SYSTEMIC LUPUS ERYTHEMATOSUS

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested a new drug called KZR-616 in 69 people with lupus, some of whom also had kidney inflammation (lupus nephritis). The goal was to check safety and see if the drug could reduce protein in the urine, a sign of kidney improvement. Participants received weekly injecti…

This early-stage study tested a drug called itolizumab (EQ001) in 52 adults with lupus, some of whom also had active kidney disease. The main goal was to check the drug's safety and how the body processes it. Researchers also looked at how the drug attaches to immune cells to bet…

This study looked at the long-term safety and effectiveness of Benlysta, a medication for systemic lupus erythematosus (SLE), in over 1,500 patients in everyday medical practice. Researchers tracked participants for 52 weeks, monitoring side effects, disease activity, and quality…

This study tested an experimental drug called nipocalimab in 228 adults with active systemic lupus erythematosus (SLE), a chronic autoimmune disease. Participants received either the drug or a placebo to see if it could reduce lupus symptoms and flares over 24 weeks. The goal was…

This study tested the drug tofacitinib in 13 young adults aged 18 to 45 with moderate to severe lupus skin disease. The goal was to see if the drug is safe and can reduce skin symptoms. Participants took the drug for up to 76 weeks, and doctors measured how well it worked using a…

This study tested an experimental pill called enpatoran in 456 adults with lupus (SLE) and related skin lupus (CLE). The goal was to see if it can reduce disease activity and improve symptoms when added to standard treatments. Participants took either enpatoran or a placebo for 2…

This study tested a drug called emapalumab in 33 children and adults with a severe immune overreaction (macrophage activation syndrome) linked to Still's disease or lupus. The goal was to see if the drug could safely calm the inflammation when high-dose steroids weren't enough. T…

This early-stage study tested a drug called telitacicept in 16 children with lupus. The goal was to see how the drug moves through the body and if it helps control the disease. While not a cure, it may offer a new way to manage lupus symptoms in young patients.

This study tested two blood thinners, rivaroxaban and warfarin, in 43 people with antiphospholipid syndrome (APS) who had a stroke. The goal was to see which drug better prevents further brain damage over 24 months. Participants took either rivaroxaban twice daily or warfarin dai…

This study tested an oral medication called GLPG3667 in 186 adults with active systemic lupus erythematosus (SLE). Participants took the drug or a placebo once daily for 48 weeks. The goal was to see if the drug could reduce lupus disease activity and improve symptoms, while moni…

This study tested a new drug, DS-7011a, in 26 adults with systemic lupus erythematosus (SLE), an autoimmune disease that causes inflammation and organ damage. The main goal was to check the drug's safety and how the body processes it. This is an early-stage trial, so it focuses o…

This study tested whether taking coenzyme Q10 (a natural supplement) along with standard lupus treatment can improve health in children with lupus. Sixty children aged 6-16 with moderate to severe lupus took either CoQ10 or a placebo for 3 months. Researchers measured changes in …

This study tested an experimental drug called cenerimod in 105 adults with active lupus. The goal was to see if it safely reduces certain immune cells in the blood, which may help control the disease. Participants continued their usual lupus medications during the trial.

This study looked at whether the drug anifrolumab, when added to standard care, can prevent long-term organ damage in adults with active systemic lupus erythematosus (SLE). Researchers compared data from 561 patients who received anifrolumab in earlier trials to similar patients …

This study tested whether a one-time infusion of stem cells from umbilical cords could help adults with severe lupus that doesn't respond to standard treatments. 81 participants received either the stem cells or a placebo, along with their usual care. The main goal was to see if …

This study tested a drug called belimumab in children aged 5 to 17 with active lupus. The goal was to see if adding belimumab to standard treatment could better control the disease and reduce symptoms over 52 weeks. A total of 93 children took part, receiving either belimumab or …

This study looked at how a lupus medicine called belimumab works in Chinese children aged 5 to 17 who had already received the IV form for 48 weeks. The goal was to check the drug levels in the blood and see if switching to a shot under the skin is safe. Sixteen children took par…

This study looked at whether adding belimumab to standard treatment is safe and works for Chinese children aged 5 to 17 with active lupus. 67 kids took part. The goal was to see if the drug could reduce disease activity and track any side effects over one year.

