Memorial Sloan Kettering Cancer Center

This phase 2 study tests whether combining NKTR-214 and nivolumab can shrink tumors in people with advanced sarcoma that has spread. About 88 participants aged 12 and older will receive the drug combination. The main goal is to see how many patients have their tumors shrink or di…

This study is for people with certain blood cancers (like leukemia or lymphoma) who are getting a stem cell transplant from a donor. The goal is to see if giving two drugs, palifermin and leuprolide acetate, can help the immune system bounce back faster after the transplant. Abou…

This early-phase study tests a new type of CAR T cell therapy for adults with large B-cell lymphoma that has come back or not responded to treatment. The therapy uses specially modified immune cells to find and attack cancer cells. The main goals are to check safety and find the …

This study tests whether giving a combination of two immunotherapy drugs (nivolumab and ipilimumab) before surgery can shrink melanoma tumors and prevent the cancer from coming back. About 28 adults with stage III melanoma that can be surgically removed will receive the drugs bef…

This study tests whether two drugs, lenvatinib and pembrolizumab, can shrink or slow the growth of advanced adenoid cystic carcinoma and other salivary gland cancers that have come back or spread. About 64 participants will receive the combination to see how well it works and how…

This early-phase study tests a combination of two drugs, glofitamab and lenalidomide, in 39 adults with mantle cell lymphoma that returned or didn't respond to prior treatment, including a BTK inhibitor. The goal is to see if the combination is feasible and effective. Participant…

This study compares two different ways of giving the immunotherapy drug atezolizumab together with standard chemotherapy (gemcitabine and cisplatin) for people with advanced bladder cancer that has spread. One group gets chemotherapy first, then atezolizumab; the other gets atezo…

This study tests whether combining the drug durvalumab with radiation therapy can delay cancer worsening in people with locally advanced non-small cell lung cancer, without using chemotherapy. About 61 adults with stage II or III lung cancer will receive this treatment. The goal …

This study tests a combination of three drugs (rituximab, bendamustine, and melphalan) followed by a stem cell transplant using the patient's own cells. It is designed for older adults with multiple myeloma or certain lymphomas. The goal is to see if this approach causes fewer se…

This study tests whether combining two immunotherapy drugs—pembrolizumab and BCG—can keep high-risk T1 bladder cancer from coming back. About 45 participants will receive this combination as their first treatment, with the goal of avoiding the need for bladder removal surgery. Th…

This study tests a medicated cream (ruxolitinib) against standard moisturizers for a chronic skin condition called graft-versus-host disease that can occur after a stem cell transplant. About 24 people aged 12 and older will take part. The goal is to see if the cream safely reduc…

This phase 2 trial tests how long patients with stage II or III rectal cancer should wait after chemoradiation before surgery. The goal is to find the best timing to shrink tumors, reduce side effects, and make surgery easier. About 248 participants will receive radiation plus ch…

This study tests whether giving a personalized dose of a drug called r-ATG before a stem cell transplant can help the immune system recover faster and reduce serious side effects. It includes children and adults with leukemia or myelodysplastic syndrome. The goal is to improve su…

This study tests whether a very low-carb (ketogenic) diet, a low-carb diet, or the diabetes drug canagliflozin can prevent high blood sugar caused by the cancer drug alpelisib. The goal is to see if controlling blood sugar helps alpelisib work better in people with advanced PIK3C…

This study tests a new type of radiation therapy for men with intermediate-risk prostate cancer. The treatment uses very high doses of radiation in just a few sessions, guided by MRI to target the tumor precisely. The goal is to see if this approach is safe and feasible, with 35 …

This study tests whether the drug niraparib can help control advanced soft tissue sarcoma that has certain DNA repair mutations. About 8 adults with inoperable or spreading sarcoma will receive niraparib to see if it slows tumor growth and is safe. The goal is to find a new treat…

This study tests the safety of a drug called RP-3500 combined with radiation therapy for people whose metastatic solid tumors have a specific gene change (ATM mutation). The goal is to find the best dose that causes few side effects and to see if the treatment can control tumor g…

This study tests whether combining three drugs—nivolumab (an immunotherapy), FOLFOX (standard chemo), and regorafenib (a targeted therapy)—can safely control HER2-negative metastatic esophagogastric cancer. About 39 adults with advanced disease that has spread will receive this c…

This study tests whether giving radiation therapy before standard CAR T cell treatment is safe and helpful for people with B-cell lymphoma that has come back or not responded to treatment. About 20 adults will receive a special split-course of radiation aimed at all active cancer…

This study tests whether giving a precise, high-dose form of radiation (SBRT) within a week before surgery is safe for people with cancer that has spread to their bones. The goal is to see if this approach reduces the chance of the cancer returning in the treated bone. The study …

