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Could Hands-Only CPR be just as good as standard CPR?

NCT ID NCT03981107

Disease control Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two types of CPR for people who have a cardiac arrest outside a hospital: hands-only CPR (chest compressions without rescue breaths) versus standard CPR (compressions plus rescue breaths). The trial will include over 3,000 adults whose cardiac arrest is witnessed and who have a bystander with prior CPR training. The goal is to see if hands-only CPR is at least as effective as standard CPR at helping people survive for 30 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Chest compression only CPR (hands-only CPR)
What this could lead to
If hands-only CPR works as well as standard CPR, it could simplify training and encourage more bystanders to act, potentially saving more lives from cardiac arrest.
What could go wrong
This is a large trial, but it only includes trained bystanders and witnessed arrests. Results may not apply to all situations, and hands-only CPR might be less effective for certain causes of cardiac arrest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 3,260 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2017

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Unconsciousness with no, abnormal or agonal breathing (suspected OHCA) * The suspected OHCA is witnessed (seen or heard) * Any Bystander at the scene has previous training in CPR Exclusion Criteria: * Age below 18 years * Collapse is not witnessed * Bystander has no prior CPR training * Obvious asphyxia (i.e. hanging, foreign body, suffocation, strangulation) * Obvious drug overdose / intoxication * Pregnancy * Trauma (penetrating, blunt, burn injury) Post randomisation exclusion Criteria from data analysis: * Not EMS-verified cardiac arrest * Previous do not resuscitate (DNR) decision

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest Cardiopulmonary resuscitation Out-of-hospital cardiac arrest

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AREU, Agenzia Regionale Emergenza Urgenza

    RECRUITING

    Bergamo, Italy

  • SOS Alarm AB

    RECRUITING

    Stockholm, Sweden

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