Personalized chemo dosing may boost CAR T-Cell success in leukemia
NCT ID NCT07223021
First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 21 times
Summary
This study tests whether giving a personalized dose of fludarabine (a chemotherapy drug) before CAR T-cell therapy can improve outcomes for children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia. About 130 participants will be randomly assigned to receive either standard or personalized fludarabine dosing. The goal is to see if the personalized approach helps keep the cancer away longer and reduces side effects.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Children's Hospital of Philadelphia (Data Collection Only)
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Cincinnati Children's Hospital Medical Center (Data Collection Only)
RECRUITINGCincinnati, Ohio, 45229, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Conditions
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