Karolinska Institutet

This study tests if giving young children (ages 6 months to 3 years) a daily powder containing small amounts of 10 common food allergens (like milk, egg, and peanut) can safely cure their food allergies. 80 children with confirmed allergies will receive either the treatment or a …

This study tests two careful methods for treating deep cavities in children's permanent molars and premolars. Instead of removing all decay, dentists leave a small amount of soft tissue near the nerve to protect it. One method does this in a single visit, the other in two visits …

This study is testing whether people with displaced hand fractures can avoid surgery and instead use early, unrestricted movement and rehabilitation. 552 adults with a single displaced spiral or oblique fracture of the index to pinky finger bones will be randomly assigned to eith…

This study tests whether allowing patients with severe psychiatric conditions to admit themselves to inpatient care (instead of doctors deciding) can reduce involuntary admissions and improve well-being. Over 500 participants in Stockholm, Sweden, can self-admit up to three times…

This study tests whether adding a digital behavioral tool called Evira to standard obesity medication (liraglutide or semaglutide) helps teens with obesity lose more weight than medication alone. Forty adolescents aged 12-17 will be randomly assigned to either the combination or …

This study tests whether adding stair climbing to a brisk walking routine lowers blood pressure more than walking alone. 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk walking onl…

This pilot study tests whether the drug eplerenone is safe and feasible for people with both heart failure (reduced pumping ability) and severe chronic kidney disease. Previous studies excluded such patients due to risks like high potassium. The trial will enroll 40 participants …

This study is for women under 39 with advanced endometriosis (stage III-IV) who want to get pregnant. It compares two approaches: having surgery to remove endometriosis lesions before trying IVF, versus going straight to IVF without surgery. The goal is to see which path leads to…

This study compares two types of CPR for people who have a cardiac arrest outside a hospital: hands-only CPR (chest compressions without rescue breaths) versus standard CPR (compressions plus rescue breaths). The trial will include over 3,000 adults whose cardiac arrest is witnes…

This trial tests a therapy called SAFETY, designed to help teenagers who have recently attempted suicide. The study will include 282 youths aged 10-17 and their caregivers. Half will receive SAFETY, a family-based cognitive-behavioral program, and the other half will get enhanced…

This study tests a digital support system called Evira for treating childhood obesity. Children weigh themselves daily at home using a special scale that sends data to an app on their parent's phone and to the clinic. The goal is to see if adding this system to standard lifestyle…

This study tests whether cooling the brain quickly after a cardiac arrest (using a special nasal device) and then keeping the body cool for 24 hours helps more people survive with full brain function. About 1,000 adults aged 18-79 who have a shockable heart rhythm will be randoml…

This study tests whether replacing the arthritic thumb joint with an artificial implant provides better long-term pain relief and hand function than standard bone-removal surgery. Researchers will follow 90 people receiving the implant and compare them to 90 similar patients from…

This study tests whether a lifestyle program can help people with obsessive-compulsive disorder (OCD) become more active and lower their risk for heart disease and diabetes. Researchers will enroll 108 adults with OCD who are not very active. The program focuses on increasing dai…

This study tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and health education. Researchers want to see if it lowers blood pressure and helps…

This study tests if a supervised exercise program during chemotherapy can help eliminate breast cancer more effectively. 712 patients will either do high-intensity interval and resistance training or receive usual care. The main goal is to see if exercise increases the chance of …

This study compares two common tendon grafts used in ACL reconstruction: the semitendinosus (hamstring) and the quadriceps tendon. Researchers want to see which one provides better knee stability and function after surgery. The trial will enroll 200 active adults who plan to retu…

This study is testing new rapid tests (lateral flow and microfluidic devices) to detect respiratory infections in children and adults in Uganda, Ethiopia, and Senegal. Researchers want to see if these tests are accurate and easy to use in low-resource clinics. Participants with r…

This study tests a digital lifestyle program for adults aged 40-60 in Swedish primary care. Participants receive standard health advice plus app-based support for diet, exercise, alcohol, and smoking. The goal is to see if the program improves cholesterol and other heart health m…

This study compares a newer type of talk therapy called transdiagnostic metacognitive therapy (tMCT) with standard cognitive-behavioral therapy (CBT) for people with generalized anxiety, social anxiety, or PTSD. About 86 adults in Sweden will receive either tMCT or CBT to see whi…