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy (gemcitabine and cisplatin) is safe and effective for people with advanced bladder cancer. About 54 adults with metastatic or muscle-invasive bladder cancer will receive the combination. …

This early-phase trial tests a treatment called lifileucel (LN-144) for people with melanoma that has spread to the brain and is no longer responding to standard immunotherapy. The treatment uses a patient's own immune cells, called tumor-infiltrating lymphocytes (TILs), which ar…

This study looks at whether the number of stem cells given during a transplant affects how well the immune system recovers in people with relapsed or refractory diffuse large B-cell lymphoma. About 59 adults who have already tried one chemotherapy will receive high-dose therapy f…

This study tests two drugs, olaparib and pembrolizumab, given before standard surgery for people with triple-negative or hormone receptor-positive, HER2-negative breast cancer who have inherited DNA repair gene mutations. The goal is to see if the combination can shrink tumors en…

This study tests whether combining pembrolizumab (an immunotherapy) with gemcitabine (chemotherapy) can help people with advanced mycosis fungoides or Sézary syndrome, rare types of skin lymphoma. About 14 adults who have already tried at least one other treatment will receive th…

This study tests a combination of two drugs—an antibody called Hu3F8 and GM-CSF—in children with high-risk neuroblastoma that has come back or not responded to standard therapy. The main goal is to find a safe dose and check for side effects. About 186 participants will be enroll…

This study tests whether a lab-made antibody (Hu3F8) plus a drug called GM-CSF can help keep osteosarcoma, a type of bone cancer, from returning after it has already come back once. About 46 children and young adults (ages 1 to 40) whose cancer is in a second remission will recei…

This study tests a daily pill called erdafitinib in 20 adults whose non-muscle invasive bladder cancer has returned after standard treatments like BCG or chemotherapy. Only people whose tumors have a specific FGFR3 gene change can join. The pill blocks the faulty protein made by …

This early-phase study tests whether a personalized cancer vaccine, made from a patient's own tumor, combined with an immunotherapy drug (atezolizumab) and chemotherapy is safe for people with pancreatic cancer that has been surgically removed. About 29 adults with resectable pan…

This study tests a shorter radiation treatment called partial breast irradiation (PBI) for women with early-stage breast cancer. Instead of treating the whole breast for 5-7 weeks, PBI targets only the area where the tumor was removed, given daily for 2 weeks. The goal is to see …

This study tests whether adding the drug CC-486 to standard lenalidomide and radiation therapy is safe and works better for people with plasmacytoma, a rare blood cancer that can turn into multiple myeloma. About 21 adults with newly diagnosed or returning plasmacytoma will recei…

This study looks at how safe and effective the diabetes drug glipizide is for lowering high blood sugar in people with pancreatic cancer. About 29 adults with active pancreatic cancer and high blood sugar will take glipizide, and researchers will track their glucose levels before…

This early-phase study tests whether a patient's own immune cells (T cells) can be genetically modified to better recognize and attack prostate cancer cells. The main goal is to check the safety of different doses in men with advanced prostate cancer that no longer responds to ho…

This study tests whether adding daratumumab to three standard drugs (carfilzomib, lenalidomide, dexamethasone) is safe and effective for people newly diagnosed with multiple myeloma. About 75 participants will receive the four-drug combination. The main goal is to see how many ac…

This early-stage trial tests a new drug called ERAS-601 in 12 adults with advanced chordoma, a rare bone cancer. The goal is to see if the drug is safe and can shrink tumors or stop them from growing for at least 6 months. Participants must have cancer that has gotten worse despi…

This study tests if a shorter course of hormone therapy (ADT) combined with two types of radiation (brachytherapy and external beam) can safely prevent high-risk prostate cancer from returning or spreading. About 50 men with aggressive prostate cancer and a low-intermediate genom…

This study tests whether adding the immunotherapy drug nivolumab to radiation and another drug called bevacizumab can help people with a returning type of brain cancer called glioblastoma. The trial includes 39 adults whose tumors have a specific genetic marker (MGMT methylated) …

This study tests whether adding the drug Voraxaze (glucarpidase) to the standard treatment for central nervous system lymphoma can safely lower methotrexate levels in the blood. About 58 adults with B-cell lymphoma in the brain or spine are taking part. The goal is to reduce side…

This study is for people with Merkel cell carcinoma that has spread or can't be removed by surgery and has gotten worse after initial treatment. It tests whether giving a type of focused radiation (CART) together with the immunotherapy drug avelumab can help control the cancer. T…

