Can an amino acid boost brain radiation?

NCT ID NCT06328686

Recruiting now Symptom relief Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This early-phase trial tests whether giving the amino acid arginine alongside whole brain radiation is safe and how best to give it (by mouth or IV). Ten adults with cancer that has spread to the brain will receive arginine daily during their 10-day radiation course. The goal is to find the dose that gets the most arginine into the blood, which may help the radiation work better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Arginine (an amino acid supplement)
What this could lead to: If it works, this could point toward a way to make radiation therapy more effective for brain metastases.
What could go wrong: This is a very early, small trial with only 10 participants. It is testing safety and dosing, not yet whether it actually helps. The results may not lead to a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm metastatic malignant neoplasm in the brain Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC MALIGNANT NEOPLASM IN THE BRAIN METASTATIC MALIGNANT SOLID NEOPLASM

Contacts and locations

Locations

Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States

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