Disorder of pharynx

This study tests a combination of three immunotherapy drugs—PDS0101, M7824, and NHS-IL12—in people with advanced HPV-related cancers such as cervical, anal, and throat cancers. The goal is to see if the mix can shrink tumors or stop them from growing. Participants receive the dru…

This study compares two common substances—hydrogen peroxide and adrenaline—for controlling bleeding during tonsillectomy in children and teens aged 5 to 18. Surgeons apply one of the two to the surgical site and measure how quickly bleeding stops and how much blood is lost. The g…

This study tested whether giving the immunotherapy drug durvalumab alongside radiation works better than the standard cetuximab plus radiation for people with advanced head and neck cancer who cannot take the usual chemotherapy drug cisplatin. A total of 196 adults took part. The…

This study tested whether a lower dose of radiation therapy, with or without the chemotherapy drug cisplatin, can effectively treat advanced oropharyngeal (throat) cancer in patients who are non-smokers. The trial enrolled 316 people with p16-positive cancer, a type linked to HPV…

This study tested whether adding an extra chemotherapy drug (capecitabine) after standard treatment helps people with advanced nasopharyngeal cancer that is likely to spread. 294 patients received either standard chemoradiotherapy alone or standard treatment plus capecitabine. Th…

This phase 2 trial tested a drug called KL-A167 in 153 adults with recurrent or metastatic nasopharyngeal carcinoma (a type of throat cancer). Participants received the drug by IV every two weeks. The main goal was to see how many patients' tumors shrank or disappeared. The study…

This phase 3 trial tested whether giving only radiation therapy works as well as radiation plus chemotherapy for people with intermediate-risk nasopharyngeal cancer. The study enrolled 338 participants and used modern intensity-modulated radiation therapy (IMRT). The goal was to …

This study tested a new drug combination (TQB2618 plus penpulimab) in 47 people with advanced nasopharyngeal carcinoma that had come back or spread. Some participants had already tried standard treatments, while others were new to therapy. The goal was to see if the combination w…

This study tested whether combining two FDA-approved cancer drugs, cetuximab and nivolumab, could help people with advanced head and neck cancer that has returned or spread. A total of 95 participants received the drug combination to find the best dose and see if it improves surv…

This completed study tested the drug upadacitinib in 12 people with refractory Takayasu arteritis, a rare autoimmune disease that inflames the body's largest artery. The goal was to see if the drug could help patients who haven't responded to standard treatments achieve remission…

This study tested whether giving lower doses of radiation after surgery for head and neck cancer could reduce long-term side effects like dry mouth and trouble swallowing, while still keeping the cancer from coming back. About 200 patients with certain stages of oral, throat, or …

This phase II trial tested whether adding sorafenib to cetuximab works better than cetuximab alone for patients with advanced head and neck cancer that has come back or spread. Fifty-five adults with various types of head and neck cancer took part. The study measured how long pat…

This trial tested a new therapy for cancers caused by HPV-16, such as cervical, anal, and throat cancers. Researchers took patients' white blood cells, genetically engineered them to recognize a protein called E7 found in HPV cancer cells, and infused them back. Patients also rec…

This study tested a new way to give radiation for head and neck cancer. Instead of treating the whole neck, doctors used artificial intelligence to focus radiation only on the cancer spots. 67 patients took part to see if this approach could reduce side effects without increasing…

This study tested a treatment for people with HPV-related throat cancer. It combined a higher dose of radiation with the chemotherapy drug docetaxel. The goal was to see if this approach could better control the tumor and improve survival. The study involved 81 participants and w…

This study tested a combination of two drugs, pembrolizumab and cetuximab, in 78 people with advanced head and neck cancer that had returned or spread. The goal was to see if the combination could shrink tumors or slow the disease. Participants were grouped based on whether they …

This study tested whether adding the immunotherapy drug nivolumab to standard radiation and chemotherapy can help prevent cancer from returning in people with high-risk HPV-related throat cancer. The trial enrolled 26 participants with advanced-stage disease. Researchers measured…

This early-phase study tested a new drug called CUE-101, alone or with pembrolizumab, in 80 adults with HPV16-positive head and neck cancer that had spread or returned. The main goals were to check safety and find the right dose. Researchers also looked at whether the drug helped…

This early-phase trial tested a new type of cell therapy for people with advanced nasopharyngeal cancer linked to the Epstein-Barr virus. Nine patients received specially engineered immune cells (TCR-T cells) designed to recognize and attack the virus-infected cancer cells. The m…

This large phase 3 trial studied nearly 1,000 people with HPV-related oropharyngeal cancer to see if replacing chemotherapy with a targeted drug (cetuximab) during radiation could work as well or better. The goal was to find a treatment that controls the disease while possibly re…