This study tests whether combining two drugs, rucaparib and nivolumab, can treat advanced or metastatic leiomyosarcoma (LMS) better than standard chemotherapy. About 20 adults with LMS that cannot be removed by surgery or has spread will receive the combination. The goal is to se…

This study tests the safety of adding two immunotherapy drugs, durvalumab and tremelimumab, to standard chemotherapy and radiation for people with esophageal or gastroesophageal junction cancer. About 64 participants will receive initial chemotherapy followed by the drug combo wi…

This study tested whether adding the targeted drug cetuximab to standard chemotherapy could shrink advanced thymoma or thymic carcinoma tumors before surgery. 18 adults with stage II to IVA disease received the combination, then had their tumors removed. Researchers measured how …

This study tests the safety and effectiveness of the drug pembrolizumab in preventing cancer from returning. It includes 17 adults with MSI-H solid tumors who had surgery but still have tumor DNA in their blood. Participants receive pembrolizumab or a placebo for up to 12 months,…

This study is testing if a drug called anakinra can prevent or reduce severe brain-related side effects and dangerous immune reactions in adults receiving CAR-T cell therapy for certain B-cell cancers. The goal is to make this powerful cancer treatment safer by controlling its mo…

This study tests an experimental treatment called HB-200 for people with HPV16-positive head and neck cancer who have completed standard therapy but still show cancer-related DNA in their blood (detected by a special test). The goal is to see if HB-200 can control or eliminate an…

This study tests whether the drug pembrolizumab can shrink or stop the growth of recurrent malignant gliomas, a type of aggressive brain cancer. The drug works by activating the immune system to attack cancer cells. The trial enrolled 27 adults whose tumors have returned after pr…

This study tests whether a new imaging drug called 89Zr-ss-pertuzumab is safe for people with HER2-positive breast or other cancers. About 60 participants will receive the drug and be monitored for side effects. The goal is to improve how doctors see these cancers on scans, not t…

This study tests a new fluorescent dye, PARPi-FL, to see if it can help doctors spot oral squamous cell carcinoma during surgery. About 23 adults with mouth or throat cancer will receive the dye before their operation. Researchers will check safety at different doses and find the…

This study tests whether a plant-based diet is practical for overweight people with early blood conditions called MGUS or smoldering multiple myeloma. Researchers will measure weight loss and diet adherence over 12 weeks, and also check if the diet can prevent progression to mult…

This study looks at whether giving methadone during spinal surgery can reduce pain and the need for extra painkillers in the first three days after surgery. About 17 adults having spinal surgery for cancer will take part. Researchers will compare standard pain treatment with and …

This study tests a mindfulness program called MORE to see if it helps people with long-term cancer pain. Researchers will enroll 76 adults who have had cancer and still have pain for at least 3 months. The goal is to see if learning to focus on the present moment can reduce pain …

This study compares two types of support groups for breast cancer survivors: a Meaning-Centered Group that helps participants find purpose after cancer, and a Discussion Group that offers peer support. About 104 survivors who have finished treatment (but may still take hormone th…

This study tests a new way to calculate the dose of the chemotherapy drug melphalan for people with lymphoma who are about to have a stem cell transplant. Instead of using a standard dose based on height and weight, researchers use a model that considers how previous patients pro…

This study compares two ways of giving high-dose radiation to people whose cancer has spread to bones, spine, soft tissue, or lymph nodes. One group gets a single large dose in one day, the other gets a slightly higher total dose split over three days. The goal is to see which sc…

This study looks at whether giving siltuximab before and after an autologous stem cell transplant can reduce common side effects like fatigue, pain, and nausea in patients aged 60-75 with multiple myeloma or AL amyloidosis. The drug blocks a protein called IL-6 that is linked to …

This study tests a memory training program for breast cancer survivors who have memory problems after chemotherapy. About 60 women who had chemo 1-10 years ago will use one of two versions of a computer program (Cogmed) for 5 weeks. The goal is to see if the training improves mem…

This study tests a communication program for people with advanced cancer and their caregivers. The goal is to help them manage difficult emotions, talk about the illness, and make treatment plans together. The program is tailored for Latinx participants and aims to reduce stress …

This study looks at whether acupuncture or massage works better over time for people with advanced cancer who have pain. About 300 adults with certain advanced cancers will receive one of the two treatments. The goal is to see which approach helps more with pain, related symptoms…

This study adapts a type of counseling called Meaning-Centered Psychotherapy for Chinese immigrants with advanced cancer. The goal is to help patients maintain a sense of meaning and purpose in life despite their illness. Researchers will interview and test the adapted program wi…

This study looks at whether training doctors to communicate better can help lymphoma patients move from active treatment to survivorship. It involves 314 patients with Hodgkin's or Diffuse Large B-cell Lymphoma. The goal is to see if improved doctor-patient conversations lead to …

