Sibling rivalry: scientists hunt for clues in rheumatic disease mystery

NCT ID NCT00055055

First seen Nov 01, 2025 · Last updated Jun 16, 2026 · Updated 36 times

Summary

This study looked at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other doesn't. Researchers compared their blood cells, genes, and environmental exposures to find clues about why one got sick. Over 1,000 people took part, including siblings, twins, and healthy volunteers.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • NIEHS Clinical Research Unit (CRU)

    Research Triangle Park, North Carolina, United States

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • University of Wisconsin

    Madison, Wisconsin, 53792, United States

Conditions

Explore the condition pages connected to this study.