THYROID CANCER

This early-stage trial is testing a new oral drug, PF-07799933, in people aged 16 and older with advanced solid tumors that have a specific BRAF gene change. The drug is given alone or combined with other medicines like binimetinib or cetuximab. The study aims to find safe doses …

This early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …

This early-phase study tests a new drug called SLV-154 in about 70 people with advanced solid tumors (like head and neck, lung, breast, or ovarian cancer) that have spread. The main goal is to find a safe dose and check for side effects. Researchers will also watch for any signs …

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This study compares two approaches for treating intermediate-risk thyroid cancer after surgery. One group gets radioactive iodine as a standard precaution. The other group only gets it if a blood test and scan show signs of remaining cancer. The goal is to see if the selective ap…

This study tests whether two drugs, avutometinib and defactinib, can shrink or control certain types of advanced thyroid cancer that no longer respond to standard radioactive iodine treatment. The trial enrolls 30 adults with RAF dimer-driven differentiated or anaplastic thyroid …

This study tests an experimental oral drug called S241656 (BDTX-4933) in people with advanced solid tumors that have certain genetic changes (KRAS, BRAF, or other RAS/MAPK mutations). The trial has two parts: first, finding a safe dose, then testing how well it works alone or wit…

This program provides the experimental drug ulixertinib to people with advanced solid tumors that have certain gene mutations (MAPK pathway). It is for patients who have not responded well to or have run out of standard treatments. The goal is to control the disease and possibly …

This phase 2 trial tests the drug zanzalintinib given before surgery in 45 people with advanced thyroid cancer. The goal is to see if the drug can shrink tumors, making surgery more effective. Researchers will also monitor safety and side effects.

This study compares a new, proactive follow-up program to standard care for people who have had thyroid surgery. The program includes scheduled clinic visits, online consultations, and AI reminders to help patients stay engaged. Researchers will track whether patients complete th…

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This study tests a new oral drug called HEC169096 in people with advanced solid tumors, including thyroid cancer and non-small cell lung cancer, that have a specific RET gene change. The trial has two phases: the first finds the safest dose, and the second checks how well the dru…

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer, and give them back after a short course of chemotherapy. T…

This study compares two doses of the drug lenvatinib (24 mg vs 10 mg daily) in 34 people with advanced thyroid cancer that no longer responds to radioactive iodine. The goal is to see if the lower dose causes fewer side effects while still controlling the cancer. Participants tak…

This study looks at whether giving radiation therapy within 6 weeks after surgery can help prevent thyroid cancer from coming back in people at high risk. It includes 80 patients with various types of thyroid cancer (except undifferentiated). The main goal is to see how long they…

This study looks at whether adding radiation therapy to the usual radioactive iodine treatment can help prevent thyroid cancer from coming back in people with high-risk, advanced thyroid cancer. About 124 adults who had surgery but still have some cancer left will be randomly ass…

This early-phase study tests a new radioactive drug called 177Lu-CTR-FAPI in 12 people with thyroid cancer that has spread and is no longer responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors or lower cancer markers in t…

This study tests whether a smaller, more targeted neck surgery (selective neck dissection) works as well as the standard larger surgery (modified neck dissection) for people with papillary thyroid cancer that has spread to only 1 or 2 small lymph nodes in the side of the neck. Ab…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control advanced solid tumors like lung, pancreas, and colorectal cancers. The trial involves 54 adults whose current…

This study is testing whether giving targeted drugs before surgery can shrink tumors in people with locally advanced thyroid cancer. About 120 participants will receive one of several drug combinations based on their tumor's genetic profile. The goal is to see if this approach ma…

This study is for people with small thyroid nodules (under 2 cm) that might be cancerous. Instead of immediate surgery, which can lead to lifelong thyroid medication and other side effects, researchers want to see if regular check-ups and ultrasounds are a safe option. They will …

This study tests whether the experimental drug AL2846 can slow cancer growth in people with advanced thyroid cancer that no longer responds to radioiodine or previous targeted therapy. About 144 participants will receive either AL2846 or a placebo. The main goal is to see how lon…

