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New cocktail aims to deeply suppress myeloma from the start

NCT ID NCT03290950

First seen Oct 31, 2025 · Last updated Apr 29, 2026 · Updated 33 times

Summary

This study tests whether adding daratumumab to three standard drugs (carfilzomib, lenalidomide, dexamethasone) is safe and effective for people newly diagnosed with multiple myeloma. About 75 participants will receive the four-drug combination. The main goal is to see how many achieve minimal residual disease (MRD) negativity, meaning no cancer cells are detectable after treatment. This is a disease control study, as ongoing maintenance therapy is typically needed.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

Conditions

Explore the condition pages connected to this study.