METASTATIC MALIGNANT SOLID NEOPLASM

This early-phase trial tested a combination of two drugs, sapanisertib and ziv-aflibercept, in 83 adults with advanced solid tumors that had spread or could not be removed by surgery. The main goal was to find the safest dose and identify side effects. The approach aims to slow t…

This early-stage trial tested a new drug (AZD8186) combined with chemotherapy (docetaxel) in 23 people with advanced solid tumors that have certain gene mutations (PTEN or PIK3CB). The main goals were to find the best dose and check for side effects. The study was completed, but …

This early-stage trial tested a new drug called ALRN-6924 combined with the chemotherapy paclitaxel in 28 adults with advanced solid tumors that had spread or couldn't be removed by surgery, including a type of breast cancer. The main goal was to find the safest dose and check fo…

This study tested an oral drug called infigratinib in 17 adults with advanced or metastatic solid tumors that have specific FGFR gene mutations. The goal was to see if the drug could shrink or control the cancer by blocking overactive FGFR proteins. While not a cure, the treatmen…

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and have spread or cannot be removed by surgery. The main goal was to find the safest dose and underst…

This study tested a combination of three immunotherapy drugs (ipilimumab, nivolumab, and BMS-986156) with or without precise radiation therapy in 51 adults with advanced solid tumors that had spread to the lung, chest, or liver. The goal was to find the safest dose of BMS-986156 …

This study tested whether a pharmaceutical-grade psilocybin (from magic mushrooms) given in a group therapy setting is safe and can reduce anxiety and depression in people with metastatic cancer. 55 participants received the drug during a therapy session. The main goal was to see…

This study looked at whether a second psilocybin-assisted group therapy session is safe and helpful for people with metastatic cancer who still had anxiety after their first retreat. Fifteen participants who had a partial response to the first retreat took part. The goal was to s…

This study tested a program called PLAN to help Latino adults with advanced cancer understand and discuss their future medical care. Twenty-seven people took part to see if the program was helpful and easy to use. The goal was to improve knowledge and communication about advance …

This study tested a new website designed to help people with advanced cancer plan for end-of-life care, including medical wishes, legal documents, and financial tasks. About 100 patients took part to see if the tool made planning easier and reduced distress. The goal was to learn…