This phase II trial tests a combination of two drugs—MRG003 and pucotenlimab—in 60 people with a rare and aggressive form of thyroid cancer that cannot be removed by surgery. The goal is to see if the treatment can shrink tumors and control the disease. Participants receive the d…

This early-phase trial is testing whether giving a combination of two drugs (XL092 and cemiplimab) before surgery can help people with a rare and fast-growing thyroid cancer called anaplastic thyroid cancer. The study will enroll 12 participants to see if the treatment is safe an…

This study tests whether using a special camera (autofluorescence imaging) during thyroid cancer surgery can lower the risk of hypoparathyroidism, a condition where the parathyroid glands stop working properly. About 160 adults having their thyroid removed will be randomly assign…

This study compares a newer type of scan (I-124 PET/CT) to the standard scan (I-123 whole body imaging) for finding thyroid cancer that has spread. About 62 people with thyroid cancer will get both scans, and researchers will see if the new scan is more accurate. The goal is to i…

This study is testing a new type of PET scan that uses special radioactive tracers to find and map solid tumors in the body. The tracers target a protein called Trop2, which is often found on cancer cells. Researchers will enroll 400 people with various cancers (including bladder…

This study tests a new imaging method called vibro-acoustography (VA) to find and tell apart harmless and cancerous thyroid nodules. Researchers at Mayo Clinic will compare VA images to standard ultrasound in 650 people aged 8 and older who are at risk for thyroid cancer. The goa…

This study tests a new imaging agent called F-18 TFB for PET/CT scans in people who have had surgery and radioactive iodine for differentiated thyroid cancer but still have high tumor markers. The goal is to see if F-18 TFB finds cancer lesions better than the standard FDG PET/CT…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This phase 3 trial tests whether using artificial tears after radioactive iodine therapy can prevent tear duct blockage in thyroid cancer patients. Radioactive iodine can collect in tears and damage tear ducts, leading to blockage. 100 adults receiving high-dose radioactive iodin…

This study tests whether a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) can help reduce anxiety and depression in 300 Latino patients with advanced cancer. Participants receive either MCP-L or standard cognitive behavioral therapy over about 3 months. The goa…

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study tests whether a mushroom supplement called Ganoderma lucidum spore powder can reduce depression in women who have had thyroid cancer surgery. Three hundred participants will take either the supplement or a placebo daily for three months. Researchers will measure change…

This pilot study is testing whether a therapy called EMDR (eye movement desensitization and reprocessing) can help reduce post-traumatic stress and psychological distress in people with advanced thyroid cancer. The study will enroll 25 participants who have cancer and PTSD sympto…

This study tests a program called CARES that provides nurse navigators and counselors to rural cancer patients. The goal is to see if this support helps patients start and finish treatment more quickly and improves their quality of care. About 320 adults with solid tumors like lu…

This study tests a decision support tool that uses blood samples from the first two weeks after thyroid surgery to predict the best levothyroxine dose. Normally, dose adjustments take months of trial and error. The trial will enroll 240 patients and compare the tool's guidance to…

This study reviews 10 years of medical records from 600 adults who had thyroid surgery at Minia University Hospital. The goal is to find out which patients are most likely to develop low calcium levels after surgery, a common complication. By identifying key risk factors, doctors…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study tests two ways of preparing people with advanced thyroid cancer for a special PET scan that uses a radioactive form of iodine (I-124). The goal is to see which preparation method gives better information for calculating the right dose of radiation therapy. Thirty parti…

This study looks at how things in the environment, like chemicals, might affect how thyroid cancer grows. Researchers will collect blood samples and have participants fill out questionnaires. They hope to find patterns that could explain why some thyroid cancers are more aggressi…

This study is for people who have or might have a thyroid nodule or thyroid cancer. Researchers want to learn more about how to diagnose and treat these conditions. Participants will have standard medical tests like blood draws and scans, plus some extra research tests. The goal …

