Essential hypertension

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tested whether lowering blood pressure more aggressively than standard care reduces the risk of rupture or growth of unruptured brain aneurysms. 577 Chinese adults with small, unruptured aneurysms and high blood pressure were randomly assigned to keep their blood press…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This trial tests a special pacemaker called the BackBeat Moderato that can adjust its pacing to help control high blood pressure. Researchers will turn the device on and off for short periods in 28 people who already have the pacemaker implanted, measuring how their blood pressur…

This phase 3 study tests whether the drug AGSAVI can lower blood pressure in people with essential hypertension that is not well controlled by the drug AGLS. About 318 adults with high blood pressure will receive either AGSAVI or AGLS, and their sitting blood pressure will be mea…

This study tested a new drug called BAY3283142 in 75 people with mild to moderate high blood pressure. The drug is designed to relax blood vessels and is being developed for chronic kidney disease. Participants took different doses or a placebo for up to 10 weeks to check for saf…

This completed Phase 3 trial tested whether a single pill combining ezetimibe, rosuvastatin, and amlodipine can safely lower both cholesterol and blood pressure in 163 Korean adults with hypertension and high cholesterol. Participants took the combination pill or a control for 8 …

This Phase 3 trial tested whether adding a second drug (DWC202314) to an existing one (DWC202404) helps people whose high blood pressure isn't controlled by the first drug alone. 192 adults with essential hypertension took part. The study is now complete, and results will show if…

This study tested a comprehensive intelligent system (CHESS) to help manage high blood pressure in primary care clinics. Over 1,600 people took part, and the system aimed to lower blood pressure over 12 months. The approach used technology to support doctors and patients in bette…

This study tested a remote telehome monitoring program for 100 people with high blood pressure who receive virtual care. Participants used a special blood pressure cuff and a monitoring platform to share readings with their doctors. The goal was to see if this approach improves b…

This study tested an experimental drug called zilebesiran in 36 Japanese adults with mild to moderate high blood pressure. The goal was to see if it is safe and helps lower blood pressure over 6 months. Participants received either the drug or a placebo, and researchers monitored…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study looked at whether omega-3 supplements from plants can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured artery …

This study tested whether a smartphone app and home blood pressure monitor could help doctors personalize the dose of the blood pressure drug Zestril for each patient without needing in-person visits. Twenty adults with uncomplicated high blood pressure participated. The goal was…

This Phase 3 trial tested whether adding a third drug (DWC202314) to a two-drug combination pill works better for people with essential hypertension that isn't controlled by the two-drug pill alone. 198 participants took either the two-drug or three-drug combination once daily. T…

This study tested whether adding lower leg heat therapy (soaking legs in warm water) to a standard blood pressure pill helps older women with high blood pressure more than the pill alone. 134 women aged 60-85 participated, either soaking in 42°C water or neutral 33°C water for 8 …

This study tested a generic version of the blood pressure drug nifedipine against the brand-name version in 50 adults with mild-to-moderate high blood pressure in Colombia. The goal was to see if the generic pill controls blood pressure just as well after 8 weeks. Participants ha…

This completed trial tested a new, noninvasive device that uses focused ultrasound to destroy a small amount of fat around the kidney. The goal was to lower blood pressure in people with mild hypertension who were not taking medication. 79 participants were randomly assigned to r…

This study looked at whether adding paced or diaphragmatic breathing to mat Pilates can improve heart and lung fitness, reduce shortness of breath, lower stress and anxiety, and boost quality of life in people with stage II high blood pressure. Sixty-three adults aged 40 to 50 to…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This study tested whether a computer program (Simcyp) could predict the right doses of two blood pressure drugs, nebivolol and carvedilol, for people with liver cirrhosis and high blood pressure. Forty patients were randomly assigned to one of the two drugs and monitored for thre…

This early-phase trial tested a single dose of SGB-3908, an experimental injectable drug, in 40 healthy volunteers and people with mild high blood pressure. The main goal was to check safety and how the body processes the drug. Researchers also looked at changes in a blood protei…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study tested whether drinking rosemary tea for 45 days can lower blood pressure in men with mild hypertension. Fifty-four men participated, with half drinking rosemary tea and half a placebo. The researchers measured blood pressure and checked how rosemary affects a key enzy…