This study compares a new type of therapy that combines computer exercises with therapist sessions (blended CBT) to standard prolonged exposure therapy for PTSD. About 160 adults with PTSD will receive one of the two treatments at outpatient clinics in Sweden. The goal is to see …

This study tests whether a therapist-guided online cognitive-behavior therapy program can help reduce obsessive-compulsive disorder (OCD) symptoms in children and teens with autism. About 220 participants will receive the online treatment or a comparison condition. The goal is to…

This study tests a group-based program called GEARS that teaches emotion regulation skills to adults with ADHD. Researchers will compare 150 participants who receive GEARS to those on a waiting list, measuring changes in emotional control, ADHD symptoms, and quality of life. The …

This study tests an online, therapist-guided program to help cancer survivors who have anxiety, depression, or fear of cancer returning. About 400 adults in Sweden who finished cancer treatment at least 6 months ago will take part. The goal is to see which parts of the 10-week on…

Up to 25% of pregnant women experience mental health issues like depression and anxiety. This trial tests a mobile app called HealthyMoms4MentalHealth designed to promote psychological wellbeing during pregnancy. Researchers will enroll 440 pregnant women in Sweden and measure ch…

This study tests whether patients having robotic hysterectomy for benign conditions or endometrial cancer can safely go home the same day instead of staying overnight. 300 patients will be randomly assigned to day-care or overnight stay. Researchers will measure quality of life a…

This study tests whether a 5-day intensive version of prolonged exposure therapy can treat PTSD as effectively as the standard 15-week approach. 140 adults with PTSD will be randomly assigned to either the intensive format or weekly sessions. Researchers will also look at cost-ef…

This study tests an online program called POET that helps teens (ages 12-17) learn to manage their emotions. The goal is to reduce mental health symptoms like anxiety and depression. Participants will be followed for up to 10 years to see if the benefits last.

This study is testing a support program for teens and young adults (ages 16-30) who have just been diagnosed with cancer. The program includes a meeting with a special team and a structured course called PRISM that teaches skills like stress management and goal setting. About 130…

This study tests an internet-based therapy program (IERITA) for teens aged 13-17 who have self-harmed in the past three months. The therapy focuses on helping teens manage their emotions and reduce self-injury. Researchers will track whether teens stop self-harming for at least 3…

This study looks at whether a type of talking therapy (cognitive behavioral therapy) can help reduce severe fatigue in primary care patients. About 190 adults aged 18-67 with long-lasting fatigue will either get the therapy or usual care. The goal is to see if the therapy improve…

This study tests whether internet-based cognitive behavioral therapy (iCBT) can improve quality of life and reduce ADHD symptoms, anxiety, depression, and stress in adults. Two hundred adults with ADHD in Sweden will be randomly assigned to receive iCBT right away or after a wait…

This study tests a culturally and language-adapted internet-based therapy (i-CBT) for Farsi/Dari-speaking migrants and refugees aged 15-29 who have symptoms of anxiety, depression, grief, or trauma. Participants will receive the therapy over 6-10 weeks, and researchers will compa…

This study is testing whether a type of talk therapy called metacognitive therapy (MCT) can be delivered in a group setting for people with post-traumatic stress disorder (PTSD) in regular psychiatric care. The goal is to see if it is practical and acceptable to patients, and to …

This study tests two digital treatments for children aged 8-17 with chronic stomach pain caused by gut-brain interaction disorders. After a 4-week online education program, participants are randomly assigned to either internet-based cognitive behavioral therapy (iCBT) or gut-dire…

This study reviews medical records of 150 children who had cleft palate surgery. It compares those who received a standard painkiller (morphine) alone to those who also got a nerve block in the cheek area. The goal is to see if the nerve block reduces the need for morphine, lower…

This study tests an online therapy program (CBT) designed to help people who had a heart attack and still feel very anxious about their heart. The goal is to reduce fear, improve quality of life, and encourage physical activity. About 176 adults who had a heart attack at least 6 …

This study compares two ways of giving a lung-opening medicine (surfactant) to premature babies with breathing problems. The newer method uses a soft mask placed in the throat instead of a breathing tube down the windpipe. Researchers want to see if the gentler method works just …

This study tests an online cognitive behavioral therapy program for children aged 8-17 with functional abdominal pain disorders (stomach pain with no clear physical cause). The goal is to see if the therapy can reduce pain and improve daily life. Researchers will also measure how…