This study tests whether a nerve block in the neck, given during thyroid surgery, can lower the body's stress response. 48 adults will be split into two groups: one gets standard anesthesia, the other gets the same plus a nerve block. Researchers will measure stress markers in bl…

This study aims to uncover genetic factors that increase the risk of thyroid cancer, especially in children and families with a strong history of the disease. Researchers will collect medical history and blood or saliva samples from 250 participants to look for inherited gene cha…

This study tests a new AI chatbot that gives personalized health information to people with thyroid cancer before and after surgery. Researchers want to see if using the chatbot helps patients feel more ready to go home and recover better compared to standard education. About 150…

This study is creating a large database of medical information and blood samples from 350 adults receiving metabolic radiotherapy for thyroid, prostate, or neuroendocrine cancers. The goal is to provide researchers with valuable data to better understand these treatments. No new …

This study tests whether a special type of MRI, called hyperpolarized MRI, can predict how well thyroid and head/neck cancers respond to radiation or drug therapy before surgery. About 42 participants will get this imaging scan before and after starting treatment. The goal is to …

This study aims to improve a prediction model that helps doctors know how difficult a less invasive thyroid surgery might be. Researchers will observe 300 people with thyroid cancer or benign nodules to see which factors, like age, weight, and tumor size, affect surgery difficult…

This study aims to create and test a scoring system called RTAS to evaluate how well surgeons perform robotic thyroidectomy, a surgery to remove all or part of the thyroid gland. Researchers will observe 200 participants with thyroid cancer or benign nodules who are having this s…

This study is gathering information from 100 adults with a type of thyroid cancer that no longer responds to standard radioactive iodine treatment. Doctors are using special medications called redifferentiating agents to try to make the cancer respond again. The goal is to track …

This study is testing new MRI techniques to get more detailed images of head and neck and thyroid cancers. About 200 adults will have extra MRI scans before, during, or after treatment. The goal is to see if these scans can provide early clues about how well a treatment is workin…

This study follows 500 thyroid cancer patients who had partial or total thyroid removal to see how they feel after surgery. Researchers use a special questionnaire to measure symptoms and quality of life over time. The goal is to learn how to improve recovery and care for future …

This pilot study is testing whether active monitoring (regular ultrasounds and check-ups) is as good as or better than immediate biopsy for people with small thyroid nodules that look suspicious on ultrasound. Twenty adults with nodules under 2 cm will be randomly assigned to eit…

This study observes adults with advanced thyroid cancer who are receiving standard treatments in real-world settings, not in clinical trials. Researchers aim to understand barriers to accessing care and how well patients tolerate and respond to available medications. About 459 pa…

This study looks at how changing thyroid hormone levels affect the way the body uses sugar and fat. Researchers will study people with Graves' disease (whose thyroid hormones are too high) and people with thyroid cancer (whose hormones are intentionally raised). Participants will…

This study looks at whether having a pharmacist review all medications (including those from other doctors) can improve safety for cancer patients receiving targeted radionuclide therapy. The study will include 600 adults with thyroid cancer, metastatic prostate cancer, or neuroe…

This study looks at why some samples from thyroid nodule biopsies are not good enough for diagnosis. About 160 people with thyroid nodules will have their biopsy samples checked right away to see if more samples are needed. The goal is to find factors that lead to poor samples, s…

This study tests whether a special decision aid website helps people with intermediate-risk thyroid cancer make informed choices about radioactive iodine (RAI) treatment. About 408 participants will be randomly assigned to use either the decision aid or a standard information web…

This study tests a special collar worn around the neck that measures radiation exposure in people with thyroid cancer or Graves' disease receiving radioactive iodine therapy. The goal is to see if this device gives more accurate dosing information than current methods, potentiall…

This study tests a decision aid for people with small thyroid nodules or early thyroid cancer. Participants get extra information to help them choose a treatment that matches their values. They fill out surveys about their satisfaction and decision-making process. The goal is to …