Chinese University Of Hong Kong

This phase 2 trial tests whether combining sacituzumab govitecan (a targeted antibody-drug conjugate) with pembrolizumab (an immunotherapy) before and after surgery can improve outcomes for people with resectable non-small cell lung cancer (NSCLC). Participants receive four cycle…

This study looks at whether taking a synbiotic supplement (a mix of probiotics and prebiotics) and eating more fruits and vegetables can lower the risk of obesity and related health problems in Hong Kong Chinese adults. One hundred overweight or obese participants will follow the…

This study tests whether giving children with fish allergy small, increasing doses of codfish protein (oral immunotherapy) can help them tolerate fish without reactions. 70 children aged 2 to 10 will receive either codfish or a placebo for 12 months, then be tested for desensitis…

This study tests a procedure called PIPAC, which turns chemotherapy drugs into a mist and sprays them directly into the abdomen. It is for people with stomach cancer that has spread to the lining of the belly. The goal is to see if this approach is safe and can help control the d…

This study tests a peer-facilitated program (Peer-RESIM) for adults who have had a first episode of psychosis. The program includes 10 sessions over 4 months, led by trained peer support workers, to help participants improve self-care and recovery. Researchers will compare this t…

This study tests a 10-session program called AIM-AT, which uses acceptance-based techniques to help people with recent-onset psychosis better understand their illness and stick to their medication. The trial involves 126 participants in Hong Kong and tracks their medication adher…

This study looks at 70 people with liver cancer who had bleeding from enlarged veins in the esophagus. It compares two procedures—an ultrasound-guided injection of a glue-like substance versus a banding technique—to see which better prevents future bleeding. The goal is to find t…

This study tests a new surgical technique to close macular holes in people with high myopia without using a gas bubble. The standard approach requires a gas bubble that blurs vision and forces patients to keep their head down for days. The new method uses a gel-like substance to …

This study tests if matching when you eat to your natural sleep-wake pattern (chronotype) helps reduce deep belly fat and improve health. Over 12 weeks, 90 inactive adults with central obesity will follow either a matched or mismatched eating schedule, or a control diet. The goal…

This study tests a new robotic tool called the EndoR Surgical System for removing early-stage colorectal lesions. The goal is to see if it can make the procedure safer and more effective than current methods. Six adults aged 18 to 85 with superficial colorectal lesions will take …

This study tests whether the sleep medication trazodone can slow memory loss in people with mild cognitive impairment and obstructive sleep apnea. Researchers will measure changes in blood markers and thinking skills over one year. 134 participants are enrolled in this double-bli…

This study tests a treatment plan for people with stage IVA nasopharyngeal cancer (a type of nose and throat cancer). Participants receive a combination of the immunotherapy drug pembrolizumab and chemotherapy before and during radiation, followed by maintenance pembrolizumab for…

This study compares two types of radiation therapy for low- or intermediate-risk prostate cancer in Asian men. One method, SBRT, delivers high-dose radiation in fewer sessions, while the other, IMRT, uses more standard daily doses. The main goal is to see which approach better pr…

This phase 2 trial tests a two-step approach for high-risk rectal cancer: first, a strong chemotherapy cocktail (FOLFOXIRI), followed by radiation combined with a chemo pill (capecitabine). The goal is to shrink tumors before surgery, making them easier to remove. The study invol…

This study tests a new urine test called CercaTest™ Red to predict preeclampsia in pregnant women who show signs of the condition. Preeclampsia is a serious complication involving high blood pressure and organ damage. The test is designed to be used at the point of care, giving q…

This study tests whether an artificial intelligence (AI) system can accurately identify the type of colon polyps during a colonoscopy, compared to standard visual inspection by the doctor. Over 1,700 adults having a colonoscopy will be randomly assigned to either AI-assisted or s…

This study tests a new digital scope (SpyGlass DS) to help doctors tell cancerous from non-cancerous narrowings in the bile duct. About 40 adults with bile duct strictures will undergo the procedure during a standard ERCP exam. The goal is to see if the digital scope improves dia…

This study tests a new MRI technique that measures liver fat, fibrosis, and inflammation in a single 14-second breath-hold, without needles or contrast dye. Researchers will scan 120 people with fatty liver disease (60 with simple steatosis and 60 with NASH) and compare results t…

This study tests whether an artificial intelligence system (called CADe) can help doctors spot early stomach cancers during endoscopy. About 260 people at high risk for stomach cancer will have two endoscopies: one without the AI and one with it. The goal is to see if the AI redu…

This study tests whether taking doxycycline before potential exposure to STIs works better than taking it after exposure. 300 men who have sex with men will be randomly assigned to one of two groups and followed for 2 years. The goal is to see which approach better prevents chlam…

This Phase 3 trial tests whether a meningitis B vaccine (Bexsero) can prevent gonorrhea infections in men who have sex with men. 150 participants in Hong Kong will receive either the vaccine or a placebo. Researchers will compare infection rates and monitor safety.