This study tests a new anonymous online therapy program called Restory for people with PTSD after sexual abuse. It is designed for 140 adults who have experienced sexual violence at least one month ago. The therapy uses a type of talk therapy done over the internet, and the goal …

This study tests a new, fast-paced therapy for teenagers with PTSD. Instead of weekly sessions over months, teens get a 5-day intensive treatment that combines talk therapy, eye movement therapy, physical activity, and parent support. The goal is to see if this approach is practi…

This study tests a stepped care model for children aged 8-16 who have trouble controlling anger or show defiant or aggressive behavior. It starts with a brief internet-based parenting support program (Step 1). If more help is needed, families can then choose from additional optio…

This study looks at whether giving people with generalized anxiety disorder the power to choose between two internet-based treatments helps them feel better and stick with the program. About 440 adults will either pick their preferred therapy or be assigned one randomly. The goal…

This study tests whether a therapist-guided online cognitive-behavioral therapy (CBT) program can reduce symptoms of body dysmorphic disorder (BDD) in children and teens aged 12-18. About 154 participants will receive the online treatment or a control, with follow-up at 6 months.…

This study tests whether yoga-based exercises, done online or in person, can improve sleep, mood, and quality of life for people with chronic migraine or cluster headache. About 40 adults aged 18-65 with these conditions will participate. The goal is to see if adding yoga to stan…

This study tracks 80 children under 18 with a tracheostomy who need anesthesia for a routine airway exam. Researchers want to find out how often serious complications happen and if certain factors like age or ventilator use raise the risk. The goal is to gather data to make anest…

This study looks at whether doing a repeat kidney biopsy one year after starting treatment for lupus nephritis helps doctors decide if more treatment is needed. About 206 patients with a first episode of lupus nephritis will be randomly assigned to either have a repeat biopsy or …

This study looks at how much pollution and waste come from two ways of treating certain hand fractures: surgery or just letting the bone heal naturally with a splint or tape. Researchers will track 30 adults for a year, measuring things like carbon emissions and trash. The goal i…

This study follows 91 people who had jaw joint surgery (arthroscopy or disc removal) about 10 years ago. Researchers want to see if the improvements seen at 6 months still hold up over the long term, and how the joint changes on X-rays over time. The goal is to understand how sta…

This study will follow 50,000 adults having planned non-cardiac surgery at two hospitals in Sweden. Researchers want to see if how much physical activity people report doing before surgery can help predict complications like infections, heart problems, or death. The goal is to fi…

This study looks at whether putting fruit stands in schools helps students eat more fruit, and if adding a health-awareness campaign makes a bigger difference. About 300 Swedish students aged 7 to 19 will use a phone app to take pictures of their meals and snacks. The goal is to …

This study is testing a screening tool called Start-MSK that helps physiotherapists sort people with muscle or joint pain into low, medium, or high risk for long-term problems. Researchers will follow 300 adults for 6 months to see if the tool can predict who will recover well an…

This study tests whether keeping the thumb in a cast for four weeks after surgery reduces the risk of tendon rupture compared to the standard early active motion therapy. About 380 patients in Sweden will be randomly assigned to one of the two rehab programs. The goal is to find …

This study looks at whether the number of steps a person takes each day (tracked by their phone) is linked to how well they recover after non-cardiac surgery. Researchers will follow 264 adults and measure days spent at home alive within 30 days after surgery. The goal is to see …

This study looks at the best way to treat nerve injuries in the fingers. It compares surgery with wearing a cast. About 166 adults with a cut nerve in one finger will be randomly assigned to one of the two treatments. The main goal is to see how well feeling returns after one yea…

This study looks at how weight loss changes the way people with advanced cancer feel about their bodies. Researchers will survey 800 participants from different countries to understand differences related to gender and location. The goal is to create better, fairer nutrition advi…

This study is observing 600 people to better detect dementia with Lewy bodies (DLB) and its early stages. Researchers will collect medical tests, brain scans, and fluid samples to understand how the disease progresses. The goal is to improve diagnosis and find new treatment targe…

This study looks at how stroke changes the way the brain handles walking while doing another task, like listening or navigating. Researchers will monitor brain activity in 50 stroke survivors as they walk on different paths and respond to sounds. The goal is to better understand …

This study aims to understand how immune cells differ in diabetic patients whose foot ulcers heal versus those whose ulcers do not heal. Researchers will collect blood and tissue samples from 40 participants and analyze the cells using advanced genetic techniques. The goal is to …

