Vasculitis

This study followed 591 adults with eosinophilic granulomatosis with polyangiitis (EGPA) across Europe to see how well mepolizumab 300mg every 4 weeks works over the long term in everyday medical practice. Researchers looked at disease control, lung function, and safety by review…

This trial tests whether a special catheter protector, called I.V. House UltraDressing, can help peripheral IV catheters stay in place longer and cause fewer complications in adult cancer patients. Participants are randomly assigned to receive either the standard transparent dres…

This study looked at 159 people with granulomatosis with polyangiitis (GPA), a rare disease that causes inflammation of blood vessels. Participants were randomly assigned to either stay on a low 5 mg daily dose of prednisone or slowly stop it over six months. The goal was to see …

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This study tested whether adding rituximab to standard steroid treatment helps adults with IgA vasculitis (a disease causing inflamed blood vessels) achieve remission without needing steroids long-term. 75 participants with new or relapsing disease were randomly assigned to recei…

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This study tested a special bandage (dressing) that contains a germ-killing ingredient called chlorhexidine for IV tubes placed in the arm. The goal was to see if it reduces infections and other complications compared to the standard bandage. About 300 patients in Australia and F…

This study tested whether the drug rituximab, given with steroids, works better than steroids alone for people with a rare disease called microscopic polyangiitis that inflames small blood vessels. Only 8 patients took part, and the goal was to see if the combination could preven…

This study looked at whether adding a steroid called prednisolone to the usual treatment (immunoglobulin and aspirin) could reduce heart artery damage in children with Kawasaki disease. Over 3,200 children took part. The goal was to see if the combination therapy lowers the chanc…

This study tested a drug called interleukin-2 (IL-2) in 10 people with hepatitis C-related vasculitis that did not get better with usual treatments. The goal was to see if IL-2 could boost the body's immune regulation and control the disease. Participants received IL-2 injections…

This phase 3 trial tested secukinumab, a biologic drug, in 354 people with giant cell arteritis (GCA), a condition causing inflamed arteries. Participants received either secukinumab or a placebo, along with a steroid taper. The goal was to see if secukinumab could help more peop…

This completed study tested the drug upadacitinib in 12 people with refractory Takayasu arteritis, a rare autoimmune disease that inflames the body's largest artery. The goal was to see if the drug could help patients who haven't responded to standard treatments achieve remission…

This study looked at how an intravenous (IV) form of secukinumab is processed by the body and whether it is safe for adults with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). These conditions cause inflammation in blood vessels or muscles, leading to pain and stiffn…

This study tested the drug secukinumab (Cosentyx) in 151 adults with newly diagnosed giant cell arteritis, a condition causing inflamed blood vessels. Participants were in remission and received either secukinumab or a placebo, along with a steroid taper. The goal was to see if s…

This study tested the drug upadacitinib (RINVOQ) in 429 people with giant cell arteritis, a condition causing inflamed blood vessels. Participants took the drug or a placebo along with steroids. The goal was to see if upadacitinib helps achieve remission faster and with less ster…

This early-phase study tested a combination of atorvastatin and anakinra in 5 children with Kawasaki disease who had coronary artery abnormalities. The goal was to see if these drugs could safely reduce artery inflammation and prevent future heart problems. The study focused on s…

This study followed about 300 people with EGPA (a rare disease causing inflammation in blood vessels) who were treated with Nucala injections for up to 2 years. Researchers monitored side effects, how well the drug controlled symptoms, and how long it took for the disease to flar…

This completed study looked at the safety and effectiveness of FASENRA (benralizumab) in 51 Korean adults with severe eosinophilic asthma or eosinophilic granulomatosis with polyangiitis (EGPA). Researchers tracked side effects and how well the drug controlled symptoms during rou…

This early study looked at a new drug, MT-2990, in 5 people with ANCA-associated vasculitis, a rare disease where the immune system attacks blood vessels. The goal was to see if the drug is safe and how it affects disease activity. Researchers measured changes in symptoms, imagin…

This study tested whether the drug rituximab can help people with a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA) achieve remission better than standard treatments. 107 adults with active EGPA were randomly assigned to receive either rituximab or conven…

This study tested a drug called TA-650 in 31 children with Kawasaki disease whose fever did not go away after standard IVIG treatment. The goal was to see if TA-650 could bring down the fever faster and prevent damage to heart arteries compared to another immunoglobulin treatment…

This study tested a device called the JETi system to remove blood clots from veins or arteries in the arms or legs. It included 12 adults of Asian descent in Hong Kong. The goal was to see how well the device cleared clots and if it caused serious side effects like bleeding or re…

This study looked at 201 Canadian patients with ANCA-associated vasculitis to see if cheaper biosimilar versions of rituximab work as well as the original drug. Researchers compared disease control, side effects, and how long it took to get insurance approval for treatment. The g…

