THYROID CANCER

This early-phase study tests a new drug called SLV-154 in about 70 people whose solid tumors (like head and neck, lung, breast, or ovarian cancer) have spread. The main goal is to find a safe dose and watch for side effects. Participants must have a confirmed diagnosis and be in …

This study looks at whether closely monitoring small thyroid nodules (under 2 cm) with regular ultrasounds is a safe and effective alternative to immediate surgery. The goal is to avoid unnecessary operations and the need for lifelong thyroid medication. Researchers will follow 1…

This study tests whether a less extensive neck surgery (selective neck dissection) works as well as the standard more extensive surgery (modified neck dissection) for people with papillary thyroid cancer that has spread to a small number of lymph nodes in the side of the neck. Ab…

This study tests whether two drugs, avutometinib and defactinib, can shrink or control certain types of advanced thyroid cancer that no longer respond to standard radioiodine treatment. The trial includes 30 adults with either differentiated or anaplastic thyroid cancer that has …

This study tests whether two drugs, MRG003 and pucotenlimab, can shrink tumors in people with a rare and aggressive type of thyroid cancer (ATC or PDTC) that has spread or cannot be removed by surgery. About 60 adults with EGFR-positive tumors will receive the combination every t…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This early-phase study is testing a new radioactive drug called 177Lu-CTR-FAPI in 12 people with thyroid cancer that has spread and is no longer responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors or slow the disease. Th…

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The goal is to find a safe dose and see if t…

This study tests whether adding radiation therapy to the usual radioactive iodine treatment can better prevent thyroid cancer from coming back in the neck area. It includes 124 people with high-risk differentiated thyroid cancer who had surgery but still have some cancer left beh…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control or shrink advanced solid tumors like lung, pancreas, and colorectal cancers. The study involves 54 adults who…

This early-phase study tests a new oral drug, PF-07799933, in people aged 16 and older with advanced solid tumors (like melanoma, lung, or colon cancer) that have a specific BRAF gene change and have stopped responding to standard treatments. The drug is given alone or combined w…

This early-phase trial tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part.

This study tests a drug called zanzalintinib given before surgery to people with advanced thyroid cancer. The goal is to see if the drug can shrink tumors and make surgery more effective. About 45 adults will take part, and researchers will also monitor for side effects.

This study tests whether using a special imaging technique called autofluorescence during thyroid cancer surgery can lower the risk of hypoparathyroidism, a condition where the parathyroid glands stop working properly. The trial will involve 160 adults who are scheduled for total…

This program provides ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific genetic changes (MAPK pathway mutations) and who have run out of standard treatments. The goal is to control the cancer, not cure it. Participants may take ulixertinib…

This study looks at whether giving radiation therapy after surgery can help prevent thyroid cancer from coming back in people with a high risk of recurrence. About 80 adults with certain types of thyroid cancer will receive adjuvant radiotherapy. Researchers will track how long p…

This early-phase study tests whether giving two drugs (XL092 and cemiplimab) before surgery can help remove a rare and fast-growing thyroid cancer called anaplastic thyroid cancer. The study includes 12 adults whose cancer has a specific gene change (BRAF V600E). The main goals a…

This study tests whether a lower dose of the drug lenvatinib works as well as the standard higher dose for people with advanced thyroid cancer that no longer responds to radioactive iodine. About 34 participants will be randomly assigned to take either 24 mg or 10 mg daily. The g…

This early-phase study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, and others). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. About 554 …

This study compares two ways of treating intermediate-risk thyroid cancer: giving everyone radioactive iodine (RAI) versus using a blood test and scan to decide who really needs it. About 476 adults with papillary, follicular, or Hürthle cell thyroid cancer will take part. The go…

This study tests a new drug called AL2846 in people with advanced thyroid cancer that no longer responds to radioiodine or previous targeted therapy. About 144 participants will receive either AL2846 or a placebo to see if the drug can delay cancer growth. The goal is to offer a …

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study compares a newer type of scan (I-124 PET/CT) with the usual scans (I-123 and I-131) to see if it can better detect where thyroid cancer has spread in the body. About 62 people with thyroid cancer who have had their thyroid removed will get both scans. The goal is to se…

This study compares a new PET imaging agent, F-18 TFB, with the standard FDG PET/CT to find leftover thyroid cancer in 50 patients who have had surgery and radioactive iodine therapy. Participants have high levels of thyroglobulin (Tg) in their blood, which may signal cancer, but…

