Stanford University

This trial tests whether an AI chatbot called MICA, combined with weekly text reminders, can help emergency department patients reduce risky alcohol use. About 750 adults who report heavy drinking will be randomly assigned to use MICA or receive usual care. The study tracks how m…

This early-phase study tests whether the drug sarilumab can safely help adults with chronic graft-versus-host disease (cGVHD) that did not improve with the standard drug belumosudil. Ten participants will receive sarilumab alone, and researchers will monitor side effects and drug…

This trial tests a new automated radiation method that precisely targets bone marrow and lymph nodes before a stem cell transplant. The goal is to kill cancer cells while reducing damage to healthy tissues. Participants have high-risk myeloid cancers like acute myeloid leukemia o…

This early-phase trial tests whether a combination of total lymphoid irradiation (a type of radiation) and anti-thymocyte globulin (an antibody drug) can help liver transplant recipients safely stop taking immunosuppressive drugs. The study will enroll 12 adults receiving a liver…

This early-phase trial tests a personalized cell therapy (rapcabtagene autoleucel) in 20 adults with large B-cell lymphoma who still have traces of cancer after initial treatment. The goal is to see if the therapy can make those traces disappear, potentially lowering the risk of …

This study tests whether insulin eye drops can protect the optic nerve in people with open-angle glaucoma. Researchers will give 90 participants either insulin drops or placebo daily for up to 12 months. The main goal is to check safety, but they will also measure vision changes …

This early study tests whether the drug CAEL-101/anselamimab can bind to and shrink abnormal protein deposits (amyloid) in people with AL amyloidoma. Five adults with measurable amyloid deposits will receive the drug and be monitored for up to 72 weeks. The goal is to see if the …

This first-in-human trial tests a genetic drug called TS1-ASO in 5 children with Timothy Syndrome, a rare condition causing severe heart and brain problems. The drug is injected into the spine to target the genetic root of the disease. The main goal is to check safety and how the…

This study tests whether a remote dietary program can help people with early to intermediate age-related macular degeneration (AMD) lower their blood sugar and increase protective nutrients called carotenoids. About 32 participants will receive coaching to improve their eating ha…

This phase 2 trial tests whether adding tiprelestat (elafin) to standard care improves blood flow in the lungs for people with pulmonary arterial hypertension (PAH). About 90 adults with moderate to severe PAH will receive either a daily injection of tiprelestat or a placebo for …

This phase 2 trial compares a new type of radiation called LATTICE radiotherapy with standard palliative radiation for people who have large metastatic tumors (over 2.5 cm). The LATTICE method delivers a very high dose to the center of the tumor while keeping lower doses to the s…

This pilot study tests whether a noninvasive ultrasound device can safely help clear waste from the brain in people at risk for Alzheimer's. Fifteen adults with signs of amyloid buildup will receive either real or sham ultrasound sessions over four weeks. The main goal is to chec…

This study tests whether placing a special amnion membrane graft under the nipple during mastectomy can prevent nipple death. The trial includes 30 people having either gender-affirming or preventive mastectomy. Half get the graft, half get standard care, and neither they nor the…

This study will test if using artificial intelligence to find calcium buildup in heart arteries from chest CT scans people already had can improve cholesterol treatment. Researchers will notify patients and their doctors about the finding, aiming to start or strengthen cholestero…

This study tests whether patients can safely stop the drug tacrolimus earlier than usual after a stem cell transplant. Tacrolimus is given to prevent graft-versus-host disease (GVHD), but newer methods have lowered GVHD risk. The trial will enroll 50 people with blood cancers and…

This study looks at whether starting an automated insulin delivery (AID) system within two weeks of a type 1 diabetes diagnosis helps young patients manage their blood sugar more easily. Sixteen youth newly diagnosed with type 1 diabetes will be offered the system and followed fo…

The Reset trial, led by Stanford University, aims to find the best combination of four dietary strategies for weight loss in a fully digital program. 208 adults with overweight or obesity will receive a 12-week remote intervention that includes daily self-weighing, weekly lessons…

This early trial tests whether baricitinib, an immune-calming drug already used for arthritis, can reduce heart inflammation in people with cardiac sarcoidosis. Ten adults will take the drug for 16 weeks alongside their usual steroid-sparing medication. Researchers will use PET s…

This study looks at whether a noninvasive finger monitor can predict how pregnant women, including those with severe preeclampsia, respond to fluids. Researchers will compare the finger device to standard heart ultrasound in 88 women. The goal is to find a simpler way to guide fl…

