Second look inside the kidney: could repeat biopsies improve lupus care?
NCT ID NCT04449991
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 42 times
Summary
This study looks at whether doing a repeat kidney biopsy one year after starting treatment for lupus nephritis helps doctors decide if more treatment is needed. About 206 patients with a first episode of lupus nephritis will be randomly assigned to either have a repeat biopsy or not. The goal is to see if the biopsy group has better kidney function and fewer relapses over the next few years.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Karolinska University Hospital
RECRUITINGStockholm, 17676, Sweden
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could show that repeat biopsies help doctors tailor treatment to reduce kidney damage and improve long-term kidney function in lupus nephritis patients.
What could go wrong
This is an early-stage observational study, not a treatment trial. The biopsy is a procedure with risks like bleeding or infection, and the benefit of repeat biopsies is not yet proven.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.