This phase II trial tested whether adding the immunotherapy drug nivolumab (Opdivo) to standard chemoradiation helps treat stage II-IVB nasopharyngeal carcinoma, a type of throat cancer. Forty patients received nivolumab infusions every two weeks alongside cisplatin chemotherapy …

This phase 2 trial tested whether adding the immunotherapy drug pembrolizumab after standard chemoradiotherapy could help people with advanced nasopharyngeal carcinoma. Fifty-three patients received either pembrolizumab or a placebo every three weeks for up to a year. The main go…

This early-phase study tested a shorter, more intense radiation schedule (completed in 3 weeks instead of the usual 6) combined with chemotherapy for people with HPV-related throat cancer. The goal was to find the safest dose that still controls the cancer. Only 24 patients took …

This study tested a new combination of chemotherapy drugs (nab-paclitaxel, cisplatin, and fluorouracil) given before standard chemoradiation in 60 people with advanced nasopharyngeal cancer. The goal was to see if this approach could shrink tumors and improve survival. The trial …

This study tested whether a special infant formula containing lactoferrin and human milk oligosaccharides (HMOs) could improve immunity in newborns. 240 healthy full-term babies were randomly assigned to receive either the test formula, a standard formula, or breast milk for 12 m…

This early-phase trial tested a combination of two drugs — IRX-2 and durvalumab — in 19 people with advanced head and neck cancer that could not be cured by standard treatments. The goal was to see if the combination was safe and could boost the immune response inside tumors. The…

This study looked at 65 people with advanced head and neck cancer that had spread to lymph nodes. It compared two approaches: having surgery to remove affected lymph nodes before chemo-radiation, versus chemo-radiation alone. The goal was to see if upfront surgery could reduce tr…

This study tested a smartphone app to help young adult cancer survivors (ages 18-39) lose weight. The app tracked diet and activity as part of a behavioral weight loss program. The goal was to see if this approach was practical and well-liked by participants. The study involved 6…

This early-phase trial tested whether adding the immunotherapy drug pembrolizumab to standard chemoradiation is safe and effective for people with advanced head and neck cancer. 59 participants received pembrolizumab before, during, and after their regular treatment. The goal was…

This early-phase study tested a combination of two immunotherapy drugs, BGB-A445 and tislelizumab, in 204 people with advanced solid tumors including lung, head and neck, and nasopharyngeal cancers. The main goals were to check safety and find the best dose. The trial is now comp…

This phase II trial tested whether adding the targeted drug cetuximab to standard chemotherapy and radiation could help prevent head and neck cancer from coming back after surgery. The study enrolled 53 patients with certain high-risk features. The main goal was to see how many p…

This study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…

This Phase 2 trial tested a combination of two immunotherapies—PDS0101 and pembrolizumab (Keytruda)—in 95 adults with HPV16-positive head and neck cancer that had returned or spread. The goal was to see if the combo could shrink tumors or slow the disease. Participants received b…

This early-phase trial tested whether a special fluoride treatment (silver diamine fluoride) can prevent tooth decay in 56 head and neck cancer patients undergoing radiation therapy. Patients received a one-time professional application of the silver solution plus a fluoride gel …

This completed phase I/II trial tested two experimental vaccines, HB-201 and HB-202, in 198 people with HPV 16+ cancers. The goal was to find a safe dose and see if the vaccines could shrink tumors. Participants received the vaccines alone or with standard treatments like pembrol…

This phase 3 trial tested whether adding the immunotherapy drug toripalimab to standard chemotherapy helps people with recurrent or metastatic nasopharyngeal cancer live longer without their disease getting worse. About 289 adults with advanced cancer that could not be treated wi…

This study tested a new way to find small cancer spots in neck lymph nodes of people with nasopharyngeal cancer. Researchers combined MRI scans with a special ultrasound that uses a contrast agent. They aimed to create a better rule for spotting these tiny metastases. 348 patient…

This study tested a new mouthwash-based DNA test to see if it can find HPV in saliva, which might help detect HPV-related throat cancer early. Researchers compared results from 360 people — some with throat cancer and some without. The goal was to see how accurate the test is at …

This study collected speech recordings from 501 people, including those with oral or oropharyngeal cancer and healthy volunteers. Researchers are developing AI models to analyze voice patterns and detect cancer early. The goal is to create a non-invasive, low-cost screening tool.

