Essential hypertension

This study looks at whether the medication Entresto (sacubitril/valsartan) helps Japanese patients with essential hypertension achieve blood pressure targets recommended by Japanese guidelines. Researchers will analyze electronic medical records from a large database, focusing on…

This study tests a program where people with slightly high blood pressure use a home monitor and get support from a community health worker. The goal is to see if this helps keep blood pressure from rising to dangerous levels. About 600 adults from 20 health centers are taking pa…

This study tested a generic version of the blood pressure drug nifedipine against the brand-name version in 50 adults with mild-to-moderate high blood pressure in Colombia. The goal was to see if the generic pill controls blood pressure just as well after 8 weeks. Participants ha…

This clinical trial is testing whether two experimental oral medications, AD-224A and AD-224B, can safely lower blood pressure in people with essential hypertension (high blood pressure with no known cause). About 254 participants will take one of the drugs or a placebo once dail…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This trial tests whether a six-session behavioral program that combines standard hypertension self-management with climate change awareness and heatwave preparedness can improve quality of life, reduce psychological distress, and lower blood pressure in adults with high blood pre…

This study tests whether teaching people with high blood pressure about the Mediterranean diet can help lower their blood pressure and improve their quality of life. About 70 adults with hypertension will either receive diet education or standard care, and their progress is track…

This study tests whether an artificial intelligence system called optima4BP can improve blood pressure control in people with hypertension. The AI analyzes a patient's medications and recommends the best drug adjustments—adding, removing, replacing, or changing doses. Researchers…

This pilot study explores whether an eight-week mindfulness course or a short guided forest bathing program can lower stress and blood pressure in women over 60 who are already taking medication for hypertension. Sixty women are split into three groups: one learns mindfulness, on…

This study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…

This study tests whether helping people who sleep less than 6.5 hours per night extend their sleep can lower their blood pressure. Researchers will compare an 8-week sleep coaching program to general health education in 110 adults with prehypertension or mild hypertension. The ma…

This phase 3 trial tests whether adding Sacubitril/Allisartan to amlodipine can lower blood pressure more effectively than amlodipine alone in people with essential hypertension. Participants are adults aged 18–75 whose blood pressure remains high despite taking amlodipine. The s…

This phase 3 trial tests whether adding amlodipine to Sacubitril/Allisartan can lower blood pressure more effectively than Sacubitril/Allisartan alone in people with essential hypertension. Participants whose blood pressure remains high after four weeks on Sacubitril/Allisartan a…

This phase 2 trial tests whether a new combination pill, QR12000, can lower blood pressure more effectively than existing medications in people with moderate to severe essential hypertension. Participants are randomly assigned to receive either QR12000, one of its components, or …

This study tests whether a new generic tablet containing selexipag works the same as the brand-name drug Uptravi. Healthy adults aged 18 to 55 take a single dose of each version under fed conditions, and researchers compare how much drug gets into the bloodstream. The goal is to …

This study tests whether community health workers (CHWs) who screen patients for social needs like food, housing, or transportation and connect them to resources can improve blood sugar and blood pressure control. About 3,120 adults with uncontrolled diabetes or hypertension from…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This early-stage study tested a new drug called QCZ484 in 56 healthy volunteers and people with mild hypertension. The main goal was to check safety and how the body handles the drug. Participants received a single injection of either QCZ484 or a placebo, and researchers monitore…

This clinical trial is testing a new medication called HGP2102 for people with essential hypertension, or high blood pressure. The study compares HGP2102 to a control drug to see how well it lowers blood pressure over a full 24-hour period. Participants are adults with high blood…

This study tested whether lowering blood pressure more aggressively than standard care reduces the risk of rupture or growth of unruptured brain aneurysms. 577 Chinese adults with small, unruptured aneurysms and high blood pressure were randomly assigned to keep their blood press…

