Immunotherapy combo shows promise in advanced nasopharyngeal cancer trial
NCT ID NCT03581786
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This phase 3 trial tested whether adding the immunotherapy drug toripalimab to standard chemotherapy helps people with recurrent or metastatic nasopharyngeal cancer live longer without their disease getting worse. About 289 adults with advanced cancer that could not be treated with local therapies were randomly assigned to receive either toripalimab plus chemo or a placebo plus chemo. The main goal was to see if the combination slowed cancer progression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
toripalimab (an immunotherapy drug) combined with chemotherapy (gemcitabine and cisplatin)
What this could lead to
If it works, this could offer a new first-line treatment option for people with advanced nasopharyngeal cancer, potentially slowing disease progression.
What could go wrong
This is a completed phase 3 trial, but results are not yet widely available. Immunotherapy can cause immune-related side effects, and not all patients may benefit.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Guangzhou, Guangdong, 510095, China
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Affiliated Hospital of Guangdong Medical University
Zhanjiang, Guangzhou, 130012, China
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Cancer Hospital of Shantou University Medical College
Shantou, Guangzhou, 515031, China
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Cancer Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, 100021, China
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Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital
Taoyuan, 333, Taiwan
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China Medical University Hospital
Taichung, 404, Taiwan
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Fudan University Cancer Hospital
Shanghai, Shanghai Municipality, 200032, China
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Fujian Medical University Union Hospital
Fuzhou, Fujian, 350000, China
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Fujian Provincial Cancer Hospital
Fuzhou, Fujian, 350000, China
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Hainan General Hospital (Hainan Province People's Hospital)
Haikou, Hainan, 570311, China
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Hebei Oncology Hospital
Shijiazhuang, Hebei, 50011, China
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Hunan Cancer Hospital
Changsha, Hunan, 410013, China
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Jiangsu Oncology Hospital
Nanjing, Jiangsu, 210000, China
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Jiangxi Cancer Hospital
Nanchang, Jiangxi, 330029, China
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Liuzhou Worker's Hospital
Liuzhou, Guangxi, 545000, China
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Nanfang Hospital
Guangzhou, Guangdong, 510515, China
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National Cancer Centre
Singapore, 169610, Singapore
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National Cheng Kung University Hospital
Tainan, 704, Taiwan
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Shanghai General Hospital
Shanghai, Shanghai Municipality, 200080, China
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Shenzhen People's Hospital
Shenzhen, Guangdong, 518020, China
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Sun Yat-Sen University Cancer Center
Guangzhou, Guangdong, 510060, China
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TaiChung Veterans General Hospital
Taichung, 40705, Taiwan
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Taipei Veterans General Hospital
Taipei, 112, Taiwan
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Tan Tock Seng Hospital
Singapore, 308433, Singapore
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The Affiliated Cancer Hospital of Guizhou Medical University
Guiyang, Guizhou, 550000, China
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The Fifth Affiliated Hospital Sun Yat-Sen University - Medical Oncology
Zhuhai, Guangzhou, 519000, China
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The People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, Guangxi, 530021, China
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The Second Xiangya Hospital of Central South University
Changsha, Hunan, 410011, China
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Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & TechnologyTongji Hospital
Wuhan, Hubei, 430030, China
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Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, 430023, China
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West China Hospital, Sichuan University
Chengdu, Sichuan, 610041, China
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Zhejiang Cancer Hospital
Hangzhou, Zhejiang, 310022, China