This study tested whether injecting a radioactive tracer around oropharynx tumors and using SPECT-CT scans can map lymph node drainage. Twelve patients with oropharynx cancer participated. The goal was to see if this imaging method is practical and could help guide treatment deci…

This study tested a new blood test (liquid biopsy) to see if it could find any cancer left behind after surgery in 103 people with HPV-related head and neck cancer. The goal was to catch remaining disease early, which could help doctors decide if more treatment is needed. The tes…

This trial investigates whether a low-level diode laser can prevent or reduce severe mouth sores (mucositis) caused by radiation and chemotherapy in people with advanced head and neck cancer. Participants receive either real laser therapy or a non-functional placebo laser during …

This study tested whether giving families educational materials, alcohol-based hand sanitizers, and surgical face masks could reduce the spread of colds and flu among household members. Researchers followed 2,788 people in 450 households in Northern Manhattan for 15 months. They …

This study tested a small clip attached to the breathing tube used during anesthesia to see if it could prevent sore throat, voice changes, and trouble swallowing after surgery. 100 adults having surgery with general anesthesia took part. The clip is designed to reduce pressure o…

This study tested two types of radiation therapy for nasopharyngeal cancer (a cancer in the upper throat). One group received standard photon radiation plus carbon ion therapy, and the other received proton radiation plus carbon ion therapy. The main goal was to see which approac…

This study compared two ways to remove tonsils in 66 people with chronic tonsillitis: using a harmonic scalpel (ultrasonic energy) versus traditional cold steel instruments. The main goal was to see if the harmonic scalpel causes less pain three days after surgery. Researchers al…

This study tested a special lollipop containing the painkiller diclofenac to help children aged 4 to 12 manage pain after having their tonsils removed. Fifty children received a weight-adjusted dose every 8 hours for the first day after surgery. The goal was to see if the lollipo…

This study looked at whether taking a probiotic called LP28 can help older adults fight off colds and feel better. 102 people who had at least two colds in the past year took part. Researchers measured cold symptoms and immune cell levels to see if the probiotic made a difference…

This study compared three different tonsil surgery methods in 72 people with chronic tonsillitis. The goal was to see which technique causes less pain, bleeding, and faster healing. Researchers measured outcomes like surgery time, blood loss, and recovery to find the best approac…

This study tested whether a pain plan without strong opioids works as well as one with opioids for children after tonsil surgery. Sixty-two kids aged 3 to 17 were randomly assigned to get either morphine plus other drugs or a combo of dexmedetomidine, acetaminophen, and ketorolac…

This study tested a new swallowing exercise for people who have trouble swallowing after treatment for head and neck cancer. The exercise trains patients to start swallowing while breathing out, which may help prevent food or liquid from entering the airway. 88 survivors particip…

This phase 3 trial tested whether ulinastatin, a drug that blocks certain enzymes, can reduce severe mouth sores caused by chemoradiotherapy in 179 patients with advanced nasopharyngeal cancer. Patients received either standard care or ulinastatin alongside their cancer treatment…

This study tested a new type of radiation therapy that adjusts the treatment beam each day based on the patient's current anatomy. The goal was to see if this daily adaptive approach could reduce chronic dry mouth (xerostomia) compared to standard radiation in 50 people with head…

This study tested whether shining a red LED light on mouth sores caused by radiation therapy can help them heal. 28 people with head or neck cancer who already had mild sores received a 7-minute light treatment before each radiation session. The main goal was to see if the sores …

This study compared two surgical techniques for removing tonsils in 60 adults with chronic tonsillitis. Coblation uses low-temperature energy to remove tissue, while cold dissection uses traditional cutting. The goal was to see which method causes less pain and fewer infections a…

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study looked at whether acupuncture can reduce dry mouth (xerostomia) caused by radiation therapy in people with head and neck cancer. A total of 258 participants were randomly assigned to receive acupuncture or usual care. The main goal was to see if acupuncture improved dr…

This completed study looked at how two different Robitussin cough syrup regimens affect quality of life in 244 adults with coughs from the common cold. One group used a single daytime/nighttime syrup, while the other used separate daytime and nighttime syrups. Researchers measure…

This study tested whether a low dose (4.5 mg) of naltrexone, a drug already used for alcoholism, can improve physical health and quality of life in people with vasculitis. Sixty participants took either the drug or a placebo daily for six weeks. The goal was to see if the drug le…

This study tested whether giving children a single oral dose of steroid right after tonsillectomy can reduce pain and lower the need for strong painkillers. It involved 163 children aged 3 to 12 having outpatient tonsil surgery. Researchers measured pain scores and opioid use for…

This study tested whether using computer-based virtual planning before jaw reconstruction surgery improves patients' quality of life compared to standard surgery. 132 adults with oral or oropharyngeal cancer who needed a fibula free-flap reconstruction took part. The main goal wa…

This Phase 3 trial tested whether a single pill containing paracetamol (pain reliever/fever reducer), fexofenadine (antihistamine), and phenylephrine (decongestant) works better than a placebo for treating cold and flu symptoms. 567 adults in Brazil took the combo pill or a place…

