Karolinska Institutet

This early-stage study tested a new DNA vaccine called N-pVAX1 in 15 healthy adults to see if it is safe and can trigger an immune response against Crimean-Congo hemorrhagic fever (CCHF), a severe viral disease. Participants received three doses of the vaccine over 12 weeks. The …

This study tested whether having a dental professional clean the teeth of older adults in their own homes every three months, combined with using a high-fluoride toothpaste daily, could prevent root cavities. The study included 194 adults aged 65 and older who needed help with da…

This study tested whether a nasal spray made from dissolved Itulazax tablets can reliably diagnose birch pollen allergy. 89 adults with birch allergy received the spray, and researchers measured nasal symptoms and airflow to confirm allergic reactions. The goal is to replace an o…

This study tested a culturally adapted online therapy (iCBT) for Arabic-speaking refugee and migrant youth aged 15-29 who had symptoms of anxiety, depression, insomnia, grief, or stress. 125 participants were randomly assigned to receive the therapy or be in a control group. The …

This study tested whether an online reading game called Grapholearn helps Swedish children with developmental language disorder (DLD) improve their reading skills. 67 children from special schools played the game or did usual activities. The goal was to see if the game could boos…

This study tested a digital group program called 'Fewer Falls in MS' for people with multiple sclerosis who had fallen in the past year. 240 participants either joined the 8-session online program or received a fall prevention brochure. The program aimed to reduce falls and impro…

This study tested whether children and teens with stomach pain or irritable bowel syndrome could benefit from listening to hypnotherapy audio files at home. 32 participants used the recordings to help calm the connection between their brain and gut. The goal was to see if this ap…

This study tested whether small belly hernias can be safely repaired in a regular clinic room using local anesthesia, instead of in a full operating room. 37 adults with small hernias took part. The approach was found to be safe, with good pain control and high patient satisfacti…

This study looked at how spinal manipulative therapy (like chiropractic adjustments) affects heart rate variability and pain sensitivity in 131 adults with long-term or recurring neck pain. Researchers also tested a new way to measure the body's natural pain control system. The g…

This study checked if children and teens with obesity who used a special treatment tool (combining digital and in-person care) were at risk for developing eating disorders like anorexia or binge eating. Researchers looked at medical records of 312 patients to see if any showed si…

This study looked at whether adults with type 2 diabetes are more likely to get malaria and other parasitic infections than people without diabetes. Researchers in Cameroon followed 406 participants for one year, testing blood and stool samples at four visits. The goal was to und…

This study examined whether PSA blood tests for prostate cancer improve survival in men aged 75-79. Researchers analyzed data from over 257,000 Swedish men without prior prostate cancer, comparing those who were screened to those who were not. The goal was to see if screening red…

This study examined over 121,000 ERCP procedures for gallstone removal to see if the level of sedation affects how well the stones are cleared. Researchers found that deeper sedation may help doctors remove stones more successfully the first time. The goal was to learn which seda…

This study tested a personalized care transition support for 213 people who had a stroke or TIA and were leaving the hospital. The goal was to see if this support improved how patients experienced their care transition, their understanding of health information, and their ability…