THYROID CANCER

This early-phase trial tested whether combining two drugs, vemurafenib and copanlisib, can help radioactive iodine therapy shrink tumors in people with advanced thyroid cancer that no longer responds to standard radioiodine treatment. Only 8 participants with a specific BRAF gene…

This study tested a drug called ZD6474 (vandetanib) in 331 people with advanced medullary thyroid cancer that could not be removed by surgery. The goal was to see if the drug could slow tumor growth compared to a placebo. Results focused on how long patients lived without their c…

This study looked at whether combining fun video-game exercises (exergaming) with a Mediterranean diet could help people recovering from thyroid cancer surgery. Eighty adults who had their thyroid removed were split into groups: some did exergaming, some followed a Mediterranean …

This study tested two daily doses (150 mg vs 300 mg) of the drug vandetanib in 81 adults with advanced medullary thyroid cancer that had spread or caused symptoms. The goal was to see which dose better shrinks tumors and to compare side effects. Participants took the drug by mout…

This study tested an artificial intelligence (AI) system called Vision-LSTM to see how well it could diagnose thyroid nodules from ultrasound images. Researchers used data from 401 patients with a specific type of nodule (TI-RADS 4b) and compared the AI's accuracy to that of juni…

This study tested whether adding dexmedetomidine to a standard neck nerve block improves pain control after thyroid surgery. Fifty-eight adults aged 30-59 were randomly assigned to receive the nerve block with or without the added medicine. The goal was to see if the combination …

This study tested a new ultrasonic surgical system for cutting and sealing tissue during thyroid cancer surgery. It involved 136 patients who needed open or endoscopic surgery. The goal was to see if the new tool works as well as current methods.

This study tested whether using a virtual reality headset with a relaxation app could lower anxiety in people about to have their thyroid removed. 82 adults took part. Researchers measured stress levels before and after the VR session. The goal was to see if this simple, drug-fre…

This study tested whether applying a gel made of oxidized regenerated cellulose and hyaluronic acid during thyroid surgery can reduce internal scarring (adhesions) and related discomfort. 45 adults having their first thyroid surgery for goiter or cancer took part. The goal was to…

This study compared two types of thyroid surgery: one using a microscope and the standard approach. Researchers measured blood loss, nerve damage, and calcium problems in 74 patients aged 18 to 65 with thyroid cancer or other thyroid issues. The goal was to see if the microscopic…

This study looked at how the drug selpercatinib changes body composition in people with thyroid cancer. Fifteen adults on the drug had their lean body mass and daily energy use measured. The goal was to understand the drug's effects on the body, not to treat the cancer itself.

This pilot study tested a tool called CQUPLE to help 50 patients newly diagnosed with low-risk thyroid cancer make informed treatment choices. Participants were randomly assigned to receive the tool or usual care before their surgeon visit. The study measured how acceptable and f…

This study tested a digital conversation aid to help patients and doctors make shared decisions about thyroid biopsy. Researchers enrolled 107 adults with thyroid nodules to see if using the tool during clinic visits was practical. The goal was to gather information for a future …

This study looked at 49 adults having thyroid surgery to see if changing head position affects the optic nerve sheath diameter, a measure of pressure around the brain. Researchers used ultrasound to measure the nerve before and after positioning. They also checked for post-surger…

This study tested a special type of radioactive iodine (124-I) to measure how much radiation each thyroid cancer tumor receives during standard treatment with 131-I. Twenty adults with thyroid cancer that had spread were scanned to see if 124-I could predict which tumors would re…

This study looked at 314 patients with small, single thyroid cancers (1-3 cm) that had no signs of spread before surgery. Doctors planned to remove only half the thyroid, but checked lymph nodes during the operation. They found that over half of patients had cancer in those nodes…