This study is testing a new type of PET scan that uses a special tracer to find a protein called Trop2 on cancer cells. The goal is to see if this scan can detect and monitor many types of solid tumors more accurately than current methods. About 400 adults with or suspected of ha…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study tests whether using artificial tears right after radioactive iodine therapy can prevent tear duct blockages in thyroid cancer patients. Radioactive iodine can get into tears and damage the tear ducts, causing blockages over time. The trial will follow 100 adults for tw…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests whether a special mushroom powder (Ganoderma lucidum spores) can reduce depression in women who have had thyroid cancer surgery. Three hundred female participants will take either the mushroom powder or a placebo for three months. The goal is to see if it improve…

This study tests a decision support tool that uses early blood tests to predict the best dose of levothyroxine (thyroid hormone) after thyroid removal surgery. Normally, finding the right dose takes months of trial and error. The tool aims to get patients to the correct dose fast…

This study looks back at 600 adults who had their thyroid removed at Minia University Hospital over 10 years. The goal is to find out which patients are more likely to develop low calcium levels after surgery, a common complication. By identifying risk factors like age, lab resul…

This study looks at factors that can make thyroid nodule biopsy samples unusable, so doctors can get a clear diagnosis the first time. Researchers will collect samples from 160 people with thyroid nodules and check them right away for quality. The goal is to find ways to reduce r…

This study is looking at how well treatment given before surgery works for people with advanced thyroid cancer. Researchers will measure tumor shrinkage using scans and lab tests, and track how patients do over time. About 120 participants will be observed to see if this approach…

This study aims to learn more about how to diagnose and treat thyroid nodules and thyroid cancer. It will include up to 2,500 people with known or suspected thyroid issues, as well as family members at genetic risk. Researchers will collect blood, tissue, and imaging data to bett…

This study collects data from 459 adults with advanced thyroid cancer who are receiving standard treatments outside of clinical trials. The goal is to understand barriers to accessing care and how well patients tolerate and respond to available medications. It focuses on real-wor…

This study is collecting information from 100 adults with a type of thyroid cancer that does not respond to standard radioactive iodine treatment. Doctors are using special medications called redifferentiating agents to try to make the cancer respond to radioactive iodine again. …

This study follows 500 people who had partial or total thyroid removal for thyroid cancer. Researchers will track symptoms and quality of life using a special questionnaire. The goal is to learn how patients feel after surgery to improve future care. No new treatments are being t…

This study involves 300 people with thyroid cancer or benign nodules who will undergo surgery through the mouth or under the chin. Researchers want to improve a prediction model that helps doctors know how difficult the surgery will be, so they can better plan and train for it. T…

This pilot study compares two approaches for managing thyroid nodules that look suspicious on ultrasound: immediate biopsy (usual care) versus active monitoring with regular ultrasounds. The goal is to see which approach leads to less anxiety and better quality of life for patien…

This study looks at how changing thyroid hormone levels affects the way the body uses sugar and fat for energy. Researchers will study 60 people with Graves' disease (whose thyroid levels are lowered with medication) and thyroid cancer (whose levels are raised with medication). P…

This study is testing new MRI techniques to get more detailed information about head and neck and thyroid cancers. Researchers will scan 200 adults with these cancers to see if the new methods can help predict how well treatment is working. The goal is to improve understanding of…

This study tests a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner after diagnosis and finish it faster. The study will include 320 adults with solid tumors like lu…

This study aims to develop and test a scoring system called RTAS to evaluate how well surgeons perform robotic thyroidectomy, a surgery to remove all or part of the thyroid gland. The study will include 200 adults with thyroid cancer or benign thyroid nodules who are having this …

This study looks at how things in the environment, like chemicals, might affect thyroid cancer. Researchers will collect small blood samples and have participants fill out questionnaires. The goal is to see if certain exposures are linked to more aggressive cancer or recurrence. …

This study involves 30 people with high-risk thyroid cancer that has spread. Researchers want to see if using a special PET scan with a radioactive tracer (124-I) can better predict the right radiation dose for treatment. Participants will be prepared in two different ways (with …

This study is creating a large database of clinical information and blood samples from 350 adults receiving metabolic radiotherapy for thyroid cancer, prostate cancer, or neuroendocrine tumors. The goal is to provide researchers with valuable data to better understand these treat…

This study tests whether a special website helps people with intermediate-risk thyroid cancer make better decisions about radioactive iodine (RAI) treatment. About 408 participants will be randomly assigned to use either the decision aid website or a standard information site. Re…

This study looks at whether having a radiopharmacist review a patient's full medication list before they receive targeted radionuclide therapy (TRT) can improve safety. TRT is a type of radiation treatment that targets cancer cells while sparing healthy tissue. Researchers will c…

This study is testing a special collar worn around the neck that measures how the body processes radioactive iodine used to treat thyroid cancer and Graves disease. The goal is to see if this device can give doctors better information to personalize the dose for each patient, pot…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…