METASTATIC MALIGNANT SOLID NEOPLASM

This early-phase study is testing a new type of cell therapy for people with advanced solid tumors, including melanoma, that have spread and are not responding to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack c…

This early-stage trial aims to find a safe and effective dose of a new drug, ZEN003694, when given with the standard chemotherapy capecitabine. It is for adults with advanced solid tumors (like colorectal cancer) that have spread or cannot be removed by surgery and have worsened …

This study aims to find out which type of focused radiation therapy works better for patients with cancer that has spread to the brain. It compares a single, high-dose treatment to a series of smaller doses spread out over time. Researchers want to see which method better control…

This study is testing whether the chemotherapy drug pemetrexed works better for people with advanced cancers that have spread and carry specific genetic mutations. It will enroll 64 adults with metastatic bladder cancer or other solid tumors who have already tried other treatment…

This early-stage trial is testing three different drug combinations to find safe doses and see if they can help control advanced solid tumors that have spread. The study will enroll about 111 adults with specific genetic features in their cancer. Researchers aim to see if combini…

This early-phase study aims to find a safe and tolerable dose of a new drug combination for people with advanced breast cancer and other solid tumors that have a protein called HER2. The trial will test pidnarulex, which aims to stop tumor cell growth, together with an existing t…

This is a first-in-human study testing a new, personalized cell therapy for people with advanced solid tumors that have spread and contain a specific genetic change called KRAS G12V. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to recogniz…

This study is testing whether a combination of two oral drugs, ZEN-3694 and talazoparib, can shrink or stop the growth of advanced solid tumors that have specific genetic features. It aims to enroll 88 adults whose cancer has progressed despite prior treatments. A key goal is to …

This early-stage study is testing the safety of a personalized vaccine designed to train a patient's immune system to attack their specific cancer. It is for adults with advanced breast cancer, melanoma, or non-small cell lung cancer that has continued to grow despite standard tr…

This is the first human study of a new chemotherapy drug called TR-002. It aims to find the safest dose and understand side effects for people with advanced solid tumors, including pancreatic cancer, that have stopped responding to standard treatments. The study will enroll 52 pa…

This study is testing whether combining three different cancer drugs is safe and effective for treating advanced solid tumors that have spread or returned after standard treatments. The three drugs work in different ways: one helps the immune system attack cancer, one blocks tumo…

This study is testing a new three-part treatment for patients with advanced cancer that has spread to the lungs or liver. The goal is to see if a drug called NBTXR3, which is injected directly into a tumor, makes cancer cells more sensitive to radiation. Patients also receive an …

This study is testing whether a pill called larotrectinib can help control advanced solid tumors that have a specific genetic feature (NTRK gene amplification). The trial is for patients aged 16 and older whose cancer has spread and who have already tried standard treatments. Res…

This trial is a large screening program that matches patients with advanced solid tumors to one of many smaller treatment studies. It uses genetic testing on a patient's tumor to find specific mutations. Patients are then assigned to a drug combination designed to target those mu…

This study is testing if giving radiation therapy to high-risk, painless bone metastases can prevent serious bone complications like fractures or spinal cord compression. It will compare adding radiation to the usual care (like bone-strengthening drugs) in 280 cancer patients who…

This study aims to find the best radiation method for treating cancer that has spread to the brain. It compares giving one large radiation dose versus spreading the same total radiation over three smaller treatments. Researchers want to see which approach better controls the brai…

This early study is testing whether giving patients the amino acid arginine alongside standard whole-brain radiation therapy is safe and might make the radiation work better against cancer that has spread to the brain. Researchers are comparing whether taking arginine by mouth or…

This early-stage study aims to find the safest dose of two oral drugs—ZEN003694 and abemaciclib—when given together to patients with advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 45 adults and teens (12+) with specific cancers, inc…

This early-stage study is testing a new combination of two drugs, DS-8201a and olaparib, for people with advanced cancers that have a protein called HER2. The main goal is to find the safest and most effective dose. Researchers will also check if the treatment helps shrink or con…

This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific mutations in genes that help repair DNA damage. It is enrolling 36 adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, an…

This early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced solid tumors that have a specific marker called HER2. The treatment pairs an existing targeted cancer drug with a new pill that aims to block cancer cells' ability to…

This study is testing whether adding an immunotherapy drug called durvalumab to standard chemotherapy is safe and can help the immune system better fight cancer. It is for adults with advanced solid tumors that have spread or cannot be removed by surgery. Researchers will monitor…

