THYROID CANCER

This study is testing if using a special camera that makes parathyroid glands glow under infrared light during thyroid cancer surgery helps surgeons see and protect them better. The goal is to reduce the risk of a common complication called hypoparathyroidism, which requires life…

This study compares two surgical approaches for papillary thyroid cancer that has spread to a limited number of lymph nodes in the neck. It aims to see if a more targeted, less extensive surgery (selective neck dissection) is as safe and effective at preventing cancer recurrence …

This early-phase study is testing a new type of cell therapy for people with advanced solid tumors, including melanoma, that have spread and are not responding to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack c…

This study is testing a new oral drug, S241656, alone and in combination with other cancer therapies. It aims to find a safe and effective dose for adults with advanced cancers, including lung, pancreatic, and colorectal cancers, that have specific genetic mutations like KRAS or …

This program provides access to an investigational drug called ulixertinib for patients with advanced cancers that have specific genetic changes (MAPK pathway mutations). It is for people who have run out of other treatment options. The drug aims to control the cancer's growth, e…

This study is testing a new experimental drug called CNSI-Fe, which is an iron-loaded nanoparticle suspension injected directly into tumors. The goal is to see if it is safe and can help control cancer in people with advanced solid tumors that have stopped responding to standard …

This early-stage study is testing whether giving two drugs, XL092 and cemiplimab, before surgery is safe and helpful for people with a very aggressive type of thyroid cancer that lacks a specific genetic change (BRAF V600E). The goal is to see if this drug combination can shrink …

This study is testing whether a support program called CARES helps rural cancer patients start treatment sooner and complete it faster. The program provides navigation help and counseling sessions alongside usual cancer care. Researchers will compare outcomes for 320 patients who…

This study aims to see if radiation therapy given after surgery helps prevent thyroid cancer from returning in the neck area for patients at high risk of recurrence. It will observe 80 patients whose cancer has features that make it more likely to come back, such as not being ful…

This study is testing whether closely monitoring small thyroid nodules is a safe alternative to immediate surgery. Researchers will follow 165 adults with small nodules for up to 5 years to see if the nodules grow or require surgery. The goal is to help patients avoid surgery ris…

This study is testing whether combining two drugs, MRG003 and pucotenlimab, can help control an aggressive form of thyroid cancer that has spread or cannot be surgically removed. It is for adults whose cancer tests positive for a specific marker called EGFR. The goal is to see if…

This study is testing a new type of PET/CT scan to help doctors calculate the best and safest dose of radioactive iodine treatment for people with advanced thyroid cancer. It will compare two different methods of preparing the body for treatment. The goal is to see if this new sc…

This study is testing whether a new capsule called AL2846 can help control advanced thyroid cancer that has stopped responding to standard treatments. It will compare AL2846 against a placebo in 144 adults whose cancer has progressed despite previous therapy. The main goal is to …

This study is testing a new computer tool designed to help doctors find the right dose of thyroid replacement medication (levothyroxine) much faster for patients who have had their thyroid removed. The tool uses early blood test results to predict the best dose, aiming to get pat…

This study is testing if a new drug called zanzalintinib can shrink advanced thyroid tumors before surgery. The goal is to make the surgery safer and easier to perform for patients with complex, hard-to-remove cancers. Researchers will give the drug to about 45 adults, then measu…

This study is for people with advanced thyroid cancer that has stopped responding to standard radioactive iodine treatment. Researchers want to see if a lower daily dose of the drug lenvatinib (10 mg) works as well as the standard higher dose (24 mg) while causing fewer side effe…

This study aims to improve safety for cancer patients receiving targeted radiation therapy by having pharmacists review all their medications. Researchers will enroll 600 adults with thyroid cancer, prostate cancer, or neuroendocrine tumors to test whether detailed medication rev…

This study is testing whether adding radiation therapy to the standard treatment helps prevent high-risk thyroid cancer from coming back in the neck area. Patients who have had surgery but still have some cancer cells left will be randomly assigned to receive either the standard …

This is the first human study of an experimental drug called SLV-154 for people with advanced solid tumors that have spread. The main goal is to find the highest safe dose and understand how the body processes the drug. About 70 adults with one of ten specific advanced cancers wh…

This early-stage study is testing a new oral medicine called PF-07799933, both alone and combined with other drugs, for people with advanced solid tumors that have a specific BRAF gene change and have stopped responding to standard treatments. The main goals are to find a safe do…

This is an early-stage study to test the safety and find the right dose of a new radioactive drug called 177Lu-CTR-FAPI for people with advanced thyroid cancer. The drug is designed to find and deliver radiation directly to cancer cells. The study will enroll 12 patients to see h…

