Real-world data on keytruda and opdivo for HPV throat cancer could shape future trials

NCT ID NCT06771674

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at 662 patients with HPV-positive throat cancer that had spread or come back. Researchers wanted to see how patients were treated with pembrolizumab (Keytruda) or nivolumab (Opdivo), with or without chemotherapy, in real-world settings. The goal was to gather information on patient characteristics, treatment patterns, and outcomes to help design better clinical trials in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

pembrolizumab (Keytruda) and nivolumab (Opdivo), with or without chemotherapy

What this could lead to

If successful, this study could help design better future trials by comparing real-world outcomes with clinical trial data.

What could go wrong

This is an observational study, not a test of a new treatment. It only looks back at existing data, so it cannot prove what works best.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Head and Neck Neoplasms human papillomavirus-related squamous cell carcinoma oropharynx squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck squamous cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Cardinal Health

    Dublin, Ohio, 43017, United States