Boosting defenses: can extra vaccine doses protect vulnerable patients?

NCT ID NCT03069703

Summary

This study tested whether giving stronger or extra doses of pneumonia vaccines could better protect patients with a rare autoimmune disease (ANCA-associated vasculitis) who are taking a drug called rituximab. Rituximab weakens the immune system, making these patients more prone to severe infections. Researchers compared the standard two-shot vaccine schedule against two more intense schedules to see which one triggered a better protective immune response and was safe.

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Contacts and locations

Locations

  • Pôle de Médecine Interne, Centre de référence " Maladies systémiques et autoimmunes rares, en particulier Vascularites nécrosantes et Sclérodermies systémiques " Hôpital Cochin, Assistance Publique-Hôpitaux de Paris

    Paris, Paris, 75014, France

Conditions

Explore the condition pages connected to this study.