This study compares two behavioral programs for young women aged 14-22: a new one called Priorities, which helps build self-worth beyond weight and shape, and The Body Project, an established eating disorder prevention program. Researchers want to see which is more effective at r…

This study tests whether replacing soil floors with concrete floors in rural Bangladeshi homes can reduce stillbirths and deaths in the first month of life. Researchers will compare 196 households that received concrete floors to those that kept soil floors, tracking pregnancies …

Stanford University is testing a free online toolkit called Smart Talk to see if it can prevent cannabis use among middle and high school students. The study will enroll 10,800 students across participating schools. The curriculum includes lessons, quizzes, and activities to chan…

This clinical trial tests whether taking daily low-dose aspirin and lansoprazole can prevent preterm birth in pregnant women at high risk. The study uses a special screening method to identify those most likely to benefit. About 670 women will be enrolled, taking the medication f…

This study in Uganda will test whether giving children both the R21 malaria vaccine and two different malaria prevention medicines works better than the vaccine alone. About 1,290 children will take part. The goal is to see if the combination can reduce malaria cases more effecti…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard aspirin or clopidogrel therapy can prevent another stroke or heart attack in people who have recently had a stroke or mini-stroke. About 2,000 participants will take either cilostazol or a pl…

This pilot study compares recorded gut-directed hypnosis to an educational recording for hospitalized patients with chronic gut problems, such as irritable bowel syndrome or inflammatory bowel disease. Participants listen to the recordings over the phone while in the hospital for…

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This Stanford study tests whether a personalized audiobook, created by a large language model and delivered through virtual reality, can help children feel less anxious during hospital stays and needle procedures. The study will enroll 20 English-speaking children admitted for at…

This study tests whether ganaxolone, a drug already approved for certain seizures, can reduce irritability in autistic children aged 5 to 17. About 66 participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if it improves emotional regulation …

This study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …

This study tests a group-based program called the Thinking Healthy Extended Program (THEP) for new mothers with mild to moderate depression. The program is delivered at community health centers in China and aims to improve maternal mental health and child development. Researchers…

This pilot study tests whether a community health worker (promotora) can help Latinx patients recently diagnosed with colorectal cancer. Sixty participants will either get a navigator for up to 6 months or just a list of social services. The goal is to see if this support improve…

Stanford University is testing a music-based intervention called STAMM-S for people aged 14-35 with suicidal thoughts. Participants listen to machine-learning-generated music for 20 minutes daily over 25 days and receive education on using music to improve mood. The study aims to…

This study tests whether tracking only high-calorie, low-nutrition foods (Red Zone Foods) works as well as tracking all foods and calories for weight loss. About 328 adults with overweight or obesity will use a digital program for 12 months. The goal is to see if a simpler approa…

This study tests a new program that helps young Hispanic/Latino adults who survived childhood cancer communicate better with their families and doctors. The program uses a community health worker to guide conversations before and after a clinic visit. The study will enroll 18 sur…

This study tests whether a specially designed, better-tasting liquid diet can be used for two weeks by adults with chronic pancreatitis who have bothersome stomach symptoms. The diet is an easy-to-absorb formula that replaces all food for 14 days. Researchers want to see if peopl…

This pilot study tests a software tool called NEXT that gives personalized advice on insulin and carbohydrate adjustments before and after exercise for adults with type 1 diabetes. Twenty participants will try three different approaches to managing their blood sugar around exerci…

This early-stage study will give 20 bladder cancer patients cannabigerol (CBG) gummies before and after surgery to see if they are safe and tolerable. The goal is to improve quality of life and reduce symptoms during recovery. Researchers will monitor side effects and how well pa…

This pilot study tests whether a special shoe that vibrates can safely help people with Parkinson's disease who experience freezing of gait — a sudden inability to move their feet while walking. Twenty participants will wear the smartshoes and researchers will measure how well th…

This study tests whether augmented reality (AR) and virtual reality (VR) can help teenagers aged 11 to 17 overcome their fear of needles and blood. Participants will use a special headset to gradually face their fears in a safe, computer-generated environment. The goal is to redu…

Stanford University is testing a wearable ultrasound device that targets peripheral nerves to reduce chronic pain. The device is placed on the skin over the painful area and delivers focused ultrasound waves. In this early study, 90 adults with nerve-related pain will attend a si…

This study tests whether giving psilocybin—a psychedelic drug being studied for depression—under general anesthesia can hide its mind-altering effects. That would allow researchers to run a truly blinded trial where neither patients nor doctors know who got the real drug. Ten adu…