This study aims to see how well the drug T-DXd works in real-world settings for patients with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients with various solid tumors (excluding breast, lung,…

This study is testing whether a combination of two drugs, avutometinib and defactinib, can help control advanced thyroid cancers that have specific genetic changes and have stopped responding to standard radioactive iodine treatment. The trial will enroll about 30 adults with two…

This early-stage study is testing the safety and initial effects of a new oral medicine, PF-07799544, when taken with another drug, PF-07799933. It is for adults with advanced solid tumors, like melanoma or lung cancer, that have a specific genetic change called a BRAF V600 mutat…

This study is looking at whether giving medication before surgery helps shrink advanced thyroid tumors that have grown into nearby structures. Researchers will follow 120 patients who receive this pre-surgery treatment and then undergo tumor removal, comparing them to patients wh…

This large trial is comparing two approaches for patients with intermediate-risk thyroid cancer after surgery. One group receives standard radioactive iodine treatment. The other group only gets this treatment if specific blood tests and scans suggest it's needed. The goal is to …

This study is testing a new type of imaging scan to see if it can better detect and monitor many different solid tumors. The scan uses a special tracer that attaches to a protein called Trop2, which is often found on cancer cells. Researchers will compare this new scan to standar…

This study aims to improve the accuracy of thyroid nodule biopsies, which are used to detect cancer. It will investigate how factors like needle size and sampling technique affect whether a biopsy sample contains enough cells for a clear diagnosis. The goal is to reduce the numbe…

This study is testing a new type of PET/CT scan to see if it can find thyroid cancer tumors better than the current standard scan. It is for people who have had surgery and radioactive iodine treatment but still have signs of cancer in their blood. The goal is to improve detectio…

This study is testing whether a new type of PET scan using a radioactive tracer called I-124 can find thyroid cancer that has spread (metastasized) more accurately than the current standard scans (I-123 or I-131). Researchers will compare the new scan results to the standard ones…

This study is testing a new blood test designed to detect many types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can accurately spot cancer signals and identify where in the body the cancer started. The t…

This study is testing whether using artificial tears after radioactive iodine treatment for thyroid cancer can prevent a painful side effect called tear duct blockage. Researchers want to see if washing away radioactive particles from the eyes with these drops reduces inflammatio…

This is a small pilot study to see if it's feasible to compare two ways of managing small thyroid nodules that look suspicious on ultrasound. The study will compare the anxiety levels and quality of life of people who get an immediate biopsy (usual care) versus those who are clos…

This study aims to understand how environmental exposures, like certain chemicals, might affect thyroid cancer risk and how aggressive it becomes. Researchers will enroll 500 adults with thyroid nodules who are scheduled for surgery. They will collect small blood samples and use …

This study is testing a special wearable collar device that continuously measures radiation around the neck. The goal is to see if it can provide more detailed information than current methods about how patients with thyroid cancer or Graves' disease absorb radioactive iodine tre…

This study looks back at 10 years of patient records to find out why some people develop low calcium levels after thyroid surgery, a common complication. By analyzing data from 600 patients, researchers aim to identify which factors—like patient health, surgical details, or lab r…

This study is creating a database of health information and blood samples from cancer patients receiving targeted radiation therapy. Researchers will collect data from 350 adults with thyroid, prostate, or neuroendocrine cancers to better understand how these treatments work and …

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study is a global registry that aims to understand how patients with advanced thyroid cancer respond to standard treatments outside of traditional clinical trials. It will track survival and quality of life in about 459 patients to identify barriers to care and see how well …

This study is testing whether a special website helps people recently diagnosed with a moderate-risk thyroid cancer make a more informed decision about radioactive iodine treatment. About 408 participants will be randomly assigned to either use this interactive decision aid websi…

This study aims to understand how changes in thyroid hormone levels affect the body's metabolism. It will observe 60 people with Graves' disease or thyroid cancer as their hormone levels are intentionally adjusted with medication. Researchers will perform sugar tolerance tests to…

This study aims to learn more about how to best diagnose and treat thyroid nodules and thyroid cancer. It will enroll up to 2,500 adults and children who have or are suspected of having a thyroid nodule or cancer, or who have a family risk. Researchers will collect blood, tissue,…

This study is testing new MRI scanning methods to see if they can provide better information about head, neck, and thyroid cancers. Researchers want to find specific signs on the MRI scans, called biomarkers, that might predict how well a tumor will respond to treatment early on.…