This early-stage trial is testing a new drug called CBX-12 in patients with advanced solid tumors that have spread to other parts of the body. The drug works by damaging cancer cell DNA to kill tumors. Researchers will study how the drug affects cancer cells, measure tumor respon…

This study is testing if targeted radiation can help control cancer that has spread and started growing again after treatment with immunotherapy drugs. It will involve about 230 adults with metastatic solid tumors or blood cancers. Researchers aim to see if this 'salvage' radiati…

This early-stage study is testing the safety of a new, minimally invasive procedure called PIPAC. It delivers chemotherapy as a fine mist directly into the abdomen for people with advanced ovarian, uterine, stomach, colon, or appendix cancers that have spread to the abdominal lin…

This is an early safety study testing a drug called novobiocin in people with advanced solid tumors that have specific mutations affecting DNA repair. The main goal is to find the safest dose and understand the side effects. Researchers hope the drug will block a cancer cell's ba…

This early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced cancers that have a specific marker called HER2. The trial focuses on stomach and gastroesophageal junction cancers that have spread or cannot be removed by surgery, …

This study is testing an oral medication called avapritinib for people with advanced solid tumors that have spread and have specific genetic changes (mutations in the CKIT or PDGFRA genes). The drug aims to block the signals that help these tumor cells grow, potentially controlli…

This is an early-stage study testing a new oral drug called pidnarulex in patients with advanced solid tumors that have spread. The main goals are to see how safe the drug is, find the right dose, and understand how it affects cancer cells. Researchers will also check if the drug…

This study is testing if adding a second drug (panitumumab) to a targeted cancer pill (sotorasib) works better than the pill alone for patients with advanced solid tumors that have a specific KRAS G12C mutation. It is for people whose cancer has spread and who have already tried …

This study is testing a new, personalized vaccine designed to target the unique proteins on a patient's own cancer cells. It is being given alongside an existing immunotherapy drug (pembrolizumab) to see if the combination is safe and can help control advanced solid tumors that h…

This early-stage trial is testing a new combination of two oral drugs, peposertib and tuvusertib, in adults with advanced solid tumors that have spread and stopped responding to standard treatments. The main goals are to find the safest and most effective dose of the drug pair an…

This is an early safety study for a new drug called TAK-243 in adults with advanced solid tumors or lymphoma. The main goal is to find the safest dose and understand the side effects. Researchers will give the drug to about 95 patients and closely monitor how their bodies handle …

This is the first study in people testing a new oral drug called MTI-301 for advanced solid cancers that have spread or cannot be removed by surgery. The main goal is to find the highest safe dose and understand the drug's side effects in 42 patients whose cancers have not respon…

This study aims to see if matching patients to one of three targeted cancer drugs works better for treating advanced solid tumors. It will enroll 500 adults whose cancer has spread and who have specific proteins (Trop-2, nectin-4, or HER2) in their tumor. Patients will first be s…

This early-phase trial is testing a new combination of two drugs, temozolomide and M1774, for people with advanced cancers that have spread. The main goals are to find the safest and most effective dose and to see if the combination can shrink or stabilize tumors, especially in a…

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…

This study is testing a new support program for parents who have advanced cancer that has spread or returned. The program provides education and video sessions to help parents manage stress, talk to their children about cancer, and improve family wellbeing. It is for patients wit…

This study is testing a new, single-dose radiation treatment for people with painful cancer that has spread to their bones. The new method, called biology-guided radiation therapy (BgRT), uses a PET scan signal to guide the radiation beam in real-time to the most active parts of …

This study collects leftover tissue and blood samples from cancer patients during their normal medical procedures. The samples are stored and used to create living cancer models in the lab. These models help scientists better understand cancer and test potential new drugs, but pa…

This early-phase study is testing a new type of PET scan to see if it can detect changes in the body's cancer-fighting immune cells after radiation therapy. It will enroll about 10 adults with metastatic solid tumors or lymphoma who are scheduled to receive a precise form of radi…

This study aims to understand why some patients with advanced cancers like melanoma and lung cancer respond well to a common immunotherapy (anti-PD-1), while others do not. Researchers will collect blood samples from 500 patients to measure specific markers in immune cells during…

This study aims to collect tumor tissue samples from patients with various cancers to test a new diagnostic platform called Elephas. The goal is to see how accurately this tool can predict whether patients will respond to immunotherapy treatments before they begin. Researchers wi…