differences in memory detail and self-concept, witho…

This study tested whether custom-made cutting guides, created from each patient's CT scan, can improve the accuracy of knee replacement surgery. Researchers enrolled 20 adults with end-stage knee osteoarthritis to see if these guides lead to better implant positioning. The goal i…

This study looked at how people with dementia with Lewy bodies experience their sense of self, including memory and self-concept. Researchers compared 61 participants with dementia, Alzheimer's, and healthy aging using memory tests and brain scans. The goal was to understand whic…

This study looked at whether a simple blood test can monitor lung cancer progression without needing to sample the tumor directly. Researchers checked for genetic changes in the blood of 200 lung cancer patients. The goal was to see if this non-invasive method could track how the…

This study looked at how well-trained runners' hearts and lungs respond to running on a treadmill at different slopes—downhill, flat, and uphill. Eight athletes participated to see if downhill running uses less oxygen and causes less fatigue. The goal was to better understand how…

This study explored why some women with rheumatoid arthritis feel better during pregnancy while those with lupus may get worse. Researchers looked at tiny molecules called microRNAs in blood, urine, and placenta from 50 pregnant women. The goal was to find new biomarkers to predi…

This study looked at how 238 adults with shoulder dislocations were treated in the emergency room at a French hospital. The goal was to find ways to reduce pain during the procedure to put the shoulder back in place. Researchers reviewed past cases to suggest better, more consist…

This study tested whether medical students who practiced lumbar punctures on an augmented reality simulator performed better on real patients than those who learned the usual way. Sixty patients needing a lumbar puncture took part. The simulator uses haptic feedback to mimic the …

This study aims to establish normal values for a breathing test called the interrupter technique in healthy adults. The test requires very little cooperation from the patient, making it ideal for people who have difficulty performing standard lung function tests. Researchers meas…

This study looked at sleep problems in 37 adults with non-small cell lung cancer. Researchers used questionnaires to measure sleep quality and plan a simple guide for doctors to diagnose and treat these issues. The goal is to help patients sleep better and improve their quality o…

This study looked at 30 adults having major spine surgery to see how a lung-opening technique (alveolar recruitment maneuver) affects breathing and blood flow when done in the usual face-down position versus lying on the back. The goal is to learn which position is safer and help…

This study looked at B cells (a type of immune cell) from 30 people with non-active lupus and compared them to B cells from healthy volunteers. The goal was to find genetic differences that might explain lupus even when symptoms are quiet. No treatment was given—only blood sample…

This study aims to create a reference set of normal nerve fiber density values in the skin of healthy adults. By measuring these fibers in 300 people without pain or nerve problems, researchers hope to improve the accuracy of diagnosing small fiber neuropathy. The results will he…

This study looked at how moderate exercise changes the way the body processes different types of dietary fat in men with obesity. Twelve men aged 18 to 55 with a BMI over 25 and a sedentary lifestyle participated. Researchers used stable isotopes and tissue samples to measure fat…

This study looked at whether carefully selecting patients can improve healing of knee infections after a one-step knee replacement. Researchers reviewed 60 patients who had this surgery between 2000 and 2010. The goal was to see if using specific patient criteria leads to better …

This study looked at a newer way to take prostate tissue samples using MRI guidance through the perineum (the area between the scrotum and anus) instead of the standard method through the rectum. The goal was to see if this approach causes fewer complications and hospital readmis…

This study tested how accurately an ultrasound fusion system can guide a needle into a tissue lesion. Researchers compared the planned needle path shown by the system to the actual path seen on a CT scan. The goal was to see if this method is more precise than using ultrasound or…

This study tested a smartphone app designed to help patients decide when to take certain medications after surgery. 37 adults who had surgery at a French hospital used the app, and researchers checked if the app's suggestions matched those of a healthcare professional. The goal w…

This study looked at 88 people aged 11 or older who finished braces and got a permanent wire glued behind their lower front teeth to keep them straight. Researchers compared two ways of preparing the teeth before gluing: sandblasting the enamel versus cleaning with pumice. The go…

This study looked at 27 adults with a severe immune system problem called Common Variable Immune Deficiency (CVID), who also had low white blood cells (neutropenia) and swollen lymph nodes (lymphoproliferation). The goal was to find gene changes that might cause these severe symp…

This study looked at how the heart and lungs of 10 people with moderate COPD respond during a 30-minute exercise test with short bursts of high-intensity work. Researchers measured blood pressure in the lungs and overall heart function. They found that lung blood pressure dropped…

This study looked at how light affects alertness and thinking in healthy adults after staying awake all night. 18 volunteers aged 18-40 were tested on fatigue, hormone levels, and mental performance. The goal is to find ways to help people with sleep problems stay sharp.

This study looked at 10 people with liver cancer (HCC) who were getting a standard treatment called chemoembolization (c-TACE). The goal was to see if mixing the chemotherapy drug doxorubicin with salt water or a contrast dye changes how the drug spreads inside the tumor. Researc…

This study looked at 80 people who had hip or knee replacement infections and needed another surgery. Doctors wanted to see if giving antibiotics before the operation (instead of after taking samples) changes the results of infection tests. The goal was to find out if this new ap…

This study looked at how the body naturally calms down allergic inflammation after exposure to grass pollen. Researchers measured special fats (lipid mediators) in 20 people with hay fever to see how these substances change over time. The goal was to understand the body's own pro…

This study looked at how deaf people who were born deaf process reading in their brains. Researchers used brain scans to compare deaf and hearing readers. The goal was to understand how the brain adapts to reading without ever hearing speech sounds. 60 adults who are deaf and hav…

This study followed 300 people who had a blood clot in their leg or lung (venous thromboembolism). The goal was to track how many had another clot or bleeding problems over time, and to find out why some clots happen without a known cause. Researchers collected information to bet…

This study looked at how two anxiety medications, lorazepam and diazepam, affect memory and brain activity in 22 healthy young adults. Participants took a single dose of one of the drugs and then performed memory tasks while their brains were scanned with fMRI. The goal was to un…

This study looked at 300 adults having outpatient surgery to see how often a condition called akathisia (a feeling of severe restlessness) occurs with two different anti-nausea drugs: Droperidol and Ondansetron. The goal was to find out if Droperidol causes more akathisia than On…

This study looked at how different types of light influence sleep, brain waves, and mental performance in healthy adults aged 18 to 40. Researchers measured sleep quality, attention, and memory using various tests. The goal was to better understand light's effects on the body and…

This study looked at whether a family of proteins called GPCRs, found on the surface of cells, can be used as biomarkers to diagnose or track chronic lung diseases like asthma and COPD. Researchers analyzed blood samples from 205 people (healthy volunteers and patients) to see if…

This study looked at 77 younger patients (60 or under) who had a mechanical aortic valve replacement. Researchers wanted to see if a mismatch between the valve size and the patient's body affects heart recovery and exercise ability over the long term. Participants underwent stres…

This study looked at how moving the head forward or backward changes pressure under the feet while standing still. 87 healthy adults aged 18 to 30 stood on a pressure-measuring platform. The goal was to understand the link between head alignment and foot pressure distribution.

This study looked at how many hospital workers in Strasbourg, France, had antibodies against the virus that causes COVID-19. About 1,466 staff members were tested to see if they had been infected, especially after a large outbreak linked to a religious event. The goal was to unde…

This study looked at 500 adults who had hernia repair surgery with a mesh implant and later developed an infection. Researchers aimed to find out what germs cause these infections, when they happen, and what factors help people recover. The goal is to improve how doctors manage t…