This study tested whether a gel called PuraBond, applied to the surgical wound during mouth or throat surgery, can reduce pain and bleeding afterward. 73 patients were randomly assigned to receive the gel or not. Researchers measured pain levels over 30 days and tracked complicat…

This study looks at how regular winter swimming—bathing in cold open water during winter—affects blood cells, blood flow, and stress-fighting enzymes in healthy men. Researchers compare winter swimmers to a control group who never swim in cold water and have a sedentary lifestyle…

This study tested a drug called suzetrigine, which blocks a specific nerve channel (NaV1.8) involved in pain signaling. In 67 healthy volunteers, tiny amounts were injected into the skin alongside a placebo and lidocaine. Participants received six different types of brief pain (e…

This completed study reviewed the medical records of 210 people with aortitis (inflammation of the aorta) or retroperitoneal fibrosis (scar tissue in the abdomen). The goal was to find patterns in symptoms, lab tests, and imaging that could help doctors tell different types of th…

This study tested whether a defined mixture of live gut bacteria from a healthy donor (MET-4) is safe and can be detected in patients with advanced oropharyngeal cancer receiving standard chemoradiation. Thirty participants took the bacteria by mouth daily for up to four weeks. T…

This study looked at how repeatable and reproducible ADC maps are for measuring head and neck cancer in 58 adults. Participants had MRI scans using a standard method to see if results were consistent across different machines and sessions. The goal was to improve the reliability …

This study looked at whether three blood proteins (pre-albumin, retinol binding protein, and transferrin) can help detect early malnutrition in people with advanced nasopharyngeal cancer undergoing chemoradiotherapy. Researchers tracked 60 patients to see if these proteins change…

This completed study used artificial intelligence to examine electronic health records from 10,000 head and neck cancer patients. The goal was to create models that can predict the risk of cancer coming back or progressing, and to identify which patients might live longer after i…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This completed study looked at 7 patients with advanced nasopharyngeal carcinoma (stage N3) to see if doing neck dissection (surgery to remove lymph nodes) before radiation therapy could improve outcomes. The goal was to understand if this approach reduces the chance of cancer co…

This completed study looked at whether circulating tumor cells (CTCs) in the blood can help predict or detect early return of oropharyngeal cancer. Researchers took blood samples from 12 patients at different times (diagnosis, after treatment, and during follow-up) and analyzed t…

This study tested whether a mathematical model could help doctors choose the best radiation schedule for people with HPV-positive throat cancer. The goal was to see if personalized dosing could shrink tumors faster than standard treatment. Fifty-five adults took part, and researc…

This study looked at 150 children and adults who had their tonsils removed using one of three surgical methods: BiZact, coblation, or bipolar. Researchers measured pain after surgery, how long the operation took, when patients could eat solid food again, and how much the devices …

This study looked at 33 people who had surgery for oral or throat cancer and received a collagen patch (Tachosil) to help rebuild the area. Researchers asked patients to fill out questionnaires about their swallowing and voice the day before surgery, and again at 1 month and 6 mo…

This study looked at 16 people with a type of throat cancer (squamous cell carcinoma of the oropharynx). Researchers used two types of scans—PET and MRI—to measure oxygen levels inside the tumors. They also checked tumor samples under a microscope to see if the scan results match…

This study tested whether a thin, flexible tube with pressure sensors (high-resolution manometry) can pinpoint where the airway gets blocked during sleep in people with obstructive sleep apnea. 18 adults and children underwent both the standard scope test and the new tube method.…

This study followed 240 people with head and neck cancer to see how their swallowing changed from diagnosis to 18 months after their first treatment. Researchers used a questionnaire called the Deglutition Handicap Index (DHI) to measure patients' own experience of swallowing pro…

This study tests two new monitoring techniques—long loop reflexes (F-waves) and near-infrared spectroscopy (NIRS)—to detect spinal cord ischemia early after thoracoabdominal aortic aneurysm repair. Current methods work during surgery but are too painful for awake patients afterwa…

This study looked at 662 patients with HPV-positive throat cancer that had spread or come back. Researchers wanted to see how patients were treated with pembrolizumab (Keytruda) or nivolumab (Opdivo), with or without chemotherapy, in real-world settings. The goal was to gather in…

This completed study tested a French version of a swallowing questionnaire for people who had their throat and voice box removed due to cancer. Researchers wanted to see if the translated survey works well for French-speaking patients. The study involved 225 adults who could read…

This study looked at 78 people with Takayasu arteritis, a rare disease that causes narrowing of the main artery from the heart. Researchers compared those who had surgery or a procedure to open the artery with those who got only medication. The goal was to see which group lived l…