Memorial Sloan Kettering Cancer Center

This study tests a personalized treatment plan for people with HER2+ breast cancer that has spread. Doctors use a special blood test (ctDNA) and scans to decide when to increase or decrease therapy, along with treatments to prevent spread to the brain. The goal is to see if this …

This study tests whether giving a personalized dose of fludarabine (a chemotherapy drug) before CAR T-cell therapy can improve outcomes for children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia. About 130 participants will be randomly assign…

This study tests whether combining bexarotene (a vitamin A-like drug) with ultra-low dose total skin electron beam radiation is safe and effective for people with a type of skin lymphoma called mycosis fungoides. About 20 adults with stage IB or higher disease will receive both t…

This study tests whether adding two targeted drugs (tucatinib and trastuzumab) to standard chemotherapy can make HER2-positive rectal cancer disappear or shrink significantly before surgery. About 37 adults with locally advanced disease will receive the combination, then be check…

This study tests whether a cord blood transplant can help children and young adults (up to age 21) with life-threatening blood cancers or non-cancer blood disorders who do not have a matched family donor. The main goal is to see how many patients are alive without treatment-relat…

This study tests whether adding the experimental drug evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better than chemotherapy alone for people with metastatic triple-negative breast cancer who also have metabolic dysfunction (like insulin resistance). About 55 p…

This study tests a combination of three drugs (zanubrutinib, obinutuzumab, and venetoclax) in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have not had prior treatment. The goal is to see if the combo can make the cancer undetectable in t…

This study tests a new treatment called ADCLEC.syn1 CAR T cells for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The main goal is to find the safest dose by monitoring side effects in small groups of participants. About 40 peop…

This study tests whether adding cyclophosphamide to elranatamab helps people with multiple myeloma that has returned or not responded to prior treatments. The trial enrolls 26 adults with specific risk factors that might make elranatamab alone less effective. The main goal is to …

This program provides access to an investigational drug called L-MTP-PE for people with osteosarcoma, a type of bone cancer. The drug works by activating white blood cells to help the immune system kill cancer cells. It is available to patients of any age who have had surgery to …

This early-stage study tests a drug called codrituzumab in children and young adults (ages 1 to 21) whose solid tumors have come back or not responded to treatment and carry a specific protein called GPC3. The main goal is to find a safe dose and see how the body handles the drug…

This study tests a combination of two drugs, alectinib and duvelisib, for people with a rare type of blood cancer called ALK+ anaplastic large cell lymphoma that has come back or not responded to prior treatment. The goal is to find the safest and most effective doses and see how…

This early-phase trial tests the safety of giving deferoxamine directly into the fluid around the brain and spine for people with leptomeningeal metastases (cancer spread to the lining of the brain). Researchers will find the best dose with the fewest side effects. About 35 adult…

This study tests if two drugs, revumenib and mezigdomide, are safe for people with acute leukemias that have returned or not responded to prior therapy. It includes patients aged 12 and older with specific genetic subtypes (KMT2A-r, NUP98-r, NPM1-m). The goal is to find the best …

This study tests whether combining two targeted drugs (gilteritinib plus ivosidenib or enasidenib) is safe and effective for people with a hard-to-treat form of acute myeloid leukemia (AML) that has returned or not responded to treatment. The trial enrolls 18 adults whose leukemi…

This study tests the safety of combining two drugs, lorlatinib and ramucirumab, for people with advanced ALK-rearranged non-small cell lung cancer. Researchers will find the best dose that causes few side effects, then check if it helps control the cancer. About 56 adults with me…

This study is testing whether giving two immunotherapy drugs (cemiplimab and fianlimab) before surgery to remove a kidney tumor is safe and practical. The researchers want to see if this approach shrinks the tumor and does not delay the planned operation. Ten adults with advanced…

This study tests if a new technique called irreversible electroporation (IRE) works as well as standard radiation boost for men with intermediate-risk prostate cancer. About 224 participants will receive standard radiation plus either an IRE boost or a radiation boost. The main g…

This early-phase study tests a radioactive drug (131-I apamistamab) given before CAR T-cell therapy for people with relapsed or refractory B-cell acute lymphoblastic leukemia or diffuse large B-cell lymphoma. The goal is to find a safe dose and see if the combination is tolerable…

This study tests a combination of four drugs (CyBorD plus daratumumab) for people with kidney damage caused by abnormal proteins from a blood condition called monoclonal gammopathy. The goal is to see if the treatment is safe and can improve kidney function. About 20 adults with …

This study tests a new way to prepare people with sickle cell disease or beta-thalassemia for a stem cell transplant from a half-matched donor. Before the transplant, patients receive drugs to lower their immune system, which may help prevent serious side effects like graft failu…