This study tests whether using brain wave (EEG) monitoring to guide anesthesia during surgery can reduce postoperative delirium—a common side effect in older adults that can lead to lasting memory problems. Researchers will train anesthesia providers to interpret EEG data and adj…

This study tests a single 90-minute therapy session for teens aged 13-18 who have experienced trauma and are waiting for longer treatment. The session teaches coping skills and understanding of trauma cues. About 40 teens in New Zealand will take part to see if this approach is p…

This study tests a new device called the Origin Intubation System to help doctors place breathing tubes more easily on the first try. About 15 adults having planned surgery with general anesthesia will take part. The goal is to see if the device reduces time and improves success …

This study tests an automated programming method for deep brain stimulation (DBS) in people with Parkinson's disease. Fifteen participants who recently had DBS surgery will try the new algorithm and perform motor tasks like walking and finger tapping. The goal is to see if the au…

This study looks at whether the type of education patients receive about a single propofol sedation session can change how well it works for depression. Twenty adults with moderate to severe major depressive disorder will get one propofol infusion and be randomly assigned to eith…

This study will follow 100 people with keratoconus or corneal ectasia who undergo CTAK surgery. Researchers will use a questionnaire before and after surgery to measure changes in vision quality and overall quality of life. The goal is to see if this surgical approach helps patie…

This Stanford study tests whether a short virtual reality mindfulness session can improve mental well-being and reduce anxiety in hospitalized adults. 42 participants will try the VR app and also receive standard care, acting as their own comparison. The goal is to see if immersi…

This study will test a device called Accuro 3S that uses real-time ultrasound to help doctors place epidural needles more accurately. Researchers hope it will reduce the number of failed blocks and needle sticks in women receiving labor epidurals or spinal anesthesia for cesarean…

Stanford University is testing a digital app called Postpartum Companion to help mothers recover after childbirth. The app provides videos and articles on physical, emotional, and social wellbeing. Sixty new mothers will use the app for 12 weeks, and researchers will measure how …

This study compares two well-known early autism interventions, ESDM and PRT, to see which one helps young children with autism improve their communication skills more. Researchers will enroll 140 children aged 2 to 5 and randomly assign them to one of the two therapies for 24 wee…

This study tests whether giving a medicine called dexmedetomidine during a second-trimester dilation and evacuation (D&E) can lower the chances of severe grief and post-traumatic stress after the procedure. About 100 people having a D&E in the operating room will be randomly assi…

This study looks at whether surgically repairing a nail bed injury leads to better nail appearance and less pain compared to just cleaning and bandaging the injury. About 100 people with nail injuries will be randomly assigned to one of the two treatments. The goal is to find out…

This study will test whether using technology like virtual reality headsets, tablets with games, or other gadgets can help reduce anxiety and pain in children aged 4 to 17 during minor procedures such as lumbar punctures or heart catheterizations. About 200 kids will be randomly …

This study is testing a new audio-based game called Mystic Pets to see if it can help distract children aged 4-17 from emotional distress while they are in the hospital. About 20 children at Lucile Packard Children's Hospital will try the game and give feedback on how easy and en…

This study compares two different epidural pain relief methods during labor to see which one mothers prefer. About 150 women planning a vaginal delivery will receive standard epidural care and answer short surveys about their pain and satisfaction. The goal is to find out which a…

This pilot study tests whether personalized text messages created by a large language model (AI) can encourage people to be more physically active. Fifty adults will receive daily prompts on their iPhones and Apple Watches for 14 days, comparing personalized messages to generic o…

This study tests whether a lower dose of cabergoline can safely prevent lactation and breast discomfort after second-trimester abortion or pregnancy loss. The standard dose works but can be costly and cause side effects. Researchers will enroll 36 people to compare the reduced do…

This early-phase study tests whether a mixture of 157 live bacteria from healthy stool, called MITI 001, is safe for people with diarrhea-predominant irritable bowel syndrome (IBS-D). The goal is to restore healthy gut function and ease symptoms. Only 13 adults with specific sign…

This pilot study from Stanford tests whether a stellate ganglion block (a nerve block in the neck) can reduce symptoms of Postural Tachycardia Syndrome (POTS). Twenty adults with POTS will receive either the nerve block or a sham injection. Researchers will track changes in auton…

This study tests if Acoustic Resonance Therapy (ART) can relieve symptoms of Empty Nose Syndrome (ENS), a condition where past nose surgery leaves patients feeling blocked despite open airways. ART uses sound vibrations to clear mucus and reduce inflammation. About 40 adults with…

This study will test whether taking acetaminophen (Tylenol) by mouth works as well as getting it through an IV for pain after lumbar spine fusion surgery. About 180 adults will be randomly assigned to receive either oral or IV acetaminophen for 48 hours after their operation. The…