This study tests whether sending HIV self-test kits to men who have sex with men on a subscription basis encourages them to test more regularly. 240 participants in Hong Kong will receive reminders to test during a control period, then receive actual test kits during an intervent…

This study tests a new program called Building Respectful Online Space (BROS) to prevent cyberbullying among Hong Kong teens aged 12 to 15. About 120 students will be split into two groups: one receives the BROS program, the other a healthy diet lesson. Researchers will check if …

This study tests whether a 3-year program of diet advice, exercise coaching, and behavior support can prevent type 2 diabetes in 800 women who had gestational diabetes. Participants will receive personalized meal plans and regular sessions with dietitians and exercise instructors…

This study tests whether a nurse-led sailing program can improve resilience, self-esteem, and social skills in school-aged children with autism. About 184 children aged 7 to 12 will either take part in a 6-day sailing program or do simple craft activities. Researchers will compar…

This study tests whether an app that provides cognitive behavioral therapy for insomnia, enhanced with an AI chatbot, can help young people (ages 18-25) sleep better. Half of the 168 participants will use the app with the chatbot, and the other half will use the same app without …

This study tests whether sitting under a bright light for 30 minutes each day for six weeks can improve mood in people with bipolar depression who also tend to be evening types. Seventy adults will be randomly assigned to either the bright light or a placebo device. The goal is t…

This study tests a fixed-dose combination of netupitant and palonosetron (NEPA) to prevent nausea and vomiting in breast cancer patients receiving chemotherapy with adriamycin and cyclophosphamide. The trial includes 55 women in Hong Kong and tracks how well the drug works during…

This study tests a special cooling cap (Orbis Paxman system) to prevent hair loss in Chinese women with breast cancer undergoing chemotherapy. 25 participants will use the cap during chemo sessions. The goal is to see if it safely reduces hair loss and improves quality of life.

This study tests a school-based program called WeJoy+WeHop for primary 3 to 5 students. WeJoy uses cognitive behavioral therapy to help with emotions and thinking, while WeHop involves interactive floor games that get kids moving. Researchers want to see if the program improves d…

This study tests a new, non-invasive treatment using low-intensity ultrasound to stimulate a deep brain area (the hippocampus) in older adults with mild memory and sleep problems. The goal is to see if it safely improves sleep quality and thinking skills. Twenty participants aged…

This study looks at why people with antiphospholipid syndrome (APS) — a condition that raises blood clot risk — may have narrowed brain arteries. Researchers will use advanced MRI scans on 60 APS patients to check for artery narrowing and plaque buildup. The goal is to better und…

This study follows 31 Chinese adults with a specific genetic mutation (IVS4+919G>A) that causes Fabry disease, a condition where harmful substances build up and damage organs, especially the heart. Researchers use advanced heart scans and blood tests to track how the disease prog…

This study looks at 1,600 adults in Hong Kong who have been diagnosed with asthma or COPD to find out how many have both conditions (called Asthma-COPD Overlap). Researchers will track their health for 3 years to see how they do and whether their treatment matches guidelines. The…

This study looks at 1,800 adults hospitalized with pneumonia in Hong Kong. Researchers use a simple urine test to identify which types of pneumococcus bacteria are causing the infections. The goal is to understand which strains are most common, which can help improve future vacci…

This study looks at whether a new ultrasound technique done through the stomach (endoscopic ultrasound elastography) can better predict serious liver problems in people with chronic liver disease. Researchers will measure liver and spleen stiffness in 50 patients and compare resu…

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

This study looks at the gut bacteria of 120 adults with and without fatty pancreas to see if certain bacteria are linked to the condition. Researchers will use MRI to measure fat in the pancreas and compare the microbiome of different groups. The goal is to find non-invasive mark…

This study enrolls 2000 women who had gestational diabetes into a registry to improve their long-term health follow-up. Participants receive reminders for regular check-ups on blood sugar, blood pressure, and other health markers over 3 years. A subgroup may also join a lifestyle…

This study looks at how liver stiffness (hardness) affects treatment results in people with liver cancer. About 207 patients will be followed to see if stiffness predicts survival and treatment side effects. The goal is to help doctors choose the best therapy for each patient.