This study tests whether pembrolizumab, a drug that helps the immune system attack cancer, can shrink tumors in people with ultra-rare sarcomas. About 32 adults with specific rare sarcoma types that have come back or spread will receive the drug. The goal is to see if the treatme…

This study tests whether combining two drugs, abemaciclib and cabozantinib, is safe and effective for people with advanced kidney cancer that has not responded to immunotherapy. About 43 adults with clear cell or translocation renal cell carcinoma will receive different doses to …

This study tests giving radiotherapy before mastectomy instead of after, so women with advanced breast cancer can have immediate reconstruction using their own tissue. The goal is to see if this approach is safe and has fewer wound problems than the standard delayed reconstructio…

This early-phase study tests the safety of an experimental drug (BMS-986504) when given together with standard cancer treatments. It includes up to 60 adults with advanced mesothelioma, stomach/esophageal cancer, or bladder cancer whose tumors lack the MTAP gene. The main goal is…

This study tests whether the drug elacestrant, alone or combined with abemaciclib, can shrink or control advanced or recurrent ER+ endometrial cancer. It is for people who have already tried platinum chemotherapy and a PD-1 inhibitor. The goal is to see how many patients respond …

This study tests whether two drugs, azacitidine and venetoclax, can eliminate or reduce small amounts of leukemia that remain after standard chemotherapy in people with acute myeloid leukemia (AML). Participants are adults planning to receive a donor stem cell transplant (bone ma…

This study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink tumors in people with advanced head and neck cancer that has returned or spread after initial treatment. About 40 adults whose cancer worsened after first-line therapy will receive the c…

This study tests whether the drug enfortumab vedotin can shrink or slow the growth of adenoid cystic carcinoma (ACC) that has spread or come back. About 34 adults with advanced ACC will receive the drug and be monitored for side effects and tumor response. The goal is to find a n…

This early-stage study tests a new treatment called MQ710, made from a modified virus, injected directly into tumors. It is for people with advanced solid tumors that have not responded to standard treatments. The main goal is to find the highest safe dose of MQ710 when given alo…

This study tests a chemotherapy plan called N10 for children with high-risk neuroblastoma, a rare and aggressive cancer. The goal is to see if this reduced treatment is safe and can shrink tumors effectively. About 45 children under 19 with newly diagnosed high-risk neuroblastoma…

This study tests a technique called acute normovolemic hemodilution (ANH) during ovarian cancer surgery. Before surgery, some blood is removed and replaced with fluids, then returned later. The goal is to see if this reduces the need for donor blood transfusions. About 86 adults …

This study tests whether adding BIO 300 to standard chest radiation can prevent severe lung inflammation (pneumonitis) in people with early-stage non-small cell lung cancer who also have interstitial lung disease (lung scarring). About 25 adults will receive the combination and b…

This study tests whether the drug TSR-042, given before standard chemoradiotherapy and surgery, can improve outcomes for people with advanced mismatch repair deficient (dMMR) solid tumors. About 200 adults with locally advanced disease that hasn't spread will receive the drug, th…

This study tests whether two drugs, mirdametinib and palbociclib, can safely control advanced liposarcoma that has spread or cannot be removed. About 54 adults with this rare cancer will receive different doses to find the best one. The goal is to stop the cancer from growing for…

This study tests whether adding the immunotherapy drug pembrolizumab to chemotherapy given directly into the affected arm or leg (via isolated limb infusion) can delay cancer growth in people with advanced sarcoma. About 30 participants aged 12 and older will be enrolled. The goa…

This study tests whether a combination of three drugs (fianlimab, cemiplimab, and ipilimumab) can safely shrink tumors in people with advanced melanoma that no longer responds to standard PD-1 therapy. About 88 adults with locally advanced or metastatic melanoma will participate.…

This study tests whether two immunotherapy drugs, botensilimab and balstilimab, can shrink or eliminate locally advanced rectal tumors that are mismatch repair proficient (MMRp/MSS). About 40 adults with stage II or III rectal cancer will receive the drugs before standard chemoth…

This study tests a new radioactive drug, 177Lu-PSMA-617, to see if it is safe for people with a fast-growing type of brain tumor called IDH wild type glioma. The drug targets a protein (PSMA) found on these tumor cells and delivers radiation directly to them. About 20 adults whos…

This study looks at whether a more aggressive approach to managing high blood pressure during breast cancer treatment is safer and better at lowering blood pressure and reducing heart damage than the usual approach. About 130 women with breast cancer and high blood pressure will …

This study is for people with metastatic cancer that has spread and who have a specific gene change called an ATM mutation. Researchers want to see if a lower dose of radiation can still control the tumor, which might mean fewer side effects. About 40 adults will take part, and t…

