Essential hypertension

This early-stage study tests a new drug called ADX-850 in 28 people with mild to moderate high blood pressure. The drug uses siRNA technology to target genes involved in blood pressure regulation. The main goal is to check safety and how the drug moves through the body, with a se…

This study tests a smartphone app called Liebria designed to help people manage high blood pressure. 328 adults with high blood pressure used the app at home to track and lower their readings. The goal is to see if the app can help control blood pressure and improve daily life.

This study tests a program where people with slightly high blood pressure use a home monitor and get support from a community health worker. The goal is to see if this helps keep blood pressure from rising to dangerous levels. About 600 adults from 20 health centers are taking pa…

This early-phase study tests a single injection of ART101 in 16 adults with high blood pressure. The goal is to see if it is safe and how it affects blood pressure over 24 weeks. Participants receive either 600 mg or 800 mg of the drug and are closely monitored.

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This phase 3 trial tests a procedure called renal denervation, where a small amount of alcohol is injected around the kidney nerves to calm overactive signals that raise blood pressure. 142 people with uncontrolled hypertension will either get the real procedure or a sham (fake) …

This study tests a device that uses ultrasound to disrupt overactive nerves in the kidneys, which can drive high blood pressure. About 282 adults with hypertension will either get the real procedure or a sham (fake) procedure. The goal is to see if this treatment safely lowers bl…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study tests if a smartphone app called OptiZ can help people with high blood pressure get better control of their condition. Participants use the app to track their blood pressure, medication, and side effects, and share reports with their doctor for personalized dose adjust…

This study tests whether community health workers (CHWs) who screen patients for social needs like food, housing, or transportation and connect them to resources can improve blood sugar and blood pressure control. About 3,120 adults with uncontrolled diabetes or hypertension from…

This trial tests whether trained village health workers, using a smartphone app, can effectively manage high blood pressure in rural Lesotho. About 1,350 participants with either uncontrolled or controlled hypertension will receive either community-based care (medication and moni…

This study tests a new fixed-dose combination pill containing three blood pressure medicines (telmisartan, amlodipine, and chlorthalidone) against another triple combination (with hydrochlorothiazide instead of chlorthalidone) in elderly patients whose blood pressure is not well …

This study tests a dual GIP/GLP-1 drug (a type of diabetes medication) in 120 adults in Kazakhstan who have both chronic heart failure and type 2 diabetes. Participants take the drug for 40 weeks and have regular heart tests, blood work, and genetic checks. The goal is to see if …

This study tests whether helping people who sleep less than 6.5 hours per night extend their sleep can lower their blood pressure. Researchers will compare an 8-week sleep coaching program to general health education in 110 adults with prehypertension or mild hypertension. The ma…

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This study tests whether motivational interviewing, a type of counseling, can help people with high blood pressure living in semi-rural areas better understand their condition, feel more confident, and stick to their treatment. About 100 adults aged 25-59 will either receive four…

This study was designed to test whether a new fixed-dose combination of two blood pressure medicines (olmesartan and chlorthalidone) works as well as an existing combination (olmesartan and hydrochlorothiazide) in people with untreated high blood pressure. The trial was withdrawn…

This study aimed to compare two different combination pills for controlling high blood pressure: one with olmesartan and chlorthalidone, and another with olmesartan and hydrochlorothiazide (Benicar HCT). The trial was planned for people with uncontrolled hypertension but was with…

This study tests whether eating wild blueberry powder every day can lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. Researchers will measure artery function and stiffness over time. The …

This program allows individual patients with vascular disease or end-stage kidney disease on dialysis to request an experimental lab-grown blood vessel (ATEV) if they have no other treatment options and cannot join a clinical study. The vessel is designed to replace or bypass dam…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This study will test a telehealth group prenatal care program called Centering HER in 72 low-income, predominantly Black pregnant women in Kansas who are at moderate or high risk for preeclampsia. Participants will receive routine care plus seven doula-led virtual group sessions,…

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study aimed to see if a personalized exercise app (Gingko Active) could improve physical function in adults aged 45 and older better than a standard exercise booklet. The trial was withdrawn before any participants enrolled, so no results are available. The app was designed …

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study follows 200 adults with high blood pressure and gum disease to see how gum health affects blood pressure and cholesterol levels over 6 to 12 months. Researchers will measure triglycerides and LDL cholesterol to understand the link. The goal is to learn whether treating…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study planned to compare virtual clinic visits (using video calls on tablets) with in-person visits for people with vascular diseases. Doctors would classify patients as low, moderate, or high risk for treatment after each visit type. The goal was to see if virtual visits co…

This study is testing a new smartphone app called ENHANCe that helps family doctors manage patients with high blood pressure using home blood pressure readings. The app scans home readings and gives the doctor a recommendation on how to adjust treatment. The study will enroll 116…

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study looks at whether a special training program can help family doctors use focused heart ultrasound (FoCUS) to accurately detect common heart conditions like heart failure and valve disease. About 500 patients will get both a family doctor's FoCUS and a cardiologist's ful…

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study looks at whether immune cells (monocytes) can be used as a simple test to diagnose salt-sensitive high blood pressure. Researchers will give 20 adults with high blood pressure a high-salt and low-salt diet to see how their blood pressure and immune cells change. The go…

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study is following 10,000 adults who are having a heart MRI for medical reasons. Researchers want to see if the MRI results can help predict who will have heart problems in the future, like heart attacks or heart failure. The goal is to better understand how MRI scans can gu…

This study aimed to create a 12-month profile of patients admitted for vascular surgery at University Hospital Limerick in Ireland. The goal was to understand patient characteristics like frailty and other health conditions to improve hospital services and reduce length of stay. …