This study looks at how lung cancer patients and their doctors talk to each other. Researchers want to see if good communication affects how patients feel and their health results. About 294 patients will join, and doctors will also get training to improve their communication ski…

This study is creating large registries for non-communicable diseases (like heart disease and cancer) in sub-Saharan Africa. Researchers will collect health data and stool samples from nearly 7,000 adults, including healthy volunteers, to better understand these diseases and impr…

This study gathers information from 49 patients with relapsed or hard-to-treat multiple myeloma and their doctors. The goal is to understand why some patients do not receive advanced cell therapies like stem cell transplants or CAR T-cell therapy. By identifying these barriers, r…

This study searches for brand-new gene changes that appear in children but not in their parents, which might raise cancer risk. Researchers will compare DNA from 1,275 cancer patients (with breast, colon, or other cancers) and their healthy parents. The goal is to find these hidd…

This study looks at a different way to offer genetic testing to people with ovarian, prostate, or pancreas cancer. Instead of always sending patients to a genetic counselor, doctors may offer the test directly, and counselors share results by phone. The goal is to see how this af…

This study looks at how prostate cancer changes after radiation treatment using special MRI scans. The goal is to help doctors better understand and manage the disease without surgery. About 120 men with newly diagnosed prostate cancer will take part. The results may lead to quic…

This study follows 600 people with non-muscle invasive bladder cancer to see how lifestyle choices like smoking and body weight affect the chance of the cancer coming back. Researchers will track these habits over time and check for cancer recurrence. The goal is to understand wh…

This study tests a new training program called PACT for nurses caring for patients with advanced gastrointestinal cancer. The program aims to help nurses better involve and support family caregivers. Researchers will observe how often nurses use these skills and whether it improv…

This study looks at how the bacteria naturally living in the colon might affect colorectal cancer risk in people with Lynch syndrome or other inherited colon polyp conditions. Researchers will collect stool samples, colon tissue, and diet/lifestyle questionnaires from 77 particip…

This study aims to improve how doctors estimate survival for people with cancer that has spread to their bones. Researchers will combine doctor assessments and patient-reported health status to create a more accurate prediction model. The study involves 230 adults scheduled for s…

This study looks at whether a ketogenic diet—a very low-carbohydrate diet that makes the body burn fat for energy—is safe and tolerable for overweight or obese patients with newly diagnosed endometrial cancer. Nineteen participants will follow the diet before their surgery. The m…

This study looks at whether training Black men who have already completed a colon cancer screening test (FIT) can encourage three of their friends or family members to also get tested. The goal is to see if this peer outreach approach increases screening rates in the Black commun…

This study looks at whether a home-based treadmill walking program can change certain markers of prostate cancer in men with low-risk disease who are not receiving active treatment. About 36 men will either follow a prescribed exercise plan or continue their usual routines. The g…

This study looks at whether combining PET/MRI scans with blood and tissue tests can create a detailed profile of high-grade serous ovarian cancer. About 10 people with advanced ovarian cancer will take part. The goal is to better predict how tumors respond to treatment, which cou…

This study tests a new imaging tool called MSOT that uses light and sound to create pictures of tumors. About 12 people with breast cancer or melanoma will get an MSOT scan before their usual biopsy. The goal is to see if MSOT can find tumors as well as standard methods like ultr…

This study measures how cisplatin chemotherapy affects the inner lining of blood vessels (endothelium) in men with germ cell tumors. It compares 44 participants: those receiving cisplatin and those who had surgery only. The goal is to understand why cisplatin may increase long-te…

This study looks at how different antibiotics change the community of helpful bacteria in the gut of people who have received a stem cell transplant. These patients often develop fever and low white blood cell counts, requiring antibiotics. The goal is to understand which antibio…

This study looks at how prostate cancer survivors' thinking and memory (called cognitive function) may be linked to other issues like anxiety, depression, and trouble sleeping. Researchers will also examine how social factors, cancer details, and treatments might play a role. Abo…

This study looks at how surviving a pediatric brain tumor affects children's thinking, memory, and behavior. Researchers will follow 42 children who have completed treatment for certain brain tumors. The goal is to learn more about the long-term effects of cancer and its treatmen…

This study uses a tiny amount of a radioactive tracer called 124I-PUH71 to take PET scans of cancer patients. The goal is to see where the tracer goes in the body and how long it stays in the blood. This information will help researchers plan future studies using higher doses of …

This early-phase study tests whether a special PET scan using an experimental tracer called 18F-FAC can show how much of the standard chemotherapy drug gemcitabine is taken up by pancreatic tumors. About 30 adults with pancreatic cancer will receive the tracer before starting tre…