This early-phase study tests an experimental cell therapy called MB-CART19.1 for people with central nervous system lymphoma (CNSL) that has returned or not responded to prior treatments. The therapy uses a patient's own immune cells, modified to target cancer, and is made on-sit…

This study tests a new imaging tracer called 89Zr-DFO-SC16.56 that attaches to a protein (DLL3) found on some cancer cells. The goal is to see if it is safe and can help doctors see small cell lung cancer on PET scans. About 53 people with certain cancers will take part. The stud…

This study tests whether watching an educational video can increase interest in a preventive surgery called opportunistic salpingectomy (removing the fallopian tubes) to lower ovarian cancer risk. About 266 women aged 45 or older who are at average risk and not planning future ch…

This study tests if the drug mogamulizumab can prevent adult T-cell leukemia/lymphoma (ATL) in people infected with HTLV-1 who are at higher risk due to changes in their T-cells. About 134 participants will receive a limited course of the drug to reduce the virus level in their b…

This study tests if a material called Stimulan Rapid Cure, which releases antibiotics directly into the surgical site, can lower the chance of infection in women getting breast tissue expanders after mastectomy. About 392 women will take part. The goal is to see if this local tre…

This study looks at two different walking programs for women with breast cancer who are getting chemotherapy. One program has a set amount of walking each week, while the other adjusts the walking level based on how each woman responds. The goal is to see which approach better im…

This study looks at two common choices during bladder cancer surgery: using a ureteral stent (a tube to drain urine) and giving a drug called alvimopan to help the bowels work sooner. About 530 adults having their bladder removed will be randomly assigned to get one or both optio…

This study looks at whether a Hospital-at-Home program can safely monitor people with small cell lung cancer after they receive the drug tarlatamab, instead of keeping them in the hospital. About 70 adults will be enrolled. The goal is to see if home monitoring reduces the number…

This study tests whether the herbal formula Ma-Zi-Ren-Wan (MZRW) can improve bowel movements in cancer survivors who have chronic constipation. About 70 participants will receive either MZRW or a placebo for 2 weeks. The researchers will also look at how MZRW affects the gut micr…

This study compares two virtual therapies—music therapy and cognitive-behavioral therapy—to see which better reduces anxiety in people who have had cancer. About 368 adults who are cancer-free or stable and have significant anxiety will participate. Researchers will also explore …

This study adapts a counseling approach called Meaning Centered Psychotherapy to better support Latinos with advanced cancer. Researchers will test if this culturally tailored program improves spiritual well-being and reduces anxiety and depression. About 190 adults with stage II…

This study tests whether a virtual mind-body program called Integrative Medicine at Home (IM@Home) can reduce fatigue and improve well-being in adults with head/neck, thoracic, gynecologic, or melanoma cancers. Participants will receive the program while undergoing treatments lik…

This study tests whether shining a special light (photobiomodulation) inside the mouth can safely ease painful sores from chronic graft-versus-host disease, a common complication after a stem cell transplant. About 44 people aged 4 and older who have mouth sores that didn't impro…

This study looks at how a drug called enfortumab vedotin affects the nerves of people with advanced bladder cancer that has spread. Researchers will measure nerve function with simple tests before and during treatment. The goal is to better understand nerve damage, not to test a …

This study aims to understand how skin conditions related to cancer or cancer treatments affect the well-being of patients and survivors. Over 1,000 participants will fill out questionnaires about their skin condition. The goal is to improve how doctors treat these skin issues an…

This study uses advanced MRI scans to measure water movement inside tumors, which may give doctors more information about the cancer. Researchers will compare these new MRI images with standard tests to see if they can predict how well a patient responds to treatment. The study i…

This study looks at whether people with unexplained weight loss who get lung cancer screening are more likely to have or develop lung cancer. Researchers will use low-dose CT scans and blood tests to find tumors early. The goal is to see if weight loss can help catch lung cancer …

This study is looking at how well cardiac MRI scans can show the details of blood clots that form in the right atrium of the heart due to central venous catheters in adult cancer patients. The goal is to help doctors choose the best treatment for these clots. About 150 participan…

This study looks at how a plant-based diet or supplements (omega-3, curcumin, or probiotics) change butyrate levels in the stool of people with smoldering multiple myeloma or MGUS. About 200 participants will be followed for 2 weeks. The goal is to understand how diet affects gut…

This study tests a program that screens cancer patients for emotional distress and connects them to mental health services. It involves 50 English- and Spanish-speaking adults with new solid tumor cancers at Jamaica Hospital Medical Center in New York City. The goal is to see if …

This study is building a database of health information from 500 adults with bone metastases that cause symptoms. Researchers will track how long participants live and what treatments they receive. The goal is to learn more about this condition, not to test a new drug or therapy.