This study tested an experimental drug, cenerimod, in 427 adults with moderate to severe systemic lupus erythematosus (SLE). The goal was to see if cenerimod could reduce lupus disease activity over 6 months compared to a placebo. Participants took one of four doses of cenerimod …

This study looked at the long-term safety of an experimental drug called BMS-986165 in people with systemic lupus erythematosus (SLE). A total of 261 participants who had already completed an earlier lupus study were enrolled. Researchers tracked side effects, serious health even…

This study tested whether taking probiotics (beneficial bacteria) can help people with active lupus, an autoimmune disease. Forty adults with lupus took probiotics to see if it would reduce disease activity and improve their quality of life. The goal was to find a simple, safe wa…

This study tested whether hydroxychloroquine, a drug used for malaria and lupus, could prevent or slow the development of lupus in 187 people who had early signs but not full-blown disease. Participants received either the drug or a placebo, and researchers tracked how many progr…

This study looked at whether qi gong, a gentle practice of movement and breathing, can help people with systemic lupus erythematosus (SLE) feel better day-to-day. Thirty-three adults with lupus took part in qi gong classes for three months. Researchers measured changes in quality…

This study tested a drug called JBT-101 (lenabasum) in 109 adults with lupus who had joint pain. The goal was to see if it could reduce pain better than a placebo over 84 days. Participants took the drug by mouth and reported their daily pain levels. The trial is complete, and re…

This study tested a non-invasive device that stimulates the vagus nerve through the ear to see if it can reduce fatigue in people with lupus. 75 participants received either active or sham stimulation over two phases. The main goal was to measure changes in fatigue using a standa…

This study tested a program to help African American adults with lupus manage stress. Thirty participants learned stress-reduction techniques and had their stress levels and quality of life measured. The goal was to see if the program could lower stress and improve well-being.

This early-stage study tested the safety of a new drug called SHR-2173 in 30 adults with systemic lupus erythematosus (SLE). Participants received multiple injections under the skin to see if the drug is safe and how the body processes it. The goal is to eventually help control l…

This study looked at over 107,000 people in Germany to understand the long-term side effects of steroid medications (glucocorticoids) used for conditions like asthma, arthritis, and lupus. Researchers compared those who took steroids with those who did not, tracking problems like…

This study looked at how lupus changes the way the body adapts to exercise. Researchers wanted to understand if certain immune signals make it harder for people with lupus to get fit. 55 adults with lupus took part in a 12-week exercise program to measure changes in heart and lun…

This study looked at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other doesn't. Researchers compared their blood cells, genes, and environmental exposures to find clues about why one got sick. Over 1,000 people took part, includ…

This study followed over 3,000 adults with active lupus for up to 5 years to see how safe and effective Benlysta (belimumab) is compared to standard care alone. Researchers tracked serious side effects like infections, cancer, and psychiatric events. The goal was to gather real-w…

This study looked at how lupus affects breathing, daily activity, and tiredness. Researchers compared 50 people with lupus to healthy volunteers using breathing tests, a 6-minute walk, and questionnaires. The goal was to find early signs of lung problems so doctors can treat them…

This study looked at 621 adults with moderate to severe lupus to see how active their disease was during doctor visits. Researchers collected information from past and current medical records to measure disease activity using a standard scoring tool. The goal was to better unders…

This study explored why some women with rheumatoid arthritis feel better during pregnancy while those with lupus may get worse. Researchers looked at tiny molecules called microRNAs in blood, urine, and placenta from 50 pregnant women. The goal was to find new biomarkers to predi…

This study looked at B cells (a type of immune cell) from 30 people with non-active lupus and compared them to B cells from healthy volunteers. The goal was to find genetic differences that might explain lupus even when symptoms are quiet. No treatment was given—only blood sample…

This study looked at how faithfully people with active lupus take their medication, especially hydroxychloroquine. Researchers measured drug levels in the blood of 307 patients across multiple countries. The goal was to understand how common it is for patients to skip doses, whic…

This study tested whether a short training for rheumatologists could help them provide more equitable care to Black/African American and lower-income patients. Over 200 patients and their doctors took part. The training focused on seeing each patient as an individual rather than …

This study looked at whether a nurse-led care management program could help high-risk lupus patients get better outpatient care and avoid unnecessary emergency room visits and hospital stays. Researchers worked with 35 adults who had lupus and had recently missed appointments or …

This study looked at tiny particles in the blood and urine of 208 people with lupus or scleroderma. Researchers measured changes in these particles over 12 months to see if they could help predict disease activity or lead to new treatments. The goal was to better understand these…

This study looked at 193 people with lupus nephritis (kidney inflammation caused by lupus) in five Gulf countries. Researchers collected information on their symptoms, treatments, and quality of life, but did not test any new medicine. The goal was to better understand the diseas…

This study looked at putting a shared decision-making tool into practice for people with lupus. The tool is a computer program that helps patients and doctors make treatment decisions together. Researchers tracked how many eligible patients used the tool and asked clinic staff if…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This completed study looked at information from 1,000 people with lupus to understand the challenges they face and where doctors may be missing the mark. Researchers reviewed existing data, talked with specialists, and built agreement on how to improve patient care and use new to…