This study tested whether rosuvastatin, a common cholesterol-lowering drug, could reduce early signs of artery hardening in 121 people with ANCA-associated vasculitis. Participants were in remission and received either rosuvastatin or a placebo for up to 2 years. The goal was to …

This study tested whether giving a stronger pneumococcal vaccine schedule (either two doses close together or a single larger dose) followed by a standard booster could improve immune protection in 96 adults with ANCA-associated vasculitis who are also receiving rituximab therapy…

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This study tested whether rituximab (given as an infusion every 6 months) is better than azathioprine (daily pills) at keeping eosinophilic granulomatosis with polyangiitis (EGPA) in remission. 98 adults with newly diagnosed or relapsing EGPA who had already achieved remission to…

This study tested whether rituximab, a targeted antibody therapy, is better than azathioprine, a standard immune-suppressing drug, at preventing relapses in people with ANCA-associated vasculitis. 117 patients who had achieved remission were randomly assigned to receive either ri…

This study looked at whether giving rituximab for 46 months instead of the usual 18 months can better prevent relapses of ANCA-associated vasculitis, a rare autoimmune disease that causes blood vessel inflammation. 97 patients who were already in remission after initial rituximab…

This small pilot study looked at whether the drug pirfenidone is safe and effective for people with a specific type of lung scarring (pulmonary fibrosis) linked to MPO antibodies or vasculitis. Seven adults took the drug for a year, and researchers measured changes in lung functi…

This study tests a daily pill called ALK-001, a modified form of vitamin A, to see if it can slow the growth of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 300 people with the condition took either the drug or a place…

This study tested whether adding azathioprine to standard corticosteroid treatment helps people with certain types of vasculitis (blood vessel inflammation) achieve remission and avoid relapses. 114 newly diagnosed patients without poor prognosis factors took part. The goal was t…

This completed study observed over 1,000 people with psoriasis who were prescribed OTEZLA (apremilast) for the first time. Researchers tracked side effects, symptom improvement, and quality of life over several years. The goal was to see how well the drug works in real-world sett…

This study tested two ways of giving rituximab to people with ANCA-associated vasculitis, a rare disease where the immune system attacks blood vessels. All 166 participants were in remission and received rituximab either on a fixed schedule or only when certain blood markers (ANC…

This study tested whether chewing gum can help doctors diagnose giant cell arteritis (Horton's disease), a condition where blood vessels become inflamed. The idea is that chewing may trigger jaw pain in people with the disease, making it easier to spot. Researchers compared resul…

This study looked at whether a PET/CT scan of the head arteries can accurately diagnose giant cell arteritis, a type of blood vessel inflammation. Researchers compared the scan results to those from ultrasound and MRI in 70 patients suspected of having the condition. The goal was…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage eight common conditions (like pneumonia, kidney stones, and pregnancy issues) without needing extra tests. Over 160 patients took part, and researchers compared …

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

Giant cell arteritis (GCA) causes inflamed arteries and can lead to blindness if not treated quickly. This study tested a new digital PET/CT scan that can see tiny arteries in the head, which older scans missed. 92 patients with suspected GCA got both a PET/CT and an ultrasound. …

This study tested a care bundle—a set of steps including nurse training, hand washing, and special cleaning solutions—to prevent IV-related problems like swelling and vein inflammation in children. Researchers compared 200 kids in the emergency department who either got the care …

This study tests a special adhesive patch made with zinc oxide to hold catheters (thin tubes placed in veins) in place for hospitalized adults. The goal is to see if it reduces complications like the catheter moving, skin irritation, vein swelling, and pain. About 400 patients wh…

Researchers are testing whether applying ice around an intravenous catheter before an oxacillin injection can lower pain and reduce peripheral phlebitis, an inflammation of the vein. The trial enrolls 86 hospitalized adults aged 20 to 60 who receive oxacillin through a hand vein.…

This study tested whether listening to music during wound dressing changes can reduce pain in people with severe arteritis (stage 5 or 6). Twenty-five patients were asked to listen to music during their daily wound care. The main goal was to see if pain levels were lower on a 0-1…

This study looked at 52 adults with EGPA (a rare inflammatory disease) and severe chronic sinusitis with nasal polyps. They received mepolizumab 300 mg every 4 weeks. The goal was to see if the drug reduces polyp size and improves symptoms like nasal congestion and sense of smell…

This study tested whether a low dose (4.5 mg) of naltrexone, a drug already used for alcoholism, can improve physical health and quality of life in people with vasculitis. Sixty participants took either the drug or a placebo daily for six weeks. The goal was to see if the drug le…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This trial tests whether rituximab, a drug used for ANCA-associated vasculitis, leaves patients with a weakened immune system. Researchers give pneumococcal vaccines to patients treated with rituximab, patients with the disease but not on rituximab, and healthy volunteers. They c…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This study explores whether a special type of PET/CT scan, using a radioactive tracer called 18F-FDG, can accurately measure disease activity in people with granulomatosis with polyangiitis (GPA), a rare condition that causes inflammation of blood vessels. Researchers will compar…