This study adapts a program called CONVO for Spanish-speaking Latinx adults with solid tumors. The program helps patients talk with their oncology nurses about what matters to them during cancer care. Researchers will translate and culturally tailor the program for use in communi…

This study looks at why some people with blood cancers like acute leukemia receive a stem cell transplant while others do not. Researchers will track 1,365 patients to see how many get the transplant and what barriers—medical or personal—prevent it. The goal is to understand and …

This study is testing a questionnaire called PRO-AYA for teens and young adults (ages 15-39) with cancer. The goal is to see if the questions accurately capture their health and well-being. About 120 participants will fill out the survey, and some Spanish-speaking participants wi…

This early-stage study tests whether a new imaging tracer, made of tiny silica nanoparticles, can safely help doctors see prostate cancer cells before and during surgery. About 16 men with high-risk prostate cancer will receive the tracer and then have PET/MRI scans and special c…

This study follows 300 people who had surgery to remove bone tumors and then had reconstruction using bone grafts or artificial devices. Researchers will measure how well the bone heals and how much function returns over 3 years. The goal is to better understand recovery after th…

This study is testing a decision aid tool called RECONJOINT to help women with breast cancer choose the best reconstruction surgery after mastectomy. Researchers want to see if it's practical to run a larger study on how well the tool works. About 131 participants will use the to…

This study looks at how radiation from a procedure called Y90 radioembolization damages liver tumors that have spread from colon or rectal cancer. Researchers will take small tissue samples (biopsies) from the tumors after treatment to see how much cell death occurs. The goal is …

This study explores whether new MRI and CT imaging techniques can help doctors better plan radiation therapy and check how tumors respond during treatment. It involves about 837 adults aged 18 and older who are already scheduled for radiation therapy. Participants will have extra…

This study aims to develop and test a communication training program called Hematolo-GIST for doctors who treat large B-cell lymphoma. The goal is to help doctors better discuss the diagnosis and plan future care with their patients. The study will enroll 48 participants, includi…

This study creates a registry of DNA and health information from people with germ cell or testicular tumors, their blood relatives, and unrelated volunteers. By comparing these groups, researchers hope to learn why some people develop these tumors and others don't. The goal is to…

This study is collecting images of skin and mouth lesions using noninvasive tools like high-resolution OCT. The goal is to see if these images can help doctors diagnose lesions more accurately before deciding on a biopsy. The images will be stored in a database to support future …

This study asks caregivers of people with Erdheim-Chester disease and similar conditions about their supportive care needs. Researchers will survey 250 unpaid caregivers (family or friends) to learn what kind of help they need. No treatments or medications are involved—only quest…

This study compares three types of medical interpreting (remote simultaneous, consecutive, and video) to see which leads to fewer mistakes when Spanish- or Mandarin-speaking breast cancer patients talk with their English-speaking doctors. About 700 patients with stage II or III b…

This study looks at how memory, attention, and thinking skills change over time in women aged 60-80 who are long-term breast cancer survivors, compared to healthy women of the same age. Researchers will use computer tests to measure mental function and also check smoking exposure…

This study is collecting health information from 300 people with Cushing's syndrome over time to see how they do after their usual treatments like surgery, medication, or radiation. It does not test any new drug or procedure. The goal is to build a registry that helps doctors bet…

This study looks at gene changes (mutations) in cancer cells from people with solid tumors or blood cancers. Researchers use leftover tumor tissue from past surgeries or biopsies, plus a blood or saliva sample, to find mutations that might affect how a cancer responds to treatmen…

This study aims to understand the genetic and biochemical makeup of neuroblastic tumors, which can affect how aggressive the cancer is and what treatments work best. Researchers will analyze tumor samples, blood, bone marrow, and stem cells from over 2000 participants. The goal i…

This study is working on a simple test to find pancreatic cancer at an early stage and to see how well treatment is working. Researchers will study blood and tissue samples from 700 people with pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to improve early det…

This study is a registry that collects information from 100 adults with thyroid cancer that no longer responds to standard radioactive iodine treatment. Doctors are using redifferentiating medications as part of normal care to try to make the cancer respond to radioactive iodine …

This study tests whether teaching oncology doctors, nurses, and physician assistants empathic communication skills can reduce the stigma lung cancer patients often feel during medical visits. Over 1,200 healthcare providers from across the U.S. will participate in training sessio…

This study tests whether a special ultrasound (mpUS) can measure changes in vaginal tissue caused by internal radiation therapy (IVRT) for endometrial cancer. Ten participants will have ultrasound scans before and after treatment to see if the method can detect side effects like …

This study follows 600 people with early-stage lung cancer who have a type of surgery called segmentectomy. Participants fill out questionnaires before surgery, a few weeks after, and 6 months after. The goal is to see how long people stay cancer-free after the procedure.