This trial tests a special pacemaker called the BackBeat Moderato that can adjust its pacing to help control high blood pressure. Researchers will turn the device on and off for short periods in 28 people who already have the pacemaker implanted, measuring how their blood pressur…

This phase 3 study tests whether the drug AGSAVI can lower blood pressure in people with essential hypertension that is not well controlled by the drug AGLS. About 318 adults with high blood pressure will receive either AGSAVI or AGLS, and their sitting blood pressure will be mea…

This study tested a new drug called BAY3283142 in 75 people with mild to moderate high blood pressure. The drug is designed to relax blood vessels and is being developed for chronic kidney disease. Participants took different doses or a placebo for up to 10 weeks to check for saf…

This completed Phase 3 trial tested whether a single pill combining ezetimibe, rosuvastatin, and amlodipine can safely lower both cholesterol and blood pressure in 163 Korean adults with hypertension and high cholesterol. Participants took the combination pill or a control for 8 …

This Phase 3 trial tested whether adding a second drug (DWC202314) to an existing one (DWC202404) helps people whose high blood pressure isn't controlled by the first drug alone. 192 adults with essential hypertension took part. The study is now complete, and results will show if…

This study tested a comprehensive intelligent system (CHESS) to help manage high blood pressure in primary care clinics. Over 1,600 people took part, and the system aimed to lower blood pressure over 12 months. The approach used technology to support doctors and patients in bette…

This study tested a remote telehome monitoring program for 100 people with high blood pressure who receive virtual care. Participants used a special blood pressure cuff and a monitoring platform to share readings with their doctors. The goal was to see if this approach improves b…

This study tested an experimental drug called zilebesiran in 36 Japanese adults with mild to moderate high blood pressure. The goal was to see if it is safe and helps lower blood pressure over 6 months. Participants received either the drug or a placebo, and researchers monitored…

This study looked at whether omega-3 supplements from plants can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured artery …

This study tested whether a smartphone app and home blood pressure monitor could help doctors personalize the dose of the blood pressure drug Zestril for each patient without needing in-person visits. Twenty adults with uncomplicated high blood pressure participated. The goal was…

This Phase 3 trial tested whether adding a third drug (DWC202314) to a two-drug combination pill works better for people with essential hypertension that isn't controlled by the two-drug pill alone. 198 participants took either the two-drug or three-drug combination once daily. T…

This study tested whether adding lower leg heat therapy (soaking legs in warm water) to a standard blood pressure pill helps older women with high blood pressure more than the pill alone. 134 women aged 60-85 participated, either soaking in 42°C water or neutral 33°C water for 8 …

This completed trial tested a new, noninvasive device that uses focused ultrasound to destroy a small amount of fat around the kidney. The goal was to lower blood pressure in people with mild hypertension who were not taking medication. 79 participants were randomly assigned to r…

This study looked at whether adding paced or diaphragmatic breathing to mat Pilates can improve heart and lung fitness, reduce shortness of breath, lower stress and anxiety, and boost quality of life in people with stage II high blood pressure. Sixty-three adults aged 40 to 50 to…

This study tested whether a computer program (Simcyp) could predict the right doses of two blood pressure drugs, nebivolol and carvedilol, for people with liver cirrhosis and high blood pressure. Forty patients were randomly assigned to one of the two drugs and monitored for thre…

This early-phase trial tested a single dose of SGB-3908, an experimental injectable drug, in 40 healthy volunteers and people with mild high blood pressure. The main goal was to check safety and how the body processes the drug. Researchers also looked at changes in a blood protei…

This study tested whether drinking rosemary tea for 45 days can lower blood pressure in men with mild hypertension. Fifty-four men participated, with half drinking rosemary tea and half a placebo. The researchers measured blood pressure and checked how rosemary affects a key enzy…

This study tested whether drinking rosemary infusion daily for 6 weeks could help people with mild high blood pressure and high triglycerides. 47 adults took part, and researchers measured blood pressure and blood fats before and after. The goal was to see if this simple herbal d…

