University Hospital, Strasbourg, France

This study tests whether dapagliflozin, a drug used for diabetes, can help people with septic shock—a severe infection that causes organ failure. The drug aims to protect blood vessels and reduce inflammation. About 568 ICU patients will receive either dapagliflozin or a placebo,…

This study tests whether stable schizophrenia patients can safely reduce their antipsychotic medication without losing function. 288 adults aged 18-60 will be grouped by their specific psychosis type and randomly assigned to either dose reduction or standard maintenance. The goal…

This study compares two surgical approaches for women with early-stage, high-risk endometrial cancer that has a p53 gene mutation. One group will receive the standard surgery that removes many lymph nodes, while the other group will have a less invasive sentinel lymph node biopsy…

This study tests a drug called sivelestat in 120 adults with septic shock and blood clotting problems. The drug aims to restore the body's ability to break down small clots, which may improve survival. Participants will receive either the drug or a placebo for 24 hours, and docto…

This study aims to validate a new blood test that uses artificial intelligence to quickly diagnose a severe clotting disorder (DIC) in patients with septic shock. DIC is a life-threatening complication that is hard to detect early with current methods. Researchers will test the n…

This study tests whether breath samples collected in special bags remain accurate for diagnosing halitosis (bad breath) after 7 days. About 100 adults with gum disease will provide breath samples, which are analyzed immediately and again a week later. If the gas levels stay stabl…

This study aims to see if measuring a specific form of the protein alpha-synuclein in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. About 286 adults aged 50 and older with signs of either condition will have a lumbar puncture to c…

This study compares a standard mental training program (Metacognitive Training) with a personalized version for 51 adults with schizophrenia spectrum disorder. The personalized program uses machine learning to target each person's specific thinking patterns. The goal is to see wh…

This study tests a new, non-invasive light therapy (photobiomodulation) for people with Lewy body disease, a common type of dementia. The treatment uses red and infrared light to stimulate brain cells, aiming to improve thinking, movement, and quality of life. Forty adults aged 5…

This study explores whether using interactive virtual reality (VR) can help reduce pain, anxiety, and fatigue in people receiving palliative care. Twenty hospitalized adults with a life expectancy of at least one month will try daily VR sessions where they can interact with a cal…

This study tests a special type of melatonin (a natural sleep hormone) in children and teens aged 2 to 17 with PTSD who have serious sleep problems like trouble falling asleep, waking up often, or nightmares. The goal is to see if it helps them sleep longer and better, and if tha…

This study tests whether using a virtual reality (VR) headset for 10 minutes a day can help reduce pain, anxiety, and fatigue in people receiving palliative care. About 40 adults with complex needs will be randomly assigned to either a fully immersive VR experience or a less imme…

This study compares a new under-the-tongue painkiller (sublingual sufentanil) to standard oral morphine for managing pain after surgery. Researchers want to see if the new drug helps patients recover their health faster and better. About 1,150 adults having surgery will take part…

This study tests whether a personalized follow-up program, based on patients' own reports of how they feel, can improve recovery after complex surgery. About 276 adults with complex care needs will be randomly assigned to either receive this extra support or standard care. The go…

This study tests a new way to help people going through alcohol withdrawal feel less anxious. It combines hypnosis with aromatherapy, using a calming scent to trigger the relaxation learned during hypnosis. About 80 adults in a hospital addiction unit will either get this combine…

This study compares dialectical behavior therapy (DBT) — given either in-person or online via videos — to usual treatment for adults with addiction and emotional regulation difficulties. The goal is to see if DBT improves emotional control and reduces impulsive behavior. About 12…

This study looks at whether treating a first-time collapsed lung (pneumothorax) at home, instead of in the hospital, can improve quality of life. About 386 adults aged 18 to 50 will be randomly assigned to either outpatient care or standard inpatient care. The main goal is to see…

This study tests whether using virtual reality (VR) with calming scripts can lower anxiety and pain during wisdom tooth extraction. Sixty adults aged 18 to 65 who need at least two lower wisdom teeth removed will either get standard care or VR distraction. The goal is to see if V…

This study looks at 200 people who have internuclear ophthalmoplegia, an eye movement problem often linked to multiple sclerosis (MS). Researchers want to see how many of these people later develop MS and find clues that might help doctors diagnose MS sooner. By reviewing past me…

This study tests a new DNA technology called long-read genome sequencing in 20 children with severe epilepsy whose standard genetic tests came back normal. The goal is to find hidden genetic causes that standard tests miss, which could lead to better treatments and genetic counse…

This observational study will examine whether a protein called the GLP-1 receptor, found on certain blood cells, is linked to the severity of peripheral artery disease (PAD). Researchers will compare 50 adults with mild versus severe PAD by analyzing a single extra blood sample t…

This study looks at how parents react emotionally and psychologically when their newborn tests positive for spinal muscular atrophy (SMA) through routine screening. Researchers will interview about 36 parents in two French regions and ask them to complete questionnaires about anx…

This study looks at how emotions change throughout the menstrual cycle in autistic women. Researchers will compare them to women with borderline personality disorder, premenstrual dysphoric disorder, and women without any diagnosed condition. The goal is to better understand emot…

This study looks at whether measuring the fluorescence of certain white blood cells (neutrophils) can help doctors quickly identify sepsis patients at risk of severe complications like organ failure or septic shock. Researchers will analyze blood samples from 492 adults in the em…

This study looks at how blood clots break down in cancer patients who also have bleeding disorders. Researchers will measure a protein called plasminogen in 150 adults with blood cancers, solid tumors, or septic shock. The goal is to gather data for a larger study that could help…

This study aims to better understand why some people's immune cells attack their own body, causing autoimmune diseases like lupus and scleroderma. Researchers will analyze blood samples from 200 adults with these conditions to identify and measure specific harmful immune cells. T…

This study will check if 3D models made from CT scans without contrast dye are as accurate as regular 2D CT scans with dye for planning minimally invasive lung cancer surgery. About 50 adults with early-stage lung cancer will take part. The goal is to see if the 3D method can rel…

This study looks at how a non-invasive brain stimulation technique called rTMS affects two different areas of the cerebellum—one tied to movement and one tied to thinking. Forty healthy adults will receive either stimulating, inhibiting, or fake stimulation, and researchers will …

This study tests whether using less contrast dye during brain scans for unruptured aneurysms can still produce clear images. About 244 adults will be randomly assigned to receive either the standard dye amount or a reduced amount. The goal is to find a safer, more comfortable way…

This study will follow 100 intensive care patients on ECMO (a heart-lung machine) to see if changes in a blood marker called D-dimer can predict serious bleeding within 24 hours. Bleeding is a major risk for these patients, and finding a way to forecast it could help doctors act …

This study looks at how fatigue affects walking and balance in people with Charcot-Marie-Tooth type 1A (CMT1A), a common inherited nerve disorder. Researchers will compare 44 participants (22 with CMT1A and 22 healthy volunteers) using muscle tests, brain stimulation, and movemen…

This study looks at whether people with relapsing-remitting multiple sclerosis (RRMS) can have a relapse—new or worsening symptoms—without any visible inflammation on an MRI scan. Researchers will follow 136 adults who are having a suspected relapse, performing early brain and sp…