Experimental vaccines show promise against HPV-Driven cancers
NCT ID NCT04180215
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed phase I/II trial tested two experimental vaccines, HB-201 and HB-202, in 198 people with HPV 16+ cancers. The goal was to find a safe dose and see if the vaccines could shrink tumors. Participants received the vaccines alone or with standard treatments like pembrolizumab. The study focused on safety and early signs of effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
HB-201 and HB-202 (therapeutic vaccines targeting HPV 16+ cancers)
What this could lead to
If successful, this could lead to a new treatment option for HPV 16+ cancers, potentially shrinking tumors or slowing disease progression.
What could go wrong
This is an early-phase trial (phase I/II), so results may not confirm effectiveness. Side effects or lack of tumor response are possible, and the approach may not work for all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Amsterdam UMC, Locatie VUMC
Amsterdam, 1081, Netherlands
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Centro Integral Oncologico Clara Campal
Madrid, 28050, Spain
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Froedtert Hospital and Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Greenville Hospital System University Medical Center (ITOR)
Greenville, South Carolina, 29605, United States
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Grossman School of Medicine
New York, New York, 10016, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Hospital Universitario Virgen Macarena
Seville, 410009, Spain
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Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
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Hospital de la Santa Creu i Sant Pau
Barcelona, 8041, Spain
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Loyola University Medical School
Maywood, Illinois, 60153, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10021, United States
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Montefiore-Einstein Center for Cancer Care
The Bronx, New York, 10461, United States
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Nebraska Methodist Hospital
Omaha, Nebraska, 68114, United States
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O'Neal Comprehensive Cancer Center at UAB
Birmingham, Alabama, 35294, United States
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Perlmutter Cancer Center at NYU Langone Hospital-Long Island
New York, New York, 11501, United States
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Providence Portland Medical Center
Portland, Oregon, 97213, United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
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Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
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The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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UCLA (University of California, Los Angeles)
Los Angeles, California, 90095, United States
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USC/Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of Arkansas for Medical Sciences, Cancer Institute, Clinical Trials Office
Fayetteville, Arkansas, 72205, United States
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University of Chicago Medical Center
Chicago, Illinois, 60637, United States
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University of Iowa Hospitals & Clinics
Iowa City, Iowa, 52242, United States
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University of Kansas Medical Center
Fairway, Kansas, 66205, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Virgina Health System
Charlottesville, Virginia, 22908, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States