This completed pilot study tested whether a special diet made from tartary buckwheat could help lower blood pressure in 130 adults with mild hypertension. Participants added the buckwheat formulation to their regular meals and were compared to those receiving standard care. The s…

This study tested whether adding amlodipine to the blood pressure drug LCZ696 works better than LCZ696 alone. About 718 adults with mild-to-moderate high blood pressure that wasn't well controlled by LCZ696 took part. The goal was to see if the combination lowers blood pressure m…

This study looked at 19 people with sleep apnea and mild high blood pressure. It compared a drug called bosentan to the standard CPAP machine to see if the drug could lower blood pressure just as well. The goal was to find a simpler way to manage heart risks in sleep apnea patien…

This study tested a new medicine called ALN-AGT01 in 394 adults with mild-to-moderate high blood pressure. The goal was to see if it could safely lower blood pressure over three months. Participants received either the drug or a placebo, and blood pressure was measured continuous…

This study tested whether a grape seed extract supplement called Enovita can lower blood pressure in adults with elevated blood pressure or stage 1 hypertension. Eighty participants took either the supplement or a placebo twice daily for 8 weeks. Researchers measured changes in b…

This Phase 3 trial tested whether taking two experimental drugs, BR1018B and BR1018C, together can safely lower both blood pressure and LDL cholesterol. The study involved 156 adults with essential hypertension and primary hypercholesterolemia. Participants were randomly assigned…

This study tested whether a smartphone app called LowSalt4Life can help people with high blood pressure reduce their sodium intake and improve blood pressure. The app provides tips and reminders to eat less salt. 410 participants with high blood pressure used the app, and researc…

This study tested whether taking a magnesium glycinate supplement (480 mg daily) for 12 weeks could lower blood pressure in adults with untreated high blood pressure. 59 participants were randomly assigned to get the supplement or a placebo. The goal was to see if this simple min…

This completed study tested a comprehensive strategy to help manage high blood pressure and diabetes in primary care clinics in Brazil. Over 5,800 adult patients from resource-limited areas took part. The strategy included telehealth tools, education for healthcare workers, and s…

This study tested whether adding a muscle relaxation technique to aerobic exercise improves heart and lung health more than exercise alone in people with stage 1 hypertension. Forty adults aged 18-45 participated. The relaxation group did 15 minutes of progressive muscle relaxati…

This Phase 3 trial tested whether taking two blood pressure medications (AZM and AML) together works better than taking either one alone. About 890 adults with mild-to-moderate high blood pressure took part. The study lasted 8 weeks and compared different doses of the combination…

This study tested whether a specially trained nurse (Advanced Practice Nurse) could help people with high blood pressure get it under control. Over 480 adults with essential hypertension received either usual care or an extra nurse visit that included health education, medication…

This study looked at 105 people to find the best blood test values for diagnosing primary hyperaldosteronism, a condition where the adrenal glands make too much aldosterone hormone, causing high blood pressure. Researchers measured aldosterone and renin levels using advanced lab …

This study tested whether a simple blood test, called the aldosterone renin ratio (ARR), could help doctors find more cases of primary aldosteronism—a common but often missed cause of high blood pressure that can be cured with surgery or treated with specific medications. Researc…

This study looked at whether a new blood marker called EM66 can help doctors tell the difference between high blood pressure caused by rare adrenal tumors (pheochromocytoma or paraganglioma) and regular high blood pressure. Researchers measured EM66 levels in 60 adults with eithe…

This study tested whether an automatic blood pressure machine (WatchBP Office) gives more accurate readings than the traditional manual method in 149 Chinese adults with high blood pressure. The automatic machine takes several readings and averages them, which may reduce the 'whi…

This study trained community health workers to screen Black men for early signs of high blood pressure. Participants received lifestyle advice and were connected to doctors and social services. The goal was to prevent hypertension from getting worse.