This study tested whether drinking rosemary infusion daily for 6 weeks could help people with mild high blood pressure and high triglycerides. 47 adults took part, and researchers measured blood pressure and blood fats before and after. The goal was to see if this simple herbal d…

This completed pilot study tested whether a special diet made from tartary buckwheat could help lower blood pressure in 130 adults with mild hypertension. Participants added the buckwheat formulation to their regular meals and were compared to those receiving standard care. The s…

This study tested whether adding amlodipine to the blood pressure drug LCZ696 works better than LCZ696 alone. About 718 adults with mild-to-moderate high blood pressure that wasn't well controlled by LCZ696 took part. The goal was to see if the combination lowers blood pressure m…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study looked at 19 people with sleep apnea and mild high blood pressure. It compared a drug called bosentan to the standard CPAP machine to see if the drug could lower blood pressure just as well. The goal was to find a simpler way to manage heart risks in sleep apnea patien…

This study tested a new medicine called ALN-AGT01 in 394 adults with mild-to-moderate high blood pressure. The goal was to see if it could safely lower blood pressure over three months. Participants received either the drug or a placebo, and blood pressure was measured continuous…

This study tested whether a grape seed extract supplement called Enovita can lower blood pressure in adults with elevated blood pressure or stage 1 hypertension. Eighty participants took either the supplement or a placebo twice daily for 8 weeks. Researchers measured changes in b…

This early-stage study tested a new drug called QCZ484 in 56 healthy volunteers and people with mild hypertension. The main goal was to check safety and how the body handles the drug. Participants received a single injection of either QCZ484 or a placebo, and researchers monitore…

This Phase 3 trial tested whether taking two experimental drugs, BR1018B and BR1018C, together can safely lower both blood pressure and LDL cholesterol. The study involved 156 adults with essential hypertension and primary hypercholesterolemia. Participants were randomly assigned…

This study tested whether a smartphone app called LowSalt4Life can help people with high blood pressure reduce their sodium intake and improve blood pressure. The app provides tips and reminders to eat less salt. 410 participants with high blood pressure used the app, and researc…

This study tested whether taking a magnesium glycinate supplement (480 mg daily) for 12 weeks could lower blood pressure in adults with untreated high blood pressure. 59 participants were randomly assigned to get the supplement or a placebo. The goal was to see if this simple min…

This completed study tested a comprehensive strategy to help manage high blood pressure and diabetes in primary care clinics in Brazil. Over 5,800 adult patients from resource-limited areas took part. The strategy included telehealth tools, education for healthcare workers, and s…

This study tested whether adding a muscle relaxation technique to aerobic exercise improves heart and lung health more than exercise alone in people with stage 1 hypertension. Forty adults aged 18-45 participated. The relaxation group did 15 minutes of progressive muscle relaxati…

This Phase 3 trial tested whether taking two blood pressure medications (AZM and AML) together works better than taking either one alone. About 890 adults with mild-to-moderate high blood pressure took part. The study lasted 8 weeks and compared different doses of the combination…

This study tested whether a specially trained nurse (Advanced Practice Nurse) could help people with high blood pressure get it under control. Over 480 adults with essential hypertension received either usual care or an extra nurse visit that included health education, medication…

This study looked at 105 people to find the best blood test values for diagnosing primary hyperaldosteronism, a condition where the adrenal glands make too much aldosterone hormone, causing high blood pressure. Researchers measured aldosterone and renin levels using advanced lab …

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study tested whether a simple blood test, called the aldosterone renin ratio (ARR), could help doctors find more cases of primary aldosteronism—a common but often missed cause of high blood pressure that can be cured with surgery or treated with specific medications. Researc…

This study looked at whether a new blood marker called EM66 can help doctors tell the difference between high blood pressure caused by rare adrenal tumors (pheochromocytoma or paraganglioma) and regular high blood pressure. Researchers measured EM66 levels in 60 adults with eithe…

This study tested whether an automatic blood pressure machine (WatchBP Office) gives more accurate readings than the traditional manual method in 149 Chinese adults with high blood pressure. The automatic machine takes several readings and averages them, which may reduce the 'whi…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study trained community health workers to screen Black men for early signs of high blood pressure. Participants received lifestyle advice and were connected to doctors and social services. The goal was to prevent hypertension from getting worse.

