Chinese University Of Hong Kong

This study tests a new procedure called duodenal recellularization therapy for people recently diagnosed with type 2 diabetes. The goal is to see if it can help control blood sugar without needing diabetes medications. The study will include 40 participants and follow them for 24…

This study tests whether adding a very low dose (4 mg) of the steroid prednisolone to standard rheumatoid arthritis (RA) medications helps control disease better than standard care alone. About 112 adults newly diagnosed with active RA will take either prednisolone or a placebo f…

This study compares two surgical methods for treating a sudden, life-threatening tear in the main artery (acute type A aortic dissection). About 150 adults will be randomly assigned to receive either a standard partial repair (hemiarch) or a more extensive repair with a frozen st…

This study tests whether a chatbot that gives personalized advice can help men who have sex with men in Hong Kong reduce chemsex (using drugs before or during sex) and related HIV risks. About 100 men will be split into two groups: one gets weekly videos on chemsex harm reduction…

This study tests a procedure called ReCET that uses mild electrical pulses to treat the lining of the small intestine. It aims to improve blood sugar control and reduce fat in the liver for people with type 2 diabetes and fatty liver disease who haven't had success with standard …

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase the chance of pregnancy. About 288 women with infertility will be randomly assigned to receive either standard IUI or IUI with PRP…

This study looks at whether semaglutide, a drug used for diabetes, can slow down artery hardening in people with psoriatic arthritis who do not have diabetes. Psoriatic arthritis raises the risk of heart problems, and this drug may help by reducing inflammation and improving meta…

This pilot study will test a new synbiotic formula (SGR11) in 50 adults with mild-to-moderate ulcerative colitis, a type of inflammatory bowel disease. Participants will take the supplement daily for 8 weeks and complete symptom questionnaires, stool tests, and blood tests to see…

This study will follow 100 adults with von Hippel-Lindau (VHL) disease who choose to take belzutifan. Researchers will track how well the drug shrinks tumors, its side effects, and its impact on quality of life and healthcare costs. The goal is to understand the drug's real-world…

This study tests whether giving laxatives before inserting a dialysis catheter can prevent blockages. About 398 adults with kidney failure needing peritoneal dialysis will take part. Half will get laxatives before surgery, half will not. The goal is to see if this simple step red…

This study tests whether a respiratory syncytial virus (RSV) vaccine can reduce moderate-to-severe COPD flare-ups in people who have frequent attacks. Researchers will enroll 320 COPD patients who have had at least two flare-ups in the past year despite using standard inhalers. H…

This study tests a 6-week program designed for people with high blood pressure who have low health literacy. Participants attend three in-person and three phone sessions to learn how to manage their condition. The goal is to see if this approach helps lower blood pressure and imp…

This study tests a 3-month coaching program for people with coronary heart disease to help them reduce sitting time and increase physical activity. Participants will attend face-to-face and phone sessions focused on changing daily habits. The goal is to see if this approach impro…

This study tests a temporary pacing technique to slow the heart rate in people with atrial fibrillation (a common heart rhythm problem) whose hearts beat too fast and who cannot take standard medications. The approach uses gentle electrical pulses to calm the heart's electrical s…

This study tests whether a modified Chinese herbal formula (Qing-Zao-Jiu-Fei decoction) can help people with pneumoconiosis, a chronic lung disease caused by inhaling dust. Eighty adults will receive either the herbal granules or a placebo for 16 weeks. Researchers will measure c…

This study tests whether adding fludrocortisone to the usual steroid treatment (hydrocortisone) can help control septic shock better. It is a small pilot trial with 32 critically ill adults in the ICU. The main goal is to see if a larger, more definitive study is possible, not ye…

This study aims to see if a new liquid biopsy test, which measures TB DNA in fluid from around the lungs, can accurately diagnose tuberculous pleuritis (TB of the lining around the lungs). Current tests often miss the infection or require an invasive needle biopsy. The new test m…

This study looks at whether adding a special PET scan (18F-PSMA) to standard MRI can better find aggressive prostate cancers in men whose MRI results are unclear. About 250 men with suspicious but not definitive MRI findings will be randomly assigned to get either MRI-guided biop…

This study tests a new blood test that looks for TB DNA in the blood as a way to diagnose lung tuberculosis without needing a bronchoscopy (a scope inserted into the lungs). The test will be compared to the standard bronchoscopy method in 600 adults who cannot produce sputum or h…

This study tests a smartphone app called GoodShleep+ that gives personalized, in-the-moment tips to help people with sleep or circadian problems. About 80 adults in Hong Kong will either use the app for 8 weeks or continue their usual care. The goal is to see if the app improves …

This study tests whether myofunctional therapy—special exercises for the tongue, face, and breathing muscles—can help children aged 6 to 12 with obstructive sleep apnea. About 174 children will be split into two groups: one gets the therapy plus standard care, the other gets stan…

