THYROID CANCER

This study tests whether the immunotherapy drug pembrolizumab (Keytruda) can shrink or control anaplastic thyroid cancer, a rare and fast-growing cancer that has not responded to standard treatments. Twelve adults with advanced disease that cannot be cured by surgery or radiation…

This study looks at whether low-risk thyroid cancer patients need radioactive iodine treatment after having their thyroid removed. About 500 patients are being followed to see if skipping this treatment affects cancer recurrence or survival. The goal is to find out if we can safe…

This study tested the drug pembrolizumab in over 1,600 people with various advanced solid tumors that had stopped responding to standard treatments. The goal was to see if the drug could shrink or control the tumors. The trial focused on identifying which patients were most likel…

This study tests a targeted drug called regorafenib in people with a rare type of advanced thyroid cancer (medullary thyroid cancer) that has spread. The goal is to see if the drug can stop or slow cancer growth. Eight adults whose cancer worsened after prior treatments took part…

This phase 2 study tests whether adding the immunotherapy drug pembrolizumab to the chemotherapy drug docetaxel can shrink tumors in people with advanced thyroid or salivary gland cancers that are not responding to standard treatments. About 46 adults with these rare, hard-to-tre…

This study looks at whether removing only the thyroid gland works as well as also removing nearby lymph nodes in people with low-risk thyroid cancer. About 352 adults with small to medium-sized thyroid tumors will be randomly assigned to one of two surgeries. The goal is to see i…

This study tests whether a drug called PDR001, combined with either trametinib or dabrafenib, is safe and effective for people with thyroid cancer that no longer responds to standard radioactive iodine treatment. The trial enrolled 19 adults whose cancer had worsened. The main go…

This early study tests whether a laser inserted through the skin can safely destroy small thyroid cancers without surgery. Ten adults with papillary thyroid microcarcinoma (tumors 13 mm or smaller) will receive the laser treatment, then have the treated area removed six months la…

This study tests the drug vemurafenib in 24 people with advanced papillary thyroid cancer. The drug blocks a gene mutation that fuels cancer growth, aiming to shrink tumors before surgery. Researchers will measure changes in tumor size and biomarkers in blood and tissue to see ho…

This study tests an artificial intelligence (AI) system that helps doctors read thyroid ultrasound images. The goal is to see if the AI can make diagnoses more accurate and faster than traditional methods. About 2,000 adults with suspected thyroid problems will take part across 1…

This study tests a new imaging method called Cerenkov luminescence to take pictures of thyroid cancer and tumors in the neck, collarbone, armpit, or groin. About 102 adults with thyroid cancer or other cancers will receive a standard PET scan or radioactive therapy, then have thi…

This study aims to validate a new test that measures tiny molecules called microRNAs in thyroid nodule samples. The goal is to more accurately tell if a nodule is cancerous or not, especially when standard tests are unclear. Researchers will compare the test results with ultrasou…

This study looks at whether proteins found in urine can help doctors diagnose follicular thyroid cancer before surgery. Currently, the only way to confirm this cancer is by removing the thyroid and checking it under a microscope. Researchers are testing urine samples from 50 peop…

This study explores whether substances found in urine can help doctors track thyroid cancer after treatment. Researchers are measuring specific proteins in the urine of 103 patients who had their thyroid removed. The goal is to find a simple, non-invasive way to monitor the disea…

This study looks at 5000 people who had a thyroid nodule found on a PET-CT scan. It compares survival rates between those who had a follow-up thyroid ultrasound within 3 months and those who did not. The goal is to see if skipping the ultrasound leads to worse survival over 7 yea…

This study looks at how the way thyroid cancer patients prepare for a radioactive iodine scan affects breast tissue. Researchers want to see if the method of preparation changes prolactin levels and breast uptake of the scan. The study includes 39 women with thyroid cancer who ar…

This study was designed to measure the thickness of the carotid artery (a key blood vessel in the neck) in people having thyroid surgery. The goal was to see if changes in artery thickness after surgery relate to the type of thyroid disease, hormone levels, or other heart risk fa…

This study follows 107 thyroid cancer patients who need radioiodine therapy or scans. It compares two preparation methods: Thyrogen injection versus Eltroxin withdrawal. The goal is to observe differences in depression symptoms, metabolism, and other health markers. No new treatm…

This study tests whether an artificial intelligence (AI) tool can help medical students and doctors more accurately stage thyroid cancer and assess risk. About 70 participants will review patient cases, some with AI help and some without. The goal is to see if the AI assistant im…