SYSTEMIC LUPUS ERYTHEMATOSUS

This study tests a new treatment for people with lupus, scleroderma, dermatomyositis, or polymyositis. The treatment uses a patient's own immune cells, modified to find and attack faulty B cells that drive the disease. The goal is to control the disease and reduce symptoms, but o…

This study compares a newer drug, telitacicept, against the standard treatment cyclophosphamide for lung scarring caused by lupus. About 100 adults with mild-to-moderate lung involvement will receive one of the two treatments for a year. The goal is to see if telitacicept better …

This early-stage study tests a new medicine called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check if the drug is safe and how the body processes it. About 63 participants will receive either the drug or a placebo, and the …

This early-phase study tests a new treatment called CC-97540, which uses a patient's own immune cells engineered to target and destroy faulty B cells. It is for people with severe forms of lupus, myositis, scleroderma, or rheumatoid arthritis that have not responded to standard t…

This study tests whether a daily pill called upadacitinib can safely control disease activity in adults with moderate-to-severe lupus. About 1,000 participants will receive either the drug or a placebo for 52 weeks, with some continuing for up to 2 more years. The goal is to redu…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with other treatments. The goal is to see if th…

This early-stage study tests a new medicine called MK-1045 in people with lupus or rheumatoid arthritis. The main goal is to check if the drug is safe and tolerable at different doses. About 21 participants will take part to help researchers understand how the body processes the …

This study is building a large database and sample bank from 5,000 adults with rheumatic diseases like rheumatoid arthritis, lupus, and ankylosing spondylitis. Researchers will collect medical information and blood or tissue samples over time to find links between patient outcome…