This study tested whether a slow, rhythmic breathing technique called resonant breathing can help lower blood pressure, heart rate, and stress in adults with mild hypertension. Fifty adults aged 30-65 with stage I hypertension and no serious health issues practiced this breathing…

This study looked at whether adding virtual reality (VR) and classical music to standard blood pressure medication can help people who come to the emergency room with very high blood pressure (hypertensive urgency). 130 adults with high blood pressure but no organ damage were ran…

This study tested two exercise programs—aerobic exercise and physiological ischemic training—in 60 adults with grade 2 high blood pressure. Over 6 weeks, researchers measured changes in blood markers, fitness, muscle strength, and quality of life. The goal is to see which approac…

This study tested two ways of doing exercise at home for people with high blood pressure. One group exercised with a live physiotherapist on video calls, while the other followed pre-recorded videos. Over 8 weeks, researchers measured changes in exercise capacity, blood pressure,…

This study tested whether a short lesson on good sleep habits could improve sleep quality and blood pressure in adults with high blood pressure. 138 people took part, with half receiving the lesson and a sleep diary, and the other half getting usual care. After 8 weeks, researche…

This study looks at how often chronic kidney disease (CKD) is diagnosed in adults with high blood pressure who have early signs of kidney trouble but no prior CKD diagnosis. Researchers will review medical records and follow patients over time to see how many are formally diagnos…

This completed study looked at 111 people to see if measuring blood flow in the skin can help assess cardiovascular risk in those with resistant hypertension (high blood pressure that doesn't respond to multiple drugs). Researchers used a laser device to check how well tiny blood…

This completed study in Syria examined whether certain genetic variations in the apelin system are linked to coronary artery disease and high blood pressure. Researchers analyzed blood samples from 223 participants, including healthy controls and patients with heart disease and h…

This small pilot study looked at whether a short exercise program could help older adults (ages 55-75) with high blood pressure improve their thinking skills. Researchers measured changes in fitness, eye blood vessels, and blood markers. The goal was to see if exercise might reve…

This study looked at how blood pressure medications affect brain blood flow and the nervous system in older adults with high blood pressure. Researchers gave 27 participants either a drug or a placebo for 1-2 weeks and measured brain blood flow, cognitive function, and nerve acti…

This completed study looked at 50 adults with high blood pressure to see if dysfunctional breathing (abnormal breathing patterns) is related to how well they can exercise and keep their balance. Participants filled out a breathing questionnaire and performed balance and walking t…

This completed study looked at why people on chronic hemodialysis often have high blood pressure between sessions. Researchers measured weight gain, heart function, and blood chemicals in 32 stable dialysis patients. The goal was to understand the relative roles of fluid gain, ho…

This study tested whether a computer program (Clinical Decision Support System) helps doctors follow official treatment guidelines for patients with both high blood pressure and atrial fibrillation (an irregular heartbeat). Researchers compared clinics using the program to those …

This study tested whether a special ketone drink (KE4) could improve kidney function and lower blood pressure in 20 people with essential hypertension. Participants took the drink or a placebo for five days, then switched after a break. The goal was to see changes in blood pressu…

This early-stage study tested a new drug called AD-227 in 70 healthy adults. Researchers wanted to see if taking a single combination tablet works as well as taking two separate pills (AD-227A and AD-227B) in terms of safety and how the drug moves through the body. The study is a…

This completed study looked at 66 teens aged 10-19 with high blood pressure to find out what stops them from being physically active. Researchers used three surveys to measure barriers, expectations, and home environment. The goal is to use this information to create better suppo…

This early-stage study tested how the body processes three experimental drugs (BR1018, BR1018A, and BR1018B) in 60 healthy adults. The goal was to measure drug levels and check safety, not to treat any condition. Results will guide future studies for high blood pressure and high …

This study tested a new laser-based device (Laser Doppler Vibrometer) to measure how stiff the arteries are in 100 people with high blood pressure. The goal was to see if this painless, non-invasive method works as well as the standard techniques (applanation tonometry and echotr…