This study looks at how the natural microbes and chemical profiles in couples' bodies relate to IVF outcomes. Researchers will collect samples from 1000 couples and track whether they have a baby, miscarriage, or other pregnancy results. The goal is to find patterns that might he…

This observational study looks at how bacteria in the gut and mouth are linked to epilepsy and whether they affect how well seizure medicines work. Researchers will collect stool, saliva, and blood samples from 1,500 people with newly diagnosed epilepsy and healthy controls. By a…

This study looks at children with tracheostomies to see if serious airway problems can be spotted early by symptoms parents or doctors notice. Researchers will compare these symptoms with what a camera inside the airway (endoscopy) finds. The goal is to understand how reliable sy…

This study is looking at whether brain scans (fMRI) can help predict how well people with depression, social anxiety, or insomnia will respond to internet-delivered cognitive behavioral therapy (iCBT). Researchers will compare brain scan data with patients' own reports to see whi…

This study looks at whether internet-based exposure-focused cognitive behavioral therapy (Exp-CBT) can objectively change how people with fibromyalgia experience pain. About 45 participants will undergo pain tests before and after 10 weeks of online therapy. The goal is to unders…

This study looks at whether planning workouts around the menstrual cycle helps female athletes get fitter and stronger. About 111 women who exercise regularly will be placed into different training groups based on their cycle phase. Researchers will measure changes in aerobic fit…

This study looks at how two weeks of simulated low gravity affects the brain's control of movement and muscle health. Twenty-four healthy adults will have one leg unloaded using crutches and a special shoe. Afterward, they walk on a treadmill in lunar gravity during a parabolic f…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This observational study tests whether using computer models to personalize drug doses can help optimize tuberculosis (TB) treatment. About 30 adults with pulmonary TB will have their drug levels measured and doses adjusted early in treatment. The goal is to see if this approach …

This study looks at how red blood cells (RBCs) from people with type 2 diabetes and heart attacks differ from healthy ones. Researchers will test these cells in the lab to see how they affect heart and blood vessel function. The goal is to find new ways to treat heart disease by …

This study explores whether a simple at-home HPV test can help women in war-torn Ukraine get screened for cervical cancer. About 1,000 women aged 30-60 who haven't had a recent negative HPV test will receive a self-sampling kit. The goal is to see if this approach is practical an…

This observational study looks at children under 18 who have a tracheostomy (a breathing tube in the windpipe). Researchers want to find out how common feeding difficulties are in these children and whether those difficulties are linked to their quality of life. The study will in…

This study looks at 90 people with a heart condition called mitral valve prolapse who need surgery to fix a leaky valve. Researchers want to see if the surgery reduces dangerous heart rhythm problems and scarring in the heart muscle. Participants will have heart scans and wear a …

This study looks at 300,000 surgical patients in Stockholm to see how the COVID-19 pandemic impacted their recovery. Researchers will track deaths, complications, and how long people stayed in the hospital. The goal is to understand the pandemic's effects on surgical care, not to…

This study follows 450 people with Parkinson's disease for four years to learn why some become less active and what helps them stay active. Participants wear activity monitors and complete tests and questionnaires. The goal is to identify early warning signs of declining activity…

This study looks at new blood tests to see if they can better measure how well bleeding treatments work in people with hemophilia who have developed inhibitors (antibodies that block standard treatment). About 20 patients will give blood samples before and after receiving bypassi…

This study is testing a new blood test that looks for DNA from the donor heart to catch early signs of rejection in heart transplant patients. Researchers will compare the test results with standard heart biopsies to see if the blood test is accurate. The goal is to make monitori…

This study tests a method called Feedback Informed Treatment (FIT) in social services. 400 people receiving help for issues like substance use, family problems, or housing will regularly rate their progress and the care they get. The goal is to see if this feedback helps prevent …

This study looks at whether beetroot juice, which contains natural nitrates, can safely lower blood pressure in the lungs of people with a serious type of pulmonary embolism (blood clot in the lung). The trial involves 36 adults who will receive either beetroot juice or a placebo…

This study looks at whether a campaign called Choosing Wisely can safely reduce unnecessary tests and treatments in intensive care units (ICUs). About 10,000 adult patients in Swedish ICUs will take part. The goal is to see if this approach lowers costs and improves care without …