Karolinska Institutet

This early-stage study tested a new DNA vaccine called N-pVAX1 to see if it is safe and can trigger an immune response against Crimean-Congo hemorrhagic fever, a serious viral disease. Fifteen healthy adults received three doses of the vaccine through the skin with a mild electri…

This study compares two common surgeries for thumb arthritis: total joint replacement (arthroplasty) and trapeziectomy (removing a small bone). Researchers will analyze data from 1,000 patients aged 45 and older to see which surgery provides better pain relief and function after …

This pilot study tested whether giving two quick defibrillation shocks instead of one could help people whose hearts stop suddenly outside a hospital. Researchers enrolled 40 adults with a shockable heart rhythm who did not respond to the first shock. The goal was to see if this …

This study tested an online self-management program designed to help people with multiple sclerosis prevent falls. The program was developed with input from patients and covers various fall risk factors. 45 adults with MS participated to see if the program was easy to use and hel…

This study tested whether having a dental professional clean the teeth of older adults in their own homes every three months, combined with a special high-fluoride toothpaste, could prevent root cavities. The study included 194 adults aged 65 and older who needed daily care. Rese…

This pilot study tested whether small ventral hernias (belly button or upper abdomen) can be safely repaired in an outpatient clinic using only local anesthesia, instead of in a full operating room. 37 adults with small hernias (less than 2 cm) underwent the procedure. The goal w…

This study tested a digital group program called 'Fewer Falls in MS' to help people with multiple sclerosis prevent falls. 240 participants who had fallen in the past year took part. The program included weekly online sessions and home exercises. Researchers compared fall rates a…

This study tested two early treatments for stress-related ill-health in primary care: a nurse-led collaborative care program and therapist-guided self-help CBT. 172 adults with mild-to-moderate stress symptoms took part. The goal was to see if the simpler nurse-led approach works…

This study tested whether spinal manipulation therapy, combined with stretching, can reduce neck pain and affect heart rate variability in 131 adults with long-term neck pain. Participants were randomly assigned to receive either spinal manipulation plus stretching or stretching …

This study tested whether an online reading game called Grapholearn helps Swedish children with developmental language disorder (DLD) improve their reading skills. 67 children played the game for 5 weeks, and their progress was compared to children who played a math game or atten…

This study tested whether scented nose plugs make smell training more effective for people with a reduced sense of smell after a viral infection like COVID-19. 120 adults with hyposmia were split into two groups: one did regular smell training, the other used scented nose plugs. …

This study tested a culturally adapted online therapy (iCBT) for Arabic-speaking refugee and migrant youth aged 15-29 with symptoms of anxiety, depression, insomnia, grief, and trauma. 125 participants were randomly assigned to receive the therapy or be in a control group. The go…

This study looked at whether a special breathing muscle training program could help people with long COVID who have weak breathing muscles. 44 adults who had COVID-19 and weak inspiratory muscles were assigned to either do breathing exercises plus physical exercise, or just physi…

This study tested an internet-based cognitive behavior therapy (CBT) program for people with stress-related disorders like adjustment disorder or exhaustion disorder. 300 adults in Sweden participated, and the program was compared to an active control group. The goal was to see i…

This study tested if listening to hypnotherapy audio files can help children and teens with stomach pain and bowel problems linked to stress. 32 participants used the audio treatment at home. The goal was to see if this approach is practical and effective, potentially offering a …

This study looked at over 121,000 procedures to remove gallstones from the bile duct using a scope (ERCP). Researchers wanted to see if the level of sedation given during the procedure affected whether stones were left behind. They found that deeper sedation might help the doctor…

This study in Cameroon followed 406 adults with and without type 2 diabetes for one year to see if diabetes raises the risk of malaria and other parasitic infections. Researchers tested blood and stool samples at four time points. The goal was to understand how diabetes and relat…

This study worked with 49 stroke patients, their families, and healthcare teams to design and test a more personalized way to move from the hospital to home rehabilitation. The goal was to improve the quality of care transitions and health literacy. The study did not test a treat…

This completed study tested whether a dissolved birch pollen allergy tablet (Itulazax) can be used as a nasal spray to confirm birch pollen allergy. 89 adults with birch pollen allergy received the spray and a placebo spray to see if it caused typical allergy symptoms like sneezi…

This study compared two versions of a standard health questionnaire (EQ-5D-3L and EQ-5D-5L) in nearly 7,000 people with inflammatory joint diseases like rheumatoid arthritis and ankylosing spondylitis. Participants completed both surveys during routine visits, and researchers che…

This study tested a program to help people with stroke or TIA transition from hospital to home. 213 participants received either the program or usual care. The program focused on improving communication, health literacy, and medication management. Researchers measured quality of …

This study tested an electronic alert system that reminds doctors to screen, monitor, and refer patients with chronic kidney disease (CKD). It involved 66 primary care centers in Stockholm, covering about 780,000 people. The goal was to see if the system improves detection and ma…

This study looked at how much children with hearing loss and their caregivers understand about what caused the hearing loss. Researchers asked 156 participants to fill out questionnaires about the type and cause of their hearing loss and whether knowing the cause matters to them.…

This study looked at how well a new dialysis solution works compared to the usual one in people with kidney failure who are on peritoneal dialysis. Seven stable patients each tried both solutions during a single 4-hour session. The goal was to measure fluid removal and changes in…

This study examined whether taking statins (cholesterol-lowering drugs) before major non-cardiac surgery helps patients live longer and recover faster. Researchers tracked 70,000 adults who had elective surgery, comparing those on statins to those not. The goal was to see if stat…

This study analyzed data from over 257,000 Swedish men aged 75-79 to see if PSA-based screening improves survival. Since no clinical trials have focused on this age group, researchers used past medical records to compare men who were screened with those who were not. The goal is …

This small study tested whether adding exercise (stationary biking) to standard sensory training could improve sensation and reduce pain after nerve injuries in the arm or hand. Seven adults who had a nerve injury between 2010 and 2025 took part. The goal was to see if this appro…

This study checked if children and teens with obesity who used a digi-physical treatment tool (daily home measurements) later developed eating problems like binge eating or anorexia. Researchers reviewed medical records of 312 patients at a Swedish hospital. The goal was to see h…