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This study tested whether a slow, rhythmic breathing technique called resonant breathing can help lower blood pressure, heart rate, and stress in adults with mild hypertension. Fifty adults aged 30-65 with stage I hypertension and no serious health issues practiced this breathing…

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This study looked at whether adding virtual reality (VR) and classical music to standard blood pressure medication can help people who come to the emergency room with very high blood pressure (hypertensive urgency). 130 adults with high blood pressure but no organ damage were ran…

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study tested two exercise programs—aerobic exercise and physiological ischemic training—in 60 adults with grade 2 high blood pressure. Over 6 weeks, researchers measured changes in blood markers, fitness, muscle strength, and quality of life. The goal is to see which approac…

This study tested two ways of doing exercise at home for people with high blood pressure. One group exercised with a live physiotherapist on video calls, while the other followed pre-recorded videos. Over 8 weeks, researchers measured changes in exercise capacity, blood pressure,…

This study tested whether a short lesson on good sleep habits could improve sleep quality and blood pressure in adults with high blood pressure. 138 people took part, with half receiving the lesson and a sleep diary, and the other half getting usual care. After 8 weeks, researche…

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This completed study looked at 111 people to see if measuring blood flow in the skin can help assess cardiovascular risk in those with resistant hypertension (high blood pressure that doesn't respond to multiple drugs). Researchers used a laser device to check how well tiny blood…

This completed study in Syria examined whether certain genetic variations in the apelin system are linked to coronary artery disease and high blood pressure. Researchers analyzed blood samples from 223 participants, including healthy controls and patients with heart disease and h…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This small pilot study looked at whether a short exercise program could help older adults (ages 55-75) with high blood pressure improve their thinking skills. Researchers measured changes in fitness, eye blood vessels, and blood markers. The goal was to see if exercise might reve…

This study looked at how blood pressure medications affect brain blood flow and the nervous system in older adults with high blood pressure. Researchers gave 27 participants either a drug or a placebo for 1-2 weeks and measured brain blood flow, cognitive function, and nerve acti…

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This completed study looked at 50 adults with high blood pressure to see if dysfunctional breathing (abnormal breathing patterns) is related to how well they can exercise and keep their balance. Participants filled out a breathing questionnaire and performed balance and walking t…

This completed study looked at why people on chronic hemodialysis often have high blood pressure between sessions. Researchers measured weight gain, heart function, and blood chemicals in 32 stable dialysis patients. The goal was to understand the relative roles of fluid gain, ho…

This study tested whether a computer program (Clinical Decision Support System) helps doctors follow official treatment guidelines for patients with both high blood pressure and atrial fibrillation (an irregular heartbeat). Researchers compared clinics using the program to those …

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study tested whether a special ketone drink (KE4) could improve kidney function and lower blood pressure in 20 people with essential hypertension. Participants took the drink or a placebo for five days, then switched after a break. The goal was to see changes in blood pressu…

This early-stage study tested a new drug called AD-227 in 70 healthy adults. Researchers wanted to see if taking a single combination tablet works as well as taking two separate pills (AD-227A and AD-227B) in terms of safety and how the drug moves through the body. The study is a…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This completed study looked at 66 teens aged 10-19 with high blood pressure to find out what stops them from being physically active. Researchers used three surveys to measure barriers, expectations, and home environment. The goal is to use this information to create better suppo…

This early-stage study tested how the body processes three experimental drugs (BR1018, BR1018A, and BR1018B) in 60 healthy adults. The goal was to measure drug levels and check safety, not to treat any condition. Results will guide future studies for high blood pressure and high …

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This study tested a new laser-based device (Laser Doppler Vibrometer) to measure how stiff the arteries are in 100 people with high blood pressure. The goal was to see if this painless, non-invasive method works as well as the standard techniques (applanation tonometry and echotr…