SYSTEMIC LUPUS ERYTHEMATOSUS

This study tests whether regularly measuring the amount of mycophenolate mofetil in the blood helps more people with lupus kidney disease achieve kidney remission. One hundred adults with active lupus nephritis will be split into two groups: one gets standard dosing, the other ge…

This study tests a new treatment called FT819 for people with lupus that has caused moderate to severe kidney disease (lupus nephritis) and hasn't improved with standard therapies. FT819 uses specially engineered immune cells from a donor to target and calm the overactive immune …

This study compares two drugs, telitacicept and belimumab, for people with systemic lupus erythematosus (SLE) aged 18-65. It aims to see which drug better controls disease activity and kidney problems. Participants choose their treatment with their doctor, and the study tracks th…

This early-phase study tests a new drug called budoprutug in 30 adults with active lupus who haven't responded well to standard treatments. The drug targets and depletes certain immune cells (B cells) to help control the disease. The main goals are to check safety and how the bod…

This study tests whether a diet tailored to a person's genetic makeup can help control lupus and improve quality of life. Researchers will screen 100 adults with lupus for specific genes (HLA DQ2 and DQ8) and then assign those who have them to either a personalized diet plan or n…

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This early-stage study tests a new treatment called HN2302 in 12 adults with lupus or scleroderma. The therapy aims to reprogram the body's immune cells to attack faulty cells causing the disease. The main goal is to check safety, while also seeing if it reduces symptoms.

This study tests a new medicine called TQH3906 for people with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The trial will involve 198 participants and aims to see if the drug can reduce lupus symptoms better than a placebo. It is a Phase 2 study, meaning it …

This study tests a drug called anifrolumab in children aged 5 to 18 with moderate to severe lupus. The goal is to see how the drug moves through the body and if it is safe. Participants will continue their usual lupus treatments while receiving the study drug. The trial involves …

This early study tests a new treatment called CHT105 for people with lupus nephritis that hasn't improved with standard care. CHT105 uses donor immune cells engineered to find and destroy the faulty immune cells driving the disease. Fourteen adults will receive a single infusion …

This early-stage study tests an experimental treatment called P-CD19CD20-ALLO1 in 162 adults with severe lupus that hasn't improved with standard therapies. The treatment uses specially engineered immune cells to target and potentially reset the immune system. The main goals are …

This study looks at whether a 12-week aerobic exercise program can improve thinking skills and reduce disease activity in people with lupus. Researchers will test memory, attention, and walking ability before and after the program. The goal is to see if exercise can ease lupus-re…

This study will test whether virtual Reiki therapy can help reduce pain and improve quality of life for people with lupus. Twenty adults with lupus will continue their usual medical care and also receive one virtual Reiki session per week for 8 weeks. The study will measure chang…

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find unique biological markers that could …

This study aims to better understand why some people's immune cells attack their own body, causing autoimmune diseases like lupus and scleroderma. Researchers will analyze blood samples from 200 adults with these conditions to identify and measure specific harmful immune cells. T…

This study tracks how the lupus medication Saphnelo (anifrolumab) is being used in women aged 15 to 50 who could become pregnant. Researchers will analyze health records from millions of women across several countries to see how many are prescribed the drug and what their health …

This early-stage study will test the safety and tolerability of a new drug called ACT100 in 48 healthy adults. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measure how the drug moves through the body. This is the first …