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Could radiation alone be enough for some nasopharyngeal cancers?

NCT ID NCT02633202

Completed Disease control Sponsor: Sun Yat-sen University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested whether giving only radiation therapy works as well as radiation plus chemotherapy for people with intermediate-risk nasopharyngeal cancer. The study enrolled 338 participants and used modern intensity-modulated radiation therapy (IMRT). The goal was to see if skipping chemotherapy could reduce side effects without harming treatment success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Cisplatin chemotherapy plus intensity-modulated radiation therapy (IMRT)
What this could lead to
If successful, this could show that radiation alone is enough for intermediate-risk nasopharyngeal cancer, sparing patients from chemotherapy side effects.
What could go wrong
This is a completed phase 3 trial, but results may not apply to all patients or settings. The chemotherapy regimen used is intensive and may cause significant side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nasopharyngeal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NASOPHARYNGEAL CARCINOMA

Contacts and locations

Locations

  • Sun Yat-sen University Cancer Center

    Guangzhou, Guangdong, 510060, China

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