This study tests whether automated text message reminders can encourage people with hearing loss to get hearing aids. Researchers will enroll 190 adults who have been recommended for hearing aids but do not yet use them. Participants will receive texts with basic information abou…

The EMBRACE study aims to see if giving low-income and minority patients extra support from a research assistant helps them feel more in control of their healthcare and make better decisions with their doctors. About 138 adults in the Monterey area who get care from a primary car…

This study from Stanford University will look at how people react when they learn their Lewy Body Disease biomarker test results. Researchers will interview and survey 40 participants, both with and without symptoms, to measure distress and other responses over time. The goal is …

This study follows 800 people who are already scheduled to receive ketamine infusions for chronic pain as part of their regular care. Researchers will use surveys to track pain levels, opioid use, and overall well-being for up to 16 weeks. A comparison group includes patients who…

This study tests a tablet game called Mystic Wizard, designed to help children aged 7-14 who have received a solid organ transplant learn about their daily medications. In the game, players act as a young wizard who must give 'potions' to keep a magical flame (representing their …

This study will look at 200 children having both an endoscopy and colonoscopy. Researchers want to find out if stopping Miralax (a bowel prep laxative) 1, 2, 3, or 4 hours before anesthesia affects how much liquid stays in the stomach or how clean the colon is. The goal is to imp…

This Stanford study has two goals: find blood markers that show when the body is stressed by heat, and test two simple cooling tools—a hand-cooling table and a cold bandana. Thirty healthy adults will exercise in a hot lab setting to mimic real-world conditions. The results could…

This study compares two common methods of repairing the uterus during a C-section: lifting the uterus out of the abdomen to stitch it, or leaving it inside. Researchers want to see which method causes less bleeding, less nausea, and a better experience for the mother. About 60 wo…

This study tests different strategies to get family members more involved when a loved one starts treatment for substance use disorder. Researchers will ask 100 family members to try and rank various engagement methods online. The goal is to find which approaches work best to hel…

This study tests whether a new online program can help families understand their inherited cancer risk and encourage relatives to get low-cost genetic testing. Researchers will enroll 400 adults who carry a cancer-related gene change and their family members. The goal is to see i…

This study tests a digital app called WONE to see if it can help Stanford-affiliated people (ages 18-65) build resilience and manage stress. About 260 participants will use the app, which offers personalized tips and optional wearable data feedback. The goal is to measure how wel…

Stanford University is enrolling 50 adults aged 18–64 to collect vital signs using a blood pressure cuff, EKG, and PPG. The goal is to use this data to develop a noninvasive, continuous blood pressure monitoring device that could replace traditional cuffs. This is an observationa…

This study tests whether a brain stimulation treatment for depression called iTBS can be improved by customizing it to each person's brain signals. Researchers will use EEG to measure brain responses and find the best stimulation settings for 80 adults with treatment-resistant de…

This online study tests whether a short animated storytelling video can increase people's intention to get screened for colorectal cancer. Researchers will recruit 3,000 U.S. adults who have not yet been screened and randomly show them either the animated video or a plain text de…

This study at Stanford University will test how the brain responds when visual information is turned into patterns of sound or touch. Two hundred blind and sighted participants will use special devices (BrainPort and AI Sight) for 5 weeks. Researchers will use brain scans and per…

This study looks at whether a health tracking platform can improve the health of elderly people who are frail. Over 1,000 seniors will use the platform for a year, and researchers will also figure out which health surveys best predict frailty. The goal is to find better ways to p…

This study uses smartphone sensors and health questionnaires to measure physical activity and heart health in 15,000 US adults aged 18 and older. Participants will use an app on their iOS or Android phone to track steps, heart rate, and answer health questions. The study also tes…

This study aims to understand how medications used during medical procedures affect patients' feelings of liking or disliking the drug. About 100 adults scheduled for surgery will rate their drug liking and have their brain activity measured. The results will help doctors better …

This study tests a new curriculum that teaches high school students in construction career programs how building design can impact community health and environmental justice. Forty students aged 14-18 will be randomly assigned to either the new curriculum or the standard one. Ove…

This Stanford study will look at how an implanted vagus nerve stimulation device changes brain activity in 12 adults with treatment-resistant depression. Researchers will measure brain waves and heart signals to understand the device's effects. It is an early, exploratory study f…

This Stanford study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve memory formation in healthy older adults (ages 65-80) compared to younger adults (ages 18-30). The stimulation is given during learning tasks, and researchers will also l…