This study uses French national health data to compare the risk of major heart problems—like heart attack, stroke, and death—in people with Takayasu arteritis versus similar people without the disease. It also looks at how steroid use may affect these risks. The goal is to better…

This completed study reviewed the medical records of 210 people with aortitis (inflammation of the aorta) or retroperitoneal fibrosis (scar tissue in the abdomen). The goal was to find patterns in symptoms, lab tests, and imaging that could help doctors tell different types of th…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This observational study followed 198 adults aged 50–85 with giant cell arteritis or polymyalgia rheumatica to understand how common treatments (glucocorticoids and interleukin-6 inhibitors) affect diabetes risk. Researchers tracked blood sugar levels and other markers over time.…

This study looked at 366 women having their first planned cesarean section to see if closing the uterine incision with one layer of stitches or two layers affects the chance of developing a uterine niche (a small pocket in the scar). Participants were asked about symptoms like sp…

This study looked at the heart health of 61 children who had Kawasaki disease 5 years earlier and were treated with IVIG. Researchers compared them to healthy children using blood tests, blood pressure, artery stiffness, and heart imaging. The goal was to find early signs of hear…

This study looked at immune cells from 138 people with Wegener's granulomatosis, a rare disease causing inflammation of blood vessels. Researchers measured levels of a protein called DAP12 in different immune cells to understand how the disease works. No new treatment was tested;…

This study explores the experiences of 20 intensive care nurses in managing phlebitis, a painful vein inflammation often caused by IV lines. Through face-to-face interviews, researchers aim to uncover common challenges and helpful strategies. The goal is to improve prevention and…

This study looked at whether a type of immune cell called T CD8 plays a role in Horton's disease, a condition that causes inflammation in blood vessels. Researchers took extra blood samples and performed standard tests on 30 newly diagnosed patients to measure these immune cells.…

This study looked at over 1,600 people with giant cell arteritis, a condition that inflames blood vessels and raises heart risks. Researchers compared tocilizumab and methotrexate to see which better prevents heart attacks, strokes, or death. Using French health data, they analyz…

This study compared two types of IV catheters—closed and open—in 100 patients in a respiratory intensive care unit. The goal was to see which type stays functional longer without complications like thrombophlebitis. Researchers measured dwell time and catheter-related issues to f…

This study looked at blood samples from 41 people with giant cell arteritis (Horton's disease), a condition that causes inflammation in blood vessels. Researchers examined specific immune cells called regulatory T cells to see if they are defective in this disease. The goal is to…

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This study compares two blood-filtering techniques—plasma exchange and immunoadsorption—in 40 patients with severe kidney failure caused by ANCA vasculitis or Goodpasture disease. The goal is to see which method removes disease-causing antibodies more quickly. Results may help do…

This study tested a decision-support tool called DOACT that helps doctors choose the right blood thinner for patients with blood clots in veins or lungs. Researchers compared how well the tool performed against artificial intelligence models and doctors' own judgment. The goal wa…

This study observed 66 children diagnosed with rheumatoid purpura in three French hospital emergency rooms. Researchers tracked how well doctors followed official care guidelines and surveyed family doctors about their knowledge of the condition. The goal was to identify obstacle…

This study examined blood samples from 100 children with Henoch Schönlein Purpura (HSP) and a control group to see if regulatory T cells (Tregs) are missing or not working properly. The goal was to learn more about the disease, not to test a new treatment. Researchers measured Tr…

This study looked at over 550,000 people who received Eylea® injections for eye conditions to find out how often retinal vasculitis (a rare eye inflammation) occurs. Researchers used a large US registry and medical records to confirm cases. The goal was to better understand the s…

This completed study analyzed data from nearly 290,000 patients who received aflibercept (Eylea) injections for various retinal diseases. The goal was to estimate how often retinal vasculitis (inflammation of blood vessels in the eye) occurs in real-world clinical practice. Resea…

This study tests two new monitoring techniques—long loop reflexes (F-waves) and near-infrared spectroscopy (NIRS)—to detect spinal cord ischemia early after thoracoabdominal aortic aneurysm repair. Current methods work during surgery but are too painful for awake patients afterwa…

This study looked at how certain immune cells, called neutrophils, behave in people with granulomatosis with polyangiitis (GPA), a rare blood vessel inflammation disease. Researchers collected blood samples from 93 participants, including patients with GPA and other related condi…

This study looked at 78 people with Takayasu arteritis, a rare disease that causes narrowing of the main artery from the heart. Researchers compared those who had surgery or a procedure to open the artery with those who got only medication. The goal was to see which group lived l…