This study tests whether a nostalgia-based group program can reduce loneliness in older adults living in the community. About 294 people aged 60 and over who feel lonely will take part. They will join sessions that use memories and shared experiences to improve social connections…

This study tests a new, non-invasive brain stimulation technique called so-tDCS in 80 older adults (60-85 years) who have memory concerns and poor sleep. Participants will receive either real or sham stimulation for 4 weeks. Researchers will measure changes in memory, sleep quali…

This study tests whether fezolinetant can reduce hot flashes in men receiving hormone therapy (ADT) for prostate cancer. About 54 men will be randomly assigned to receive the drug or a placebo. The main goal is to see if the drug lowers the severity and frequency of hot flashes, …

This study explores whether a special blood product called pure platelet-rich plasma (P-PRP) can improve sperm movement when mixed with semen in a lab. Researchers will first standardize how to make P-PRP, then test it on sperm samples from 248 volunteers. The goal is to see if P…

This study tests a smartphone app called GoodShleep that gives personalized, in-the-moment tips to help people with sleep and circadian problems. About 77 adults in Hong Kong will wear a sleep tracker and answer quick surveys to see if tailored suggestions work better than generi…

This study will test a new robotic surgical system designed to be more affordable than current options. The goal is to see if it can perform colorectal surgery safely and effectively, with fewer complications and less pain. The study will involve 12 adults with colorectal tumors …

This study looks at whether a 6-week mindfulness program can help hotel employees feel less stressed, happier, and more effective at work. About 60 hotel staff in Hong Kong will take part. Researchers will measure changes in stress, anxiety, and job satisfaction using surveys and…

This study tests whether taking two natural supplements—butyrate and taurine—can prevent chronic pain after heart surgery. About 216 adults having open-heart surgery will take the supplements or a placebo daily for three months. The goal is to see if this simple approach reduces …

This study aims to see if following a culturally-adapted Mediterranean diet can help reduce symptoms of depression in adults in Hong Kong. Researchers will enroll 90 participants with moderate depression and a low-quality diet to test the diet's effects. They will also explore wh…

This study aims to see which treatment for early-stage lung cancer—surgery or a less invasive ablation—best preserves lung function over time. Researchers will use machine learning to combine 3D CT scans and breathing tests to predict outcomes for each patient. About 192 adults w…

This study creates a long-term registry for people with Achilles tendon problems (like tears or chronic pain) and healthy adults. Researchers will track 200 participants over up to five years using physical tests, ultrasounds, and questionnaires to see which treatments work best …

This study aims to find out how often RSV (a respiratory virus) causes illness in adults in Hong Kong. Researchers will collect samples from 10,000 adults with cold-like symptoms to measure infection rates and severe cases. The goal is to provide data that could guide future vacc…

This pilot study will test if a thin, flexible camera inserted into the urinary tract under local anesthesia can safely and effectively monitor for cancer recurrence in people who have had kidney-sparing surgery for upper tract urothelial carcinoma. Ten adults who meet the criter…

This early study tests a new robotic system designed to help doctors remove early-stage rectal tumors through a scope, avoiding the need for surgical cuts. Ten adults with non-cancerous or early cancerous growths in the rectum will take part. The main goals are to see if the robo…

This study uses machine learning to predict how well people recover after anterior cruciate ligament (ACL) reconstruction surgery. Researchers will measure muscle strength and size, along with other factors, to identify patients who may not respond well to standard rehabilitation…

This study looks at 150 adults hospitalized for a COPD flare-up to find hidden heart and kidney problems. Researchers will screen patients and track their health over time to understand risks for future flare-ups and hospital readmissions. The goal is to improve care by combining…

This study follows 160 adults in Hong Kong to see if their daily rest-activity patterns can predict who develops major depressive disorder. Researchers will track sleep, activity, and mood over time to find distinctive rhythm profiles linked to depression. No treatment is given; …

This study will test a new single-port surgical robot called SHURUI for chest surgeries like lung removal and tumor resection. The goal is to see if it is safe and effective, with the potential for less pain and quicker recovery. About 40 adults aged 18-75 who need chest surgery …

This online study with 2,800 Hong Kong adults tests whether front-of-package warning labels about added sugar reduce people's intention to buy sugary drinks. Participants will choose beverages in a simulated shopping task. The goal is to see if simple labels can nudge consumers t…

This study looks at how well ovarian tissue freezing works for young cancer patients (ages 0-18) who may lose fertility due to cancer treatment. Researchers will track 100 participants from Hong Kong Children's Hospital to see pregnancy rates and surgical complications after tran…

This study aims to see if the amount of progesterone in the blood on the day of embryo transfer is linked to pregnancy rates in frozen embryo cycles. Researchers will follow 370 women aged 18-42 undergoing hormone replacement therapy and frozen embryo transfer. The goal is to bet…

This pilot study tests a 12-week telehealth program for frail adults aged 65 and older who have just left the hospital. The program uses activity sensors and pedometers to support physical and mental recovery at home. Researchers will check if the program is practical and liked b…