Can a computer help heal trauma? new study tests blended therapy for PTSD
NCT ID NCT05758987
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares a new type of therapy that combines computer exercises with therapist sessions (blended CBT) to standard prolonged exposure therapy for PTSD. About 160 adults with PTSD will receive one of the two treatments at outpatient clinics in Sweden. The goal is to see if the new approach is just as effective at reducing PTSD symptoms.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 160 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2023
- Expected to finish
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Oct 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * PTSD according to Diagnostic and Statistical Manual of mental disorders 5 as primary problem * ≥ 18 years * Basic knowledge of speaking and writing Swedish * No other psychological treatment at the same time * No ongoing threats or violence * If antidepressant medication, stable dose 6 weeks before starting treatment * Have access to the internet and a computer * Willingness/ability to participate after receiving information about what participation entails Exclusion Criteria: * Other diagnosis or problem is assessed as primary to PTSD * Moderate to severe suicidal risk * PTSD from childhood trauma that the person cannot remember
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Karolinska Institutet
RECRUITINGStockholm, Sweden
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a therapist on a screen ease both trauma and pain?
- Zapping the Brain's fear hub: a new hope for PTSD?
- Can a drug combo or therapy dogs ease PTSD?
- Can six short writing sessions ease PTSD in underserved patients?
- Can a psychedelic compound help veterans and first responders with PTSD and alcohol use disorder?