Karolinska Institutet

This study tests whether giving small daily doses of multiple allergenic foods (like milk, egg, and peanut) can safely cure food allergies in children aged 6 months to 3 years. About 80 children with confirmed allergies will receive either the treatment or a placebo for 2 years. …

This study tests a new digital tool called Evira that helps families manage childhood obesity. Kids weigh themselves at home daily and share results with their clinic through an app. The goal is to see if adding this tool to standard lifestyle treatment improves weight control. A…

This study looks at whether adding stair climbing to daily routines can lower blood pressure more than brisk walking alone. It includes 450 adults aged 35+ who have high blood pressure, are overweight, and are not very active. Participants will be split into three groups: stair w…

This study tests a drug called eplerenone in 40 people who have both heart failure with reduced pumping function and severe chronic kidney disease. The goal is to see if it is safe and can help improve symptoms and reduce hospital visits. Participants will take the drug and be cl…

This study looks at 350 women under 39 with advanced endometriosis (stage III-IV) who want to get pregnant. It compares two approaches: having surgery to remove endometriosis tissue before starting IVF, or going straight to IVF without surgery. The goal is to see which method lea…

This study tests an internet-based cognitive behavioral therapy (iCBT) program for 200 adults in Sweden who have ADHD. The goal is to see if the online therapy can improve quality of life and reduce ADHD symptoms, anxiety, depression, and stress. Participants will be randomly ass…

This study tests a new, fast-paced therapy for teens aged 13–17 with PTSD. Instead of months of weekly sessions, the program packs EMDR, talk therapy, exercise, and parent support into just 5 days. Researchers want to see if this approach is practical and acceptable in Swedish cl…

This study compares two types of talk therapy for people with anxiety disorders (generalized anxiety, social anxiety, or PTSD). One therapy, metacognitive therapy (MCT), focuses on changing how people think about their own thoughts. The other, cognitive-behavioral therapy (CBT), …

This study tests an online cognitive behavioral therapy program for children aged 8-17 with functional abdominal pain disorders, which cause frequent stomach pain without a clear physical cause. The goal is to see if the therapy helps children manage pain and improve daily life. …

This study tests a mobile app designed to support mental health during pregnancy and after birth. About 440 pregnant women will use the app or receive standard care. The goal is to see if the app helps them feel more resilient and reduces symptoms of depression and anxiety.

This study tests whether an online cognitive behavioral therapy (CBT) program can help children aged 8-17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma symptoms. About…

This study tests if an online therapy program (CBT) can help people who had a heart attack feel less anxious about their heart and improve their quality of life. About 176 adults who had a heart attack at least 6 months ago and still have significant heart-related fear will parti…

This study is testing a stepped care approach to help children aged 8-16 who have trouble controlling anger or show defiant or aggressive behavior. The program starts with a brief online parenting support course. If more help is needed, families can try a virtual reality (VR)-ass…

This study tests an internet-based therapy called IERITA for teenagers aged 13-17 who have hurt themselves on purpose (nonsuicidal self-injury). The therapy helps teens learn to manage their emotions. The goal is to see if this online approach is practical and helpful, so it can …

This study tests an online program called POET that teaches teens (ages 12-17) how to manage their emotions to reduce mental health problems. About 388 participants will be randomly assigned to receive POET or usual care. The goal is to see if the program helps ease symptoms and …

This study is testing whether a supervised exercise program (high-intensity interval and resistance training) during chemotherapy can help eliminate breast cancer more effectively. 712 patients will be randomly assigned to either the exercise program or usual care. The main goal …

This study explores whether group-based metacognitive therapy (MCT) is practical and well-liked by adults with PTSD in regular psychiatric care. About 30 participants will attend group sessions, and researchers will track how many complete the treatment, report side effects, and …

This study compares two groups of women having robotic hysterectomy: one group goes home the same day, the other stays overnight. Researchers want to see if same-day discharge leads to faster recovery and similar safety. About 300 women with benign conditions or endometrial cance…

This study compares two ways of giving surfactant, a medicine that helps premature babies' lungs work better. The standard method uses a breathing tube placed into the windpipe, which can be uncomfortable and risky. The newer method uses a soft mask placed in the throat. The goal…

This study looks at children with tracheostomies to see if serious airway problems can be detected early through symptoms reported by parents or doctors. Researchers will compare these reports with findings from routine camera exams of the airway. The goal is to understand how re…

This study looks at 90 people with a heart condition called mitral valve prolapse who need surgery to fix a leaky valve. Researchers want to see if the surgery reduces dangerous heart rhythms and scarring in the heart muscle. Participants will have heart scans and wear a heart mo…

This study looks at how the natural bacteria (microbiome) and chemical profiles (metabolome) in couples undergoing IVF might affect their chances of getting pregnant and having a baby. Researchers will collect samples from both partners and track outcomes like fertilization, misc…

This study looks at whether using a computer model to personalize the dose of tuberculosis (TB) drugs can help patients get the right amount of medicine. About 30 adults with pulmonary TB will have their drug levels measured, and doctors will use that information to adjust doses …

This study is testing whether a blood test that looks for donor DNA can help doctors spot heart transplant rejection earlier and more easily. Researchers will collect blood samples from 120 adult heart transplant recipients in Sweden and compare the results with standard heart bi…

This study looks at whether beetroot juice, which contains natural nitrates, can safely lower blood pressure in the lungs of people with serious blood clots (pulmonary embolism). About 36 adults with signs of heart strain will receive either beetroot juice or a placebo for five d…

This study looks at whether a campaign called 'Choosing Wisely' can safely reduce unnecessary medical tests in intensive care units (ICUs). About 10,000 adult ICU patients in Sweden will take part. The goal is to see if using fewer tests affects survival rates and other outcomes.

This study looks at how bacteria in the gut and mouth are linked to different types of epilepsy and whether they affect how well seizure medicines work. Researchers will collect samples from 1500 people with newly diagnosed epilepsy and healthy volunteers. The goal is to find pat…

This study looks at whether planning workouts around menstrual cycle phases improves fitness in female athletes. About 111 healthy women who exercise regularly will be placed into different training schedules over three cycles. The goal is to provide clear, evidence-based advice …

This study follows 91 people who had jaw joint surgery (arthroscopy or discectomy) for disc displacement about 10 years ago. Researchers want to see if the improvement seen at 6 months after surgery is still there a decade later. Participants will have a check-up and a jaw X-ray …

This study tests a method called FIT (Feedback Informed Treatment) in social services. Clients regularly rate their main problems and how they feel about the help they receive. The goal is to see if this feedback helps prevent dropouts and improves outcomes for 400 people dealing…

This study looks at how the COVID-19 pandemic impacted people who had surgery in Stockholm, Sweden. Researchers will track up to 300,000 patients to see if death rates, complications, or hospital stays changed during the pandemic. The goal is to understand the pandemic's effects,…

This study looks at whether an online exposure-based cognitive behavioral therapy can objectively change how people with fibromyalgia experience pain. About 45 participants will undergo pain tests before and after treatment to measure pain thresholds and tolerance. The goal is to…

This study looks at two ways to get students to eat more fruit: putting fruit stands in schools, or adding a health-awareness campaign alongside the stands. About 300 Swedish students aged 7-19 will take photos of their meals using an app so researchers can track fruit intake. Th…

This study looks at how red blood cells (RBCs) influence heart health, especially in people with type 2 diabetes. Researchers will collect RBCs from 500 participants (those with diabetes, heart attack survivors, and healthy volunteers) and test them in the lab to understand how t…